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Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function.

Moore YE, Conway LC, Wobst HJ, Brandon NJ, Deeb TZ, Moss SJ.

Front Mol Neurosci. 2019 Jul 23;12:173. doi: 10.3389/fnmol.2019.00173. eCollection 2019.


Identification of a Core Amino Acid Motif within the α Subunit of GABAARs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures.

Nathanson AJ, Zhang Y, Smalley JL, Ollerhead TA, Rodriguez Santos MA, Andrews PM, Wobst HJ, Moore YE, Brandon NJ, Hines RM, Davies PA, Moss SJ.

Cell Rep. 2019 Jul 16;28(3):670-681.e8. doi: 10.1016/j.celrep.2019.06.014.


Metabotropic, but not allosteric, effects of neurosteroids on GABAergic inhibition depend on the phosphorylation of GABAA receptors.

Parakala ML, Zhang Y, Modgil A, Chadchankar J, Vien TN, Ackley MA, Doherty JJ, Davies PA, Moss SJ.

J Biol Chem. 2019 Aug 9;294(32):12220-12230. doi: 10.1074/jbc.RA119.008875. Epub 2019 Jun 25.


Phosphorylation of Glutamine Synthetase on Threonine 301 Contributes to Its Inactivation During Epilepsy.

Huyghe D, Denninger AR, Voss CM, Frank P, Gao N, Brandon N, Waagepetersen HS, Ferguson AD, Pangalos M, Doig P, Moss SJ.

Front Mol Neurosci. 2019 May 21;12:120. doi: 10.3389/fnmol.2019.00120. eCollection 2019.


Tonic Activation of GluN2C/GluN2D-Containing NMDA Receptors by Ambient Glutamate Facilitates Cortical Interneuron Maturation.

Hanson E, Armbruster M, Lau LA, Sommer ME, Klaft ZJ, Swanger SA, Traynelis SF, Moss SJ, Noubary F, Chadchankar J, Dulla CG.

J Neurosci. 2019 May 8;39(19):3611-3626. doi: 10.1523/JNEUROSCI.1392-18.2019. Epub 2019 Mar 7.


Neuroactive Steroids Reverse Tonic Inhibitory Deficits in Fragile X Syndrome Mouse Model.

Modgil A, Vien TN, Ackley MA, Doherty JJ, Moss SJ, Davies PA.

Front Mol Neurosci. 2019 Feb 5;12:15. doi: 10.3389/fnmol.2019.00015. eCollection 2019.


The African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension (African-PREDICT): Design, recruitment and initial examination.

Schutte AE, Gona PN, Delles C, Uys AS, Burger A, Mels CM, Kruger R, Smith W, Fourie CM, Botha S, Lammertyn L, van Rooyen JM, Gafane-Matemane LF, Mokwatsi GG, Breet Y, Kruger HS, Zyl TV, Pieters M, Zandberg L, Louw R, Moss SJ, Khumalo IP, Huisman HW.

Eur J Prev Cardiol. 2019 Mar;26(5):458-470. doi: 10.1177/2047487318822354. Epub 2019 Jan 6.


GIRK currents in VTA dopamine neurons control the sensitivity of mice to cocaine-induced locomotor sensitization.

Rifkin RA, Huyghe D, Li X, Parakala M, Aisenberg E, Moss SJ, Slesinger PA.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9479-E9488. doi: 10.1073/pnas.1807788115. Epub 2018 Sep 18.


Potentiating KCC2 activity is sufficient to limit the onset and severity of seizures.

Moore YE, Deeb TZ, Chadchankar H, Brandon NJ, Moss SJ.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10166-10171. doi: 10.1073/pnas.1810134115. Epub 2018 Sep 17.


Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin.

Hines RM, Maric HM, Hines DJ, Modgil A, Panzanelli P, Nakamura Y, Nathanson AJ, Cross A, Deeb T, Brandon NJ, Davies P, Fritschy JM, Schindelin H, Moss SJ.

