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Serum Polyunsaturated Fatty Acids Correlate with Serum Cytokines and Clinical Disease Activity in Crohn's Disease.

Scoville EA, Allaman MM, Adams DW, Motley AK, Peyton SC, Ferguson SL, Horst SN, Williams CS, Beaulieu DB, Schwartz DA, Wilson KT, Coburn LA.

Sci Rep. 2019 Feb 27;9(1):2882. doi: 10.1038/s41598-019-39232-z.


Alterations in Lipid, Amino Acid, and Energy Metabolism Distinguish Crohn's Disease from Ulcerative Colitis and Control Subjects by Serum Metabolomic Profiling.

Scoville EA, Allaman MM, Brown CT, Motley AK, Horst SN, Williams CS, Koyama T, Zhao Z, Adams DW, Beaulieu DB, Schwartz DA, Wilson KT, Coburn LA.

Metabolomics. 2018 Jan;14(1):17. doi: 10.1007/s11306-017-1311-y. Epub 2017 Dec 29.


The Presence of Diabetes and Higher HbA1c Are Independently Associated With Adverse Outcomes After Surgery.

Yong PH, Weinberg L, Torkamani N, Churilov L, Robbins RJ, Ma R, Bellomo R, Lam QT, Burns JD, Hart GK, Lew JF, Mårtensson J, Story D, Motley AN, Johnson D, Zajac JD, Ekinci EI.

Diabetes Care. 2018 Jun;41(6):1172-1179. doi: 10.2337/dc17-2304. Epub 2018 Mar 26.


Reevaluation of the role of Pex1 and dynamin-related proteins in peroxisome membrane biogenesis.

Motley AM, Galvin PC, Ekal L, Nuttall JM, Hettema EH.

J Cell Biol. 2015 Dec 7;211(5):1041-56. doi: 10.1083/jcb.201412066.


Selenium deficiency occurs in some patients with moderate-to-severe cirrhosis and can be corrected by administration of selenate but not selenomethionine: a randomized controlled trial.

Burk RF, Hill KE, Motley AK, Byrne DW, Norsworthy BK.

Am J Clin Nutr. 2015 Nov;102(5):1126-33. doi: 10.3945/ajcn.115.110932. Epub 2015 Oct 14.


Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage.

Barrett CW, Reddy VK, Short SP, Motley AK, Lintel MK, Bradley AM, Freeman T, Vallance J, Ning W, Parang B, Poindexter SV, Fingleton B, Chen X, Washington MK, Wilson KT, Shroyer NF, Hill KE, Burk RF, Williams CS.

J Clin Invest. 2015 Jul 1;125(7):2646-60. doi: 10.1172/JCI76099. Epub 2015 Jun 8.


Selenoprotein P is the major selenium transport protein in mouse milk.

Hill KE, Motley AK, Winfrey VP, Burk RF.

PLoS One. 2014 Jul 28;9(7):e103486. doi: 10.1371/journal.pone.0103486. eCollection 2014.


Selenoprotein P and apolipoprotein E receptor-2 interact at the blood-brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration.

Burk RF, Hill KE, Motley AK, Winfrey VP, Kurokawa S, Mitchell SL, Zhang W.

FASEB J. 2014 Aug;28(8):3579-88. doi: 10.1096/fj.14-252874. Epub 2014 Apr 23.


Deficiency of the exportomer components Pex1, Pex6, and Pex15 causes enhanced pexophagy in Saccharomyces cerevisiae.

Nuttall JM, Motley AM, Hettema EH.

Autophagy. 2014 May;10(5):835-45. doi: 10.4161/auto.28259. Epub 2014 Mar 18.


Sepp1(UF) forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1.

Kurokawa S, Eriksson S, Rose KL, Wu S, Motley AK, Hill S, Winfrey VP, McDonald WH, Capecchi MR, Atkins JF, Arnér ES, Hill KE, Burk RF.

