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Pre-surgical neoadjuvant oncolytic virotherapy confers protection against rechallenge in a murine model of breast cancer.

Martin NT, Roy DG, Workenhe ST, van den Wollenberg DJM, Hoeben RC, Mossman KL, Bell JC, Bourgeois-Daigneault MC.

Sci Rep. 2019 Feb 12;9(1):1865. doi: 10.1038/s41598-018-38385-7.


Bats and Coronaviruses.

Banerjee A, Kulcsar K, Misra V, Frieman M, Mossman K.

Viruses. 2019 Jan 9;11(1). pii: E41. doi: 10.3390/v11010041. Review.


Commentary: Phyllostomid bat microbiome composition is associated to host phylogeny and feeding strategies.

Banerjee A, Pérez-López E, Mossman K.

Front Microbiol. 2018 Nov 22;9:2863. doi: 10.3389/fmicb.2018.02863. eCollection 2018. No abstract available.


Redesigning care: adapting new improvement methods to achieve person-centred care.

Bhattacharyya O, Blumenthal D, Stoddard R, Mansell L, Mossman K, Schneider EC.

BMJ Qual Saf. 2019 Mar;28(3):242-248. doi: 10.1136/bmjqs-2018-008208. Epub 2018 Sep 21. No abstract available.


Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis.

Zakaria C, Sean P, Hoang HD, Leroux LP, Watson M, Workenhe ST, Hearnden J, Pearl D, Truong VT, Robichaud N, Yanagiya A, Tahmasebi S, Jafarnejad SM, Jia JJ, Pelin A, Diallo JS, Le Boeuf F, Bell JC, Mossman KL, Graber TE, Jaramillo M, Sonenberg N, Alain T.

PLoS Pathog. 2018 Aug 23;14(8):e1007264. doi: 10.1371/journal.ppat.1007264. eCollection 2018 Aug.


IL-15 and IFN-γ signal through the ERK pathway to inhibit HCV replication, independent of type I IFN signaling.

Vahedi F, Lee AJ, Collins SE, Chew MV, Lusty E, Chen B, Dubey A, Richards CD, Feld JJ, Russell RS, Mossman KL, Ashkar AA.

Cytokine. 2018 Jun 13. pii: S1043-4666(18)30254-0. doi: 10.1016/j.cyto.2018.06.006. [Epub ahead of print]


Direct binding and internalization of diverse extracellular nucleic acid species through the collagenous domain of class A scavenger receptors.

Baid K, Nellimarla S, Huynh A, Boulton S, Guarné A, Melacini G, Collins SE, Mossman KL.

Immunol Cell Biol. 2018 Oct;96(9):922-934. doi: 10.1111/imcb.12052. Epub 2018 Apr 26.


Multiple mini interview (MMI) for general practice training selection in Australia: interviewers' motivation.

Burgess A, Roberts C, Sureshkumar P, Mossman K.

BMC Med Educ. 2018 Jan 25;18(1):21. doi: 10.1186/s12909-018-1128-z.


Critical Interactions between Immunogenic Cancer Cell Death, Oncolytic Viruses, and the Immune System Define the Rational Design of Combination Immunotherapies.

van Vloten JP, Workenhe ST, Wootton SK, Mossman KL, Bridle BW.

J Immunol. 2018 Jan 15;200(2):450-458. doi: 10.4049/jimmunol.1701021. Review.


Textured Breast Implants: A Closer Look at the Surface Debris Under the Microscope.

Webb LH, Aime VL, Do A, Mossman K, Mahabir RC.

Plast Surg (Oakv). 2017 Aug;25(3):179-183. doi: 10.1177/2292550317716127. Epub 2017 Jun 28.


Type I Interferon Induced by Streptococcus suis Serotype 2 is Strain-Dependent and May Be Beneficial for Host Survival.

Auger JP, Santinón A, Roy D, Mossman K, Xu J, Segura M, Gottschalk M.

Front Immunol. 2017 Aug 28;8:1039. doi: 10.3389/fimmu.2017.01039. eCollection 2017.


Interferon-Dependent Induction of Clr-b during Mouse Cytomegalovirus Infection Protects Bystander Cells from Natural Killer Cells via NKR-P1B-Mediated Inhibition.

Kirkham CL, Aguilar OA, Yu T, Tanaka M, Mesci A, Chu KL, Fine JH, Mossman KL, Bremner R, Allan DSJ, Carlyle JR.

J Innate Immun. 2017;9(4):343-358. doi: 10.1159/000454926. Epub 2017 Mar 14.


Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection.

Lee AJ, Chen B, Chew MV, Barra NG, Shenouda MM, Nham T, van Rooijen N, Jordana M, Mossman KL, Schreiber RD, Mack M, Ashkar AA.