Nat Commun. 2018 Aug 7;9(1):3130. doi: 10.1038/s41467-018-05481-1.


Relationship between gait kinematics and walking energy expenditure during pregnancy in South African women.

Krkeljas Z, Moss SJ.

BMC Sports Sci Med Rehabil. 2018 Jun 19;10:11. doi: 10.1186/s13102-018-0100-x. eCollection 2018.


Locally Reducing KCC2 Activity in the Hippocampus is Sufficient to Induce Temporal Lobe Epilepsy.

Kelley MR, Cardarelli RA, Smalley JL, Ollerhead TA, Andrew PM, Brandon NJ, Deeb TZ, Moss SJ.

EBioMedicine. 2018 Jun;32:62-71. doi: 10.1016/j.ebiom.2018.05.029. Epub 2018 Jun 5.


Self-Reported Physical Activity is Not a Valid Method for Measuring Physical Activity in 15-Year-Old South African Boys and Girls.

Monyeki MA, Moss SJ, Kemper HCG, Twisk JWR.

Children (Basel). 2018 Jun 6;5(6). pii: E71. doi: 10.3390/children5060071.


Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway.

Fan J, Zhao RQ, Parro C, Zhao W, Chou HY, Robert J, Deeb TZ, Raynoschek C, Barichievy S, Engkvist O, Maresca M, Hicks R, Meuller J, Moss SJ, Brandon NJ, Wood MW, Kulic I, Wellington CL.

J Lipid Res. 2018 May;59(5):830-842. doi: 10.1194/jlr.M081851. Epub 2018 Mar 21.


Inability to suppress the stress-induced activation of the HPA axis during the peripartum period engenders deficits in postpartum behaviors in mice.

Melón LC, Hooper A, Yang X, Moss SJ, Maguire J.

Psychoneuroendocrinology. 2018 Apr;90:182-193. doi: 10.1016/j.psyneuen.2017.12.003. Epub 2017 Dec 21.


The small molecule CLP257 does not modify activity of the K+-Cl- co-transporter KCC2 but does potentiate GABAA receptor activity.

Cardarelli RA, Jones K, Pisella LI, Wobst HJ, McWilliams LJ, Sharpe PM, Burnham MP, Baker DJ, Chudotvorova I, Guyot J, Silayeva L, Morrow DH, Dekker N, Zicha S, Davies PA, Holenz J, Duggan ME, Dunlop J, Mather RJ, Wang Q, Medina I, Brandon NJ, Deeb TZ, Moss SJ.

Nat Med. 2017 Dec 7;23(12):1394-1396. doi: 10.1038/nm.4442. No abstract available.


Molecular architecture of potassium chloride co-transporter KCC2.

Agez M, Schultz P, Medina I, Baker DJ, Burnham MP, Cardarelli RA, Conway LC, Garnier K, Geschwindner S, Gunnarsson A, McCall EJ, Frechard A, Audebert S, Deeb TZ, Moss SJ, Brandon NJ, Wang Q, Dekker N, Jawhari A.

Sci Rep. 2017 Nov 28;7(1):16452. doi: 10.1038/s41598-017-15739-1.


N-Ethylmaleimide increases KCC2 cotransporter activity by modulating transporter phosphorylation.

Conway LC, Cardarelli RA, Moore YE, Jones K, McWilliams LJ, Baker DJ, Burnham MP, Bürli RW, Wang Q, Brandon NJ, Moss SJ, Deeb TZ.

J Biol Chem. 2017 Dec 29;292(52):21253-21263. doi: 10.1074/jbc.M117.817841. Epub 2017 Nov 1.


Diversity oriented biosynthesis via accelerated evolution of modular gene clusters.

Wlodek A, Kendrew SG, Coates NJ, Hold A, Pogwizd J, Rudder S, Sheehan LS, Higginbotham SJ, Stanley-Smith AE, Warneck T, Nur-E-Alam M, Radzom M, Martin CJ, Overvoorde L, Samborskyy M, Alt S, Heine D, Carter GT, Graziani EI, Koehn FE, McDonald L, Alanine A, Rodríguez Sarmiento RM, Chao SK, Ratni H, Steward L, Norville IH, Sarkar-Tyson M, Moss SJ, Leadlay PF, Wilkinson B, Gregory MA.

