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Items: 38


Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis.

Levasseur EM, Yamada K, Piñeros AR, Wu W, Syed F, Orr KS, Anderson-Baucum E, Mastracci TL, Maier B, Mosley AL, Liu Y, Bernal-Mizrachi E, Alonso LC, Scott D, Garcia-Ocaña A, Tersey SA, Mirmira RG.

Sci Signal. 2019 Dec 3;12(610). pii: eaax0715. doi: 10.1126/scisignal.aax0715.


A novel GCN5b lysine acetyltransferase complex associates with distinct transcription factors in the protozoan parasite Toxoplasma gondii.

Harris MT, Jeffers V, Martynowicz J, True JD, Mosley AL, Sullivan WJ Jr.

Mol Biochem Parasitol. 2019 Sep;232:111203. doi: 10.1016/j.molbiopara.2019.111203. Epub 2019 Aug 2.


Methods review: Mass spectrometry analysis of RNAPII complexes.

Burriss KH, Mosley AL.

Methods. 2019 Apr 15;159-160:105-114. doi: 10.1016/j.ymeth.2019.03.013. Epub 2019 Mar 19. Review.


Writing a wrong: Coupled RNA polymerase II transcription and RNA quality control.

Peck SA, Hughes KD, Victorino JF, Mosley AL.

Wiley Interdiscip Rev RNA. 2019 Jul;10(4):e1529. doi: 10.1002/wrna.1529. Epub 2019 Mar 7. Review.


Loss of Nmp4 optimizes osteogenic metabolism and secretion to enhance bone quality.

Shao Y, Wichern E, Childress PJ, Adaway M, Misra J, Klunk A, Burr DB, Wek RC, Mosley AL, Liu Y, Robling AG, Brustovetsky N, Hamilton J, Jacobs K, Vashishth D, Stayrook KR, Allen MR, Wallace JM, Bidwell JP.

Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E749-E772. doi: 10.1152/ajpendo.00343.2018. Epub 2019 Jan 15.


Casein Kinase II Phosphorylation of Spt6 Enforces Transcriptional Fidelity by Maintaining Spn1-Spt6 Interaction.

Dronamraju R, Kerschner JL, Peck SA, Hepperla AJ, Adams AT, Hughes KD, Aslam S, Yoblinski AR, Davis IJ, Mosley AL, Strahl BD.

Cell Rep. 2018 Dec 18;25(12):3476-3489.e5. doi: 10.1016/j.celrep.2018.11.089.


Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization.

Watkins DS, True JD, Mosley AL, Baucum AJ 2nd.

Proteomes. 2018 Dec 17;6(4). pii: E53. doi: 10.3390/proteomes6040053. Erratum in: Proteomes. 2019 Feb 13;7(1):.


Endoplasmic reticulum stress alters ryanodine receptor function in the murine pancreatic β cell.

Yamamoto WR, Bone RN, Sohn P, Syed F, Reissaus CA, Mosley AL, Wijeratne AB, True JD, Tong X, Kono T, Evans-Molina C.

J Biol Chem. 2019 Jan 4;294(1):168-181. doi: 10.1074/jbc.RA118.005683. Epub 2018 Nov 12.


Quantitative phosphoproteomic analysis identifies novel functional pathways of tumor suppressor DLC1 in estrogen receptor positive breast cancer.

Gökmen-Polar Y, True JD, Vieth E, Gu Y, Gu X, Qi GD, Mosley AL, Badve SS.

PLoS One. 2018 Oct 2;13(10):e0204658. doi: 10.1371/journal.pone.0204658. eCollection 2018.


Function of inhibitor of Bruton's tyrosine kinase isoform α (IBTKα) in nonalcoholic steatohepatitis links autophagy and the unfolded protein response.

Willy JA, Young SK, Mosley AL, Gawrieh S, Stevens JL, Masuoka HC, Wek RC.

J Biol Chem. 2017 Aug 25;292(34):14050-14065. doi: 10.1074/jbc.M117.799304. Epub 2017 Jul 14.


Phosphatase Rtr1 Regulates Global Levels of Serine 5 RNA Polymerase II C-Terminal Domain Phosphorylation and Cotranscriptional Histone Methylation.

Hunter GO, Fox MJ, Smith-Kinnaman WR, Gogol M, Fleharty B, Mosley AL.

