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Items: 31

1.

Combined statin and angiotensin-converting enzyme (ACE) inhibitor treatment increases the lifespan of long-lived F1 male mice.

Spindler SR, Mote PL, Flegal JM.

Age (Dordr). 2016 Dec;38(5-6):379-391. doi: 10.1007/s11357-016-9948-4. Epub 2016 Sep 2.

2.

Nordihydroguaiaretic Acid Extends the Lifespan of Drosophila and Mice, Increases Mortality-Related Tumors and Hemorrhagic Diathesis, and Alters Energy Homeostasis in Mice.

Spindler SR, Mote PL, Lublin AL, Flegal JM, Dhahbi JM, Li R.

J Gerontol A Biol Sci Med Sci. 2015 Dec;70(12):1479-89. doi: 10.1093/gerona/glu190. Epub 2014 Nov 7.

3.

Dietary supplementation with Lovaza and krill oil shortens the life span of long-lived F1 mice.

Spindler SR, Mote PL, Flegal JM.

Age (Dordr). 2014 Jun;36(3):9659. doi: 10.1007/s11357-014-9659-7. Epub 2014 May 10.

4.

Lifespan effects of simple and complex nutraceutical combinations fed isocalorically to mice.

Spindler SR, Mote PL, Flegal JM.

Age (Dordr). 2014 Apr;36(2):705-18. doi: 10.1007/s11357-013-9609-9. Epub 2013 Dec 28.

5.

Metformin improves healthspan and lifespan in mice.

Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ, Schwab M, Pollak M, Zhang Y, Yu Y, Becker KG, Bohr VA, Ingram DK, Sinclair DA, Wolf NS, Spindler SR, Bernier M, de Cabo R.

Nat Commun. 2013;4:2192. doi: 10.1038/ncomms3192.

6.
7.

β1-Adrenergic receptor blockade extends the life span of Drosophila and long-lived mice.

Spindler SR, Mote PL, Li R, Dhahbi JM, Yamakawa A, Flegal JM, Jeske DR, Li R, Lublin AL.

Age (Dordr). 2013 Dec;35(6):2099-109. doi: 10.1007/s11357-012-9498-3. Epub 2013 Jan 15.

8.

Screening candidate longevity therapeutics using gene-expression arrays.

Spindler SR, Mote PL.

Gerontology. 2007;53(5):306-21. Epub 2007 Jun 15. Review.

PMID:
17570924
9.

Gene expression and physiologic responses of the heart to the initiation and withdrawal of caloric restriction.

Dhahbi JM, Tsuchiya T, Kim HJ, Mote PL, Spindler SR.

J Gerontol A Biol Sci Med Sci. 2006 Mar;61(3):218-31.

PMID:
16567370
10.

Identification of potential caloric restriction mimetics by microarray profiling.

Dhahbi JM, Mote PL, Fahy GM, Spindler SR.

Physiol Genomics. 2005 Nov 17;23(3):343-50. Epub 2005 Sep 27.

PMID:
16189280
11.

Temporal linkage between the phenotypic and genomic responses to caloric restriction.

Dhahbi JM, Kim HJ, Mote PL, Beaver RJ, Spindler SR.

Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5524-9. Epub 2004 Mar 25.

12.

Additive regulation of hepatic gene expression by dwarfism and caloric restriction.

Tsuchiya T, Dhahbi JM, Cui X, Mote PL, Bartke A, Spindler SR.

Physiol Genomics. 2004 May 19;17(3):307-15.

PMID:
15039484
13.

Hepatic gene expression profiling of streptozotocin-induced diabetes.

Dhahbi JM, Mote PL, Cao SX, Spindler SR.

Diabetes Technol Ther. 2003;5(3):411-20.

PMID:
12828825
14.

Postprandial induction of chaperone gene expression is rapid in mice.

Dhahbi JM, Cao SX, Mote PL, Rowley BC, Wingo JE, Spindler SR.

J Nutr. 2002 Jan;132(1):31-7.

