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Structural insights into flagellar stator-rotor interactions.

Chang Y, Moon KH, Zhao X, Norris SJ, Motaleb MA, Liu J.

Elife. 2019 Jul 17;8. pii: e48979. doi: 10.7554/eLife.48979. [Epub ahead of print]


Iron oxide nanoparticulate system as a cornerstone in the effective delivery of Tc-99 m radionuclide: a potential molecular imaging probe for tumor diagnosis.

Swidan MM, Khowessah OM, El-Motaleb MA, El-Bary AA, El-Kolaly MT, Sakr TM.

Daru. 2019 Jun;27(1):49-58. doi: 10.1007/s40199-019-00241-y. Epub 2019 Jan 31.


Radioiodination and biodistribution of newly synthesized 3-benzyl-2-([3-methoxybenzyl]thio)benzo[g]quinazolin-4-(3H)-one in tumor bearing mice.

Al-Salahi R, Moustapha ME, Abuelizz HA, Alharthi AI, Alburikan KA, Ibrahim IT, Marzouk M, Motaleb MA.

Saudi Pharm J. 2018 Dec;26(8):1120-1126. doi: 10.1016/j.jsps.2018.06.001. Epub 2018 Jun 6.


Outcome of Transcanalicular Endolaser and External Dacryocystorhinostomy in Chronic Dacryocystitis.

Islam MR, Wadud SA, Akhanda AH, Rahman MS, Habibullah M, Kabir MS, Rahman MH, Motaleb MA, Islam MM, Haque M, Chowdhury FQ.

Mymensingh Med J. 2018 Oct;27(4):673-678.


Cryo-electron tomography of periplasmic flagella in Borrelia burgdorferi reveals a distinct cytoplasmic ATPase complex.

Qin Z, Tu J, Lin T, Norris SJ, Li C, Motaleb MA, Liu J.

PLoS Biol. 2018 Nov 9;16(11):e3000050. doi: 10.1371/journal.pbio.3000050. eCollection 2018 Nov.


Radiosynthesis, molecular modeling studies and biological evaluation of 99mTc-Ifosfamide complex as a novel probe for solid tumor imaging.

Motaleb MA, El-Safoury DM, Abd-Alla WH, Awad GAS, Sakr TM.

Int J Radiat Biol. 2018 Dec;94(12):1134-1141. doi: 10.1080/09553002.2019.1524945. Epub 2018 Oct 29.


Dioximes: Synthesis and biomedical applications.

Motaleb MA, Selim AA.

Bioorg Chem. 2019 Feb;82:145-155. doi: 10.1016/j.bioorg.2018.10.011. Epub 2018 Oct 6. Review.


A tetratricopeptide repeat domain protein has profound effects on assembly of periplasmic flagella, morphology and motility of the lyme disease spirochete Borrelia burgdorferi.

Moon KH, Zhao X, Xu H, Liu J, Motaleb MA.

Mol Microbiol. 2018 Nov;110(4):634-647. doi: 10.1111/mmi.14121. Epub 2018 Oct 15.


Rational design and synthesis of new tetralin-sulfonamide derivatives as potent anti-diabetics and DPP-4 inhibitors: 2D & 3D QSAR, in vivo radiolabeling and bio distribution studies.

Abd El-Karim SS, Anwar MM, Syam YM, Nael MA, Ali HF, Motaleb MA.

Bioorg Chem. 2018 Dec;81:481-493. doi: 10.1016/j.bioorg.2018.09.021. Epub 2018 Sep 12.


Radioiodination and biological distribution of a new s-triazine derivative for tumor uptake evaluation.

Motaleb MA, Ibrahim IT, Sarhan MO, Zaghary WA.

J Labelled Comp Radiopharm. 2018 Dec;61(14):1058-1068. doi: 10.1002/jlcr.3682. Epub 2018 Oct 9.


I-131 doping of silver nanoparticles platform for tumor theranosis guided drug delivery.

Sakr TM, Khowessah OM, Motaleb MA, Abd El-Bary A, El-Kolaly MT, Swidan MM.

Eur J Pharm Sci. 2018 Sep 15;122:239-245. doi: 10.1016/j.ejps.2018.06.029. Epub 2018 Jul 5.


Synthesis, characterization, radiolabeling and biodistribution of a novel cyclohexane dioxime derivative as a potential candidate for tumor imaging.