Free Radic Biol Med. 2014 Apr;69:67-76. doi: 10.1016/j.freeradbiomed.2014.01.010. Epub 2014 Jan 14.


Intra-ER sorting of the peroxisomal membrane protein Pex3 relies on its luminal domain.

Fakieh MH, Drake PJ, Lacey J, Munck JM, Motley AM, Hettema EH.

Biol Open. 2013 Jun 25;2(8):829-37. doi: 10.1242/bio.20134788. eCollection 2013 Aug 15.


Dietary selenium deficiency exacerbates DSS-induced epithelial injury and AOM/DSS-induced tumorigenesis.

Barrett CW, Singh K, Motley AK, Lintel MK, Matafonova E, Bradley AM, Ning W, Poindexter SV, Parang B, Reddy VK, Chaturvedi R, Fingleton BM, Washington MK, Wilson KT, Davies SS, Hill KE, Burk RF, Williams CS.

PLoS One. 2013 Jul 4;8(7):e67845. doi: 10.1371/journal.pone.0067845. Print 2013.


Maternal-fetal transfer of selenium in the mouse.

Burk RF, Olson GE, Hill KE, Winfrey VP, Motley AK, Kurokawa S.

FASEB J. 2013 Aug;27(8):3249-56. doi: 10.1096/fj.13-231852. Epub 2013 May 7.


Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis.

Hill KE, Wu S, Motley AK, Stevenson TD, Winfrey VP, Capecchi MR, Atkins JF, Burk RF.

J Biol Chem. 2012 Nov 23;287(48):40414-24. doi: 10.1074/jbc.M112.421404. Epub 2012 Oct 4.


Atg36: the Saccharomyces cerevisiae receptor for pexophagy.

Motley AM, Nuttall JM, Hettema EH.

Autophagy. 2012 Nov;8(11):1680-1. doi: 10.4161/auto.21485. Epub 2012 Aug 9.


Pex3-anchored Atg36 tags peroxisomes for degradation in Saccharomyces cerevisiae.

Motley AM, Nuttall JM, Hettema EH.

EMBO J. 2012 Jun 29;31(13):2852-68. doi: 10.1038/emboj.2012.151. Epub 2012 May 29.


Fecal selenium excretion is regulated by dietary selenium intake.

Pedrosa LF, Motley AK, Stevenson TD, Hill KE, Burk RF.

Biol Trace Elem Res. 2012 Dec;149(3):377-81. doi: 10.1007/s12011-012-9430-9. Epub 2012 May 6.


Peroxisome biogenesis: recent advances.

Nuttall JM, Motley A, Hettema EH.

Curr Opin Cell Biol. 2011 Aug;23(4):421-6. doi: 10.1016/ Review.


Establishing optimal selenium status: results of a randomized, double-blind, placebo-controlled trial.

Hurst R, Armah CN, Dainty JR, Hart DJ, Teucher B, Goldson AJ, Broadley MR, Motley AK, Fairweather-Tait SJ.

Am J Clin Nutr. 2010 Apr;91(4):923-31. doi: 10.3945/ajcn.2009.28169. Epub 2010 Feb 24.


Extracellular glutathione peroxidase (Gpx3) binds specifically to basement membranes of mouse renal cortex tubule cells.

Olson GE, Whitin JC, Hill KE, Winfrey VP, Motley AK, Austin LM, Deal J, Cohen HJ, Burk RF.

Am J Physiol Renal Physiol. 2010 May;298(5):F1244-53. doi: 10.1152/ajprenal.00662.2009. Epub 2009 Dec 16.


A dual function for Pex3p in peroxisome formation and inheritance.

Munck JM, Motley AM, Nuttall JM, Hettema EH.

J Cell Biol. 2009 Nov 16;187(4):463-71. doi: 10.1083/jcb.200906161. Epub 2009 Nov 9.


How peroxisomes multiply.

Hettema EH, Motley AM.