Nat Commun. 2017 Oct 31;8(1):1206. doi: 10.1038/s41467-017-01344-3.


Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABAA receptors at inhibitory synapses.

Mukherjee J, Cardarelli RA, Cantaut-Belarif Y, Deeb TZ, Srivastava DP, Tyagarajan SK, Pangalos MN, Triller A, Maguire J, Brandon NJ, Moss SJ.

Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):11763-11768. doi: 10.1073/pnas.1705075114. Epub 2017 Oct 16.


A Role for Prefrontal Cortical NMDA Receptors in Murine Alcohol-Heightened Aggression.

Newman EL, Terunuma M, Wang TL, Hewage N, Bicakci MB, Moss SJ, DeBold JF, Miczek KA.

Neuropsychopharmacology. 2018 May;43(6):1224-1234. doi: 10.1038/npp.2017.253. Epub 2017 Oct 20.


Socio-Demographic and Lifestyle Factors Predict 5-Year Changes in Adiposity among a Group of Black South African Adults.

Nienaber-Rousseau C, Sotunde OF, Ukegbu PO, Myburgh PH, Wright HH, Havemann-Nel L, Moss SJ, Kruger IM, Kruger HS.

Int J Environ Res Public Health. 2017 Sep 20;14(9). pii: E1089. doi: 10.3390/ijerph14091089.


Seizing Control of KCC2: A New Therapeutic Target for Epilepsy.

Moore YE, Kelley MR, Brandon NJ, Deeb TZ, Moss SJ.

Trends Neurosci. 2017 Sep;40(9):555-571. doi: 10.1016/j.tins.2017.06.008. Epub 2017 Aug 10. Review.


Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant.

Wobst HJ, Delsing L, Brandon NJ, Moss SJ.

PLoS One. 2017 May 16;12(5):e0177181. doi: 10.1371/journal.pone.0177181. eCollection 2017.


Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro.

Wobst HJ, Wesolowski SS, Chadchankar J, Delsing L, Jacobsen S, Mukherjee J, Deeb TZ, Dunlop J, Brandon NJ, Moss SJ.

Front Mol Neurosci. 2017 Feb 24;10:46. doi: 10.3389/fnmol.2017.00046. eCollection 2017.


Deficits in the activity of presynaptic γ-aminobutyric acid type B receptors contribute to altered neuronal excitability in fragile X syndrome.

Kang JY, Chadchankar J, Vien TN, Mighdoll MI, Hyde TM, Mather RJ, Deeb TZ, Pangalos MN, Brandon NJ, Dunlop J, Moss SJ.

J Biol Chem. 2017 Apr 21;292(16):6621-6632. doi: 10.1074/jbc.M116.772541. Epub 2017 Feb 17.


G Protein-Gated Potassium Channels: A Link to Drug Addiction.

Rifkin RA, Moss SJ, Slesinger PA.

Trends Pharmacol Sci. 2017 Apr;38(4):378-392. doi: 10.1016/ Epub 2017 Feb 7. Review.


Level of agreement between physical activity levels measured by ActiHeart and the International Physical Activity Questionnaire in persons with intellectual disability.

Moss SJ, Czyz SH.

Disabil Rehabil. 2018 Feb;40(3):360-366. doi: 10.1080/09638288.2016.1258092. Epub 2016 Dec 14.


Endogenous and synthetic neuroactive steroids evoke sustained increases in the efficacy of GABAergic inhibition via a protein kinase C-dependent mechanism.

Modgil A, Parakala ML, Ackley MA, Doherty JJ, Moss SJ, Davies PA.

Neuropharmacology. 2017 Feb;113(Pt A):314-322. doi: 10.1016/j.neuropharm.2016.10.010. Epub 2016 Oct 12.