Motaleb MA, Selim AA, El-Tawoosy M, Sanad MH, El-Hashash MA.

Int J Radiat Biol. 2018 Jun;94(6):590-596. doi: 10.1080/09553002.2018.1466067. Epub 2018 Apr 27.


Integrated technological and management solutions for wastewater treatment and efficient agricultural reuse in Egypt, Morocco, and Tunisia.

Frascari D, Zanaroli G, Motaleb MA, Annen G, Belguith K, Borin S, Choukr-Allah R, Gibert C, Jaouani A, Kalogerakis N, Karajeh F, Ker Rault PA, Khadra R, Kyriacou S, Li WT, Molle B, Mulder M, Oertlé E, Ortega CV.

Integr Environ Assess Manag. 2018 Jul;14(4):447-462. doi: 10.1002/ieam.4045. Epub 2018 May 15.


Development, Potential Anticancer Activity and the Receptor Profile of Different Functionalized 1,3,5-Triazine Derivatives.

Sarhan MO, Motaleb MA, Ibrahim IT, Anwar MM, Zaghary WA.

Mini Rev Med Chem. 2018;18(15):1302-1320. doi: 10.2174/1389557517666170927160256. Review.


Design, synthesis and biological evaluation of some novel sulfonamide derivatives as apoptosis inducers.

Mohamed KO, Nissan YM, El-Malah AA, Ahmed WA, Ibrahim DM, Sakr TM, Motaleb MA.

Eur J Med Chem. 2017 Jul 28;135:424-433. doi: 10.1016/j.ejmech.2017.04.069. Epub 2017 Apr 27.


131I-trazodone: preparation, quality control and in vivo biodistribution study by intranasal and intravenous routes as a hopeful brain imaging radiopharmaceutical.

Motaleb MA, Ibrahim IT, Sayyed ME, Awad GAS.

Rev Esp Med Nucl Imagen Mol. 2017 Nov - Dec;36(6):371-376. doi: 10.1016/j.remn.2017.03.001. Epub 2017 Apr 27. English, Spanish.


Borrelia burgdorferi CheY2 Is Dispensable for Chemotaxis or Motility but Crucial for the Infectious Life Cycle of the Spirochete.

Xu H, Sultan S, Yerke A, Moon KH, Wooten RM, Motaleb MA.

Infect Immun. 2016 Dec 29;85(1). pii: e00264-16. doi: 10.1128/IAI.00264-16. Print 2017 Jan.


Synthesis of (125) I-lamivudine and (125) I-lamivudine-ursodeoxycholic acid codrug.

Motaleb MA, Abo-Kul M, Ibrahim SM, Saad SM, Arafat M.

J Labelled Comp Radiopharm. 2016 Sep;59(11):451-3. doi: 10.1002/jlcr.3434. Epub 2016 Aug 26.


Spirochetes flagellar collar protein FlbB has astounding effects in orientation of periplasmic flagella, bacterial shape, motility, and assembly of motors in Borrelia burgdorferi.

Moon KH, Zhao X, Manne A, Wang J, Yu Z, Liu J, Motaleb MA.

Mol Microbiol. 2016 Oct;102(2):336-348. doi: 10.1111/mmi.13463. Epub 2016 Aug 9.


Associations and Risk Factors of Diabetic Maculopathy.

Islam MM, Ali M, Naher ZU, Akhanda AH, Motaleb MA, Uddin MS, Islam MR.

Mymensingh Med J. 2016 Apr;25(2):237-42.


The Borrelia burgdorferi CheY3 response regulator is essential for chemotaxis and completion of its natural infection cycle.

Novak EA, Sekar P, Xu H, Moon KH, Manne A, Wooten RM, Motaleb MA.

Cell Microbiol. 2016 Dec;18(12):1782-1799. doi: 10.1111/cmi.12617. Epub 2016 Jul 11.


Borrelia burgdorferi CheD Promotes Various Functions in Chemotaxis and the Pathogenic Life Cycle of the Spirochete.

Moon KH, Hobbs G, Motaleb MA.

Infect Immun. 2016 May 24;84(6):1743-1752. doi: 10.1128/IAI.01347-15. Print 2016 Jun.


An easy and effective method for synthesis and radiolabelling of risedronate as a model for bone imaging.

