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Tpz1TPP1 prevents telomerase activation and protects telomeres by modulating the Stn1-Ten1 complex in fission yeast.

Mennie AK, Moser BA, Hoyle A, Low RS, Tanaka K, Nakamura TM.

Commun Biol. 2019 Aug 7;2(1):297. doi: 10.1038/s42003-019-0546-8.


Tpz1TPP1 prevents telomerase activation and protects telomeres by modulating the Stn1-Ten1 complex in fission yeast.

Mennie AK, Moser BA, Hoyle A, Low RS, Tanaka K, Nakamura TM.

Commun Biol. 2019 Aug 7;2:297. doi: 10.1038/s42003-019-0546-8. eCollection 2019.


A Phase Ib/II Study of Ramucirumab in Combination with Emibetuzumab in Patients with Advanced Cancer.

Harding JJ, Zhu AX, Bauer TM, Choueiri TK, Drilon A, Voss MH, Fuchs CS, Abou-Alfa GK, Wijayawardana SR, Wang XA, Moser BA, Uruñuela A, Wacheck V, Bendell JC.

Clin Cancer Res. 2019 Sep 1;25(17):5202-5211. doi: 10.1158/1078-0432.CCR-18-4010. Epub 2019 May 29.


A role for miR-132 in learned safety.

Ronovsky M, Zambon A, Cicvaric A, Boehm V, Hoesel B, Moser BA, Yang J, Schmid JA, Haubensak WE, Monje FJ, Pollak DD.

Sci Rep. 2019 Jan 24;9(1):528. doi: 10.1038/s41598-018-37054-z.


DeepSNP: An End-to-End Deep Neural Network with Attention-Based Localization for Breakpoint Detection in Single-Nucleotide Polymorphism Array Genomic Data.

Eghbal-Zadeh H, Fischer L, Popitsch N, Kromp F, Taschner-Mandl S, Gerber T, Bozsaky E, Ambros PF, Ambros IM, Widmer G, Moser BA.

J Comput Biol. 2019 Jun;26(6):572-596. doi: 10.1089/cmb.2018.0172. Epub 2018 Dec 26.


Applications of Immunomodulatory Immune Synergies to Adjuvant Discovery and Vaccine Development.

Tom JK, Albin TJ, Manna S, Moser BA, Steinhardt RC, Esser-Kahn AP.

Trends Biotechnol. 2019 Apr;37(4):373-388. doi: 10.1016/j.tibtech.2018.10.004. Epub 2018 Nov 21. Review.


LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast.

Mennie AK, Moser BA, Nakamura TM.

Nat Commun. 2018 Feb 8;9(1):586. doi: 10.1038/s41467-018-02874-0.


Surface Coating of Nanoparticles Reduces Background Inflammatory Activity while Increasing Particle Uptake and Delivery.

Moser BA, Steinhardt RC, Esser-Kahn AP.

ACS Biomater Sci Eng. 2017 Feb 13;3(2):206-213. doi: 10.1021/acsbiomaterials.6b00473. Epub 2016 Dec 1.


Population Pharmacokinetic and Exposure-Response Analyses of Prasugrel in Pediatric Patients with Sickle Cell Anemia.

Moser BA, LaBell ES, Chigutsa E, Jakubowski JA, Small DS.

Clin Pharmacokinet. 2018 Feb;57(2):243-254. doi: 10.1007/s40262-017-0556-y.


SUMO-targeted ubiquitin ligase activity can either suppress or promote genome instability, depending on the nature of the DNA lesion.

Nie M, Moser BA, Nakamura TM, Boddy MN.

PLoS Genet. 2017 May 5;13(5):e1006776. doi: 10.1371/journal.pgen.1006776. eCollection 2017 May.


A Photoactivatable Innate Immune Receptor for Optogenetic Inflammation.

Moser BA, Esser-Kahn AP.

ACS Chem Biol. 2017 Feb 17;12(2):347-350. doi: 10.1021/acschembio.6b01012. Epub 2016 Dec 29.


Tunable thermal bioswitches for in vivo control of microbial therapeutics.

Piraner DI, Abedi MH, Moser BA, Lee-Gosselin A, Shapiro MG.

