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Items: 1 to 50 of 66

1.

The Molecular Chaperone Heat Shock Protein 70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA Damage and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways.

Cho W, Jin X, Pang J, Wang Y, Mivechi NF, Moskophidis D.

Mol Cell Biol. 2019 Apr 16;39(9). pii: e00391-18. doi: 10.1128/MCB.00391-18. Print 2019 May 1.

PMID:
30745413
2.

Modulation of Heat Shock Factor 1 Activity through Silencing of Ser303/Ser307 Phosphorylation Supports a Metabolic Program Leading to Age-Related Obesity and Insulin Resistance.

Jin X, Qiao A, Moskophidis D, Mivechi NF.

Mol Cell Biol. 2018 Aug 28;38(18). pii: e00095-18. doi: 10.1128/MCB.00095-18. Print 2018 Sep 15.

3.

Targeted Deletion of Hsf1, 2, and 4 Genes in Mice.

Jin X, Eroglu B, Moskophidis D, Mivechi NF.

Methods Mol Biol. 2018;1709:1-22. doi: 10.1007/978-1-4939-7477-1_1.

4.

WITHDRAWN: Abrogation of heat shock factor 1 (Hsf1) phosphorylation deregulates its activity and lowers activation threshold, leading to obesity in mice.

Jin X, Qiao A, Moskophidis D, Mivechi NF.

J Biol Chem. 2017 Jul 19. pii: jbc.M117.789354. doi: 10.1074/jbc.M117.789354. [Epub ahead of print]

5.

The transcriptional regulator of the chaperone response HSF1 controls hepatic bioenergetics and protein homeostasis.

Qiao A, Jin X, Pang J, Moskophidis D, Mivechi NF.

J Cell Biol. 2017 Mar 6;216(3):723-741. doi: 10.1083/jcb.201607091. Epub 2017 Feb 9.

6.

Therapeutic inducers of the HSP70/HSP110 protect mice against traumatic brain injury.

Eroglu B, Kimbler DE, Pang J, Choi J, Moskophidis D, Yanasak N, Dhandapani KM, Mivechi NF.

J Neurochem. 2014 Sep;130(5):626-41. doi: 10.1111/jnc.12781. Epub 2014 Jul 4.

7.

An essential role for heat shock transcription factor binding protein 1 (HSBP1) during early embryonic development.

Eroglu B, Min JN, Zhang Y, Szurek E, Moskophidis D, Eroglu A, Mivechi NF.

Dev Biol. 2014 Feb 15;386(2):448-60. doi: 10.1016/j.ydbio.2013.12.038. Epub 2013 Dec 28.

8.

Heat shock factor Hsf1 cooperates with ErbB2 (Her2/Neu) protein to promote mammary tumorigenesis and metastasis.

Xi C, Hu Y, Buckhaults P, Moskophidis D, Mivechi NF.

J Biol Chem. 2012 Oct 12;287(42):35646-57. doi: 10.1074/jbc.M112.377481. Epub 2012 Jul 30.

9.

Inactivation of heat shock factor Hsf4 induces cellular senescence and suppresses tumorigenesis in vivo.

Jin X, Eroglu B, Cho W, Yamaguchi Y, Moskophidis D, Mivechi NF.

Mol Cancer Res. 2012 Apr;10(4):523-34. doi: 10.1158/1541-7786.MCR-11-0530. Epub 2012 Feb 21.

10.

Targeted deletion of Hsf1, 2, and 4 genes in mice.

Jin X, Eroglu B, Moskophidis D, Mivechi NF.

Methods Mol Biol. 2011;787:1-20. doi: 10.1007/978-1-61779-295-3_1.

11.

Heat shock transcription factor 1 is a key determinant of HCC development by regulating hepatic steatosis and metabolic syndrome.

Jin X, Moskophidis D, Mivechi NF.

Cell Metab. 2011 Jul 6;14(1):91-103. doi: 10.1016/j.cmet.2011.03.025.

12.

Loss of Hsp110 leads to age-dependent tau hyperphosphorylation and early accumulation of insoluble amyloid beta.