Motaleb MA, Adli AS, El-Tawoosy M, Sanad MH, AbdAllah M.

J Labelled Comp Radiopharm. 2016 Apr;59(4):157-63. doi: 10.1002/jlcr.3384. Epub 2016 Mar 9.


Preparation and biological evaluation of (99m)Tc-ropinirole as a novel radiopharmaceutical for brain imaging.

Motaleb MA, Ibrahem IT, Ayoub VR, Geneidi AS.

J Labelled Comp Radiopharm. 2016 Apr;59(4):147-52. doi: 10.1002/jlcr.3380. Epub 2016 Feb 23.


Spirochetal motility and chemotaxis in the natural enzootic cycle and development of Lyme disease.

Motaleb MA, Liu J, Wooten RM.

Curr Opin Microbiol. 2015 Dec;28:106-13. doi: 10.1016/j.mib.2015.09.006. Epub 2015 Nov 2. Review.


Motor rotation is essential for the formation of the periplasmic flagellar ribbon, cellular morphology, and Borrelia burgdorferi persistence within Ixodes scapularis tick and murine hosts.

Sultan SZ, Sekar P, Zhao X, Manne A, Liu J, Wooten RM, Motaleb MA.

Infect Immun. 2015 May;83(5):1765-77. doi: 10.1128/IAI.03097-14. Epub 2015 Feb 17.


Radioiodinated acebutolol as a new highly selective radiotracer for myocardial perfusion imaging.

Swidan MM, Sakr TM, Motaleb MA, El-Bary AA, El-Kolaly MT.

J Labelled Comp Radiopharm. 2014 Aug;57(10):593-9. doi: 10.1002/jlcr.3223. Epub 2014 Sep 5.


Initial characterization of the FlgE hook high molecular weight complex of Borrelia burgdorferi.

Miller KA, Motaleb MA, Liu J, Hu B, Caimano MJ, Miller MR, Charon NW.

PLoS One. 2014 May 23;9(5):e98338. doi: 10.1371/journal.pone.0098338. eCollection 2014.


The cyclic-di-GMP signaling pathway in the Lyme disease spirochete, Borrelia burgdorferi.

Novak EA, Sultan SZ, Motaleb MA.

Front Cell Infect Microbiol. 2014 May 1;4:56. doi: 10.3389/fcimb.2014.00056. eCollection 2014. Review.


Biodistribution of 99mTc-sunitinib as a potential radiotracer for tumor hypoxia imaging.

Sakr TM, El-Safoury DM, Awad GA, Motaleb MA.

J Labelled Comp Radiopharm. 2013 Jun 30;56(8):392-5. doi: 10.1002/jlcr.3060. Epub 2013 May 22.


Cryoelectron tomography reveals the sequential assembly of bacterial flagella in Borrelia burgdorferi.

Zhao X, Zhang K, Boquoi T, Hu B, Motaleb MA, Miller KA, James ME, Charon NW, Manson MD, Norris SJ, Li C, Liu J.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14390-5. doi: 10.1073/pnas.1308306110. Epub 2013 Aug 12.


Motility is crucial for the infectious life cycle of Borrelia burgdorferi.

Sultan SZ, Manne A, Stewart PE, Bestor A, Rosa PA, Charon NW, Motaleb MA.

Infect Immun. 2013 Jun;81(6):2012-21. doi: 10.1128/IAI.01228-12. Epub 2013 Mar 25.


The unique paradigm of spirochete motility and chemotaxis.

Charon NW, Cockburn A, Li C, Liu J, Miller KA, Miller MR, Motaleb MA, Wolgemuth CW.

Annu Rev Microbiol. 2012;66:349-70. doi: 10.1146/annurev-micro-092611-150145. Review.


Analysis of the HD-GYP domain cyclic dimeric GMP phosphodiesterase reveals a role in motility and the enzootic life cycle of Borrelia burgdorferi.

Sultan SZ, Pitzer JE, Boquoi T, Hobbs G, Miller MR, Motaleb MA.

Infect Immun. 2011 Aug;79(8):3273-83. doi: 10.1128/IAI.05153-11. Epub 2011 Jun 13.


CheY3 of Borrelia burgdorferi is the key response regulator essential for chemotaxis and forms a long-lived phosphorylated intermediate.

