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Items: 33


A Protein Complex from Human Milk Enhances the Activity of Antibiotics and Drugs against Mycobacterium tuberculosis.

Meikle V, Mossberg AK, Mitra A, Hakansson AP, Niederweis M.

Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01846-18. doi: 10.1128/AAC.01846-18. Print 2019 Feb.


HPV16 E5 is produced from an HPV16 early mRNA spliced from SD226 to SA3358.

Nilsson K, Norberg C, Mossberg AK, Schwartz S.

Virus Res. 2018 Jan 15;244:128-136. doi: 10.1016/j.virusres.2017.11.009. Epub 2017 Nov 16.


Acetylation of intragenic histones on HPV16 correlates with enhanced HPV16 gene expression.

Johansson C, Jamal Fattah T, Yu H, Nygren J, Mossberg AK, Schwartz S.

Virology. 2015 Aug;482:244-59. doi: 10.1016/j.virol.2015.02.053. Epub 2015 Apr 17.


Heterogeneous Nuclear Ribonucleoprotein C Proteins Interact with the Human Papillomavirus Type 16 (HPV16) Early 3'-Untranslated Region and Alleviate Suppression of HPV16 Late L1 mRNA Splicing.

Dhanjal S, Kajitani N, Glahder J, Mossberg AK, Johansson C, Schwartz S.

J Biol Chem. 2015 May 22;290(21):13354-71. doi: 10.1074/jbc.M115.638098. Epub 2015 Apr 15.


Suicidal Career in Severe Depression among Long-Term Survivors: In a Followup after 37-53 Years Suicide Attempts Appeared to End Long before Depression.

Crona L, Mossberg A, Brådvik L.

Depress Res Treat. 2013;2013:610245. doi: 10.1155/2013/610245. Epub 2013 Dec 23.


Eight nucleotide substitutions inhibit splicing to HPV-16 3'-splice site SA3358 and reduce the efficiency by which HPV-16 increases the life span of primary human keratinocytes.

Li X, Johansson C, Cardoso Palacios C, Mossberg A, Dhanjal S, Bergvall M, Schwartz S.

PLoS One. 2013 Sep 9;8(9):e72776. doi: 10.1371/journal.pone.0072776. eCollection 2013.


Suppression of HPV-16 late L1 5'-splice site SD3632 by binding of hnRNP D proteins and hnRNP A2/B1 to upstream AUAGUA RNA motifs.

Li X, Johansson C, Glahder J, Mossberg AK, Schwartz S.

Nucleic Acids Res. 2013 Dec;41(22):10488-508. doi: 10.1093/nar/gkt803. Epub 2013 Sep 5.


Apoptosis-like death in bacteria induced by HAMLET, a human milk lipid-protein complex.

Hakansson AP, Roche-Hakansson H, Mossberg AK, Svanborg C.

PLoS One. 2011 Mar 10;6(3):e17717. doi: 10.1371/journal.pone.0017717.


HAMLET binding to α-actinin facilitates tumor cell detachment.

Trulsson M, Yu H, Gisselsson L, Chao Y, Urbano A, Aits S, Mossberg AK, Svanborg C.

PLoS One. 2011 Mar 8;6(3):e17179. doi: 10.1371/journal.pone.0017179.


Structure and function of human α-lactalbumin made lethal to tumor cells (HAMLET)-type complexes.

Mossberg AK, Hun Mok K, Morozova-Roche LA, Svanborg C.

FEBS J. 2010 Nov;277(22):4614-25. doi: 10.1111/j.1742-4658.2010.07890.x. Review.


HAMLET interacts with lipid membranes and perturbs their structure and integrity.

Mossberg AK, Puchades M, Halskau Ø, Baumann A, Lanekoff I, Chao Y, Martinez A, Svanborg C, Karlsson R.

PLoS One. 2010 Feb 23;5(2):e9384. doi: 10.1371/journal.pone.0009384.


HAMLET treatment delays bladder cancer development.

Mossberg AK, Hou Y, Svensson M, Holmqvist B, Svanborg C.

J Urol. 2010 Apr;183(4):1590-7. doi: 10.1016/j.juro.2009.12.008. Epub 2010 Feb 21.


alpha-Lactalbumin, engineered to be nonnative and inactive, kills tumor cells when in complex with oleic acid: a new biological function resulting from partial unfolding.

Pettersson-Kastberg J, Mossberg AK, Trulsson M, Yong YJ, Min S, Lim Y, O'Brien JE, Svanborg C, Mok KH.

J Mol Biol. 2009 Dec 18;394(5):994-1010. doi: 10.1016/j.jmb.2009.09.026. Epub 2009 Sep 18.


HAMLET (human alpha-lactalbumin made lethal to tumor cells) triggers autophagic tumor cell death.

Aits S, Gustafsson L, Hallgren O, Brest P, Gustafsson M, Trulsson M, Mossberg AK, Simon HU, Mograbi B, Svanborg C.

Int J Cancer. 2009 Mar 1;124(5):1008-19. doi: 10.1002/ijc.24076.


