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Items: 1 to 50 of 55

1.

A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice.

Dai W, Laforest B, Tyan L, Shen KM, Nadadur RD, Alvarado FJ, Mazurek SR, Lazarevic S, Gadek M, Wang Y, Li Y, Valdivia HH, Shen L, Broman MT, Moskowitz IP, Weber CR.

Elife. 2019 Mar 21;8. pii: e41814. doi: 10.7554/eLife.41814.

2.

Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics.

Krause MD, Huang RT, Wu D, Shentu TP, Harrison DL, Whalen MB, Stolze LK, Di Rienzo A, Moskowitz IP, Civelek M, Romanoski CE, Fang Y.

Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11349-E11358. doi: 10.1073/pnas.1810568115. Epub 2018 Nov 14.

3.

Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development.

Steimle JD, Rankin SA, Slagle CE, Bekeny J, Rydeen AB, Chan SS, Kweon J, Yang XH, Ikegami K, Nadadur RD, Rowton M, Hoffmann AD, Lazarevic S, Thomas W, Boyle Anderson EAT, Horb ME, Luna-Zurita L, Ho RK, Kyba M, Jensen B, Zorn AM, Conlon FL, Moskowitz IP.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10615-E10624. doi: 10.1073/pnas.1811624115. Epub 2018 Oct 23.

PMID:
30352852
4.

A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human.

Singh BN, Koyano-Nakagawa N, Gong W, Moskowitz IP, Weaver CV, Braunlin E, Das S, van Berlo JH, Garry MG, Garry DJ.

Nat Commun. 2018 Oct 12;9(1):4237. doi: 10.1038/s41467-018-06617-z.

5.

A promoter interaction map for cardiovascular disease genetics.

Montefiori LE, Sobreira DR, Sakabe NJ, Aneas I, Joslin AC, Hansen GT, Bozek G, Moskowitz IP, McNally EM, Nóbrega MA.

Elife. 2018 Jul 10;7. pii: e35788. doi: 10.7554/eLife.35788.

6.

Functional Assays to Screen and Dissect Genomic Hits: Doubling Down on the National Investment in Genomic Research.

Musunuru K, Bernstein D, Cole FS, Khokha MK, Lee FS, Lin S, McDonald TV, Moskowitz IP, Quertermous T, Sankaran VG, Schwartz DA, Silverman EK, Zhou X, Hasan AAK, Luo XJ.

Circ Genom Precis Med. 2018 Apr;11(4):e002178. doi: 10.1161/CIRCGEN.118.002178. Review.

PMID:
29654098
7.

Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm.

Yang XH, Nadadur RD, Hilvering CR, Bianchi V, Werner M, Mazurek SR, Gadek M, Shen KM, Goldman JA, Tyan L, Bekeny J, Hall JM, Lee N, Perez-Cervantes C, Burnicka-Turek O, Poss KD, Weber CR, de Laat W, Ruthenburg AJ, Moskowitz IP.

Elife. 2017 Dec 27;6. pii: e31683. doi: 10.7554/eLife.31683.

8.

Chromatin-enriched lncRNAs can act as cell-type specific activators of proximal gene transcription.

Werner MS, Sullivan MA, Shah RN, Nadadur RD, Grzybowski AT, Galat V, Moskowitz IP, Ruthenburg AJ.

Nat Struct Mol Biol. 2017 Jul;24(7):596-603. doi: 10.1038/nsmb.3424. Epub 2017 Jun 19.

9.

Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation.

Zhou L, Liu J, Xiang M, Olson P, Guzzetta A, Zhang K, Moskowitz IP, Xie L.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1422-E1431. doi: 10.1073/pnas.1605137114. Epub 2017 Feb 6.

10.

TBX5: A Key Regulator of Heart Development.

Steimle JD, Moskowitz IP.

Curr Top Dev Biol. 2017;122:195-221. doi: 10.1016/bs.ctdb.2016.08.008. Epub 2016 Sep 28. Review.

11.

Correction: Foxf Genes Integrate Tbx5 and Hedgehog Pathways in the Second Heart Field for Cardiac Septation.

Hoffmann AD, Yang XH, Burnicka-Turek O, Bosman JD, Ren X, Xie L, Steimle JD, Vokes SA, McMahon AP, Kalinichenko VV, Moskowitz IP.

PLoS Genet. 2016 Dec 29;12(12):e1006533. doi: 10.1371/journal.pgen.1006533. eCollection 2016 Dec.

12.

Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm.

