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Items: 1 to 50 of 99

1.

Illuminating the virus life cycle with single-molecule FRET imaging.

Lu M, Ma X, Mothes W.

Adv Virus Res. 2019;105:239-273. doi: 10.1016/bs.aivir.2019.07.004. Epub 2019 Aug 20.

PMID:
31522706
2.

Murine Leukemia Virus Exploits Innate Sensing by Toll-Like Receptor 7 in B-1 Cells To Establish Infection and Locally Spread in Mice.

Pi R, Iwasaki A, Sewald X, Mothes W, Uchil PD.

J Virol. 2019 Oct 15;93(21). pii: e00930-19. doi: 10.1128/JVI.00930-19. Print 2019 Nov 1.

PMID:
31434732
3.

In Vivo Imaging-Driven Approaches to Study Virus Dissemination and Pathogenesis.

Uchil PD, Haugh KA, Pi R, Mothes W.

Annu Rev Virol. 2019 Sep 29;6(1):501-524. doi: 10.1146/annurev-virology-101416-041429. Epub 2019 Jul 5.

PMID:
31283440
4.

An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity.

Alsahafi N, Bakouche N, Kazemi M, Richard J, Ding S, Bhattacharyya S, Das D, Anand SP, Prévost J, Tolbert WD, Lu H, Medjahed H, Gendron-Lepage G, Ortega Delgado GG, Kirk S, Melillo B, Mothes W, Sodroski J, Smith AB 3rd, Kaufmann DE, Wu X, Pazgier M, Rouiller I, Finzi A, Munro JB.

Cell Host Microbe. 2019 Apr 10;25(4):578-587.e5. doi: 10.1016/j.chom.2019.03.002.

PMID:
30974085
5.

Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET.

Lu M, Ma X, Castillo-Menendez LR, Gorman J, Alsahafi N, Ermel U, Terry DS, Chambers M, Peng D, Zhang B, Zhou T, Reichard N, Wang K, Grover JR, Carman BP, Gardner MR, Nikić-Spiegel I, Sugawara A, Arthos J, Lemke EA, Smith AB 3rd, Farzan M, Abrams C, Munro JB, McDermott AB, Finzi A, Kwong PD, Blanchard SC, Sodroski JG, Mothes W.

Nature. 2019 Apr;568(7752):415-419. doi: 10.1038/s41586-019-1101-y. Epub 2019 Apr 10.

6.

Antibody-Induced Internalization of HIV-1 Env Proteins Limits Surface Expression of the Closed Conformation of Env.

Anand SP, Grover JR, Tolbert WD, Prévost J, Richard J, Ding S, Baril S, Medjahed H, Evans DT, Pazgier M, Mothes W, Finzi A.

J Virol. 2019 May 15;93(11). pii: e00293-19. doi: 10.1128/JVI.00293-19. Print 2019 Jun 1.

PMID:
30894474
7.

A Protective Role for the Lectin CD169/Siglec-1 against a Pathogenic Murine Retrovirus.

Uchil PD, Pi R, Haugh KA, Ladinsky MS, Ventura JD, Barrett BS, Santiago ML, Bjorkman PJ, Kassiotis G, Sewald X, Mothes W.

Cell Host Microbe. 2019 Jan 9;25(1):87-100.e10. doi: 10.1016/j.chom.2018.11.011. Epub 2018 Dec 27.

8.

HIV-1-Infected CD4+ T Cells Facilitate Latent Infection of Resting CD4+ T Cells through Cell-Cell Contact.

Agosto LM, Herring MB, Mothes W, Henderson AJ.

Cell Rep. 2018 Aug 21;24(8):2088-2100. doi: 10.1016/j.celrep.2018.07.079.

9.

HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations.

Ma X, Lu M, Gorman J, Terry DS, Hong X, Zhou Z, Zhao H, Altman RB, Arthos J, Blanchard SC, Kwong PD, Munro JB, Mothes W.

Elife. 2018 Mar 21;7. pii: e34271. doi: 10.7554/eLife.34271.

10.

NF-κB-Chromatin Interactions Drive Diverse Phenotypes by Modulating Transcriptional Noise.

Wong VC, Bass VL, Bullock ME, Chavali AK, Lee REC, Mothes W, Gaudet S, Miller-Jensen K.

Cell Rep. 2018 Jan 16;22(3):585-599. doi: 10.1016/j.celrep.2017.12.080.

11.

Publisher Correction: The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions.

Herschhorn A, Gu C, Moraca F, Ma X, Farrell M, Smith AB 3rd, Pancera M, Kwong PD, Schön A, Freire E, Abrams C, Blanchard SC, Mothes W, Sodroski JG.

Nat Commun. 2018 Jan 8;9(1):158. doi: 10.1038/s41467-017-02463-7.