Can misfolded proteins be beneficial? The HAMLET case.

Pettersson-Kastberg J, Aits S, Gustafsson L, Mossberg A, Storm P, Trulsson M, Persson F, Mok KH, Svanborg C.

Ann Med. 2009;41(3):162-76. doi: 10.1080/07853890802502614. Review.


Apoptosis and tumor cell death in response to HAMLET (human alpha-lactalbumin made lethal to tumor cells).

Hallgren O, Aits S, Brest P, Gustafsson L, Mossberg AK, Wullt B, Svanborg C.

Adv Exp Med Biol. 2008;606:217-40. doi: 10.1007/978-0-387-74087-4_8. Review.


Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET.

Brest P, Gustafsson M, Mossberg AK, Gustafsson L, Duringer C, Hamiche A, Svanborg C.

Cancer Res. 2007 Dec 1;67(23):11327-34.


Bladder cancers respond to intravesical instillation of HAMLET (human alpha-lactalbumin made lethal to tumor cells).

Mossberg AK, Wullt B, Gustafsson L, Månsson W, Ljunggren E, Svanborg C.

Int J Cancer. 2007 Sep 15;121(6):1352-9.


alpha-Lactalbumin species variation, HAMLET formation, and tumor cell death.

Pettersson J, Mossberg AK, Svanborg C.

Biochem Biophys Res Commun. 2006 Jun 23;345(1):260-70. Epub 2006 Apr 27.


Compact oleic acid in HAMLET.

Fast J, Mossberg AK, Nilsson H, Svanborg C, Akke M, Linse S.

FEBS Lett. 2005 Nov 7;579(27):6095-100. Epub 2005 Oct 6.


HAMLET kills tumor cells by apoptosis: structure, cellular mechanisms, and therapy.

Gustafsson L, Hallgren O, Mossberg AK, Pettersson J, Fischer W, Aronsson A, Svanborg C.

J Nutr. 2005 May;135(5):1299-303.


Stability of HAMLET--a kinetically trapped alpha-lactalbumin oleic acid complex.

Fast J, Mossberg AK, Svanborg C, Linse S.

Protein Sci. 2005 Feb;14(2):329-40.


Treatment of skin papillomas with topical alpha-lactalbumin-oleic acid.

Gustafsson L, Leijonhufvud I, Aronsson A, Mossberg AK, Svanborg C.

N Engl J Med. 2004 Jun 24;350(26):2663-72.


Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival.

Fischer W, Gustafsson L, Mossberg AK, Gronli J, Mork S, Bjerkvig R, Svanborg C.

Cancer Res. 2004 Mar 15;64(6):2105-12.


Alpha-lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells).

Svensson M, Fast J, Mossberg AK, Düringer C, Gustafsson L, Hallgren O, Brooks CL, Berliner L, Linse S, Svanborg C.

Protein Sci. 2003 Dec;12(12):2794-804.


HAMLET kills tumor cells by an apoptosis-like mechanism--cellular, molecular, and therapeutic aspects.

Svanborg C, Agerstam H, Aronson A, Bjerkvig R, Düringer C, Fischer W, Gustafsson L, Hallgren O, Leijonhuvud I, Linse S, Mossberg AK, Nilsson H, Pettersson J, Svensson M.

Adv Cancer Res. 2003;88:1-29. Review.


Hamlet--a complex from human milk that induces apoptosis in tumor cells but spares healthy cells.

Svensson M, Düringer C, Hallgren O, Mossberg AK, Håkansson A, Linse S, Svanborg C.

Adv Exp Med Biol. 2002;503:125-32. Review. No abstract available.


Conversion of alpha-lactalbumin to a protein inducing apoptosis.

Svensson M, Håkansson A, Mossberg AK, Linse S, Svanborg C.

Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4221-6.


A folding variant of alpha-lactalbumin with bactericidal activity against Streptococcus pneumoniae.

Håkansson A, Svensson M, Mossberg AK, Sabharwal H, Linse S, Lazou I, Lönnerdal B, Svanborg C.

Mol Microbiol. 2000 Feb;35(3):589-600. Erratum in: Mol Microbiol 2000 Apr;36(1):247.


Molecular characterization of alpha-lactalbumin folding variants that induce apoptosis in tumor cells.

Svensson M, Sabharwal H, Håkansson A, Mossberg AK, Lipniunas P, Leffler H, Svanborg C, Linse S.

J Biol Chem. 1999 Mar 5;274(10):6388-96.


Aspects on the interaction of Streptococcus pneumoniae and Haemophilus influenzae with human respiratory tract mucosa.

Håkansson A, Carlstedt I, Davies J, Mossberg AK, Sabharwal H, Svanborg C.

Am J Respir Crit Care Med. 1996 Oct;154(4 Pt 2):S187-91.


The sound world of the child. The relationship between daily activities and hearing acuity.

Axelsson A, Dengerink H, Hellström PA, Mossberg AM.

Scand Audiol. 1993;22(2):117-24.


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