Nadadur RD, Broman MT, Boukens B, Mazurek SR, Yang X, van den Boogaard M, Bekeny J, Gadek M, Ward T, Zhang M, Qiao Y, Martin JF, Seidman CE, Seidman J, Christoffels V, Efimov IR, McNally EM, Weber CR, Moskowitz IP.

Sci Transl Med. 2016 Aug 31;8(354):354ra115. doi: 10.1126/scitranslmed.aaf4891.

13.

Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.

Burnicka-Turek O, Steimle JD, Huang W, Felker L, Kamp A, Kweon J, Peterson M, Reeves RH, Maslen CL, Gruber PJ, Yang XH, Shendure J, Moskowitz IP.

Hum Mol Genet. 2016 Jul 15;25(14):3011-3028. Epub 2016 Jun 23.

14.

De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects.

Priest JR, Osoegawa K, Mohammed N, Nanda V, Kundu R, Schultz K, Lammer EJ, Girirajan S, Scheetz T, Waggott D, Haddad F, Reddy S, Bernstein D, Burns T, Steimle JD, Yang XH, Moskowitz IP, Hurles M, Lifton RP, Nickerson D, Bamshad M, Eichler EE, Mital S, Sheffield V, Quertermous T, Gelb BD, Portman M, Ashley EA.

PLoS Genet. 2016 Apr 8;12(4):e1005963. doi: 10.1371/journal.pgen.1005963. eCollection 2016 Apr.

15.

The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation.

Waldron L, Steimle JD, Greco TM, Gomez NC, Dorr KM, Kweon J, Temple B, Yang XH, Wilczewski CM, Davis IJ, Cristea IM, Moskowitz IP, Conlon FL.

Dev Cell. 2016 Feb 8;36(3):262-75. doi: 10.1016/j.devcel.2016.01.009.

16.

Many ways to break a heart.

Rowton M, Moskowitz IP.

Elife. 2015 Aug 25;4. doi: 10.7554/eLife.10040.

17.

The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model.

Polk RC, Gergics P, Steimle JD, Li H, Moskowitz IP, Camper SA, Reeves RH.

BMC Dev Biol. 2015 Jul 25;15:30. doi: 10.1186/s12861-015-0080-y.

18.

Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development.

Shamis Y, Cullen DE, Liu L, Yang G, Ng SF, Xiao L, Bell FT, Ray C, Takikawa S, Moskowitz IP, Cai CL, Yang X, Li X.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E2020-9. doi: 10.1073/pnas.1415541112. Epub 2015 Apr 6.

19.

MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus.

Quintero-Rivera F, Xi QJ, Keppler-Noreuil KM, Lee JH, Higgins AW, Anchan RM, Roberts AE, Seong IS, Fan X, Lage K, Lu LY, Tao J, Hu X, Berezney R, Gelb BD, Kamp A, Moskowitz IP, Lacro RV, Lu W, Morton CC, Gusella JF, Maas RL.

Hum Mol Genet. 2015 Apr 15;24(8):2375-89. doi: 10.1093/hmg/ddv004. Epub 2015 Jan 7.

20.

Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation.

Hoffmann AD, Yang XH, Burnicka-Turek O, Bosman JD, Ren X, Steimle JD, Vokes SA, McMahon AP, Kalinichenko VV, Moskowitz IP.

PLoS Genet. 2014 Oct 30;10(10):e1004604. doi: 10.1371/journal.pgen.1004604. eCollection 2014 Oct. Erratum in: PLoS Genet. 2016 Dec 29;12 (12 ):e1006533.

21.

A common genetic variant within SCN10A modulates cardiac SCN5A expression.

van den Boogaard M, Smemo S, Burnicka-Turek O, Arnolds DE, van de Werken HJ, Klous P, McKean D, Muehlschlegel JD, Moosmann J, Toka O, Yang XH, Koopmann TT, Adriaens ME, Bezzina CR, de Laat W, Seidman C, Seidman JG, Christoffels VM, Nobrega MA, Barnett P, Moskowitz IP.

J Clin Invest. 2014 Apr;124(4):1844-52. doi: 10.1172/JCI73140. Epub 2014 Mar 18.

22.

Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation.

Xie L, Hoffmann AD, Burnicka-Turek O, Friedland-Little JM, Zhang K, Moskowitz IP.

Dev Cell. 2012 Aug 14;23(2):280-91. doi: 10.1016/j.devcel.2012.06.006.

23.

TBX5 drives Scn5a expression to regulate cardiac conduction system function.

Arnolds DE, Liu F, Fahrenbach JP, Kim GH, Schillinger KJ, Smemo S, McNally EM, Nobrega MA, Patel VV, Moskowitz IP.