Nat Chem Biol. 2017 Jan;13(1):75-80. doi: 10.1038/nchembio.2233. Epub 2016 Nov 14.


Ccq1-Tpz1TPP1 interaction facilitates telomerase and SHREC association with telomeres in fission yeast.

Moser BA, Raguimova ON, Nakamura TM.

Mol Biol Cell. 2015 Nov 1;26(21):3857-66. doi: 10.1091/mbc.E15-07-0481. Epub 2015 Sep 9.


Human DMTF1β antagonizes DMTF1α regulation of the p14(ARF) tumor suppressor and promotes cellular proliferation.

Tschan MP, Federzoni EA, Haimovici A, Britschgi C, Moser BA, Jin J, Reddy VA, Sheeter DA, Fischer KM, Sun P, Torbett BE.

Biochim Biophys Acta. 2015 Sep;1849(9):1198-208. doi: 10.1016/j.bbagrm.2015.07.009. Epub 2015 Jul 15.


A first-in-human phase I trial of LY2780301, a dual p70 S6 kinase and Akt Inhibitor, in patients with advanced or metastatic cancer.

Azaro A, Rodon J, Calles A, Braña I, Hidalgo M, Lopez-Casas PP, Munoz M, Westwood P, Miller J, Moser BA, Ohnmacht U, Bumgardner W, Benhadji KA, Calvo E.

Invest New Drugs. 2015 Jun;33(3):710-9. doi: 10.1007/s10637-015-0241-7. Epub 2015 Apr 24.


Prasugrel in children with sickle cell disease: pharmacokinetic and pharmacodynamic data from an open-label, adaptive-design, dose-ranging study.

Styles L, Heiselman D, Heath LE, Moser BA, Small DS, Jakubowski JA, Zhou C, Redding-Lallinger R, Heeney MM, Quinn CT, Rana SR, Kanter J, Winters KJ.

J Pediatr Hematol Oncol. 2015 Jan;37(1):1-9. doi: 10.1097/MPH.0000000000000291.


Tpz1-Ccq1 and Tpz1-Poz1 interactions within fission yeast shelterin modulate Ccq1 Thr93 phosphorylation and telomerase recruitment.

Harland JL, Chang YT, Moser BA, Nakamura TM.

PLoS Genet. 2014 Oct 16;10(10):e1004708. doi: 10.1371/journal.pgen.1004708. eCollection 2014 Oct.


Impaired responsiveness to the platelet P2Y12 receptor antagonist clopidogrel in patients with type 2 diabetes and coronary artery disease.

Angiolillo DJ, Jakubowski JA, Ferreiro JL, Tello-Montoliu A, Rollini F, Franchi F, Ueno M, Darlington A, Desai B, Moser BA, Sugidachi A, Guzman LA, Bass TA.

J Am Coll Cardiol. 2014 Sep 9;64(10):1005-14. doi: 10.1016/j.jacc.2014.06.1170.


The influence of body size on the pharmacodynamic and pharmacokinetic response to clopidogrel and prasugrel: a retrospective analysis of the FEATHER study.

Jakubowski JA, Angiolillo DJ, Zhou C, Small DS, Moser BA, Ten Berg JM, Brown PB, James S, Winters KJ, Erlinge D.

Thromb Res. 2014 Sep;134(3):552-7. doi: 10.1016/j.thromres.2014.05.019. Epub 2014 May 21.


The effect of CYP2C19 gene polymorphisms on the pharmacokinetics and pharmacodynamics of prasugrel 5-mg, prasugrel 10-mg and clopidogrel 75-mg in patients with coronary artery disease.

Gurbel PA, Bergmeijer TO, Tantry US, ten Berg JM, Angiolillo DJ, James S, Lindahl TL, Svensson P, Jakubowski JA, Brown PB, Duvvuru S, Sundseth S, Walker JR, Small D, Moser BA, Winters KJ, Erlinge D.

Thromb Haemost. 2014 Sep 2;112(3):589-97. doi: 10.1160/TH13-10-0891. Epub 2014 Jul 10.


Telomere regulation during the cell cycle in fission yeast.

