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Ninety day mortality following pancreatoduodenectomy in England: has the optimum centre volume been identified?

Liu Z, Peneva IS, Evison F, Sahdra S, Mirza DF, Charnley RM, Savage R, Moss PA, Roberts KJ.

HPB (Oxford). 2018 Nov;20(11):1012-1020. doi: 10.1016/j.hpb.2018.04.008. Epub 2018 Jun 9.


Humoral immunity to memory antigens and pathogens is maintained in patients with chronic kidney disease.

Wall NA, Dominguez-Medina CC, Faustini SE, Cook CN, McClean A, Jesky MD, Perez-Toledo M, Morgan MD, Richter AG, Ferro CJ, Cockwell P, Moss PA, Henderson IR, Harper L, Cunningham AF.

PLoS One. 2018 Apr 16;13(4):e0195730. doi: 10.1371/journal.pone.0195730. eCollection 2018.


Asymptomatic Primary Infection with Epstein-Barr Virus: Observations on Young Adult Cases.

Abbott RJ, Pachnio A, Pedroza-Pacheco I, Leese AM, Begum J, Long HM, Croom-Carter D, Stacey A, Moss PAH, Hislop AD, Borrow P, Rickinson AB, Bell AI.

J Virol. 2017 Oct 13;91(21). pii: e00382-17. doi: 10.1128/JVI.00382-17. Print 2017 Nov 1.


The Transcription Factor Hobit Identifies Human Cytotoxic CD4+ T Cells.

Oja AE, Vieira Braga FA, Remmerswaal EB, Kragten NA, Hertoghs KM, Zuo J, Moss PA, van Lier RA, van Gisbergen KP, Hombrink P.

Front Immunol. 2017 Mar 24;8:325. doi: 10.3389/fimmu.2017.00325. eCollection 2017.


Citrullination of histone H3 drives IL-6 production by bone marrow mesenchymal stem cells in MGUS and multiple myeloma.

McNee G, Eales KL, Wei W, Williams DS, Barkhuizen A, Bartlett DB, Essex S, Anandram S, Filer A, Moss PA, Pratt G, Basu S, Davies CC, Tennant DA.

Leukemia. 2017 Feb;31(2):373-381. doi: 10.1038/leu.2016.187. Epub 2016 Jul 11.


Cytomegalovirus infection does not impact on survival or time to first treatment in patients with chronic lymphocytic leukemia.

Parry HM, Damery S, Hudson C, Maurer MJ, Cerhan JR, Pachnio A, Begum J, Slager SL, Fegan C, Man S, Pepper C, Shanafelt TD, Pratt G, Moss PA.

Am J Hematol. 2016 Aug;91(8):776-81. doi: 10.1002/ajh.24403. Epub 2016 Jun 1.


Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma.

Ludwig C, Williams DS, Bartlett DB, Essex SJ, McNee G, Allwood JW, Jewell E, Barkhuisen A, Parry H, Anandram S, Nicolson P, Gardener C, Seymour F, Basu S, Dunn WB, Moss PA, Pratt G, Tennant DA.

Blood Cancer J. 2015 Oct 16;5:e359. doi: 10.1038/bcj.2015.85. No abstract available.


The Cellular Localization of Human Cytomegalovirus Glycoprotein Expression Greatly Influences the Frequency and Functional Phenotype of Specific CD4+ T Cell Responses.

Pachnio A, Zuo J, Ryan GB, Begum J, Moss PA.

J Immunol. 2015 Oct 15;195(8):3803-15. doi: 10.4049/jimmunol.1500696. Epub 2015 Sep 11.


Elevated HbA(1c) levels and the accumulation of differentiated T cells in CMV(+) individuals.

Rector JL, Thomas GN, Burns VE, Dowd JB, Herr RM, Moss PA, Jarczok MN, Hoffman K, Fischer JE, Bosch JA.

Diabetologia. 2015 Nov;58(11):2596-605. doi: 10.1007/s00125-015-3731-4. Epub 2015 Aug 20.


Progesterone promotes maternal-fetal tolerance by reducing human maternal T-cell polyfunctionality and inducing a specific cytokine profile.

Lissauer D, Eldershaw SA, Inman CF, Coomarasamy A, Moss PA, Kilby MD.

Eur J Immunol. 2015 Oct;45(10):2858-72. doi: 10.1002/eji.201445404. Epub 2015 Aug 28.


CMV infection of human sinusoidal endothelium regulates hepatic T cell recruitment and activation.

