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Items: 1 to 50 of 71

1.

The pore structure of Clostridium perfringens epsilon toxin.

Savva CG, Clark AR, Naylor CE, Popoff MR, Moss DS, Basak AK, Titball RW, Bokori-Brown M.

Nat Commun. 2019 Jun 14;10(1):2641. doi: 10.1038/s41467-019-10645-8.

2.

Factor VIII cross-matches to the human proteome reduce the predicted inhibitor risk in missense mutation hemophilia A.

Hart DP, Uzun N, Skelton S, Kakoschke A, Househam J, Moss DS, Shepherd AJ.

Haematologica. 2019 Mar;104(3):599-608. doi: 10.3324/haematol.2018.195669. Epub 2018 Sep 28.

3.

Dysregulation of Alternative Poly-adenylation as a Potential Player in Autism Spectrum Disorder.

Szkop KJ, Cooke PIC, Humphries JA, Kalna V, Moss DS, Schuster EF, Nobeli I.

Front Mol Neurosci. 2017 Sep 13;10:279. doi: 10.3389/fnmol.2017.00279. eCollection 2017.

4.

The mre11 A470 alleles influence the hereditability and the segregation of telosomes in Saccharomyces cerevisiae.

Baek IJ, Moss DS, Lustig AJ.

PLoS One. 2017 Sep 8;12(9):e0183549. doi: 10.1371/journal.pone.0183549. eCollection 2017.

5.

Investigating Substitutions in Antibody-Antigen Complexes Using Molecular Dynamics: A Case Study with Broad-spectrum, Influenza A Antibodies.

Lees WD, Stejskal L, Moss DS, Shepherd AJ.

Front Immunol. 2017 Feb 15;8:143. doi: 10.3389/fimmu.2017.00143. eCollection 2017.

6.

A large-scale computational study of inhibitor risk in non-severe haemophilia A.

Shepherd AJ, Skelton S, Sansom CE, Gomez K, Moss DS, Hart DP.

Br J Haematol. 2015 Feb;168(3):413-20. doi: 10.1111/bjh.13131. Epub 2014 Sep 22.

PMID:
25244644
7.

N-linked glycans on influenza A H3N2 hemagglutinin constrain binding of host antibodies, but shielding is limited.

Pentiah K, Lees WD, Moss DS, Shepherd AJ.

Glycobiology. 2015 Jan;25(1):124-32. doi: 10.1093/glycob/cwu097. Epub 2014 Sep 16.

PMID:
25227423
8.

Structure of a C. perfringens enterotoxin mutant in complex with a modified Claudin-2 extracellular loop 2.

Yelland TS, Naylor CE, Bagoban T, Savva CG, Moss DS, McClane BA, Blasig IE, Popoff M, Basak AK.

J Mol Biol. 2014 Sep 9;426(18):3134-3147. doi: 10.1016/j.jmb.2014.07.001. Epub 2014 Jul 11.

PMID:
25020226
9.

Clostridium perfringens epsilon toxin mutant Y30A-Y196A as a recombinant vaccine candidate against enterotoxemia.

Bokori-Brown M, Hall CA, Vance C, Fernandes da Costa SP, Savva CG, Naylor CE, Cole AR, Basak AK, Moss DS, Titball RW.

Vaccine. 2014 May 13;32(23):2682-7. doi: 10.1016/j.vaccine.2014.03.079. Epub 2014 Apr 5.

10.

Identification of a key residue for oligomerisation and pore-formation of Clostridium perfringens NetB.

Fernandes da Costa SP, Savva CG, Bokori-Brown M, Naylor CE, Moss DS, Basak AK, Titball RW.

Toxins (Basel). 2014 Mar 12;6(3):1049-61. doi: 10.3390/toxins6031049.

11.

Evolution in the influenza A H3 stalk - a challenge for broad-spectrum vaccines?

Lees WD, Moss DS, Shepherd AJ.

J Gen Virol. 2014 Feb;95(Pt 2):317-24. doi: 10.1099/vir.0.059410-0. Epub 2013 Nov 1.

PMID:
24187015
12.