J Exp Med. 2017 Apr 3;214(4):1153-1167. doi: 10.1084/jem.20160880. Epub 2017 Mar 6.


Criteria to assess potential reverse innovations: opportunities for shared learning between high- and low-income countries.

Bhattacharyya O, Wu D, Mossman K, Hayden L, Gill P, Cheng YL, Daar A, Soman D, Synowiec C, Taylor A, Wong J, von Zedtwitz M, Zlotkin S, Mitchell W, McGahan A.

Global Health. 2017 Jan 25;13(1):4. doi: 10.1186/s12992-016-0225-1.


Viral Evasion Strategies in Type I IFN Signaling - A Summary of Recent Developments.

Schulz KS, Mossman KL.

Front Immunol. 2016 Nov 11;7:498. eCollection 2016. Review.


Erratum: USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation.

Torre S, Polyak MJ, Langlais D, Fodil N, Kennedy JM, Radovanovic I, Berghout J, Leiva-Torres GA, Krawczyk CM, Ilangumaran S, Mossman K, Liang C, Knobeloch KP, Healy LM, Antel J, Arbour N, Prat A, Majewski J, Lathrop M, Vidal SM, Gros P.

Nat Immunol. 2016 Nov 16;17(12):1479. doi: 10.1038/ni1216-1479c. No abstract available.


The Importance of Physiologically Relevant Cell Lines for Studying Virus-Host Interactions.

Hare D, Collins S, Cuddington B, Mossman K.

Viruses. 2016 Nov 1;8(11). pii: E297. Review.


USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation.

Torre S, Polyak MJ, Langlais D, Fodil N, Kennedy JM, Radovanovic I, Berghout J, Leiva-Torres GA, Krawczyk CM, Ilangumaran S, Mossman K, Liang C, Knobeloch KP, Healy LM, Antel J, Arbour N, Prat A, Majewski J, Lathrop M, Vidal SM, Gros P.

Nat Immunol. 2017 Jan;18(1):54-63. doi: 10.1038/ni.3581. Epub 2016 Oct 10. Erratum in: Nat Immunol. 2016 Nov 16;17 (12 ):1479.


S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.

Wang F, Alain T, Szretter KJ, Stephenson K, Pol JG, Atherton MJ, Hoang HD, Fonseca BD, Zakaria C, Chen L, Rangwala Z, Hesch A, Chan ESY, Tuinman C, Suthar MS, Jiang Z, Ashkar AA, Thomas G, Kozma SC, Gale M Jr, Fitzgerald KA, Diamond MS, Mossman K, Sonenberg N, Wan Y, Lichty BD.

Nat Immunol. 2016 May;17(5):514-522. doi: 10.1038/ni.3433. Epub 2016 Apr 4.


Membrane Perturbation-Associated Ca2+ Signaling and Incoming Genome Sensing Are Required for the Host Response to Low-Level Enveloped Virus Particle Entry.

Hare DN, Collins SE, Mukherjee S, Loo YM, Gale M Jr, Janssen LJ, Mossman KL.

J Virol. 2015 Dec 30;90(6):3018-27. doi: 10.1128/JVI.02642-15.


Assessing health program performance in low- and middle-income countries: building a feasible, credible, and comprehensive framework.

Bhattacharyya O, Mossman K, Ginther J, Hayden L, Sohal R, Cha J, Bopardikar A, MacDonald JA, Parikh H, Shahin I, McGahan A, Mitchell W.

Global Health. 2015 Dec 21;11:51. doi: 10.1186/s12992-015-0137-5.


Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells.

Duerr CU, McCarthy CD, Mindt BC, Rubio M, Meli AP, Pothlichet J, Eva MM, Gauchat JF, Qureshi ST, Mazer BD, Mossman KL, Malo D, Gamero AM, Vidal SM, King IL, Sarfati M, Fritz JH.

Nat Immunol. 2016 Jan;17(1):65-75. doi: 10.1038/ni.3308. Epub 2015 Nov 23.


Methods related to molecular virology.

Mossman K.

Methods. 2015 Nov 15;90:1-2. doi: 10.1016/j.ymeth.2015.11.001. No abstract available.


A Lymphotoxin/Type I IFN Axis Programs CD8+ T Cells To Infiltrate a Self-Tissue and Propagate Immunopathology.

Ng D, Maître B, Cummings D, Lin A, Ward LA, Rahbar R, Mossman KL, Ohashi PS, Gommerman JL.

J Immunol. 2015 Nov 15;195(10):4650-9. doi: 10.4049/jimmunol.1501053. Epub 2015 Oct 12.