Eroglu B, Moskophidis D, Mivechi NF.

Mol Cell Biol. 2010 Oct;30(19):4626-43. doi: 10.1128/MCB.01493-09. Epub 2010 Aug 2.

13.

Heat shock factor 1 deficiency via its downstream target gene alphaB-crystallin (Hspb5) impairs p53 degradation.

Jin X, Moskophidis D, Hu Y, Phillips A, Mivechi NF.

J Cell Biochem. 2009 Jun 1;107(3):504-15. doi: 10.1002/jcb.22151.

14.

Genomic and biological characterization of aggressive and docile strains of lymphocytic choriomeningitis virus rescued from a plasmid-based reverse-genetics system.

Chen M, Lan S, Ou R, Price GE, Jiang H, de la Torre JC, Moskophidis D.

J Gen Virol. 2008 Jun;89(Pt 6):1421-33. doi: 10.1099/vir.0.83464-0.

15.

Regulation of immune response and inflammatory reactions against viral infection by VCAM-1.

Ou R, Zhang M, Huang L, Flavell RA, Koni PA, Moskophidis D.

J Virol. 2008 Mar;82(6):2952-65. doi: 10.1128/JVI.02191-07. Epub 2008 Jan 23.

16.

Control of virus-specific CD8+ T-cell exhaustion and immune-mediated pathology by E3 ubiquitin ligase Cbl-b during chronic viral infection.

Ou R, Zhang M, Huang L, Moskophidis D.

J Virol. 2008 Apr;82(7):3353-68. doi: 10.1128/JVI.01350-07. Epub 2008 Jan 16.

17.

Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption.

Huang L, Min JN, Masters S, Mivechi NF, Moskophidis D.

Genesis. 2007 Aug;45(8):487-501.

PMID:
17661394
18.

Selective suppression of lymphomas by functional loss of Hsf1 in a p53-deficient mouse model for spontaneous tumors.

Min JN, Huang L, Zimonjic DB, Moskophidis D, Mivechi NF.

Oncogene. 2007 Aug 2;26(35):5086-97. Epub 2007 Feb 19.

PMID:
17310987
19.
20.

Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation.

Min JN, Zhang Y, Moskophidis D, Mivechi NF.

Genesis. 2004 Dec;40(4):205-17.

PMID:
15593327
21.

TCR affinity and negative regulation limit autoimmunity.

Gronski MA, Boulter JM, Moskophidis D, Nguyen LT, Holmberg K, Elford AR, Deenick EK, Kim HO, Penninger JM, Odermatt B, Gallimore A, Gascoigne NR, Ohashi PS.

Nat Med. 2004 Nov;10(11):1234-9. Epub 2004 Oct 3.

22.
23.

Essential requirement for both hsf1 and hsf2 transcriptional activity in spermatogenesis and male fertility.

Wang G, Ying Z, Jin X, Tu N, Zhang Y, Phillips M, Moskophidis D, Mivechi NF.

Genesis. 2004 Feb;38(2):66-80.

PMID:
14994269
25.
29.

Targeted inactivation of the sodium-calcium exchanger (Ncx1) results in the lack of a heartbeat and abnormal myofibrillar organization.

Koushik SV, Wang J, Rogers R, Moskophidis D, Lambert NA, Creazzo TL, Conway SJ.

FASEB J. 2001 May;15(7):1209-11. No abstract available.

PMID:
11344090
30.

The role of alpha/beta and gamma interferons in development of immunity to influenza A virus in mice.

Price GE, Gaszewska-Mastarlarz A, Moskophidis D.

J Virol. 2000 May;74(9):3996-4003.

31.

Viral escape by selection of cytotoxic T cell-resistant variants in influenza A virus pneumonia.

Price GE, Ou R, Jiang H, Huang L, Moskophidis D.

J Exp Med. 2000 Jun 5;191(11):1853-67.

33.

Susceptibility and resistance to antigen-induced apoptosis in the thymus of transgenic mice.