12.

The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions.

Herschhorn A, Gu C, Moraca F, Ma X, Farrell M, Smith AB 3rd, Pancera M, Kwong PD, Schön A, Freire E, Abrams C, Blanchard SC, Mothes W, Sodroski JG.

Nat Commun. 2017 Oct 19;8(1):1049. doi: 10.1038/s41467-017-01119-w. Erratum in: Nat Commun. 2018 Jan 8;9(1):158.

13.

Mutation of the Putative Immunosuppressive Domain of the Retroviral Envelope Glycoprotein Compromises Infectivity.

Eksmond U, Jenkins B, Merkenschlager J, Mothes W, Stoye JP, Kassiotis G.

J Virol. 2017 Oct 13;91(21). pii: e01152-17. doi: 10.1128/JVI.01152-17. Print 2017 Nov 1.

14.

Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins.

Herschhorn A, Ma X, Gu C, Ventura JD, Castillo-Menendez L, Melillo B, Terry DS, Smith AB 3rd, Blanchard SC, Munro JB, Mothes W, Finzi A, Sodroski J.

MBio. 2016 Oct 25;7(5). pii: e01598-16. doi: 10.1128/mBio.01598-16.

15.

Native structure of a retroviral envelope protein and its conformational change upon interaction with the target cell.

Riedel C, Vasishtan D, Siebert CA, Whittle C, Lehmann MJ, Mothes W, Grünewald K.

J Struct Biol. 2017 Feb;197(2):172-180. doi: 10.1016/j.jsb.2016.06.017. Epub 2016 Jun 23.

16.

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody.

Kong R, Xu K, Zhou T, Acharya P, Lemmin T, Liu K, Ozorowski G, Soto C, Taft JD, Bailer RT, Cale EM, Chen L, Choi CW, Chuang GY, Doria-Rose NA, Druz A, Georgiev IS, Gorman J, Huang J, Joyce MG, Louder MK, Ma X, McKee K, O'Dell S, Pancera M, Yang Y, Blanchard SC, Mothes W, Burton DR, Koff WC, Connors M, Ward AB, Kwong PD, Mascola JR.

Science. 2016 May 13;352(6287):828-33. doi: 10.1126/science.aae0474.

17.

Viruses exploit the tissue physiology of the host to spread in vivo.

Sewald X, Motamedi N, Mothes W.

Curr Opin Cell Biol. 2016 Aug;41:81-90. doi: 10.1016/j.ceb.2016.04.008. Epub 2016 May 3. Review.

18.

TRIM5 Retroviral Restriction Activity Correlates with the Ability To Induce Innate Immune Signaling.

Lascano J, Uchil PD, Mothes W, Luban J.

J Virol. 2015 Oct 14;90(1):308-16. doi: 10.1128/JVI.02496-15. Print 2016 Jan 1.

19.

Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection.

Sewald X, Ladinsky MS, Uchil PD, Beloor J, Pi R, Herrmann C, Motamedi N, Murooka TT, Brehm MA, Greiner DL, Shultz LD, Mempel TR, Bjorkman PJ, Kumar P, Mothes W.

Science. 2015 Oct 30;350(6260):563-567. doi: 10.1126/science.aab2749. Epub 2015 Oct 1.

20.

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env.

Kwon YD, Pancera M, Acharya P, Georgiev IS, Crooks ET, Gorman J, Joyce MG, Guttman M, Ma X, Narpala S, Soto C, Terry DS, Yang Y, Zhou T, Ahlsen G, Bailer RT, Chambers M, Chuang GY, Doria-Rose NA, Druz A, Hallen MA, Harned A, Kirys T, Louder MK, O'Dell S, Ofek G, Osawa K, Prabhakaran M, Sastry M, Stewart-Jones GB, Stuckey J, Thomas PV, Tittley T, Williams C, Zhang B, Zhao H, Zhou Z, Donald BR, Lee LK, Zolla-Pazner S, Baxa U, Schön A, Freire E, Shapiro L, Lee KK, Arthos J, Munro JB, Blanchard SC, Mothes W, Binley JM, McDermott AB, Mascola JR, Kwong PD.

Nat Struct Mol Biol. 2015 Jul;22(7):522-31. doi: 10.1038/nsmb.3051. Epub 2015 Jun 22.

21.

HIV cell-to-cell transmission: effects on pathogenesis and antiretroviral therapy.

Agosto LM, Uchil PD, Mothes W.

Trends Microbiol. 2015 May;23(5):289-95. doi: 10.1016/j.tim.2015.02.003. Epub 2015 Mar 9. Review.

22.

Structure and Dynamics of the Native HIV-1 Env Trimer.

Munro JB, Mothes W.

