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Items: 44

1.

Correction to Nucleoside, Nucleotide, and Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA-Polymerase.

Sofia MJ, Chang W, Furman PA, Mosley RT, Ross BS.

J Med Chem. 2017 Apr 13;60(7):3219. doi: 10.1021/acs.jmedchem.7b00427. Epub 2017 Mar 24. No abstract available.

PMID:
28339203
2.

Molecular and structural basis for the roles of hepatitis C virus polymerase NS5B amino acids 15, 223, and 321 in viral replication and drug resistance.

Lam AM, Edwards TE, Mosley RT, Murakami E, Bansal S, Lugo C, Bao H, Otto MJ, Sofia MJ, Furman PA.

Antimicrob Agents Chemother. 2014 Nov;58(11):6861-9. doi: 10.1128/AAC.03847-14. Epub 2014 Sep 2.

3.

Discovery of a novel class of potent HCV NS4B inhibitors: SAR studies on piperazinone derivatives.

Kakarla R, Liu J, Naduthambi D, Chang W, Mosley RT, Bao D, Steuer HM, Keilman M, Bansal S, Lam AM, Seibel W, Neilson S, Furman PA, Sofia MJ.

J Med Chem. 2014 Mar 13;57(5):2136-60. doi: 10.1021/jm4012643. Epub 2014 Jan 29.

PMID:
24476391
4.

Use of 2'-spirocyclic ethers in HCV nucleoside design.

Du J, Chun BK, Mosley RT, Bansal S, Bao H, Espiritu C, Lam AM, Murakami E, Niu C, Micolochick Steuer HM, Furman PA, Sofia MJ.

J Med Chem. 2014 Mar 13;57(5):1826-35. doi: 10.1021/jm401224y. Epub 2013 Oct 18.

PMID:
24079820
5.

Structure of hepatitis C virus polymerase in complex with primer-template RNA.

Mosley RT, Edwards TE, Murakami E, Lam AM, Grice RL, Du J, Sofia MJ, Furman PA, Otto MJ.

J Virol. 2012 Jun;86(12):6503-11. doi: 10.1128/JVI.00386-12. Epub 2012 Apr 11.

6.

Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics.

Chang W, Mosley RT, Bansal S, Keilman M, Lam AM, Furman PA, Otto MJ, Sofia MJ.

Bioorg Med Chem Lett. 2012 Apr 15;22(8):2938-42. doi: 10.1016/j.bmcl.2012.02.051. Epub 2012 Feb 28.

PMID:
22425564
7.

Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase.

Sofia MJ, Chang W, Furman PA, Mosley RT, Ross BS.

J Med Chem. 2012 Mar 22;55(6):2481-531. doi: 10.1021/jm201384j. Epub 2012 Jan 23. Review. No abstract available. Erratum in: J Med Chem. 2017 Apr 13;60(7):3219.

PMID:
22185586
8.

Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor γ (PPARγ) modulators.

Liu W, Lau F, Liu K, Wood HB, Zhou G, Chen Y, Li Y, Akiyama TE, Castriota G, Einstein M, Wang C, McCann ME, Doebber TW, Wu M, Chang CH, McNamara L, McKeever B, Mosley RT, Berger JP, Meinke PT.

J Med Chem. 2011 Dec 22;54(24):8541-54. doi: 10.1021/jm201061j. Epub 2011 Nov 28.

PMID:
22070604
9.

Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates.

Murakami E, Bao H, Mosley RT, Du J, Sofia MJ, Furman PA.

J Med Chem. 2011 Aug 25;54(16):5902-14. doi: 10.1021/jm200650j. Epub 2011 Jul 22.

PMID:
21755941
10.

Phenylpropenamide derivatives: anti-hepatitis B virus activity of the Z isomer, SAR and the search for novel analogs.

Wang P, Naduthambi D, Mosley RT, Niu C, Furman PA, Otto MJ, Sofia MJ.

Bioorg Med Chem Lett. 2011 Aug 1;21(15):4642-7. doi: 10.1016/j.bmcl.2011.05.077. Epub 2011 Jun 6.

PMID:
21704526
11.

What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases.

Evans JF, Ferguson AD, Mosley RT, Hutchinson JH.

Trends Pharmacol Sci. 2008 Feb;29(2):72-8. doi: 10.1016/j.tips.2007.11.006. Epub 2008 Jan 9. Review.

PMID:
18187210
12.

The differential interactions of peroxisome proliferator-activated receptor gamma ligands with Tyr473 is a physical basis for their unique biological activities.

Einstein M, Akiyama TE, Castriota GA, Wang CF, McKeever B, Mosley RT, Becker JW, Moller DE, Meinke PT, Wood HB, Berger JP.

