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Items: 1 to 50 of 139

1.

Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease.

Rodinova M, Krizova J, Stufkova H, Bohuslavova B, Askeland G, Dosoudilova Z, Juhas S, Juhasova J, Ellederova Z, Zeman J, Eide L, Motlik J, Hansikova H.

Dis Model Mech. 2019 Jul 26;12(7). pii: dmm038737. doi: 10.1242/dmm.038737.

2.

Age-Related Oxidative Changes in Primary Porcine Fibroblasts Expressing Mutated Huntingtin.

Smatlikova P, Askeland G, Vaskovicova M, Klima J, Motlik J, Eide L, Ellederová Z.

Neurodegener Dis. 2019;19(1):22-34. doi: 10.1159/000500091. Epub 2019 Jun 5.

PMID:
31167196
3.

The identification of small molecules that stimulate retinal pigment epithelial cells: potential novel therapeutic options for treating retinopathies.

Artero-Castro A, Popelka S, Jendelova P, Motlik J, Ardan T, Rodriguez Jimenez FJ, Erceg S.

Expert Opin Drug Discov. 2019 Feb;14(2):169-177. doi: 10.1080/17460441.2019.1559148. Epub 2019 Jan 8.

PMID:
30616395
4.

Adipogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells in Pig Transgenic Model Expressing Human Mutant Huntingtin.

Smatlikova P, Juhas S, Juhasova J, Suchy T, Hubalek Kalbacova M, Ellederova Z, Motlik J, Klima J.

J Huntingtons Dis. 2019;8(1):33-51. doi: 10.3233/JHD-180303.

PMID:
30584151
5.

Vocalisation as a Viable Assessment for Phenotyping Minipigs Transgenic for the Huntington Gene?

Rieke L, Schubert R, Matheis T, Muratori LM, Motlik J, Schramke S, Fels M, Kemper N, Schuldenzucker V, Reilmann R.

J Huntingtons Dis. 2018;7(3):269-278. doi: 10.3233/JHD-170284.

PMID:
30103340
6.

AAV5-miHTT Gene Therapy Demonstrates Broad Distribution and Strong Human Mutant Huntingtin Lowering in a Huntington's Disease Minipig Model.

Evers MM, Miniarikova J, Juhas S, Vallès A, Bohuslavova B, Juhasova J, Skalnikova HK, Vodicka P, Valekova I, Brouwers C, Blits B, Lubelski J, Kovarova H, Ellederova Z, van Deventer SJ, Petry H, Motlik J, Konstantinova P.

Mol Ther. 2018 Sep 5;26(9):2163-2177. doi: 10.1016/j.ymthe.2018.06.021. Epub 2018 Jun 25.

7.

Gradual Phenotype Development in Huntington Disease Transgenic Minipig Model at 24 Months of Age.

Vidinská D, Vochozková P, Šmatlíková P, Ardan T, Klíma J, Juhás Š, Juhásová J, Bohuslavová B, Baxa M, Valeková I, Motlík J, Ellederová Z.

Neurodegener Dis. 2018;18(2-3):107-119. doi: 10.1159/000488592. Epub 2018 Jun 5.

PMID:
29870995
8.

Behavioral Assessment of Stress Compensation in Minipigs Transgenic for the Huntington Gene Using Cortisol Levels: A Proof-of-Concept Study.

Schuldenzucker V, Schubert R, Muratori LM, Freisfeld F, Rieke L, Matheis T, Schramke S, Motlik J, Kemper N, Radespiel U, Reilmann R.

J Huntingtons Dis. 2018;7(2):151-161. doi: 10.3233/JHD-180285.

PMID:
29843247
9.

Supporting youth wellbeing with a focus on eating well and being active: views from an Aboriginal community deliberative forum.

Street J, Cox H, Lopes E, Motlik J, Hanson L.

Aust N Z J Public Health. 2018 Apr;42(2):127-132. doi: 10.1111/1753-6405.12763. Epub 2018 Feb 14.

PMID:
29442406
10.

Behavioral testing of minipigs transgenic for the Huntington gene-A three-year observational study.

Schuldenzucker V, Schubert R, Muratori LM, Freisfeld F, Rieke L, Matheis T, Schramke S, Motlik J, Kemper N, Radespiel U, Reilmann R.

PLoS One. 2017 Oct 9;12(10):e0185970. doi: 10.1371/journal.pone.0185970. eCollection 2017.