J Clin Invest. 2012 Jul;122(7):2509-18. doi: 10.1172/JCI62617. Epub 2012 Jun 25.

24.

Regulatory variation in a TBX5 enhancer leads to isolated congenital heart disease.

Smemo S, Campos LC, Moskowitz IP, Krieger JE, Pereira AC, Nobrega MA.

Hum Mol Genet. 2012 Jul 15;21(14):3255-63. doi: 10.1093/hmg/dds165. Epub 2012 Apr 27.

25.

Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction.

Kim EY, Chen L, Ma Y, Yu W, Chang J, Moskowitz IP, Wang J.

J Mol Cell Cardiol. 2012 Mar;52(3):638-49. doi: 10.1016/j.yjmcc.2011.11.011. Epub 2011 Dec 1.

26.

Expression of sumoylation deficient Nkx2.5 mutant in Nkx2.5 haploinsufficient mice leads to congenital heart defects.

Kim EY, Chen L, Ma Y, Yu W, Chang J, Moskowitz IP, Wang J.

PLoS One. 2011;6(6):e20803. doi: 10.1371/journal.pone.0020803. Epub 2011 Jun 3.

27.

A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus.

Friedland-Little JM, Hoffmann AD, Ocbina PJ, Peterson MA, Bosman JD, Chen Y, Cheng SY, Anderson KV, Moskowitz IP.

Hum Mol Genet. 2011 Oct 1;20(19):3725-37. doi: 10.1093/hmg/ddr241. Epub 2011 Jun 8.

28.

Defective sumoylation pathway directs congenital heart disease.

Wang J, Chen L, Wen S, Zhu H, Yu W, Moskowitz IP, Shaw GM, Finnell RH, Schwartz RJ.

Birth Defects Res A Clin Mol Teratol. 2011 Jun;91(6):468-76. doi: 10.1002/bdra.20816. Epub 2011 May 11.

29.

The emerging genetic landscape underlying cardiac conduction system function.

Arnolds DE, Chu A, McNally EM, Nobrega MA, Moskowitz IP.

Birth Defects Res A Clin Mol Teratol. 2011 Jun;91(6):578-85. doi: 10.1002/bdra.20800. Epub 2011 Apr 28. Review.

30.

Inducible recombination in the cardiac conduction system of minK: CreERT² BAC transgenic mice.

Arnolds DE, Moskowitz IP.

Genesis. 2011 Nov;49(11):878-84. doi: 10.1002/dvg.20759. Epub 2011 Aug 24.

PMID:
21504046
31.

Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected]

Moskowitz IP, Wang J, Peterson MA, Pu WT, Mackinnon AC, Oxburgh L, Chu GC, Sarkar M, Berul C, Smoot L, Robertson EJ, Schwartz R, Seidman JG, Seidman CE.

Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4006-11. doi: 10.1073/pnas.1019025108. Epub 2011 Feb 17. Erratum in: Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5921.

32.

DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis.

Shah MY, Vasanthakumar A, Barnes NY, Figueroa ME, Kamp A, Hendrick C, Ostler KR, Davis EM, Lin S, Anastasi J, Le Beau MM, Moskowitz IP, Melnick A, Pytel P, Godley LA.

Cancer Res. 2010 Jul 15;70(14):5840-50. doi: 10.1158/0008-5472.CAN-10-0847. Epub 2010 Jun 29.

33.

Genome-wide identification of mouse congenital heart disease loci.

Kamp A, Peterson MA, Svenson KL, Bjork BC, Hentges KE, Rajapaksha TW, Moran J, Justice MJ, Seidman JG, Seidman CE, Moskowitz IP, Beier DR.

Hum Mol Genet. 2010 Aug 15;19(16):3105-13. doi: 10.1093/hmg/ddq211. Epub 2010 May 28.

34.

sonic hedgehog is required in pulmonary endoderm for atrial septation.

Hoffmann AD, Peterson MA, Friedland-Little JM, Anderson SA, Moskowitz IP.

Development. 2009 May;136(10):1761-70. doi: 10.1242/dev.034157. Epub 2009 Apr 15.

35.

E2F3 plays an essential role in cardiac development and function.

King JC, Moskowitz IP, Burgon PG, Ahmad F, Stone JR, Seidman JG, Lees JA.

Cell Cycle. 2008 Dec;7(23):3775-80. Epub 2008 Dec 22.

36.

The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy.

Ahmad F, Banerjee SK, Lage ML, Huang XN, Smith SH, Saba S, Rager J, Conner DA, Janczewski AM, Tobita K, Tinney JP, Moskowitz IP, Perez-Atayde AR, Keller BB, Mathier MA, Shroff SG, Seidman CE, Seidman JG.