Mol Pharmacol. 2008 Jan;73(1):62-74. Epub 2007 Oct 16.

PMID:
17940191
13.

Androstene-3,5-dienes as ER-beta selective SERMs.

Blizzard TA, Gude C, Morgan JD 2nd, Chan W, Birzin ET, Mojena M, Tudela C, Chen F, Knecht K, Su Q, Kraker B, Mosley RT, Holmes MA, Rohrer SP, Hammond ML.

Bioorg Med Chem Lett. 2007 Nov 15;17(22):6295-8. Epub 2007 Sep 7.

PMID:
17890084
14.

The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors.

Hamblett CL, Methot JL, Mampreian DM, Sloman DL, Stanton MG, Kral AM, Fleming JC, Cruz JC, Chenard M, Ozerova N, Hitz AM, Wang H, Deshmukh SV, Nazef N, Harsch A, Hughes B, Dahlberg WK, Szewczak AA, Middleton RE, Mosley RT, Secrist JP, Miller TA.

Bioorg Med Chem Lett. 2007 Oct 1;17(19):5300-9. Epub 2007 Aug 16.

PMID:
17761416
15.

Benzo[b]thiophene-based histone deacetylase inhibitors.

Witter DJ, Belvedere S, Chen L, Secrist JP, Mosley RT, Miller TA.

Bioorg Med Chem Lett. 2007 Aug 15;17(16):4562-7. Epub 2007 Jun 6.

PMID:
17576064
16.

Attenuating pregnane X receptor (PXR) activation: a molecular modelling approach.

Gao YD, Olson SH, Balkovec JM, Zhu Y, Royo I, Yabut J, Evers R, Tan EY, Tang W, Hartley DP, Mosley RT.

Xenobiotica. 2007 Feb;37(2):124-38.

PMID:
17484516
17.

Novel glucocorticoids containing a 6,5-bicyclic core fused to a pyrazole ring: synthesis, in vitro profile, molecular modeling studies, and in vivo experiments.

Thompson CF, Quraishi N, Ali A, Mosley RT, Tata JR, Hammond ML, Balkovec JM, Einstein M, Ge L, Harris G, Kelly TM, Mazur P, Pandit S, Santoro J, Sitlani A, Wang C, Williamson J, Miller DK, Yamin TT, Thompson CM, O'Neill EA, Zaller D, Forrest MJ, Carballo-Jane E, Luell S.

Bioorg Med Chem Lett. 2007 Jun 15;17(12):3354-61. Epub 2007 Apr 5.

PMID:
17467988
18.

Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERalpha.

Dykstra KD, Guo L, Birzin ET, Chan W, Yang YT, Hayes EC, DaSilva CA, Pai LY, Mosley RT, Kraker B, Fitzgerald PM, DiNinno F, Rohrer SP, Schaeffer JM, Hammond ML.

Bioorg Med Chem Lett. 2007 Apr 15;17(8):2322-8. Epub 2007 Jan 25.

PMID:
17289385
19.

Sordarin derivatives induce a novel conformation of the yeast ribosome translocation factor eEF2.

Søe R, Mosley RT, Justice M, Nielsen-Kahn J, Shastry M, Merrill AR, Andersen GR.

J Biol Chem. 2007 Jan 5;282(1):657-66. Epub 2006 Nov 2.

20.

Tetrahydrofluorenones with conformationally restricted side chains as selective estrogen receptor beta ligands.

Wildonger KJ, Ratcliffe RW, Mosley RT, Hammond ML, Birzin ET, Rohrer SP.

Bioorg Med Chem Lett. 2006 Sep 1;16(17):4462-6. Epub 2006 Jul 11.

PMID:
16815012
21.

The discovery of tetrahydrofluorenones as a new class of estrogen receptor beta-subtype selective ligands.

Wilkening RR, Ratcliffe RW, Tynebor EC, Wildonger KJ, Fried AK, Hammond ML, Mosley RT, Fitzgerald PM, Sharma N, McKeever BM, Nilsson S, Carlquist M, Thorsell A, Locco L, Katz R, Frisch K, Birzin ET, Wilkinson HA, Mitra S, Cai S, Hayes EC, Schaeffer JM, Rohrer SP.

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3489-94. Epub 2006 May 2.

PMID:
16632357
22.

Androstenediol analogs as ER-beta-selective SERMs.

Blizzard TA, Gude C, Morgan JD 2nd, Chan W, Birzin ET, Mojena M, Tudela C, Chen F, Knecht K, Su Q, Kraker B, Mosley RT, Holmes MA, Sharma N, Fitzgerald PM, Rohrer SP, Hammond ML.

