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Items: 10


A simple genetic architecture underlies morphological variation in dogs.

Boyko AR, Quignon P, Li L, Schoenebeck JJ, Degenhardt JD, Lohmueller KE, Zhao K, Brisbin A, Parker HG, vonHoldt BM, Cargill M, Auton A, Reynolds A, Elkahloun AG, Castelhano M, Mosher DS, Sutter NB, Johnson GS, Novembre J, Hubisz MJ, Siepel A, Wayne RK, Bustamante CD, Ostrander EA.

PLoS Biol. 2010 Aug 10;8(8):e1000451. doi: 10.1371/journal.pbio.1000451.


Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication.

Vonholdt BM, Pollinger JP, Lohmueller KE, Han E, Parker HG, Quignon P, Degenhardt JD, Boyko AR, Earl DA, Auton A, Reynolds A, Bryc K, Brisbin A, Knowles JC, Mosher DS, Spady TC, Elkahloun A, Geffen E, Pilot M, Jedrzejewski W, Greco C, Randi E, Bannasch D, Wilton A, Shearman J, Musiani M, Cargill M, Jones PG, Qian Z, Huang W, Ding ZL, Zhang YP, Bustamante CD, Ostrander EA, Novembre J, Wayne RK.

Nature. 2010 Apr 8;464(7290):898-902. doi: 10.1038/nature08837. Epub 2010 Mar 17.


Fine mapping a locus controlling leg morphology in the domestic dog.

Quignon P, Schoenebeck JJ, Chase K, Parker HG, Mosher DS, Johnson GS, Lark KG, Ostrander EA.

Cold Spring Harb Symp Quant Biol. 2009;74:327-33. doi: 10.1101/sqb.2009.74.009. Epub 2009 Aug 28.


Coat variation in the domestic dog is governed by variants in three genes.

Cadieu E, Neff MW, Quignon P, Walsh K, Chase K, Parker HG, Vonholdt BM, Rhue A, Boyko A, Byers A, Wong A, Mosher DS, Elkahloun AG, Spady TC, André C, Lark KG, Cargill M, Bustamante CD, Wayne RK, Ostrander EA.

Science. 2009 Oct 2;326(5949):150-3. doi: 10.1126/science.1177808. Epub 2009 Aug 27.


An expressed fgf4 retrogene is associated with breed-defining chondrodysplasia in domestic dogs.

Parker HG, VonHoldt BM, Quignon P, Margulies EH, Shao S, Mosher DS, Spady TC, Elkahloun A, Cargill M, Jones PG, Maslen CL, Acland GM, Sutter NB, Kuroki K, Bustamante CD, Wayne RK, Ostrander EA.

Science. 2009 Aug 21;325(5943):995-8. doi: 10.1126/science.1173275. Epub 2009 Jul 16.


Morphometrics within dog breeds are highly reproducible and dispute Rensch's rule.

Sutter NB, Mosher DS, Gray MM, Ostrander EA.

Mamm Genome. 2008 Oct-Dec;19(10-12):713-23. doi: 10.1007/s00335-008-9153-6. Epub 2008 Nov 20.


Canine population structure: assessment and impact of intra-breed stratification on SNP-based association studies.

Quignon P, Herbin L, Cadieu E, Kirkness EF, Hédan B, Mosher DS, Galibert F, André C, Ostrander EA, Hitte C.

PLoS One. 2007 Dec 19;2(12):e1324.


Breed relationships facilitate fine-mapping studies: a 7.8-kb deletion cosegregates with Collie eye anomaly across multiple dog breeds.

Parker HG, Kukekova AV, Akey DT, Goldstein O, Kirkness EF, Baysac KC, Mosher DS, Aguirre GD, Acland GM, Ostrander EA.

Genome Res. 2007 Nov;17(11):1562-71. Epub 2007 Oct 4.


A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs.

Mosher DS, Quignon P, Bustamante CD, Sutter NB, Mellersh CS, Parker HG, Ostrander EA.

PLoS Genet. 2007 May 25;3(5):e79. Epub 2007 Apr 30.


A single IGF1 allele is a major determinant of small size in dogs.

Sutter NB, Bustamante CD, Chase K, Gray MM, Zhao K, Zhu L, Padhukasahasram B, Karlins E, Davis S, Jones PG, Quignon P, Johnson GS, Parker HG, Fretwell N, Mosher DS, Lawler DF, Satyaraj E, Nordborg M, Lark KG, Wayne RK, Ostrander EA.

Science. 2007 Apr 6;316(5821):112-5. Erratum in: Science. 2007 Jun 1;316(5829):1284.

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