Motaleb MA, Sultan SZ, Miller MR, Li C, Charon NW.

J Bacteriol. 2011 Jul;193(13):3332-41. doi: 10.1128/JB.00362-11. Epub 2011 Apr 29.


A novel gene inactivation system reveals altered periplasmic flagellar orientation in a Borrelia burgdorferi fliL mutant.

Motaleb MA, Pitzer JE, Sultan SZ, Liu J.

J Bacteriol. 2011 Jul;193(13):3324-31. doi: 10.1128/JB.00202-11. Epub 2011 Mar 25.


Analysis of the Borrelia burgdorferi cyclic-di-GMP-binding protein PlzA reveals a role in motility and virulence.

Pitzer JE, Sultan SZ, Hayakawa Y, Hobbs G, Miller MR, Motaleb MA.

Infect Immun. 2011 May;79(5):1815-25. doi: 10.1128/IAI.00075-11. Epub 2011 Feb 28. Erratum in: Infect Immun. 2011 Jun;79(6):2499.


Labeling of ceftriaxone for infective inflammation imaging using 99mTc eluted from 99Mo/99mTc generator based on zirconium molybdate.

Mostafa M, Motaleb MA, Sakr TM.

Appl Radiat Isot. 2010 Oct;68(10):1959-63. doi: 10.1016/j.apradiso.2010.04.031. Epub 2010 May 4.


Analysis of a Borrelia burgdorferi phosphodiesterase demonstrates a role for cyclic-di-guanosine monophosphate in motility and virulence.

Sultan SZ, Pitzer JE, Miller MR, Motaleb MA.

Mol Microbiol. 2010 Jul 1;77(1):128-42. doi: 10.1111/j.1365-2958.2010.07191.x. Epub 2010 Apr 27.


Identical phosphatase mechanisms achieved through distinct modes of binding phosphoprotein substrate.

Pazy Y, Motaleb MA, Guarnieri MT, Charon NW, Zhao R, Silversmith RE.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1924-9. doi: 10.1073/pnas.0911185107. Epub 2010 Jan 14.


The elastic basis for the shape of Borrelia burgdorferi.

Dombrowski C, Kan W, Motaleb MA, Charon NW, Goldstein RE, Wolgemuth CW.

Biophys J. 2009 Jun 3;96(11):4409-17. doi: 10.1016/j.bpj.2009.02.066.


The flat-ribbon configuration of the periplasmic flagella of Borrelia burgdorferi and its relationship to motility and morphology.

Charon NW, Goldstein SF, Marko M, Hsieh C, Gebhardt LL, Motaleb MA, Wolgemuth CW, Limberger RJ, Rowe N.

J Bacteriol. 2009 Jan;191(2):600-7. doi: 10.1128/JB.01288-08. Epub 2008 Nov 14.


Recovery of nickel, cobalt and some salts from spent Ni-MH batteries.

Rabah MA, Farghaly FE, Abd-El Motaleb MA.

Waste Manag. 2008;28(7):1159-67. Epub 2007 Aug 21.


Phosphorylation assays of chemotaxis two-component system proteins in Borrelia burgdorferi.

Motaleb MA, Miller MR, Li C, Charon NW.

Methods Enzymol. 2007;422:438-47.


CheX is a phosphorylated CheY phosphatase essential for Borrelia burgdorferi chemotaxis.

Motaleb MA, Miller MR, Li C, Bakker RG, Goldstein SF, Silversmith RE, Bourret RB, Charon NW.

J Bacteriol. 2005 Dec;187(23):7963-9.


Asymmetrical flagellar rotation in Borrelia burgdorferi nonchemotactic mutants.

Li C, Bakker RG, Motaleb MA, Sartakova ML, Cabello FC, Charon NW.

Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6169-74.


Complementation of a nonmotile flaB mutant of Borrelia burgdorferi by chromosomal integration of a plasmid containing a wild-type flaB allele.

Sartakova ML, Dobrikova EY, Motaleb MA, Godfrey HP, Charon NW, Cabello FC.

J Bacteriol. 2001 Nov;183(22):6558-64.


Borrelia burgdorferi periplasmic flagella have both skeletal and motility functions.

Motaleb MA, Corum L, Bono JL, Elias AF, Rosa P, Samuels DS, Charon NW.

Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10899-904.

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