Class A Scavenger Receptor-Mediated Double-Stranded RNA Internalization Is Independent of Innate Antiviral Signaling and Does Not Require Phosphatidylinositol 3-Kinase Activity.

Nellimarla S, Baid K, Loo YM, Gale M Jr, Bowdish DM, Mossman KL.

J Immunol. 2015 Oct 15;195(8):3858-65. doi: 10.4049/jimmunol.1501028. Epub 2015 Sep 11.


Genome-wide lentiviral shRNA screen identifies serine/arginine-rich splicing factor 2 as a determinant of oncolytic virus activity in breast cancer cells.

Workenhe ST, Ketela T, Moffat J, Cuddington BP, Mossman KL.

Oncogene. 2016 May 12;35(19):2465-74. doi: 10.1038/onc.2015.303. Epub 2015 Aug 10.


Widely Used Herpes Simplex Virus 1 ICP0 Deletion Mutant Strain dl1403 and Its Derivative Viruses Do Not Express Glycoprotein C Due to a Secondary Mutation in the gC Gene.

Cunha CW, Taylor KE, Pritchard SM, Delboy MG, Komala Sari T, Aguilar HC, Mossman KL, Nicola AV.

PLoS One. 2015 Jul 17;10(7):e0131129. doi: 10.1371/journal.pone.0131129. eCollection 2015.


Cellular Protein WDR11 Interacts with Specific Herpes Simplex Virus Proteins at the trans-Golgi Network To Promote Virus Replication.

Taylor KE, Mossman KL.

J Virol. 2015 Oct;89(19):9841-52. doi: 10.1128/JVI.01705-15. Epub 2015 Jul 15.


Consensus guidelines for the detection of immunogenic cell death.

Kepp O, Senovilla L, Vitale I, Vacchelli E, Adjemian S, Agostinis P, Apetoh L, Aranda F, Barnaba V, Bloy N, Bracci L, Breckpot K, Brough D, Buqué A, Castro MG, Cirone M, Colombo MI, Cremer I, Demaria S, Dini L, Eliopoulos AG, Faggioni A, Formenti SC, Fučíková J, Gabriele L, Gaipl US, Galon J, Garg A, Ghiringhelli F, Giese NA, Guo ZS, Hemminki A, Herrmann M, Hodge JW, Holdenrieder S, Honeychurch J, Hu HM, Huang X, Illidge TM, Kono K, Korbelik M, Krysko DV, Loi S, Lowenstein PR, Lugli E, Ma Y, Madeo F, Manfredi AA, Martins I, Mavilio D, Menger L, Merendino N, Michaud M, Mignot G, Mossman KL, Multhoff G, Oehler R, Palombo F, Panaretakis T, Pol J, Proietti E, Ricci JE, Riganti C, Rovere-Querini P, Rubartelli A, Sistigu A, Smyth MJ, Sonnemann J, Spisek R, Stagg J, Sukkurwala AQ, Tartour E, Thorburn A, Thorne SH, Vandenabeele P, Velotti F, Workenhe ST, Yang H, Zong WX, Zitvogel L, Kroemer G, Galluzzi L.

Oncoimmunology. 2014 Dec 13;3(9):e955691. eCollection 2014 Oct. Review.


Oncolytic bovine herpesvirus type 1 as a broad spectrum cancer therapeutic.

Cuddington BP, Mossman KL.

Curr Opin Virol. 2015 Aug;13:11-6. doi: 10.1016/j.coviro.2015.03.010. Epub 2015 Apr 2. Review.


The role of oncolytic virus immunotherapies to subvert cancer immune evasion.

Workenhe ST, Verschoor ML, Mossman KL.

Future Oncol. 2015;11(4):675-89. doi: 10.2217/fon.14.254. Review.


HSV cheats the executioner.

Mossman KL, Weller SK.

Cell Host Microbe. 2015 Feb 11;17(2):148-51. doi: 10.1016/j.chom.2015.01.013.


Enhanced efficacy with azacytidine and oncolytic BHV-1 in a tolerized cotton rat model of breast adenocarcinoma.

Cuddington BP, Verschoor M, Ashkar A, Mossman KL.

Mol Ther Oncolytics. 2015 Mar 25;2:15004. doi: 10.1038/mto.2015.4. eCollection 2015.


The social validity of a national assessment centre for selection into general practice training.

Burgess A, Roberts C, Clark T, Mossman K.

BMC Med Educ. 2014 Dec 21;14:261. doi: 10.1186/s12909-014-0261-6.


Handling of the cotton rat in studies for the pre-clinical evaluation of oncolytic viruses.