Clostridium perfringens epsilon toxin H149A mutant as a platform for receptor binding studies.

Bokori-Brown M, Kokkinidou MC, Savva CG, Fernandes da Costa S, Naylor CE, Cole AR, Moss DS, Basak AK, Titball RW.

Protein Sci. 2013 May;22(5):650-9. doi: 10.1002/pro.2250. Epub 2013 Apr 8.

13.

Molecular architecture and functional analysis of NetB, a pore-forming toxin from Clostridium perfringens.

Savva CG, Fernandes da Costa SP, Bokori-Brown M, Naylor CE, Cole AR, Moss DS, Titball RW, Basak AK.

J Biol Chem. 2013 Feb 1;288(5):3512-22. doi: 10.1074/jbc.M112.430223. Epub 2012 Dec 13.

14.

Visualisation of variable binding pockets on protein surfaces by probabilistic analysis of related structure sets.

Ashford P, Moss DS, Alex A, Yeap SK, Povia A, Nobeli I, Williams MA.

BMC Bioinformatics. 2012 Mar 14;13:39. doi: 10.1186/1471-2105-13-39.

15.

Structure of the food-poisoning Clostridium perfringens enterotoxin reveals similarity to the aerolysin-like pore-forming toxins.

Briggs DC, Naylor CE, Smedley JG 3rd, Lukoyanova N, Robertson S, Moss DS, McClane BA, Basak AK.

J Mol Biol. 2011 Oct 14;413(1):138-49. doi: 10.1016/j.jmb.2011.07.066. Epub 2011 Aug 3.

16.

Analysis of antigenically important residues in human influenza A virus in terms of B-cell epitopes.

Lees WD, Moss DS, Shepherd AJ.

J Virol. 2011 Sep;85(17):8548-55. doi: 10.1128/JVI.00579-11. Epub 2011 Jun 15.

17.

ImmunoGrid: towards agent-based simulations of the human immune system at a natural scale.

Halling-Brown M, Pappalardo F, Rapin N, Zhang P, Alemani D, Emerson A, Castiglione F, Duroux P, Pennisi M, Miotto O, Churchill D, Rossi E, Moss DS, Sansom CE, Bernaschi M, Lefranc MP, Brunak S, Lund O, Motta S, Lollini PL, Murgo A, Palladini A, Basford KE, Brusic V, Shepherd AJ.

Philos Trans A Math Phys Eng Sci. 2010 Jun 13;368(1920):2799-815. doi: 10.1098/rsta.2010.0067.

PMID:
20439274
18.

A computational analysis of the antigenic properties of haemagglutinin in influenza A H3N2.

Lees WD, Moss DS, Shepherd AJ.

Bioinformatics. 2010 Jun 1;26(11):1403-8. doi: 10.1093/bioinformatics/btq160. Epub 2010 Apr 13.

19.

Proteins accessible to immune surveillance show significant T-cell epitope depletion: Implications for vaccine design.

Halling-Brown M, Shaban R, Frampton D, Sansom CE, Davies M, Flower D, Duffield M, Titball RW, Brusic V, Moss DS.

Mol Immunol. 2009 Aug;46(13):2699-705. doi: 10.1016/j.molimm.2009.05.027. Epub 2009 Jun 27.

PMID:
19560824
20.

A computational Grid framework for immunological applications.

Halling-Brown MD, Moss DS, Sansom CE, Shepherd AJ.

Philos Trans A Math Phys Eng Sci. 2009 Jul 13;367(1898):2705-16. doi: 10.1098/rsta.2009.0046.

PMID:
19487206
21.

ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization.

Pappalardo F, Halling-Brown MD, Rapin N, Zhang P, Alemani D, Emerson A, Paci P, Duroux P, Pennisi M, Palladini A, Miotto O, Churchill D, Rossi E, Shepherd AJ, Moss DS, Castiglione F, Bernaschi M, Lefranc MP, Brunak S, Motta S, Lollini PL, Basford KE, Brusic V.

Brief Bioinform. 2009 May;10(3):330-40. doi: 10.1093/bib/bbp014.

PMID:
19383844
22.

Towards a lightweight generic computational grid framework for biological research.