11.

Mitochondrial Metabolism in a Large-Animal Model of Huntington Disease: The Hunt for Biomarkers in the Spermatozoa of Presymptomatic Minipigs.

Krizova J, Stufkova H, Rodinova M, Macakova M, Bohuslavova B, Vidinska D, Klima J, Ellederova Z, Pavlok A, Howland DS, Zeman J, Motlik J, Hansikova H.

Neurodegener Dis. 2017;17(4-5):213-226. doi: 10.1159/000475467. Epub 2017 Jun 21.

PMID:
28633139
12.

Reduced Levels of Tissue Inhibitors of Metalloproteinases in UVB-Irradiated Corneal Epithelium.

Ardan T, Němcová L, Bohuslavová B, Klezlová A, Popelka Š, Studenovská H, Hrnčiarová E, Čejková J, Motlík J.

Photochem Photobiol. 2016 Sep;92(5):720-7. doi: 10.1111/php.12612. Epub 2016 Aug 25.

PMID:
27317620
13.

Revelation of the IFNα, IL-10, IL-8 and IL-1β as promising biomarkers reflecting immuno-pathological mechanisms in porcine Huntington's disease model.

Valekova I, Jarkovska K, Kotrcova E, Bucci J, Ellederova Z, Juhas S, Motlik J, Gadher SJ, Kovarova H.

J Neuroimmunol. 2016 Apr 15;293:71-81. doi: 10.1016/j.jneuroim.2016.02.012. Epub 2016 Feb 20.

PMID:
27049565
14.

Mutated Huntingtin Causes Testicular Pathology in Transgenic Minipig Boars.

Macakova M, Bohuslavova B, Vochozkova P, Pavlok A, Sedlackova M, Vidinska D, Vochyanova K, Liskova I, Valekova I, Baxa M, Ellederova Z, Klima J, Juhas S, Juhasova J, Klouckova J, Haluzik M, Klempir J, Hansikova H, Spacilova J, Collins R, Blumenthal I, Talkowski M, Gusella JF, Howland DS, DiFiglia M, Motlik J.

Neurodegener Dis. 2016;16(3-4):245-59. doi: 10.1159/000443665. Epub 2016 Mar 10.

PMID:
26959244
15.

DNA damage response during mouse oocyte maturation.

Mayer A, Baran V, Sakakibara Y, Brzakova A, Ferencova I, Motlik J, Kitajima TS, Schultz RM, Solc P.

Cell Cycle. 2016;15(4):546-58. doi: 10.1080/15384101.2015.1128592. Epub 2016 Jan 8.

16.

Behavioral phenotyping of minipigs transgenic for the Huntington gene.

Schramke S, Schuldenzucker V, Schubert R, Frank F, Wirsig M, Ott S, Motlik J, Fels M, Kemper N, Hölzner E, Reilmann R.

J Neurosci Methods. 2016 May 30;265:34-45. doi: 10.1016/j.jneumeth.2015.11.013. Epub 2015 Dec 11.

PMID:
26688470
17.

Neuroimaging of a minipig model of Huntington's disease: Feasibility of volumetric, diffusion-weighted and spectroscopic assessments.

Schubert R, Frank F, Nagelmann N, Liebsch L, Schuldenzucker V, Schramke S, Wirsig M, Johnson H, Kim EY, Ott S, Hölzner E, Demokritov SO, Motlik J, Faber C, Reilmann R.

J Neurosci Methods. 2016 May 30;265:46-55. doi: 10.1016/j.jneumeth.2015.11.017. Epub 2015 Dec 1.

PMID:
26658298
18.

Minipig model of Huntington's disease: ¹H magnetic resonance spectroscopy of the brain.

Jozefovicova M, Herynek V, Jiru F, Dezortova M, Juhasova J, Juhas S, Motlik J, Hajek M.

Physiol Res. 2016;65(1):155-63. Epub 2015 Nov 24.

19.

Multiple requirements of PLK1 during mouse oocyte maturation.

Solc P, Kitajima TS, Yoshida S, Brzakova A, Kaido M, Baran V, Mayer A, Samalova P, Motlik J, Ellenberg J.

PLoS One. 2015 Feb 6;10(2):e0116783. doi: 10.1371/journal.pone.0116783. eCollection 2015.

20.

Time course of spinal doublecortin expression in developing rat and porcine spinal cord: implication in in vivo neural precursor grafting studies.