Bruns T, Zimmermann HW, Pachnio A, Li KK, Trivedi PJ, Reynolds G, Hubscher S, Stamataki Z, Badenhorst PW, Weston CJ, Moss PA, Adams DH.

J Hepatol. 2015 Jul;63(1):38-49. doi: 10.1016/j.jhep.2015.02.046. Epub 2015 Mar 12.


Health state utilities for chronic lymphocytic leukemia: importance of prolonging progression-free survival.

Kosmas CE, Shingler SL, Samanta K, Wiesner C, Moss PA, Becker U, Lloyd AJ.

Leuk Lymphoma. 2015 May;56(5):1320-6. doi: 10.3109/10428194.2014.961012. Epub 2015 Jan 14.


Cytomegalovirus drives Vδ2neg γδ T cell inflation in many healthy virus carriers with increasing age.

Alejenef A, Pachnio A, Halawi M, Christmas SE, Moss PA, Khan N.

Clin Exp Immunol. 2014 Jun;176(3):418-28. doi: 10.1111/cei.12297.


Consistent associations between measures of psychological stress and CMV antibody levels in a large occupational sample.

Rector JL, Dowd JB, Loerbroks A, Burns VE, Moss PA, Jarczok MN, Stalder T, Hoffman K, Fischer JE, Bosch JA.

Brain Behav Immun. 2014 May;38:133-41. doi: 10.1016/j.bbi.2014.01.012. Epub 2014 Jan 26.


Profile of maternal CD4 T-cell effector function during normal pregnancy and in women with a history of recurrent miscarriage.

Lissauer D, Goodyear O, Khanum R, Moss PA, Kilby MD.

Clin Sci (Lond). 2014 Mar;126(5):347-54. doi: 10.1042/CS20130247.


An attenuated temperature-sensitive strain of cytomegalovirus (tsm5) establishes immunity without development of CD8(+) T cell memory inflation.

Beswick M, Pachnio A, Al-Ali A, Sweet C, Moss PA.

J Med Virol. 2013 Nov;85(11):1968-74. doi: 10.1002/jmv.23688. Epub 2013 Jul 12.


Cytomegalovirus infection is associated with increased mortality in the older population.

Savva GM, Pachnio A, Kaul B, Morgan K, Huppert FA, Brayne C, Moss PA; Medical Research Council Cognitive Function and Ageing Study.

Aging Cell. 2013 Jun;12(3):381-7. doi: 10.1111/acel.12059. Epub 2013 Apr 19.


Antiviral therapy can reverse the development of immune senescence in elderly mice with latent cytomegalovirus infection.

Beswick M, Pachnio A, Lauder SN, Sweet C, Moss PA.

J Virol. 2013 Jan;87(2):779-89. doi: 10.1128/JVI.02427-12. Epub 2012 Oct 31.


Chemokine-mediated tissue recruitment of CXCR3+ CD4+ T cells plays a major role in the pathogenesis of chronic GVHD.

Croudace JE, Inman CF, Abbotts BE, Nagra S, Nunnick J, Mahendra P, Craddock C, Malladi R, Moss PA.

Blood. 2012 Nov 15;120(20):4246-55. doi: 10.1182/blood-2012-02-413260. Epub 2012 Sep 25.


Fetal-specific CD8+ cytotoxic T cell responses develop during normal human pregnancy and exhibit broad functional capacity.

Lissauer D, Piper K, Goodyear O, Kilby MD, Moss PA.

J Immunol. 2012 Jul 15;189(2):1072-80. doi: 10.4049/jimmunol.1200544. Epub 2012 Jun 8.


Classical ataxia telangiectasia patients have a congenitally aged immune system with high expression of CD95.

Carney EF, Srinivasan V, Moss PA, Taylor AM.

J Immunol. 2012 Jul 1;189(1):261-8. doi: 10.4049/jimmunol.1101909. Epub 2012 May 30.


Structural and energetic evidence for highly peptide-specific tumor antigen targeting via allo-MHC restriction.

Simpson AA, Mohammed F, Salim M, Tranter A, Rickinson AB, Stauss HJ, Moss PA, Steven NM, Willcox BE.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21176-81. doi: 10.1073/pnas.1108422109. Epub 2011 Dec 12.


Chronic lymphocytic leukaemia cells drive the global CD4+ T cell repertoire towards a regulatory phenotype and leads to the accumulation of CD4+ forkhead box P3+ T cells.

Piper KP, Karanth M, McLarnon A, Kalk E, Khan N, Murray J, Pratt G, Moss PA.