Halling-Brown MD, Moss DS, Shepherd AJ.

BMC Bioinformatics. 2008 Oct 2;9:407. doi: 10.1186/1471-2105-9-407.

23.

GPCRTree: online hierarchical classification of GPCR function.

Davies MN, Secker A, Halling-Brown M, Moss DS, Freitas AA, Timmis J, Clark E, Flower DR.

BMC Res Notes. 2008 Aug 21;1:67. doi: 10.1186/1756-0500-1-67.

24.

Are bacterial vaccine antigens T-cell epitope depleted?

Halling-Brown M, Sansom CE, Davies M, Titball RW, Moss DS.

Trends Immunol. 2008 Aug;29(8):374-9. doi: 10.1016/j.it.2008.06.001. Epub 2008 Jul 5.

PMID:
18603471
25.

Identification of the HLA-DM/HLA-DR interface.

Davies MN, Lamikanra A, Sansom CE, Flower DR, Moss DS, Travers PJ.

Mol Immunol. 2008 Feb;45(4):1063-70. Epub 2007 Sep 17.

PMID:
17870168
26.

Toward the atomistic simulation of T cell epitopes automated construction of MHC: peptide structures for free energy calculations.

Todman SJ, Halling-Brown MD, Davies MN, Flower DR, Kayikci M, Moss DS.

J Mol Graph Model. 2008 Feb;26(6):957-61. Epub 2007 Jul 28.

PMID:
17766153
27.

SiPep: a system for the prediction of tissue-specific minor histocompatibility antigens.

Halling-Brown M, Quartey-Papafio R, Travers PJ, Moss DS.

Int J Immunogenet. 2006 Aug;33(4):289-95.

PMID:
16893394
28.

Benchmarking pK(a) prediction.

Davies MN, Toseland CP, Moss DS, Flower DR.

BMC Biochem. 2006 Jun 2;7:18.

29.

Statistical deconvolution of enthalpic energetic contributions to MHC-peptide binding affinity.

Davies MN, Hattotuwagama CK, Moss DS, Drew MG, Flower DR.

BMC Struct Biol. 2006 Mar 20;6:5.

30.

Clostridium perfringens epsilon-toxin shows structural similarity to the pore-forming toxin aerolysin.

Cole AR, Gibert M, Popoff M, Moss DS, Titball RW, Basak AK.

Nat Struct Mol Biol. 2004 Aug;11(8):797-8. Epub 2004 Jul 18.

PMID:
15258571
31.

A novel predictive technique for the MHC class II peptide-binding interaction.

Davies MN, Sansom CE, Beazley C, Moss DS.

Mol Med. 2003 Sep-Dec;9(9-12):220-5.

32.

A Fugu-Human Genome Synteny Viewer: web software for graphical display and annotation reports of synteny between Fugu genomic sequence and human genes.

Halling-Brown M, Sansom C, Moss DS, Elgar G, Edwards YJ.

Nucleic Acids Res. 2004 May 11;32(8):2618-22. Print 2004.

33.

Clostridium absonum alpha-toxin: new insights into clostridial phospholipase C substrate binding and specificity.

Clark GC, Briggs DC, Karasawa T, Wang X, Cole AR, Maegawa T, Jayasekera PN, Naylor CE, Miller J, Moss DS, Nakamura S, Basak AK, Titball RW.

J Mol Biol. 2003 Oct 31;333(4):759-69.

PMID:
14568535
34.

Estimation of weights and validation: a marginal likelihood approach.

Lebedev AA, Tickle IJ, Laskowski RA, Moss DS.

Acta Crystallogr D Biol Crystallogr. 2003 Sep;59(Pt 9):1557-66. Epub 2003 Aug 19.

PMID:
12925785
35.

The collation of forensic DNA case data into a multi-dimensional intelligence database.

Walsh SJ, Moss DS, Kliem C, Vintiner GM.

Sci Justice. 2002 Oct-Dec;42(4):205-14.

PMID:
12632936
36.

Comparison of the variables affecting the recovery of DNA from common drinking containers.

Abaz J, Walsh SJ, Curran JM, Moss DS, Cullen J, Bright JA, Crowe GA, Cockerton SL, Power TE.