Juhasova J, Juhas S, Hruska-Plochan M, Dolezalova D, Holubova M, Strnadel J, Marsala S, Motlik J, Marsala M.

Cell Mol Neurobiol. 2015 Jan;35(1):57-70. doi: 10.1007/s10571-014-0145-7. Epub 2014 Dec 9.

PMID:
25487013
21.

Challenges of Huntington's disease and quest for therapeutic biomarkers.

Kotrcova E, Jarkovska K, Valekova I, Zizkova M, Motlik J, Gadher SJ, Kovarova H.

Proteomics Clin Appl. 2015 Feb;9(1-2):147-58. doi: 10.1002/prca.201400073. Epub 2014 Nov 2. Review.

PMID:
25290828
22.

Multiplex immunoassays for quantification of cytokines, growth factors, and other proteins in stem cell communication.

Valekova I, Skalnikova HK, Jarkovska K, Motlik J, Kovarova H.

Methods Mol Biol. 2015;1212:39-63. doi: 10.1007/7651_2014_94.

PMID:
25063502
23.

Revelation of fibroblast protein commonalities and differences and their possible roles in wound healing and tumourigenesis using co-culture models of cells.

Jarkovska K, Dvorankova B, Halada P, Kodet O, Szabo P, Gadher SJ, Motlik J, Kovarova H, Smetana K Jr.

Biol Cell. 2014 Jul;106(7):203-18. doi: 10.1111/boc.201400014. Epub 2014 May 26.

PMID:
24698078
24.

Pig models of neurodegenerative disorders: Utilization in cell replacement-based preclinical safety and efficacy studies.

Dolezalova D, Hruska-Plochan M, Bjarkam CR, Sørensen JC, Cunningham M, Weingarten D, Ciacci JD, Juhas S, Juhasova J, Motlik J, Hefferan MP, Hazel T, Johe K, Carromeu C, Muotri A, Bui J, Strnadel J, Marsala M.

J Comp Neurol. 2014 Aug 15;522(12):2784-801. doi: 10.1002/cne.23575. Epub 2014 Apr 12. Review.

PMID:
24610493
25.

Effective long-term immunosuppression in rats by subcutaneously implanted sustained-release tacrolimus pellet: effect on spinally grafted human neural precursor survival.

Sevc J, Goldberg D, van Gorp S, Leerink M, Juhas S, Juhasova J, Marsala S, Hruska-Plochan M, Hefferan MP, Motlik J, Rypacek F, Machova L, Kakinohana O, Santucci C, Johe K, Lukacova N, Yamada K, Bui JD, Marsala M.

Exp Neurol. 2013 Oct;248:85-99. doi: 10.1016/j.expneurol.2013.05.017. Epub 2013 Jun 5.

PMID:
23748136
26.

A cell-free nanofiber composite scaffold regenerated osteochondral defects in miniature pigs.

Filová E, Rampichová M, Litvinec A, Držík M, Míčková A, Buzgo M, Košťáková E, Martinová L, Usvald D, Prosecká E, Uhlík J, Motlík J, Vajner L, Amler E.

Int J Pharm. 2013 Apr 15;447(1-2):139-49. doi: 10.1016/j.ijpharm.2013.02.056. Epub 2013 Mar 7.

PMID:
23499757
27.

Single loop-and-clips technique (KING closure) for gastrotomy closure after transgastric ovariectomy: a survival experiment.

Ryska O, Martinek J, Filipkova T, Dolezel R, Juhasova J, Motlik J, Zavoral M, Ryska M.

Wideochir Inne Tech Maloinwazyjne. 2012 Dec;7(4):233-9. doi: 10.5114/wiitm.2011.28870. Epub 2012 Jun 25.

28.

A transgenic minipig model of Huntington's Disease.

Baxa M, Hruska-Plochan M, Juhas S, Vodicka P, Pavlok A, Juhasova J, Miyanohara A, Nejime T, Klima J, Macakova M, Marsala S, Weiss A, Kubickova S, Musilova P, Vrtel R, Sontag EM, Thompson LM, Schier J, Hansikova H, Howland DS, Cattaneo E, DiFiglia M, Marsala M, Motlik J.

J Huntingtons Dis. 2013;2(1):47-68. doi: 10.3233/JHD-130001.

PMID:
25063429
29.

Comparing over-the-scope clip versus endoloop and clips (KING closure) for access site closure: a randomized experimental study.