J Virol. 2015 Jun;89(11):5752-5. doi: 10.1128/JVI.03187-14. Epub 2015 Mar 11. Review.

23.

Attachment of cell-binding ligands to arginine-rich cell-penetrating peptides enables cytosolic translocation of complexed siRNA.

Zeller S, Choi CS, Uchil PD, Ban HS, Siefert A, Fahmy TM, Mothes W, Lee SK, Kumar P.

Chem Biol. 2015 Jan 22;22(1):50-62. doi: 10.1016/j.chembiol.2014.11.009. Epub 2014 Dec 24.

24.

Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions.

Munro JB, Gorman J, Ma X, Zhou Z, Arthos J, Burton DR, Koff WC, Courter JR, Smith AB 3rd, Kwong PD, Blanchard SC, Mothes W.

Science. 2014 Nov 7;346(6210):759-63. doi: 10.1126/science.1254426. Epub 2014 Oct 8.

25.

Structure and immune recognition of trimeric pre-fusion HIV-1 Env.

Pancera M, Zhou T, Druz A, Georgiev IS, Soto C, Gorman J, Huang J, Acharya P, Chuang GY, Ofek G, Stewart-Jones GB, Stuckey J, Bailer RT, Joyce MG, Louder MK, Tumba N, Yang Y, Zhang B, Cohen MS, Haynes BF, Mascola JR, Morris L, Munro JB, Blanchard SC, Mothes W, Connors M, Kwong PD.

Nature. 2014 Oct 23;514(7523):455-61. doi: 10.1038/nature13808. Epub 2014 Oct 8.

26.

TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly.

Uchil PD, Pawliczek T, Reynolds TD, Ding S, Hinz A, Munro JB, Huang F, Floyd RW, Yang H, Hamilton WL, Bewersdorf J, Xiong Y, Calderwood DA, Mothes W.

J Cell Sci. 2014 Sep 15;127(Pt 18):3928-42. doi: 10.1242/jcs.143537. Epub 2014 Jul 11.

27.

The HIV-1 Env trimer in HD.

Munro JB, Mothes W.

Structure. 2014 Jul 8;22(7):935-6. doi: 10.1016/j.str.2014.06.004.

28.

Murine leukemia virus Gag localizes to the uropod of migrating primary lymphocytes.

Li F, Sewald X, Jin J, Sherer NM, Mothes W.

J Virol. 2014 Sep;88(18):10541-55. doi: 10.1128/JVI.01104-14. Epub 2014 Jun 25.

29.

Highly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission.

Agosto LM, Zhong P, Munro J, Mothes W.

PLoS Pathog. 2014 Feb 27;10(2):e1003982. doi: 10.1371/journal.ppat.1003982. eCollection 2014 Feb.

30.

A conformational transition observed in single HIV-1 Gag molecules during in vitro assembly of virus-like particles.

Munro JB, Nath A, Färber M, Datta SA, Rein A, Rhoades E, Mothes W.

J Virol. 2014 Mar;88(6):3577-85. doi: 10.1128/JVI.03353-13. Epub 2014 Jan 8.

31.

Functional characterization of the putative hepatitis B virus core protein late domain using retrovirus chimeras.

Garcia ML, Reynolds TD, Mothes W, Robek MD.

PLoS One. 2013 Aug 29;8(8):e72845. doi: 10.1371/journal.pone.0072845. eCollection 2013.

32.

Video-rate nanoscopy using sCMOS camera-specific single-molecule localization algorithms.

Huang F, Hartwich TM, Rivera-Molina FE, Lin Y, Duim WC, Long JJ, Uchil PD, Myers JR, Baird MA, Mothes W, Davidson MW, Toomre D, Bewersdorf J.

Nat Methods. 2013 Jul;10(7):653-8. doi: 10.1038/nmeth.2488. Epub 2013 May 26.

33.

Basic residues in the matrix domain and multimerization target murine leukemia virus Gag to the virological synapse.

Li F, Jin J, Herrmann C, Mothes W.

J Virol. 2013 Jun;87(12):7113-26. doi: 10.1128/JVI.03263-12. Epub 2013 Apr 24.

34.

Cell-to-cell transmission can overcome multiple donor and target cell barriers imposed on cell-free HIV.

Zhong P, Agosto LM, Ilinskaya A, Dorjbal B, Truong R, Derse D, Uchil PD, Heidecker G, Mothes W.

PLoS One. 2013;8(1):e53138. doi: 10.1371/journal.pone.0053138. Epub 2013 Jan 7.

35.

In vivo imaging of virological synapses.

Sewald X, Gonzalez DG, Haberman AM, Mothes W.

Nat Commun. 2012;3:1320. doi: 10.1038/ncomms2338.