Construct Validity of the Neighborhood Environment Walkability Scale for Africa.

Oyeyemi AL, Conway TL, Adedoyin RA, Akinroye KK, Aryeetey R, Assah F, Cain KL, Gavand KA, Kasoma SS, Kolbe-Alexander TL, Lambert EV, Larouche R, Moss SJ, Ocansey R, Onywera VO, Prista A, Tremblay MS, Sallis JF.

Med Sci Sports Exerc. 2017 Mar;49(3):482-491. doi: 10.1249/MSS.0000000000001131.


Effects of Gabra2 Point Mutations on Alcohol Intake: Increased Binge-Like and Blunted Chronic Drinking by Mice.

Newman EL, Gunner G, Huynh P, Gachette D, Moss SJ, Smart TG, Rudolph U, DeBold JF, Miczek KA.

Alcohol Clin Exp Res. 2016 Nov;40(11):2445-2455. doi: 10.1111/acer.13215. Epub 2016 Sep 26.


Regulating the Efficacy of Inhibition Through Trafficking of γ-Aminobutyric Acid Type A Receptors.

Vien TN, Moss SJ, Davies PA.

Anesth Analg. 2016 Nov;123(5):1220-1227. Review.


Measurement of physical activity in urban and rural South African adults: a comparison of two self-report methods.

Oyeyemi AL, Moss SJ, Monyeki MA, Kruger HS.

BMC Public Health. 2016 Sep 22;16(1):1004.


Large artery stiffness is associated with gamma-glutamyltransferase in young, healthy adults: The African-PREDICT study.

Maritz M, Fourie CM, Van Rooyen JM, Moss SJ, Schutte AE.

J Am Soc Hypertens. 2016 Oct;10(10):772-781.e1. doi: 10.1016/j.jash.2016.07.006. Epub 2016 Aug 4.


Specificity vs. Generalizability: Emergence of Especial Skills in Classical Archery.

Czyż SH, Moss SJ.

Front Psychol. 2016 Aug 5;7:1178. doi: 10.3389/fpsyg.2016.01178. eCollection 2016.


Compromised GABAergic inhibition contributes to tumor-associated epilepsy.

MacKenzie G, O'Toole KK, Moss SJ, Maguire J.

Epilepsy Res. 2016 Oct;126:185-96. doi: 10.1016/j.eplepsyres.2016.07.010. Epub 2016 Jul 27.


Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency.

Ehinger JK, Piel S, Ford R, Karlsson M, Sjövall F, Frostner EÅ, Morota S, Taylor RW, Turnbull DM, Cornell C, Moss SJ, Metzsch C, Hansson MJ, Fliri H, Elmér E.

Nat Commun. 2016 Aug 9;7:12317. doi: 10.1038/ncomms12317.


Genetic Deletion of the Clathrin Adaptor GGA3 Reduces Anxiety and Alters GABAergic Transmission.

Walker KR, Modgil A, Albrecht D, Lomoio S, Haydon PG, Moss SJ, Tesco G.

PLoS One. 2016 May 18;11(5):e0155799. doi: 10.1371/journal.pone.0155799. eCollection 2016.


Managing Noncommunicable Diseases in an African Community: Effects, Compliance, and Barriers to Participation in a 4-Week Exercise Intervention.

Onagbiye SO, Moss SJ, Cameron M.

Int Q Community Health Educ. 2016 Apr;36(3):165-76. doi: 10.1177/0272684X16647357. Epub 2016 May 6.


Compromising KCC2 transporter activity enhances the development of continuous seizure activity.

Kelley MR, Deeb TZ, Brandon NJ, Dunlop J, Davies PA, Moss SJ.

Neuropharmacology. 2016 Sep;108:103-10. doi: 10.1016/j.neuropharm.2016.04.029. Epub 2016 Apr 21.


Reference ranges of handgrip strength from 125,462 healthy adults in 21 countries: a prospective urban rural epidemiologic (PURE) study.