Bioorg Med Chem Lett. 2006 Feb 15;16(4):834-8. Epub 2005 Nov 23.

PMID:
16309907
23.

Estrogen receptor ligands. Part 14: application of novel antagonist side chains to existing platforms.

Blizzard TA, Morgan JD 2nd, Chan W, Birzin ET, Pai LY, Hayes EC, DaSilva CA, Mosley RT, Yang YT, Rohrer SP, Dininno F, Hammond ML.

Bioorg Med Chem Lett. 2005 Dec 1;15(23):5124-8. Epub 2005 Oct 3.

PMID:
16203138
24.

Reagent Selector: using Synthon Analysis to visualize reagent properties and assist in combinatorial library design.

Mosley RT, Culberson JC, Kraker B, Feuston BP, Sheridan RP, Conway JF, Forbes JK, Chakravorty SJ, Kearsley SK.

J Chem Inf Model. 2005 Sep-Oct;45(5):1439-46.

PMID:
16180921
25.

Structure-activity relationship of linear tetrapeptides Tic-DPhe-Arg-Trp-NH2 at the human melanocortin-4 receptor and effects on feeding behaviors in rat.

Ye Z, MacNeil T, Weinberg DH, Kalyani RN, Tang R, Strack AM, Murphy BA, Mosley RT, Euan MacIntyre D, Van der Ploeg LH, Patchett AA, Wyvratt MJ, Nargund RP.

Peptides. 2005 Oct;26(10):2017-25.

PMID:
15993513
26.

Selective glucocorticoid receptor nonsteroidal ligands completely antagonize the dexamethasone mediated induction of enzymes involved in gluconeogenesis and glutamine metabolism.

Einstein M, Greenlee M, Rouen G, Sitlani A, Santoro J, Wang C, Pandit S, Mazur P, Smalera I, Weaver AP, Zeng YY, Ge L, Kelly T, Paiva T, Geissler W, Mosley RT, Williamson J, Ali A, Balkovec J, Harris G.

J Steroid Biochem Mol Biol. 2004 Dec;92(5):345-56. Epub 2005 Jan 21.

PMID:
15698539
27.

Estrogen receptor ligands. Part 11: Synthesis and activity of isochromans and isothiochromans.

Liu J, Birzin ET, Chan W, Yang YT, Pai LY, Dasilva C, Hayes EC, Mosley RT, Dininno F, Rohrer SP, Schaeffer JM, Hammond ML.

Bioorg Med Chem Lett. 2005 Feb 1;15(3):715-8.

PMID:
15664843
28.

Estrogen receptor ligands. II. Discovery of benzoxathiins as potent, selective estrogen receptor alpha modulators.

Kim S, Wu JY, Birzin ET, Frisch K, Chan W, Pai LY, Yang YT, Mosley RT, Fitzgerald PM, Sharma N, Dahllund J, Thorsell AG, DiNinno F, Rohrer SP, Schaeffer JM, Hammond ML.

J Med Chem. 2004 Apr 22;47(9):2171-5.

PMID:
15084115
29.

Estrogen receptor ligands. Part 1: The discovery of flavanoids with subtype selectivity.

Chen HY, Dykstra KD, Birzin ET, Frisch K, Chan W, Yang YT, Mosley RT, DiNinno F, Rohrer SP, Schaeffer JM, Hammond ML.

Bioorg Med Chem Lett. 2004 Mar 22;14(6):1417-21.

PMID:
15006374
30.

Comparison of 2-phenylspiroindenes and 2-phenylspiroindenediones as estrogen receptor ligands--modeling and binding data don't agree!

Blizzard TA, Mosley RT, Birzin ET, Chan W, Hammond ML.

Bioorg Med Chem Lett. 2004 Mar 8;14(5):1317-21.

PMID:
14980690
31.

1H-NMR studies on a potent and selective antagonist at human melanocortin receptor 4 (hMC-4R).

Victoria Silva Elipe M, Mosley RT, Bednarek MA, Arison BH.

Biopolymers. 2003 Apr;68(4):512-27.

PMID:
12666176
32.

2-Phenylspiroindenes: a novel class of selective estrogen receptor modulators (SERMs).

Blizzard TA, Morgan JD 2nd, Mosley RT, Birzin ET, Frisch K, Rohrer SP, Hammond ML.

Bioorg Med Chem Lett. 2003 Feb 10;13(3):479-83.

PMID:
12565955
33.

A simple method for visualizing the differences between related receptor sites.

Sheridan RP, Holloway MK, McGaughey G, Mosley RT, Singh SB.

J Mol Graph Model. 2002 Dec;21(3):217-25.