Tarazona R, Williams O, Moskophidis D, Smyth LA, Tanaka Y, Murdjeva M, Wack A, Mamalaki C, Kioussis D.

J Immunol. 1998 Jun 1;160(11):5397-403.

34.

Virus-specific IgD in acute viral infection of mice.

Moskophidis D, Moskophidis M, Löhler J.

J Immunol. 1997 Feb 1;158(3):1254-61.

PMID:
9013967
35.
36.

Role of virus and host variables in virus persistence or immunopathological disease caused by a non-cytolytic virus.

Moskophidis D, Battegay M, van den Broek M, Laine E, Hoffmann-Rohrer U, Zinkernagel RM.

J Gen Virol. 1995 Feb;76 ( Pt 2):381-91.

PMID:
7531218
37.

Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice.

Battegay M, Moskophidis D, Rahemtulla A, Hengartner H, Mak TW, Zinkernagel RM.

J Virol. 1994 Jul;68(7):4700-4.

38.

Functional commitment to helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity.

Corbella P, Moskophidis D, Spanopoulou E, Mamalaki C, Tolaini M, Itano A, Lans D, Baltimore D, Robey E, Kioussis D.

Immunity. 1994 Jul;1(4):269-76.

PMID:
7889414
39.
40.

Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon.

Moskophidis D, Battegay M, Bruendler MA, Laine E, Gresser I, Zinkernagel RM.

J Virol. 1994 Mar;68(3):1951-5.

41.

Peripheral clonal deletion of antiviral memory CD8+ T cells.

Moskophidis D, Laine E, Zinkernagel RM.

Eur J Immunol. 1993 Dec;23(12):3306-11. Erratum in: Eur J Immunol 1998 Sep;28(9):2978-9.

PMID:
8258345
42.

Impairment and delay of neutralizing antiviral antibody responses by virus-specific cytotoxic T cells.

Battegay M, Moskophidis D, Waldner H, Bründler MA, Fung-Leung WP, Mak TW, Hengartner H, Zinkernagel RM.

J Immunol. 1993 Nov 15;151(10):5408-15. Erratum in: J Immunol 1994 Mar 1;152(5):1635.

PMID:
7693811
43.

Effector T-cell induction and T-cell memory versus peripheral deletion of T cells.

Zinkernagel RM, Moskophidis D, Kündig T, Oehen S, Pircher H, Hengartner H.

Immunol Rev. 1993 Jun;133:199-223. Review. No abstract available.

PMID:
8225368
44.

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells.

Moskophidis D, Lechner F, Pircher H, Zinkernagel RM.

Nature. 1993 Apr 22;362(6422):758-61. Erratum in: Nature 1993 Jul 15;364(6434):262.

PMID:
8469287
45.

Immunosuppression by lymphocytic choriomeningitis virus infection: competent effector T and B cells but impaired antigen presentation.

Althage A, Odermatt B, Moskophidis D, Kündig T, Hoffman-Rohrer U, Hengartner H, Zinkernagel RM.

Eur J Immunol. 1992 Jul;22(7):1803-12.

PMID:
1623925
46.

Suppression of virus-specific antibody production by CD8+ class I-restricted antiviral cytotoxic T cells in vivo.

Moskophidis D, Pircher H, Ciernik I, Odermatt B, Hengartner H, Zinkernagel RM.

J Virol. 1992 Jun;66(6):3661-8.

47.

In vitro selection of lymphocytic choriomeningitis virus escape mutants by cytotoxic T lymphocytes.

Aebischer T, Moskophidis D, Rohrer UH, Zinkernagel RM, Hengartner H.

Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11047-51.

48.

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function.

Pircher H, Rohrer UH, Moskophidis D, Zinkernagel RM, Hengartner H.

Nature. 1991 Jun 6;351(6326):482-5.

PMID:
1710780
50.

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo.

Pircher H, Moskophidis D, Rohrer U, Bürki K, Hengartner H, Zinkernagel RM.

Nature. 1990 Aug 16;346(6285):629-33.

PMID:
1696684

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