Leong DP, Teo KK, Rangarajan S, Kutty VR, Lanas F, Hui C, Quanyong X, Zhenzhen Q, Jinhua T, Noorhassim I, AlHabib KF, Moss SJ, Rosengren A, Akalin AA, Rahman O, Chifamba J, Orlandini A, Kumar R, Yeates K, Gupta R, Yusufali A, Dans A, Avezum Á, Lopez-Jaramillo P, Poirier P, Heidari H, Zatonska K, Iqbal R, Khatib R, Yusuf S.

J Cachexia Sarcopenia Muscle. 2016 Dec;7(5):535-546. Epub 2016 Apr 12.


Proteomic Characterization of Inhibitory Synapses Using a Novel pHluorin-tagged γ-Aminobutyric Acid Receptor, Type A (GABAA), α2 Subunit Knock-in Mouse.

Nakamura Y, Morrow DH, Modgil A, Huyghe D, Deeb TZ, Lumb MJ, Davies PA, Moss SJ.

J Biol Chem. 2016 Jun 3;291(23):12394-407. doi: 10.1074/jbc.M116.724443. Epub 2016 Apr 4.


A Role for the GIRK3 Subunit in Methamphetamine-Induced Attenuation of GABAB Receptor-Activated GIRK Currents in VTA Dopamine Neurons.

Munoz MB, Padgett CL, Rifkin R, Terunuma M, Wickman K, Contet C, Moss SJ, Slesinger PA.

J Neurosci. 2016 Mar 16;36(11):3106-14. doi: 10.1523/JNEUROSCI.1327-15.2016.


NEWS for Africa: adaptation and reliability of a built environment questionnaire for physical activity in seven African countries.

Oyeyemi AL, Kasoma SS, Onywera VO, Assah F, Adedoyin RA, Conway TL, Moss SJ, Ocansey R, Kolbe-Alexander TL, Akinroye KK, Prista A, Larouche R, Gavand KA, Cain KL, Lambert EV, Aryeetey R, Bartels C, Tremblay MS, Sallis JF.

Int J Behav Nutr Phys Act. 2016 Mar 8;13:33. doi: 10.1186/s12966-016-0357-y.


Copper and protons directly activate the zinc-activated channel.

Trattnig SM, Gasiorek A, Deeb TZ, Ortiz EJ, Moss SJ, Jensen AA, Davies PA.

Biochem Pharmacol. 2016 Mar 1;103:109-17. doi: 10.1016/j.bcp.2016.02.004. Epub 2016 Feb 9.


Validity of the 16-metre PACER and six-minute walk test in adults with Down syndrome.

Boer PH, Moss SJ.

Disabil Rehabil. 2016 Dec;38(26):2575-83. doi: 10.3109/09638288.2015.1137982. Epub 2016 Feb 10.


Effect of continuous aerobic vs. interval training on selected anthropometrical, physiological and functional parameters of adults with Down syndrome.

Boer PH, Moss SJ.

J Intellect Disabil Res. 2016 Apr;60(4):322-334. doi: 10.1111/jir.12251. Epub 2016 Jan 25.


Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1.

Saito A, Taniguchi Y, Rannals MD, Merfeld EB, Ballinger MD, Koga M, Ohtani Y, Gurley DA, Sedlak TW, Cross A, Moss SJ, Brandon NJ, Maher BJ, Kamiya A.

Mol Psychiatry. 2016 Oct;21(10):1449-59. doi: 10.1038/mp.2015.203. Epub 2016 Jan 5.


Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders.

Vien TN, Modgil A, Abramian AM, Jurd R, Walker J, Brandon NJ, Terunuma M, Rudolph U, Maguire J, Davies PA, Moss SJ.

Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14805-10. doi: 10.1073/pnas.1514657112. Epub 2015 Nov 16.


Test-retest reliability and minimal detectable change scores of twelve functional fitness tests in adults with Down syndrome.

Boer PH, Moss SJ.

Res Dev Disabil. 2016 Jan;48:176-85. doi: 10.1016/j.ridd.2015.10.022. Epub 2015 Nov 21.


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