Clin Exp Immunol. 2011 Nov;166(2):154-63. doi: 10.1111/j.1365-2249.2011.04466.x.


Cytomegalovirus sero positivity dramatically alters the maternal CD8+ T cell repertoire and leads to the accumulation of highly differentiated memory cells during human pregnancy.

Lissauer D, Choudhary M, Pachnio A, Goodyear O, Moss PA, Kilby MD.

Hum Reprod. 2011 Dec;26(12):3355-65. doi: 10.1093/humrep/der327. Epub 2011 Oct 5.


Phenotypic analysis of antigen-specific T lymphocytes. Science. 1996. 274: 94-96.

Altman JD, Moss PA, Goulder PJ, Barouch DH, McHeyzer-Williams MG, Bell JI, McMichael AJ, Davis MM.

J Immunol. 2011 Jul 1;187(1):7-9. No abstract available.


CD4+CD28- T cell expansion in granulomatosis with polyangiitis (Wegener's) is driven by latent cytomegalovirus infection and is associated with an increased risk of infection and mortality.

Morgan MD, Pachnio A, Begum J, Roberts D, Rasmussen N, Neil DA, Bajema I, Savage CO, Moss PA, Harper L.

Arthritis Rheum. 2011 Jul;63(7):2127-37. doi: 10.1002/art.30366.


The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo.

Weston VJ, Oldreive CE, Skowronska A, Oscier DG, Pratt G, Dyer MJ, Smith G, Powell JE, Rudzki Z, Kearns P, Moss PA, Taylor AM, Stankovic T.

Blood. 2010 Nov 25;116(22):4578-87. doi: 10.1182/blood-2010-01-265769. Epub 2010 Aug 25.


Persistent viral infection in humans can drive high frequency low-affinity T-cell expansions.

Khan N, Cobbold M, Cummerson J, Moss PA.

Immunology. 2010 Dec;131(4):537-48. doi: 10.1111/j.1365-2567.2010.03326.x. Epub 2010 Aug 16.


CD8(+) T-cell immunity against cancer-testis antigens develops following allogeneic stem cell transplantation and reveals a potential mechanism for the graft-versus-leukemia effect.

McLarnon A, Piper KP, Goodyear OC, Arrazi JM, Mahendra P, Cook M, Clark F, Pratt G, Craddock C, Moss PA.

Haematologica. 2010 Sep;95(9):1572-8. doi: 10.3324/haematol.2009.019539. Epub 2010 May 11.


Patients with Wegener's granulomatosis demonstrate a relative deficiency and functional impairment of T-regulatory cells.

Morgan MD, Day CJ, Piper KP, Khan N, Harper L, Moss PA, Savage CO.

Immunology. 2010 May;130(1):64-73. doi: 10.1111/j.1365-2567.2009.03213.x. Epub 2010 Jan 27.


Fetal microchimerism: the cellular and immunological legacy of pregnancy.

Lissauer DM, Piper KP, Moss PA, Kilby MD.

Expert Rev Mol Med. 2009 Nov 12;11:e33. doi: 10.1017/S1462399409001264.


Adenovirus vector-specific T cells demonstrate a unique memory phenotype with high proliferative potential and coexpression of CCR5 and integrin alpha4beta7.

Chakupurakal G, Onion D, Cobbold M, Mautner V, Moss PA.

AIDS. 2010 Jan 16;24(2):205-10. doi: 10.1097/QAD.0b013e328333addf.


Secondary anchor polymorphism in the HA-1 minor histocompatibility antigen critically affects MHC stability and TCR recognition.

Nicholls S, Piper KP, Mohammed F, Dafforn TR, Tenzer S, Salim M, Mahendra P, Craddock C, van Endert P, Schild H, Cobbold M, Engelhard VH, Moss PA, Willcox BE.

Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3889-94. doi: 10.1073/pnas.0900411106. Epub 2009 Feb 20.


Early reconstitution of effector memory CD4+ CMV-specific T cells protects against CMV reactivation following allogeneic SCT.

Pourgheysari B, Piper KP, McLarnon A, Arrazi J, Bruton R, Clark F, Cook M, Mahendra P, Craddock C, Moss PA.

Bone Marrow Transplant. 2009 Jun;43(11):853-61. doi: 10.1038/bmt.2008.403. Epub 2008 Dec 22.


Direct observations of the kinetics of migrating T cells suggest active retention by endothelial cells with continual bidirectional migration.

McGettrick HM, Hunter K, Moss PA, Buckley CD, Rainger GE, Nash GB.