Mol Cell Biol. 2016 Aug 12;36(17):2236-45. doi: 10.1128/MCB.00870-15. Print 2016 Sep 1.


Quantitative Analysis of Dynamic Protein Interactions during Transcription Reveals a Role for Casein Kinase II in Polymerase-associated Factor (PAF) Complex Phosphorylation and Regulation of Histone H2B Monoubiquitylation.

Bedard LG, Dronamraju R, Kerschner JL, Hunter GO, Axley ED, Boyd AK, Strahl BD, Mosley AL.

J Biol Chem. 2016 Jun 24;291(26):13410-20. doi: 10.1074/jbc.M116.727735. Epub 2016 May 3.


Rrp6: Integrated roles in nuclear RNA metabolism and transcription termination.

Fox MJ, Mosley AL.

Wiley Interdiscip Rev RNA. 2016 Jan-Feb;7(1):91-104. doi: 10.1002/wrna.1317. Epub 2015 Nov 26. Review.


A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin.

Simon JM, Parker JS, Liu F, Rothbart SB, Ait-Si-Ali S, Strahl BD, Jin J, Davis IJ, Mosley AL, Pattenden SG.

J Biol Chem. 2015 Oct 23;290(43):26088-102. doi: 10.1074/jbc.M115.654459. Epub 2015 Sep 3.


Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.

Maganti AV, Maier B, Tersey SA, Sampley ML, Mosley AL, Özcan S, Pachaiyappan B, Woster PM, Hunter CS, Stein R, Mirmira RG.

J Biol Chem. 2015 Apr 10;290(15):9812-22. doi: 10.1074/jbc.M114.616219. Epub 2015 Feb 24.


The exosome component Rrp6 is required for RNA polymerase II termination at specific targets of the Nrd1-Nab3 pathway.

Fox MJ, Gao H, Smith-Kinnaman WR, Liu Y, Mosley AL.

PLoS Genet. 2015 Feb 13;11(2):e1004999. doi: 10.1371/journal.pgen.1004999. eCollection 2015.


RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.

Ni Z, Xu C, Guo X, Hunter GO, Kuznetsova OV, Tempel W, Marcon E, Zhong G, Guo H, Kuo WW, Li J, Young P, Olsen JB, Wan C, Loppnau P, El Bakkouri M, Senisterra GA, He H, Huang H, Sidhu SS, Emili A, Murphy S, Mosley AL, Arrowsmith CH, Min J, Greenblatt JF.

Nat Struct Mol Biol. 2014 Aug;21(8):686-695. doi: 10.1038/nsmb.2853. Epub 2014 Jul 6.


Rtr1 is a dual specificity phosphatase that dephosphorylates Tyr1 and Ser5 on the RNA polymerase II CTD.

Hsu PL, Yang F, Smith-Kinnaman W, Yang W, Song JE, Mosley AL, Varani G.

J Mol Biol. 2014 Aug 12;426(16):2970-81. doi: 10.1016/j.jmb.2014.06.010. Epub 2014 Jun 18.


The interactome of the atypical phosphatase Rtr1 in Saccharomyces cerevisiae.

Smith-Kinnaman WR, Berna MJ, Hunter GO, True JD, Hsu P, Cabello GI, Fox MJ, Varani G, Mosley AL.

Mol Biosyst. 2014 Jul;10(7):1730-41. doi: 10.1039/c4mb00109e.


Quantitative proteomics demonstrates that the RNA polymerase II subunits Rpb4 and Rpb7 dissociate during transcriptional elongation.

Mosley AL, Hunter GO, Sardiu ME, Smolle M, Workman JL, Florens L, Washburn MP.

Mol Cell Proteomics. 2013 Jun;12(6):1530-8. doi: 10.1074/mcp.M112.024034. Epub 2013 Feb 15.


Ssu72 phosphatase-dependent erasure of phospho-Ser7 marks on the RNA polymerase II C-terminal domain is essential for viability and transcription termination.

Zhang DW, Mosley AL, Ramisetty SR, Rodríguez-Molina JB, Washburn MP, Ansari AZ.

J Biol Chem. 2012 Mar 9;287(11):8541-51. doi: 10.1074/jbc.M111.335687. Epub 2012 Jan 10.