PMID:
12463640
34.

Amino acid substitution of arginine 80 in 17beta-hydroxysteroid dehydrogenase type 3 and its effect on NADPH cofactor binding and oxidation/reduction kinetics.

McKeever BM, Hawkins BK, Geissler WM, Wu L, Sheridan RP, Mosley RT, Andersson S.

Biochim Biophys Acta. 2002 Nov 19;1601(1):29-37.

PMID:
12429500
35.

A simple method for visualizing the differences between related receptor sites.

Sheridan RP, Holloway MK, McGaughey G, Mosley RT, Singh SB.

J Mol Graph Model. 2002 Aug;21(1):71-9. Corrected and republished in: J Mol Graph Model. 2002 Dec;21(3):217-25.

PMID:
12413033
36.

Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonist.

Sebhat IK, Martin WJ, Ye Z, Barakat K, Mosley RT, Johnston DB, Bakshi R, Palucki B, Weinberg DH, MacNeil T, Kalyani RN, Tang R, Stearns RA, Miller RR, Tamvakopoulos C, Strack AM, McGowan E, Cashen DE, Drisko JE, Hom GJ, Howard AD, MacIntyre DE, van der Ploeg LH, Patchett AA, Nargund RP.

J Med Chem. 2002 Oct 10;45(21):4589-93.

PMID:
12361385
37.

Combinatorial library of indinavir analogues: replacement for the aminoindanol at P2'.

Raghavan S, Yang Z, Mosley RT, Schleif WA, Gabryelski L, Olsen DB, Stahlhut M, Kuo LC, Emini EA, Chapman KT, Tata JR.

Bioorg Med Chem Lett. 2002 Oct 21;12(20):2855-8.

PMID:
12270162
38.

Structure and chemistry of apicidins, a class of novel cyclic tetrapeptides without a terminal alpha-keto epoxide as inhibitors of histone deacetylase with potent antiprotozoal activities.

Singh SB, Zink DL, Liesch JM, Mosley RT, Dombrowski AW, Bills GF, Darkin-Rattray SJ, Schmatz DM, Goetz MA.

J Org Chem. 2002 Feb 8;67(3):815-25.

PMID:
11856024
39.

Assignment of the liposidomycin diazepanone stereochemistry.

Knapp S, Morriello GJ, Nandan SR, Emge TJ, Doss GA, Mosley RT, Chen L.

J Org Chem. 2001 Aug 24;66(17):5822-31.

PMID:
11511258
40.

A combinatorial approach toward the discovery of non-peptide, subtype-selective somatostatin receptor ligands.

Berk SC, Rohrer SP, Degrado SJ, Birzin ET, Mosley RT, Hutchins SM, Pasternak A, Schaeffer JM, Underwood DJ, Chapman KT.

J Comb Chem. 1999 Sep-Oct;1(5):388-96.

PMID:
10748735
41.

Molecular interaction of Agouti protein and Agouti-related protein with human melanocortin receptors.

Tota MR, Smith TS, Mao C, MacNeil T, Mosley RT, Van der Ploeg LH, Fong TM.

Biochemistry. 1999 Jan 19;38(3):897-904.

PMID:
9893984
42.

Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.

Rohrer SP, Birzin ET, Mosley RT, Berk SC, Hutchins SM, Shen DM, Xiong Y, Hayes EC, Parmar RM, Foor F, Mitra SW, Degrado SJ, Shu M, Klopp JM, Cai SJ, Blake A, Chan WW, Pasternak A, Yang L, Patchett AA, Smith RG, Chapman KT, Schaeffer JM.

Science. 1998 Oct 23;282(5389):737-40. Erratum in: Science 1998 Nov 27;282(5394):1646.

43.

Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2.

Yang L, Berk SC, Rohrer SP, Mosley RT, Guo L, Underwood DJ, Arison BH, Birzin ET, Hayes EC, Mitra SW, Parmar RM, Cheng K, Wu TJ, Butler BS, Foor F, Pasternak A, Pan Y, Silva M, Freidinger RM, Smith RG, Chapman K, Schaeffer JM, Patchett AA.

Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10836-41.

44.

4-Aza-3-oxo-5 alpha-androst-1-ene-17 beta-N-aryl-carboxamides as dual inhibitors of human type 1 and type 2 steroid 5 alpha-reductases. Dramatic effect of N-aryl substituents on type 1 and type 2 5 alpha-reductase inhibitory potency.

Bakshi RK, Rasmusson GH, Patel GF, Mosley RT, Chang B, Ellsworth K, Harris GS, Tolman RL.

J Med Chem. 1995 Aug 18;38(17):3189-92. No abstract available.

PMID:
7650670

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