J Leukoc Biol. 2009 Jan;85(1):98-107. doi: 10.1189/jlb.0508301. Epub 2008 Oct 23.


Genotypic analysis of two hypervariable human cytomegalovirus genes.

Bradley AJ, Kovács IJ, Gatherer D, Dargan DJ, Alkharsah KR, Chan PK, Carman WF, Dedicoat M, Emery VC, Geddes CC, Gerna G, Ben-Ismaeil B, Kaye S, McGregor A, Moss PA, Pusztai R, Rawlinson WD, Scott GM, Wilkinson GW, Schulz TF, Davison AJ.

J Med Virol. 2008 Sep;80(9):1615-23. doi: 10.1002/jmv.21241.


Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion.

Austen B, Skowronska A, Baker C, Powell JE, Gardiner A, Oscier D, Majid A, Dyer M, Siebert R, Taylor AM, Moss PA, Stankovic T.

J Clin Oncol. 2007 Dec 1;25(34):5448-57. Epub 2007 Oct 29.


Persistence of fetal cells in the mother: friend or foe?

Lissauer D, Piper KP, Moss PA, Kilby MD.

BJOG. 2007 Nov;114(11):1321-5. Review.


CXCL10-CXCR3 interactions play an important role in the pathogenesis of acute graft-versus-host disease in the skin following allogeneic stem-cell transplantation.

Piper KP, Horlock C, Curnow SJ, Arrazi J, Nicholls S, Mahendra P, Craddock C, Moss PA.

Blood. 2007 Dec 1;110(12):3827-32. Epub 2007 Aug 31. Erratum in: Blood. 2008 Aug 15;112(4):1546.


The CD4+ T-cell response to adenovirus is focused against conserved residues within the hexon protein.

Onion D, Crompton LJ, Milligan DW, Moss PA, Lee SP, Mautner V.

J Gen Virol. 2007 Sep;88(Pt 9):2417-25.


The cytomegalovirus-specific CD4+ T-cell response expands with age and markedly alters the CD4+ T-cell repertoire.

Pourgheysari B, Khan N, Best D, Bruton R, Nayak L, Moss PA.

J Virol. 2007 Jul;81(14):7759-65. Epub 2007 Apr 4.


T cell recognition patterns of immunodominant cytomegalovirus antigens in primary and persistent infection.

Khan N, Best D, Bruton R, Nayak L, Rickinson AB, Moss PA.

J Immunol. 2007 Apr 1;178(7):4455-65.


Ageing is associated with a decline in peripheral blood CD56bright NK cells.

Chidrawar SM, Khan N, Chan YL, Nayak L, Moss PA.

Immun Ageing. 2006 Nov 29;3:10.


The polycomb group proteins, BMI-1 and EZH2, are tumour-associated antigens.

Steele JC, Torr EE, Noakes KL, Kalk E, Moss PA, Reynolds GM, Hubscher SG, van Lohuizen M, Adams DH, Young LS.

Br J Cancer. 2006 Nov 6;95(9):1202-11. Epub 2006 Oct 3.


Functional HY-specific CD8+ T cells are found in a high proportion of women following pregnancy with a male fetus.

Piper KP, McLarnon A, Arrazi J, Horlock C, Ainsworth J, Kilby MD, Martin WL, Moss PA.

Biol Reprod. 2007 Jan;76(1):96-101. Epub 2006 Sep 20.


DNA fusion vaccines induce epitope-specific cytotoxic CD8(+) T cells against human leukemia-associated minor histocompatibility antigens.

Rice J, Dunn S, Piper K, Buchan SL, Moss PA, Stevenson FK.

Cancer Res. 2006 May 15;66(10):5436-42.


EBV-associated mononucleosis leads to long-term global deficit in T-cell responsiveness to IL-15.

Sauce D, Larsen M, Curnow SJ, Leese AM, Moss PA, Hislop AD, Salmon M, Rickinson AB.

Blood. 2006 Jul 1;108(1):11-8. Epub 2006 Mar 16.


Soluble syndecan-1 level at diagnosis is an independent prognostic factor in multiple myeloma and the extent of fall from diagnosis to plateau predicts for overall survival.

Lovell R, Dunn JA, Begum G, Barth NJ, Plant T, Moss PA, Drayson MT, Pratt G; Working Party on Leukaemia in Adults of the National Cancer Research Institute Haematological Oncology Clinical Studies Group.

Br J Haematol. 2005 Aug;130(4):542-8.


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