PMID:
11773504
15.

Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice.

Cao SX, Dhahbi JM, Mote PL, Spindler SR.

Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10630-5. Epub 2001 Sep 4.

16.

Chaperone-mediated regulation of hepatic protein secretion by caloric restriction.

Dhahbi JM, Cao SX, Tillman JB, Mote PL, Madore M, Walford RL, Spindler SR.

Biochem Biophys Res Commun. 2001 Jun 8;284(2):335-9.

PMID:
11394882
17.

Caloric restriction alters the feeding response of key metabolic enzyme genes.

Dhahbi JM, Mote PL, Wingo J, Rowley BC, Cao SX, Walford RL, Spindler SR.

Mech Ageing Dev. 2001 Jul 31;122(10):1033-48.

PMID:
11389922
18.

Calories and aging alter gene expression for gluconeogenic, glycolytic, and nitrogen-metabolizing enzymes.

Dhahbi JM, Mote PL, Wingo J, Tillman JB, Walford RL, Spindler SR.

Am J Physiol. 1999 Aug;277(2):E352-60. doi: 10.1152/ajpendo.1999.277.2.E352.

PMID:
10444432
19.

Glucose regulation of GRP78 gene expression.

Mote PL, Tillman JB, Spindler SR.

Mech Ageing Dev. 1998 Aug 14;104(2):149-58.

PMID:
9792193
20.

Caloric intake alters the efficiency of catalase mRNA translation in the liver of old female mice.

Dhahbi JM, Tillman JB, Cao S, Mote PL, Walford RL, Spindler SR.

J Gerontol A Biol Sci Med Sci. 1998 May;53(3):B180-5.

PMID:
9597041
21.

Dietary energy tissue-specifically regulates endoplasmic reticulum chaperone gene expression in the liver of mice.

Dhahbi JM, Mote PL, Tillman JB, Walford RL, Spindler SR.

J Nutr. 1997 Sep;127(9):1758-64.

PMID:
9278556
22.

Dietary calorie restriction in mice induces carbamyl phosphate synthetase I gene transcription tissue specifically.

Tillman JB, Dhahbi JM, Mote PL, Walford RL, Spindler SR.

J Biol Chem. 1996 Feb 16;271(7):3500-6.

23.
24.

Structure and regulation of the mouse GRP78 (BiP) promoter by glucose and calcium ionophore.

Tillman JB, Mote PL, Walford RL, Spindler SR.

Gene. 1995 Jun 9;158(2):225-9.

PMID:
7607546
25.

Positive and negative thyroid hormone response elements are composed of strong and weak half-sites 10 nucleotides in length.

Kim HS, Crone DE, Sprung CN, Tillman JB, Force WR, Crew MD, Mote PL, Spindler SR.

Mol Endocrinol. 1992 Sep;6(9):1489-501.

PMID:
1435790
27.
28.

Aging alters hepatic expression of insulin receptor and c-jun mRNA in the mouse.

Mote PL, Grizzle JM, Walford RL, Spindler SR.

Mutat Res. 1991 Jan;256(1):7-12.

PMID:
1944389
29.

Dietary energy restriction in mice reduces hepatic expression of glucose-regulated protein 78 (BiP) and 94 mRNA.

Spindler SR, Crew MD, Mote PL, Grizzle JM, Walford RL.

J Nutr. 1990 Nov;120(11):1412-7.

PMID:
2231029
30.

Age-related down regulation of hepatic cytochrome P1-450, P3-450, catalase and CuZn-superoxide dismutase RNA.

Mote PL, Grizzle JM, Walford RL, Spindler SR.

Mech Ageing Dev. 1990 Mar 31;53(1):101-10.

PMID:
1691420
31.

P1-450 and P3-450 gene expression and maximum life span in mice.

Spindler SR, Koizumi A, Walford RL, Mote PL.

Mutat Res. 1989 Mar;219(2):89-94.

PMID:
2538732

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