Examining the complexity of human RNA polymerase complexes using HaloTag technology coupled to label free quantitative proteomics.

Daniels DL, Méndez J, Mosley AL, Ramisetty SR, Murphy N, Benink H, Wood KV, Urh M, Washburn MP.

J Proteome Res. 2012 Feb 3;11(2):564-75. doi: 10.1021/pr200459c. Epub 2012 Jan 3.


Highly reproducible label free quantitative proteomic analysis of RNA polymerase complexes.

Mosley AL, Sardiu ME, Pattenden SG, Workman JL, Florens L, Washburn MP.

Mol Cell Proteomics. 2011 Feb;10(2):M110.000687. doi: 10.1074/mcp.M110.000687. Epub 2010 Nov 3.


Delayed correlation of mRNA and protein expression in rapamycin-treated cells and a role for Ggc1 in cellular sensitivity to rapamycin.

Fournier ML, Paulson A, Pavelka N, Mosley AL, Gaudenz K, Bradford WD, Glynn E, Li H, Sardiu ME, Fleharty B, Seidel C, Florens L, Washburn MP.

Mol Cell Proteomics. 2010 Feb;9(2):271-84. doi: 10.1074/mcp.M900415-MCP200. Epub 2009 Nov 10.


Rtr1 is a CTD phosphatase that regulates RNA polymerase II during the transition from serine 5 to serine 2 phosphorylation.

Mosley AL, Pattenden SG, Carey M, Venkatesh S, Gilmore JM, Florens L, Workman JL, Washburn MP.

Mol Cell. 2009 Apr 24;34(2):168-78. doi: 10.1016/j.molcel.2009.02.025.


A label free quantitative proteomic analysis of the Saccharomyces cerevisiae nucleus.

Mosley AL, Florens L, Wen Z, Washburn MP.

J Proteomics. 2009 Feb 15;72(1):110-20. doi: 10.1016/j.jprot.2008.10.008. Epub 2008 Nov 8.


Statistical analysis of membrane proteome expression changes in Saccharomyces cerevisiae.

Zybailov B, Mosley AL, Sardiu ME, Coleman MK, Florens L, Washburn MP.

J Proteome Res. 2006 Sep;5(9):2339-47.


Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase.

Finlin BS, Mosley AL, Crump SM, Correll RN, Ozcan S, Satin J, Andres DA.

J Biol Chem. 2005 Dec 23;280(51):41864-71. Epub 2005 Feb 22.


Glucose regulation of insulin gene expression requires the recruitment of p300 by the beta-cell-specific transcription factor Pdx-1.

Mosley AL, Corbett JA, Ozcan S.

Mol Endocrinol. 2004 Sep;18(9):2279-90. Epub 2004 May 27.


Repression of transcription by Rgt1 in the absence of glucose requires Std1 and Mth1.

Lakshmanan J, Mosley AL, Ozcan S.

Curr Genet. 2003 Oct;44(1):19-25. Epub 2003 Jul 9.


Glucose regulates insulin gene transcription by hyperacetylation of histone h4.

Mosley AL, Ozcan S.

J Biol Chem. 2003 May 30;278(22):19660-6. Epub 2003 Mar 28.


Adenoviral gene transfer into beta-cell lines.

Mosley AL, Ozcan S.

Methods Mol Med. 2003;83:73-9. No abstract available.


Glucose-mediated phosphorylation converts the transcription factor Rgt1 from a repressor to an activator.

Mosley AL, Lakshmanan J, Aryal BK, Ozcan S.

J Biol Chem. 2003 Mar 21;278(12):10322-7. Epub 2003 Jan 13.


Functional expression and analysis of the pancreatic transcription factor PDX-1 in yeast.

Ozcan S, Mosley AL, Aryal BK.

Biochem Biophys Res Commun. 2002 Jul 19;295(3):724-9.


Case report: reporting anti-G as anti-C+D may have misleading clinical implications.

Mosley AL, Trich MB, Thomas NC, Sandler SG.

Immunohematology. 1997;13(2):58-60.


Subvalvular left ventricular outflow tract obstruction caused by "rhinonodular" calcification.

Colleran JA, Burke AP, Mosley AL Jr, Green SE, Breall JA, Virmani R.

Cardiovasc Pathol. 1995 Apr-Jun;4(2):123-6.


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