Martínek J, Ryska O, Tuckova I, Filípková T, Doležel R, Juhas S, Motlík J, Zavoral M, Ryska M.

Surg Endosc. 2013 Apr;27(4):1203-10. doi: 10.1007/s00464-012-2576-x. Epub 2012 Oct 17.

PMID:
23073683
30.

Upregulation of IL-6, IL-8 and CXCL-1 production in dermal fibroblasts by normal/malignant epithelial cells in vitro: Immunohistochemical and transcriptomic analyses.

Kolář M, Szabo P, Dvořánková B, Lacina L, Gabius HJ, Strnad H, Sáchová J, Vlček C, Plzák J, Chovanec M, Cada Z, Betka J, Fík Z, Pačes J, Kovářová H, Motlík J, Jarkovská K, Smetana K Jr.

Biol Cell. 2012 Dec;104(12):738-51. doi: 10.1111/boc.201200018.

PMID:
23043537
31.

Survival and differentiation of human embryonic stem cell-derived neural precursors grafted spinally in spinal ischemia-injured rats or in naive immunosuppressed minipigs: a qualitative and quantitative study.

Kakinohana O, Juhasova J, Juhas S, Motlik J, Platoshyn O, Galik J, Hefferan M, Yuan SH, Vidal JG, Carson CT, van Gorp S, Goldberg D, Leerink M, Lazar P, Marsala S, Miyanohara A, Keshavarzi S, Ciacci JD, Marsala M.

Cell Transplant. 2012;21(12):2603-19. doi: 10.3727/096368912X653200. Epub 2012 Aug 10.

PMID:
22889456
32.

Aurora kinase A drives MTOC biogenesis but does not trigger resumption of meiosis in mouse oocytes matured in vivo.

Solc P, Baran V, Mayer A, Bohmova T, Panenkova-Havlova G, Saskova A, Schultz RM, Motlik J.

Biol Reprod. 2012 Oct 11;87(4):85. doi: 10.1095/biolreprod.112.101014. Print 2012 Oct.

33.

Natural orifice transluminal endoscopic surgery vs laparoscopic ovariectomy: complications and inflammatory response.

Martínek J, Ryska O, Filípková T, Doležel R, Juhas S, Motlík J, Holubová M, Nosek V, Rotnáglová B, Zavoral M, Ryska M.

World J Gastroenterol. 2012 Jul 21;18(27):3558-64. doi: 10.3748/wjg.v18.i27.3558.

34.

Combinational spinal GAD65 gene delivery and systemic GABA-mimetic treatment for modulation of spasticity.

Kakinohana O, Hefferan MP, Miyanohara A, Nejime T, Marsala S, Juhas S, Juhasova J, Motlik J, Kucharova K, Strnadel J, Platoshyn O, Lazar P, Galik J, Vinay L, Marsala M.

PLoS One. 2012;7(1):e30561. doi: 10.1371/journal.pone.0030561. Epub 2012 Jan 23.

35.

Chronic spinal compression model in minipigs: a systematic behavioral, qualitative, and quantitative neuropathological study.

Navarro R, Juhas S, Keshavarzi S, Juhasova J, Motlik J, Johe K, Marsala S, Scadeng M, Lazar P, Tomori Z, Schulteis G, Beattie M, Ciacci JD, Marsala M.

J Neurotrauma. 2012 Feb 10;29(3):499-513. doi: 10.1089/neu.2011.2076. Epub 2012 Jan 13.

36.

Analysis of marker expression in porcine cell lines derived from blastocysts produced in vitro and in vivo.

Vackova I, Novakova Z, Krylov V, Okada K, Kott T, Fulka H, Motlik J.

J Reprod Dev. 2011 Oct;57(5):594-603. Epub 2011 Jun 17.

37.

The role of RanGTP gradient in vertebrate oocyte maturation.

Kaláb P, Solc P, Motlík J.

Results Probl Cell Differ. 2011;53:235-67. doi: 10.1007/978-3-642-19065-0_12. Review.

PMID:
21630149
38.

Frequency of aneuploidy related to age in porcine oocytes.

Hornak M, Jeseta M, Musilova P, Pavlok A, Kubelka M, Motlik J, Rubes J, Anger M.

PLoS One. 2011 Apr 27;6(4):e18892. doi: 10.1371/journal.pone.0018892.

39.