Cuddington B, Verschoor M, Mossman K.

J Vis Exp. 2014 Nov 24;(93):e52232. doi: 10.3791/52232.


The role of palmitoylation for protein recruitment to the inner membrane complex of the malaria parasite.

Wetzel J, Herrmann S, Swapna LS, Prusty D, John Peter AT, Kono M, Saini S, Nellimarla S, Wong TW, Wilcke L, Ramsay O, Cabrera A, Biller L, Heincke D, Mossman K, Spielmann T, Ungermann C, Parkinson J, Gilberger TW.

J Biol Chem. 2015 Jan 16;290(3):1712-28. doi: 10.1074/jbc.M114.598094. Epub 2014 Nov 25.


Trans-national scale-up of services in global health.

Shahin I, Sohal R, Ginther J, Hayden L, MacDonald JA, Mossman K, Parikh H, McGahan A, Mitchell W, Bhattacharyya O.

PLoS One. 2014 Nov 6;9(11):e110465. doi: 10.1371/journal.pone.0110465. eCollection 2014.


The validity of a behavioural multiple-mini-interview within an assessment centre for selection into specialty training.

Roberts C, Clark T, Burgess A, Frommer M, Grant M, Mossman K.

BMC Med Educ. 2014 Aug 13;14:169. doi: 10.1186/1472-6920-14-169.


Danger, diversity and priming in innate antiviral immunity.

Collins SE, Mossman KL.

Cytokine Growth Factor Rev. 2014 Oct;25(5):525-31. doi: 10.1016/j.cytogfr.2014.07.002. Epub 2014 Jul 11. Review.


Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages.

McComb S, Cessford E, Alturki NA, Joseph J, Shutinoski B, Startek JB, Gamero AM, Mossman KL, Sad S.

Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):E3206-13. doi: 10.1073/pnas.1407068111. Epub 2014 Jul 21.


Extracellular dsRNA: its function and mechanism of cellular uptake.

Nellimarla S, Mossman KL.

J Interferon Cytokine Res. 2014 Jun;34(6):419-26. doi: 10.1089/jir.2014.0002. Review.


Cancer complexity and radiation protection.

Mossman KL.

Health Phys. 2014 Jul;107(1):73-9. doi: 10.1097/HP.0000000000000054.


Combining oncolytic HSV-1 with immunogenic cell death-inducing drug mitoxantrone breaks cancer immune tolerance and improves therapeutic efficacy.

Workenhe ST, Pol JG, Lichty BD, Cummings DT, Mossman KL.

Cancer Immunol Res. 2013 Nov;1(5):309-19. doi: 10.1158/2326-6066.CIR-13-0059-T. Epub 2013 Aug 19.


Permissiveness of human cancer cells to oncolytic bovine herpesvirus 1 is mediated in part by KRAS activity.

Cuddington BP, Mossman KL.

J Virol. 2014 Jun;88(12):6885-95. doi: 10.1128/JVI.00849-14. Epub 2014 Apr 2.


Rewiring cancer cell death to enhance oncolytic viro-immunotherapy.

Workenhe ST, Mossman KL.

Oncoimmunology. 2013 Dec 1;2(12):e27138. Epub 2013 Dec 9.


Immunogenic HSV-mediated oncolysis shapes the antitumor immune response and contributes to therapeutic efficacy.

Workenhe ST, Simmons G, Pol JG, Lichty BD, Halford WP, Mossman KL.

Mol Ther. 2014 Jan;22(1):123-31. doi: 10.1038/mt.2013.238. Epub 2013 Oct 9.


Oncolytic virotherapy and immunogenic cancer cell death: sharpening the sword for improved cancer treatment strategies.

Workenhe ST, Mossman KL.

Mol Ther. 2014 Feb;22(2):251-256. doi: 10.1038/mt.2013.220. Epub 2013 Oct 19. Review.


HIV-1 gp120 induces TLR2- and TLR4-mediated innate immune activation in human female genital epithelium.

Nazli A, Kafka JK, Ferreira VH, Anipindi V, Mueller K, Osborne BJ, Dizzell S, Chauvin S, Mian MF, Ouellet M, Tremblay MJ, Mossman KL, Ashkar AA, Kovacs C, Bowdish DM, Snider DP, Kaul R, Kaushic C.

J Immunol. 2013 Oct 15;191(8):4246-58. doi: 10.4049/jimmunol.1301482. Epub 2013 Sep 16.


Novel paradigms of innate immune sensing of viral infections.

Hare D, Mossman KL.

Cytokine. 2013 Sep;63(3):219-24. doi: 10.1016/j.cyto.2013.06.001. Epub 2013 Jun 22. Review.


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