PLoS One. 2008 Jul 9;3(7):e2642. doi: 10.1371/journal.pone.0002642.

37.

A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development.

Moskowitz IP, Kim JB, Moore ML, Wolf CM, Peterson MA, Shendure J, Nobrega MA, Yokota Y, Berul C, Izumo S, Seidman JG, Seidman CE.

Cell. 2007 Jun 29;129(7):1365-76.

38.

Characterization of sinoatrial node in four conduction system marker mice.

Viswanathan S, Burch JB, Fishman GI, Moskowitz IP, Benson DW.

J Mol Cell Cardiol. 2007 May;42(5):946-53. Epub 2007 Feb 22.

39.

Complex genomic rearrangement in CCS-LacZ transgenic mice.

Stroud DM, Darrow BJ, Kim SD, Zhang J, Jongbloed MR, Rentschler S, Moskowitz IP, Seidman J, Fishman GI.

Genesis. 2007 Feb;45(2):76-82.

40.

Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis.

Feng Y, Chen MH, Moskowitz IP, Mendonza AM, Vidali L, Nakamura F, Kwiatkowski DJ, Walsh CA.

Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19836-41. Epub 2006 Dec 15.

41.

Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia.

Wolf CM, Moskowitz IP, Arno S, Branco DM, Semsarian C, Bernstein SA, Peterson M, Maida M, Morley GE, Fishman G, Berul CI, Seidman CE, Seidman JG.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18123-8. Epub 2005 Dec 6.

42.

Repression of cell-cell fusion by components of the C. elegans vacuolar ATPase complex.

Kontani K, Moskowitz IP, Rothman JH.

Dev Cell. 2005 May;8(5):787-94.

43.

The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system.

Moskowitz IP, Pizard A, Patel VV, Bruneau BG, Kim JB, Kupershmidt S, Roden D, Berul CI, Seidman CE, Seidman JG.

Development. 2004 Aug;131(16):4107-16.

44.

Cardiac electrophysiological phenotypes in postnatal expression of Nkx2.5 transgenic mice.

Wakimoto H, Kasahara H, Maguire CT, Moskowitz IP, Izumo S, Berul CI.

Genesis. 2003 Nov;37(3):144-50.

PMID:
14595838
45.

Electrophysiologic characterization and postnatal development of ventricular pre-excitation in a mouse model of cardiac hypertrophy and Wolff-Parkinson-White syndrome.

Patel VV, Arad M, Moskowitz IP, Maguire CT, Branco D, Seidman JG, Seidman CE, Berul CI.

J Am Coll Cardiol. 2003 Sep 3;42(5):942-51.

46.

Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy.

Arad M, Moskowitz IP, Patel VV, Ahmad F, Perez-Atayde AR, Sawyer DB, Walter M, Li GH, Burgon PG, Maguire CT, Stapleton D, Schmitt JP, Guo XX, Pizard A, Kupershmidt S, Roden DM, Berul CI, Seidman CE, Seidman JG.

Circulation. 2003 Jun 10;107(22):2850-6. Epub 2003 Jun 2.

PMID:
12782567
47.

Giant cell myocarditis in a 12-year-old girl with common variable immunodeficiency.

Laufs H, Nigrovic PA, Schneider LC, Oettgen H, Del NP, Moskowitz IP, Blume E, Perez-Atayde AR.

Mayo Clin Proc. 2002 Jan;77(1):92-6.

PMID:
11795251
48.

Ventricular arrhythmia vulnerability in cardiomyopathic mice with homozygous mutant Myosin-binding protein C gene.

Berul CI, McConnell BK, Wakimoto H, Moskowitz IP, Maguire CT, Semsarian C, Vargas MM, Gehrmann J, Seidman CE, Seidman JG.

Circulation. 2001 Nov 27;104(22):2734-9.

PMID:
11723028
49.

Comparison of two murine models of familial hypertrophic cardiomyopathy.

McConnell BK, Fatkin D, Semsarian C, Jones KA, Georgakopoulos D, Maguire CT, Healey MJ, Mudd JO, Moskowitz IP, Conner DA, Giewat M, Wakimoto H, Berul CI, Schoen FJ, Kass DA, Seidman CE, Seidman JG.

Circ Res. 2001 Mar 2;88(4):383-9.

PMID:
11230104
50.

Low-dose cyclosporin A therapy in children with refractory immune thrombocytopenic purpura.

Moskowitz IP, Gaynon PS, Shahidi NT, Cripe TP.

J Pediatr Hematol Oncol. 1999 Jan-Feb;21(1):77-9.

PMID:
10029820

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