J Cell Sci. 2009 Jul 15;122(Pt 14):2331-6. doi: 10.1242/jcs.034363. Review.


Combined selenium and vitamin C deficiency causes cell death in guinea pig skeletal muscle.

Hill KE, Motley AK, May JM, Burk RF.

Nutr Res. 2009 Mar;29(3):213-9. doi: 10.1016/j.nutres.2009.02.006.


Dnm1p-dependent peroxisome fission requires Caf4p, Mdv1p and Fis1p.

Motley AM, Ward GP, Hettema EH.

J Cell Sci. 2008 May 15;121(Pt 10):1633-40. doi: 10.1242/jcs.026344. Epub 2008 Apr 29.


Plasma selenium measurements in subjects from areas with contrasting gastric cancer risks in Colombia.

Camargo MC, Burk RF, Bravo LE, Piazuelo MB, Hill KE, Fontham ET, Motley AK, Yepez MC, Mora Y, Schneider BG, Correa P.

Arch Med Res. 2008 May;39(4):443-51. doi: 10.1016/j.arcmed.2007.12.004. Epub 2008 Mar 10.


Selenium deficiency activates mouse liver Nrf2-ARE but vitamin E deficiency does not.

Burk RF, Hill KE, Nakayama A, Mostert V, Levander XA, Motley AK, Johnson DA, Johnson JA, Freeman ML, Austin LM.

Free Radic Biol Med. 2008 Apr 15;44(8):1617-23. doi: 10.1016/j.freeradbiomed.2008.01.016. Epub 2008 Jan 31.


Yeast peroxisomes multiply by growth and division.

Motley AM, Hettema EH.

J Cell Biol. 2007 Jul 30;178(3):399-410. Epub 2007 Jul 23.


HIV-1 Nef-induced down-regulation of MHC class I requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2.

Lubben NB, Sahlender DA, Motley AM, Lehner PJ, Benaroch P, Robinson MS.

Mol Biol Cell. 2007 Sep;18(9):3351-65. Epub 2007 Jun 20.


Deletion of apolipoprotein E receptor-2 in mice lowers brain selenium and causes severe neurological dysfunction and death when a low-selenium diet is fed.

Burk RF, Hill KE, Olson GE, Weeber EJ, Motley AK, Winfrey VP, Austin LM.

J Neurosci. 2007 Jun 6;27(23):6207-11.


All regions of mouse brain are dependent on selenoprotein P for maintenance of selenium.

Nakayama A, Hill KE, Austin LM, Motley AK, Burk RF.

J Nutr. 2007 Mar;137(3):690-3.


The selenium-rich C-terminal domain of mouse selenoprotein P is necessary for the supply of selenium to brain and testis but not for the maintenance of whole body selenium.

Hill KE, Zhou J, Austin LM, Motley AK, Ham AJ, Olson GE, Atkins JF, Gesteland RF, Burk RF.

J Biol Chem. 2007 Apr 13;282(15):10972-80. Epub 2007 Feb 20.


Functional analysis of AP-2 alpha and mu2 subunits.

Motley AM, Berg N, Taylor MJ, Sahlender DA, Hirst J, Owen DJ, Robinson MS.

Mol Biol Cell. 2006 Dec;17(12):5298-308. Epub 2006 Oct 11.


Deletion of selenoprotein P upregulates urinary selenium excretion and depresses whole-body selenium content.

Burk RF, Hill KE, Motley AK, Austin LM, Norsworthy BK.

Biochim Biophys Acta. 2006 Dec;1760(12):1789-93. Epub 2006 Aug 18.


Effects of chemical form of selenium on plasma biomarkers in a high-dose human supplementation trial.

Burk RF, Norsworthy BK, Hill KE, Motley AK, Byrne DW.

Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):804-10.


Pretransplant islet culture: a comparison of four serum-free media using a murine model of islet transplantation.

Carter J, Karmiol S, Nagy M, McElreath R, Calloway C, Motley A, Neill A, Jang HJ, Posselt A, Stock P.