Moser BA, Chang YT, Nakamura TM.

Methods Mol Biol. 2014;1170:411-24. doi: 10.1007/978-1-4939-0888-2_22.


SUMOylation regulates telomere length by targeting the shelterin subunit Tpz1(Tpp1) to modulate shelterin-Stn1 interaction in fission yeast.

Miyagawa K, Low RS, Santosa V, Tsuji H, Moser BA, Fujisawa S, Harland JL, Raguimova ON, Go A, Ueno M, Matsuyama A, Yoshida M, Nakamura TM, Tanaka K.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5950-5. doi: 10.1073/pnas.1401359111. Epub 2014 Apr 7.


Clopidogrel metaboliser status based on point-of-care CYP2C19 genetic testing in patients with coronary artery disease.

Erlinge D, James S, Duvvuru S, Jakubowski JA, Wagner H, Varenhorst C, Tantry US, Brown PB, Small D, Moser BA, Sundseth SS, Walker JR, Winters KJ, Gurbel PA.

Thromb Haemost. 2014 May 5;111(5):943-50. doi: 10.1160/TH13-09-0767. Epub 2014 Jan 9.


Fission yeast shelterin regulates DNA polymerases and Rad3(ATR) kinase to limit telomere extension.

Chang YT, Moser BA, Nakamura TM.

PLoS Genet. 2013 Nov;9(11):e1003936. doi: 10.1371/journal.pgen.1003936. Epub 2013 Nov 7.


Higher body weight patients on clopidogrel maintenance therapy have lower active metabolite concentrations, lower levels of platelet inhibition, and higher rates of poor responders than low body weight patients.

Wagner H, Angiolillo DJ, Ten Berg JM, Bergmeijer TO, Jakubowski JA, Small DS, Moser BA, Zhou C, Brown P, James S, Winters KJ, Erlinge D.

J Thromb Thrombolysis. 2014;38(2):127-36. doi: 10.1007/s11239-013-0987-8.


Prasugrel 5 mg in the very elderly attenuates platelet inhibition but maintains noninferiority to prasugrel 10 mg in nonelderly patients: the GENERATIONS trial, a pharmacodynamic and pharmacokinetic study in stable coronary artery disease patients.

Erlinge D, Gurbel PA, James S, Lindahl TL, Svensson P, Ten Berg JM, Foley DP, Wagner H, Brown PB, Luo J, Zhou C, Moser BA, Jakubowski JA, Small DS, Winters KJ, Angiolillo DJ.

J Am Coll Cardiol. 2013 Aug 13;62(7):577-83. doi: 10.1016/j.jacc.2013.05.023. Epub 2013 Jun 7.


Tel1ATM and Rad3ATR kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast.

Moser BA, Chang YT, Kosti J, Nakamura TM.

Nat Struct Mol Biol. 2011 Nov 20;18(12):1408-13. doi: 10.1038/nsmb.2187.


The double-bromodomain proteins Bdf1 and Bdf2 modulate chromatin structure to regulate S-phase stress response in Schizosaccharomyces pombe.

Garabedian MV, Noguchi C, Ziegler MA, Das MM, Singh T, Harper LJ, Leman AR, Khair L, Moser BA, Nakamura TM, Noguchi E.

Genetics. 2012 Feb;190(2):487-500. doi: 10.1534/genetics.111.135459. Epub 2011 Nov 17.


A similarity measure for image and volumetric data based on Hermann Weyl's discrepancy.

Moser BA.

IEEE Trans Pattern Anal Mach Intell. 2011 Nov;33(11):2321-9. doi: 10.1109/TPAMI.2009.50.


Telomeres avoid end detection by severing the checkpoint signal transduction pathway.

Carneiro T, Khair L, Reis CC, Borges V, Moser BA, Nakamura TM, Ferreira MG.

Nature. 2010 Sep 9;467(7312):228-32. doi: 10.1038/nature09353.


Roles of heterochromatin and telomere proteins in regulation of fission yeast telomere recombination and telomerase recruitment.

Khair L, Subramanian L, Moser BA, Nakamura TM.