Forensic Sci Int. 2002 May 23;126(3):233-40.

PMID:
12062947
37.

Crystal structure of the C. perfringens alpha-toxin with the active site closed by a flexible loop region.

Eaton JT, Naylor CE, Howells AM, Moss DS, Titball RW, Basak AK.

J Mol Biol. 2002 May 31;319(2):275-81.

PMID:
12051905
38.

The first strain of Clostridium perfringens isolated from an avian source has an alpha-toxin with divergent structural and kinetic properties.

Justin N, Walker N, Bullifent HL, Songer G, Bueschel DM, Jost H, Naylor C, Miller J, Moss DS, Titball RW, Basak AK.

Biochemistry. 2002 May 21;41(20):6253-62.

PMID:
12009886
39.

The Bioinformatics Template Library--generic components for biocomputing.

Pitt WR, Williams MA, Steven M, Sweeney B, Bleasby AJ, Moss DS.

Bioinformatics. 2001 Aug;17(8):729-37.

PMID:
11524374
40.

Identification of residues in the carboxy-terminal domain of Clostridium perfringens alpha-toxin (phospholipase C) which are required for its biological activities.

Walker N, Holley J, Naylor CE, Flores-Díaz M, Alape-Girón A, Carter G, Carr FJ, Thelestam M, Keyte M, Moss DS, Basak AK, Miller J, Titball RW.

Arch Biochem Biophys. 2000 Dec 1;384(1):24-30.

PMID:
11147832
41.

Opening of the active site of Clostridium perfringens alpha-toxin may be triggered by membrane binding.

Titball RW, Naylor CE, Miller J, Moss DS, Basak AK.

Int J Med Microbiol. 2000 Oct;290(4-5):357-61. Review.

PMID:
11111911
42.
43.

Crystallization and preliminary X-ray diffraction studies of alpha-toxin from two different strains (NCTC8237 and CER89L43) of Clostridium perfringens.

Basak AK, Howells A, Eaton JT, Moss DS, Naylor CE, Miller J, Titball RW.

Acta Crystallogr D Biol Crystallogr. 1998 Nov 1;54(Pt 6 Pt 2):1425-8.

PMID:
10089527
44.

Error estimates of protein structure coordinates and deviations from standard geometry by full-matrix refinement of gammaB- and betaB2-crystallin.

Tickle IJ, Laskowski RA, Moss DS.

Acta Crystallogr D Biol Crystallogr. 1998 Mar 1;54(Pt 2):243-52.

PMID:
9761889
45.

Rfree and the rfree ratio. I. Derivation of expected values of cross-validation residuals used in macromolecular least-squares refinement.

Tickle IJ, Laskowski RA, Moss DS.

Acta Crystallogr D Biol Crystallogr. 1998 Jul 1;54(Pt 4):547-57.

PMID:
9761849
46.

Structure of the key toxin in gas gangrene.

Naylor CE, Eaton JT, Howells A, Justin N, Moss DS, Titball RW, Basak AK.

Nat Struct Biol. 1998 Aug;5(8):738-46.

PMID:
9699639
47.

An analysis of the antigen binding site of RT1.Aa suggests an allele-specific motif.

Thorpe CJ, Moss DS, Powis SJ, Howard JC, Butcher GW, Travers PJ.

Immunogenetics. 1995;41(5):329-31. No abstract available.

PMID:
7721357
48.

Close packing of an oligomeric eye lens beta-crystallin induces loss of symmetry and ordering of sequence extensions.

Nalini V, Bax B, Driessen H, Moss DS, Lindley PF, Slingsby C.

J Mol Biol. 1994 Mar 4;236(4):1250-8.

PMID:
8120900
49.

An algorithm for automatically generating protein topology cartoons.

Flores TP, Moss DS, Thornton JM.

Protein Eng. 1994 Jan;7(1):31-7.

PMID:
8140092
50.

Comparison of conformational characteristics in structurally similar protein pairs.

Flores TP, Orengo CA, Moss DS, Thornton JM.

Protein Sci. 1993 Nov;2(11):1811-26.

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