36.

Cell-to-cell transmission of viruses.

Zhong P, Agosto LM, Munro JB, Mothes W.

Curr Opin Virol. 2013 Feb;3(1):44-50. doi: 10.1016/j.coviro.2012.11.004. Epub 2012 Dec 5. Review.

37.

TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.

Uchil PD, Hinz A, Siegel S, Coenen-Stass A, Pertel T, Luban J, Mothes W.

J Virol. 2013 Jan;87(1):257-72. doi: 10.1128/JVI.01804-12. Epub 2012 Oct 17.

38.

Viral determinants of polarized assembly for the murine leukemia virus.

Jin J, Li F, Mothes W.

J Virol. 2011 Aug;85(15):7672-82. doi: 10.1128/JVI.00409-11. Epub 2011 May 18.

39.

TRIM5 is an innate immune sensor for the retrovirus capsid lattice.

Pertel T, Hausmann S, Morger D, Züger S, Guerra J, Lascano J, Reinhard C, Santoni FA, Uchil PD, Chatel L, Bisiaux A, Albert ML, Strambio-De-Castillia C, Mothes W, Pizzato M, Grütter MG, Luban J.

Nature. 2011 Apr 21;472(7343):361-5. doi: 10.1038/nature09976.

40.

TRIM22 inhibits HIV-1 transcription independently of its E3 ubiquitin ligase activity, Tat, and NF-kappaB-responsive long terminal repeat elements.

Kajaste-Rudnitski A, Marelli SS, Pultrone C, Pertel T, Uchil PD, Mechti N, Mothes W, Poli G, Luban J, Vicenzi E.

J Virol. 2011 May;85(10):5183-96. doi: 10.1128/JVI.02302-10. Epub 2011 Feb 23.

41.

Virus cell-to-cell transmission.

Mothes W, Sherer NM, Jin J, Zhong P.

J Virol. 2010 Sep;84(17):8360-8. doi: 10.1128/JVI.00443-10. Epub 2010 Apr 7. Review.

42.

Surface Transmission or Polarized Egress? Lessons Learned from HTLV Cell-to-Cell Transmission.

Jin J, Sherer N, Mothes W.

Viruses. 2010 Feb;2(2):601-5. doi: 10.3390/v2020601. Epub 2010 Feb 10.

43.

Directional spread of surface-associated retroviruses regulated by differential virus-cell interactions.

Sherer NM, Jin J, Mothes W.

J Virol. 2010 Apr;84(7):3248-58. doi: 10.1128/JVI.02155-09. Epub 2010 Jan 20.

44.

HIV-1 matrix dependent membrane targeting is regulated by Gag mRNA trafficking.

Jin J, Sturgeon T, Weisz OA, Mothes W, Montelaro RC.

PLoS One. 2009 Aug 7;4(8):e6551. doi: 10.1371/journal.pone.0006551.

45.

Assembly of the murine leukemia virus is directed towards sites of cell-cell contact.

Jin J, Sherer NM, Heidecker G, Derse D, Mothes W.

PLoS Biol. 2009 Jul;7(7):e1000163. doi: 10.1371/journal.pbio.1000163. Epub 2009 Jul 28.

46.

HIV Entry Revisited.

Uchil PD, Mothes W.

Cell. 2009 May 1;137(3):402-4. doi: 10.1016/j.cell.2009.04.033.

47.

Human TRIM gene expression in response to interferons.

Carthagena L, Bergamaschi A, Luna JM, David A, Uchil PD, Margottin-Goguet F, Mothes W, Hazan U, Transy C, Pancino G, Nisole S.

PLoS One. 2009;4(3):e4894. doi: 10.1371/journal.pone.0004894. Epub 2009 Mar 17.

48.

The cationic properties of SEVI underlie its ability to enhance human immunodeficiency virus infection.

Roan NR, Münch J, Arhel N, Mothes W, Neidleman J, Kobayashi A, Smith-McCune K, Kirchhoff F, Greene WC.

J Virol. 2009 Jan;83(1):73-80. doi: 10.1128/JVI.01366-08. Epub 2008 Oct 22.

49.

Retroviruses human immunodeficiency virus and murine leukemia virus are enriched in phosphoinositides.

Chan R, Uchil PD, Jin J, Shui G, Ott DE, Mothes W, Wenk MR.

J Virol. 2008 Nov;82(22):11228-38. doi: 10.1128/JVI.00981-08. Epub 2008 Sep 17.

50.

Cytonemes and tunneling nanotubules in cell-cell communication and viral pathogenesis.

Sherer NM, Mothes W.

Trends Cell Biol. 2008 Sep;18(9):414-20. doi: 10.1016/j.tcb.2008.07.003. Epub 2008 Aug 14. Review.

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