J Biol Chem. 2010 Feb 19;285(8):5327-37. doi: 10.1074/jbc.M109.078840. Epub 2009 Dec 29.


Protection and replication of telomeres in fission yeast.

Moser BA, Nakamura TM.

Biochem Cell Biol. 2009 Oct;87(5):747-58. doi: 10.1139/O09-037. Review.


Fission yeast Tel1(ATM) and Rad3(ATR) promote telomere protection and telomerase recruitment.

Moser BA, Subramanian L, Khair L, Chang YT, Nakamura TM.

PLoS Genet. 2009 Aug;5(8):e1000622. doi: 10.1371/journal.pgen.1000622. Epub 2009 Aug 28.


Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres.

Moser BA, Subramanian L, Chang YT, Noguchi C, Noguchi E, Nakamura TM.

EMBO J. 2009 Apr 8;28(7):810-20. doi: 10.1038/emboj.2009.31. Epub 2009 Feb 12.


PRAK is essential for ras-induced senescence and tumor suppression.

Sun P, Yoshizuka N, New L, Moser BA, Li Y, Liao R, Xie C, Chen J, Deng Q, Yamout M, Dong MQ, Frangou CG, Yates JR 3rd, Wright PE, Han J.

Cell. 2007 Jan 26;128(2):295-308.


Genome of invertebrate iridescent virus type 3 (mosquito iridescent virus).

Delhon G, Tulman ER, Afonso CL, Lu Z, Becnel JJ, Moser BA, Kutish GF, Rock DL.

J Virol. 2006 Sep;80(17):8439-49.


Homo-oligomerization is the essential function of the tandem BRCT domains in the checkpoint protein Crb2.

Du LL, Moser BA, Russell P.

J Biol Chem. 2004 Sep 10;279(37):38409-14. Epub 2004 Jun 30.


Retention but not recruitment of Crb2 at double-strand breaks requires Rad1 and Rad3 complexes.

Du LL, Nakamura TM, Moser BA, Russell P.

Mol Cell Biol. 2003 Sep;23(17):6150-8.


Genome sequence of a baculovirus pathogenic for Culex nigripalpus.

Afonso CL, Tulman ER, Lu Z, Balinsky CA, Moser BA, Becnel JJ, Rock DL, Kutish GF.

J Virol. 2001 Nov;75(22):11157-65.


Cell cycle regulation in Schizosaccharomyces pombe.

Moser BA, Russell P.

Curr Opin Microbiol. 2000 Dec;3(6):631-6. Review.


Mechanism of caffeine-induced checkpoint override in fission yeast.

Moser BA, Brondello JM, Baber-Furnari B, Russell P.

Mol Cell Biol. 2000 Jun;20(12):4288-94.


Morphological and molecular characterization of the Thelohania solenopsae complex (microsporidia: thelohaniidae).

Moser BA, Becnel JJ, Williams DF.

J Invertebr Pathol. 2000 Feb;75(2):174-7. No abstract available.


Analysis of the ribosomal DNA sequences of the microsporidia Thelohania and Vairimorpha of fire ants.

Moser BA, Becnel JJ, Maruniak J, Patterson RS.

J Invertebr Pathol. 1998 Sep;72(2):154-9.


Dual requirement for a newly identified phosphorylation site in p70s6k.

Moser BA, Dennis PB, Pullen N, Pearson RB, Williamson NA, Wettenhall RE, Kozma SC, Thomas G.

Mol Cell Biol. 1997 Sep;17(9):5648-55.


Effect of methoprene and diflubenzuron on larval development of the cat flea (Siphonaptera: Pulicidae).

Moser BA, Koehler PG, Patterson RS.

J Econ Entomol. 1992 Feb;85(1):112-6.


Effect of larval diet on cat flea (Siphonaptera: Pulicidae) developmental times and adult emergence.

Moser BA, Koehler PG, Patterson RS.

J Econ Entomol. 1991 Aug;84(4):1257-61.


Separation of cat flea (Siphonaptera: Pulicidae) instars by individual rearing and head width measurements.

Moser BA, Koehler PG, Patterson RS.

J Econ Entomol. 1991 Jun;84(3):922-6.


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