Transplant Proc. 2005 Oct;37(8):3446-9.


Phosphatidylinositol-(4,5)-bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2.

Höning S, Ricotta D, Krauss M, Späte K, Spolaore B, Motley A, Robinson M, Robinson C, Haucke V, Owen DJ.

Mol Cell. 2005 May 27;18(5):519-31. Erratum in: Mol Cell. 2005 Aug 19;19(4):577.


Neurological dysfunction occurs in mice with targeted deletion of the selenoprotein P gene.

Hill KE, Zhou J, McMahan WJ, Motley AK, Burk RF.

J Nutr. 2004 Jan;134(1):157-61.


Clathrin-mediated endocytosis in AP-2-depleted cells.

Motley A, Bright NA, Seaman MN, Robinson MS.

J Cell Biol. 2003 Sep 1;162(5):909-18.


Impaired neuronal migration and endochondral ossification in Pex7 knockout mice: a model for rhizomelic chondrodysplasia punctata.

Brites P, Motley AM, Gressens P, Mooyer PA, Ploegaert I, Everts V, Evrard P, Carmeliet P, Dewerchin M, Schoonjans L, Duran M, Waterham HR, Wanders RJ, Baes M.

Hum Mol Genet. 2003 Sep 15;12(18):2255-67. Epub 2003 Jul 15.


Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin.

Lui WW, Collins BM, Hirst J, Motley A, Millar C, Schu P, Owen DJ, Robinson MS.

Mol Biol Cell. 2003 Jun;14(6):2385-98. Epub 2003 Mar 20.


Combined deficiency of vitamins E and C causes paralysis and death in guinea pigs.

Hill KE, Montine TJ, Motley AK, Li X, May JM, Burk RF.

Am J Clin Nutr. 2003 Jun;77(6):1484-8.


Selenoprotein metabolism and function: evidence for more than one function for selenoprotein P.

Burk RF, Hill KE, Motley AK.

J Nutr. 2003 May;133(5 Suppl 1):1517S-20S. doi: 10.1093/jn/133.5.1517S. Review.


EpsinR: an ENTH domain-containing protein that interacts with AP-1.

Hirst J, Motley A, Harasaki K, Peak Chew SY, Robinson MS.

Mol Biol Cell. 2003 Feb;14(2):625-41. Erratum in: Mol Biol Cell. 2003 Apr;14(4):following 1743.


Deletion of selenoprotein P alters distribution of selenium in the mouse.

Hill KE, Zhou J, McMahan WJ, Motley AK, Atkins JF, Gesteland RF, Burk RF.

J Biol Chem. 2003 Apr 18;278(16):13640-6. Epub 2003 Feb 6.


Mutational spectrum in the PEX7 gene and functional analysis of mutant alleles in 78 patients with rhizomelic chondrodysplasia punctata type 1.

Motley AM, Brites P, Gerez L, Hogenhout E, Haasjes J, Benne R, Tabak HF, Wanders RJ, Waterham HR.

Am J Hum Genet. 2002 Mar;70(3):612-24. Epub 2002 Jan 7.


Plasma selenium in specific and non-specific forms.

Burk RF, Hill KE, Motley AK.

Biofactors. 2001;14(1-4):107-14.


Combined selenium and vitamin E deficiency causes fatal myopathy in guinea pigs.

Hill KE, Motley AK, Li X, May JM, Burk RF.

J Nutr. 2001 Jun;131(6):1798-802.


Caenorhabditis elegans has a single pathway to target matrix proteins to peroxisomes.

Motley AM, Hettema EH, Ketting R, Plasterk R, Tabak HF.

EMBO Rep. 2000 Jul;1(1):40-6.


Failure of selenomethionine residues in albumin and immunoglobulin G to protect against peroxynitrite.

Hondal RJ, Motley AK, Hill KE, Burk RF.

Arch Biochem Biophys. 1999 Nov 1;371(1):29-34.


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