Osteogenic differentiation of miniature pig mesenchymal stem cells in 2D and 3D environment.

Juhásová J, Juhás S, Klíma J, Strnádel J, Holubová M, Motlík J.

Physiol Res. 2011;60(3):559-71. Epub 2011 Mar 14.

40.

Mapping of the secretome of primary isolates of mammalian cells, stem cells and derived cell lines.

Skalnikova H, Motlik J, Gadher SJ, Kovarova H.

Proteomics. 2011 Feb;11(4):691-708. doi: 10.1002/pmic.201000402. Epub 2011 Jan 17. Review.

PMID:
21241017
41.

Fibrin/hyaluronic acid composite hydrogels as appropriate scaffolds for in vivo artificial cartilage implantation.

Rampichová M, Filová E, Varga F, Lytvynets A, Prosecká E, Koláčná L, Motlík J, Nečas A, Vajner L, Uhlík J, Amler E.

ASAIO J. 2010 Nov-Dec;56(6):563-8. doi: 10.1097/MAT.0b013e3181fcbe24.

PMID:
20966745
42.

Prophase I arrest and progression to metaphase I in mouse oocytes: comparison of resumption of meiosis and recovery from G2-arrest in somatic cells.

Solc P, Schultz RM, Motlik J.

Mol Hum Reprod. 2010 Sep;16(9):654-64. doi: 10.1093/molehr/gaq034. Epub 2010 May 7. Review.

43.

Analysis of dosing regimen and reproducibility of intraspinal grafting of human spinal stem cells in immunosuppressed minipigs.

Usvald D, Vodicka P, Hlucilova J, Prochazka R, Motlik J, Kuchorova K, Johe K, Marsala S, Scadeng M, Kakinohana O, Navarro R, Santa M, Hefferan MP, Yaksh TL, Marsala M.

Cell Transplant. 2010;19(9):1103-22. doi: 10.3727/096368910X503406. Epub 2010 Apr 21.

PMID:
20412634
44.

Synthetic poly(amino acid) hydrogels with incorporated cell-adhesion peptides for tissue engineering.

Studenovská H, Vodicka P, Proks V, Hlucilová J, Motlík J, Rypácek F.

J Tissue Eng Regen Med. 2010 Aug;4(6):454-63. doi: 10.1002/term.256.

PMID:
20084624
45.

AKT (protein kinase B) is implicated in meiotic maturation of porcine oocytes.

Kalous J, Kubelka M, Solc P, Susor A, Motlík J.

Reproduction. 2009 Oct;138(4):645-54. doi: 10.1530/REP-08-0461. Epub 2009 Jul 24.

PMID:
19633130
46.

Response of ependymal progenitors to spinal cord injury or enhanced physical activity in adult rat.

Cizkova D, Nagyova M, Slovinska L, Novotna I, Radonak J, Cizek M, Mechirova E, Tomori Z, Hlucilova J, Motlik J, Sulla I Jr, Vanicky I.

Cell Mol Neurobiol. 2009 Sep;29(6-7):999-1013. doi: 10.1007/s10571-009-9387-1. Epub 2009 Apr 7.

PMID:
19350385
47.

Differential regulation of galectin expression/reactivity during wound healing in porcine skin and in cultures of epidermal cells with functional impact on migration.

Klíma J, Lacina L, Dvoránková B, Herrmann D, Carnwath JW, Niemann H, Kaltner H, André S, Motlík J, Gabius HJ, Smetana K Jr.

Physiol Res. 2009;58(6):873-84. Epub 2008 Dec 17.

48.

Protein signaling pathways in differentiation of neural stem cells.

Skalnikova H, Vodicka P, Pelech S, Motlik J, Gadher SJ, Kovarova H.

Proteomics. 2008 Nov;8(21):4547-59. doi: 10.1002/pmic.200800096.

PMID:
18837464
49.

Aurora kinase A controls meiosis I progression in mouse oocytes.

Saskova A, Solc P, Baran V, Kubelka M, Schultz RM, Motlik J.

Cell Cycle. 2008 Aug;7(15):2368-76. Epub 2008 May 29.

50.

CDC25A phosphatase controls meiosis I progression in mouse oocytes.

Solc P, Saskova A, Baran V, Kubelka M, Schultz RM, Motlik J.

Dev Biol. 2008 May 1;317(1):260-9. doi: 10.1016/j.ydbio.2008.02.028. Epub 2008 Mar 4.

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