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Pembrolizumab in combination with the oncolytic virus pelareorep and chemotherapy in patients with advanced pancreatic adenocarcinoma: a Phase 1b study.

Mahalingam D, Wilkinson G, Eng KH, Fields P, Raber P, Moseley JL, Cheetham K, Coffey M, Nuovo G, Kalinski P, Zhang B, Arora SP, Fountzilas C.

Clin Cancer Res. 2019 Nov 6. pii: clincanres.2078.2019. doi: 10.1158/1078-0432.CCR-19-2078. [Epub ahead of print]


A mechanism for how Cdr1/Nim1 kinase promotes mitotic entry by inhibiting Wee1.

Opalko HE, Nasa I, Kettenbach AN, Moseley JB.

Mol Biol Cell. 2019 Oct 23:mbcE19080430. doi: 10.1091/mbc.E19-08-0430. [Epub ahead of print]


Cell Biology: Marine Yeasts Deepen the Sea of Diversity.

Allard CAH, Moseley JB.

Curr Biol. 2019 Oct 21;29(20):R1083-R1085. doi: 10.1016/j.cub.2019.09.022.


The phosphatase inhibitor Sds23 regulates cell division symmetry in fission yeast.

Schutt KL, Moseley JB.

Mol Biol Cell. 2019 Nov 1;30(23):2880-2889. doi: 10.1091/mbc.E19-05-0254. Epub 2019 Sep 25.


Carrier-Transport Study of Gallium Arsenide Hillock Defects.

Xiao C, Jiang CS, Liu J, Norman A, Moseley J, Schulte K, Ptak AJ, Gorman B, Al-Jassim M, Haegel NM, Moutinho H.

Microsc Microanal. 2019 Oct;25(5):1160-1166. doi: 10.1017/S1431927619014909.


Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories.

Ibrahim AGE, Li C, Rogers R, Fournier M, Li L, Vaturi SD, Antes T, Sanchez L, Akhmerov A, Moseley JJ, Tobin B, Rodriguez-Borlado L, Smith RR, Marbán L, Marbán E.

Nat Biomed Eng. 2019 Sep;3(9):695-705. doi: 10.1038/s41551-019-0448-6. Epub 2019 Aug 26.


European regulators' views on a wearable-derived performance measurement of ambulation for Duchenne muscular dystrophy regulatory trials.

Haberkamp M, Moseley J, Athanasiou D, de Andres-Trelles F, Elferink A, Rosa MM, Magrelli A.

Neuromuscul Disord. 2019 Jul;29(7):514-516. doi: 10.1016/j.nmd.2019.06.003. Epub 2019 Jun 7.


Stable Pom1 clusters form a glucose-modulated concentration gradient that regulates mitotic entry.

Allard CAH, Opalko HE, Moseley JB.

Elife. 2019 May 3;8. pii: e46003. doi: 10.7554/eLife.46003.


Retired Surgeons as Mentors for Surgical Training Graduates Entering Practice: An Underutilized Resource.

Kim NE, Moseley JM, O'Neal P, Whang E, Itani KMF, Kristo G.

Ann Surg. 2019 Mar 19. doi: 10.1097/SLA.0000000000003272. [Epub ahead of print]


Multistakeholder Advice at the European Medicines Agency: Is It Still Needed?

Vamvakas S, Moseley J, Vetter T.

Clin Pharmacol Ther. 2019 Apr;105(4):819-821. doi: 10.1002/cpt.1335. Epub 2019 Feb 27. No abstract available.


Development of a Retinopathy of Prematurity Activity Scale and Clinical Outcome Measures for Use in Clinical Trials.

Smith LEH, Hellström A, Stahl A, Fielder A, Chambers W, Moseley J, Toth C, Wallace D, Darlow BA, Aranda JV, Hallberg B, Davis JM; Retinopathy of Prematurity Workgroup of the International Neonatal Consortium.

JAMA Ophthalmol. 2019 Mar 1;137(3):305-311. doi: 10.1001/jamaophthalmol.2018.5984. Erratum in: JAMA Ophthalmol. 2019 Mar 1;137(3):328.


The power of agricultural data.

Woodard JD, Sherrick BJ, Atwood DM, Blair R, Fogel G, Goeser N, Gold B, Lewis J, Mattson C, Moseley J, O'Mara C, Piotti J, Salas B, Scarlett L, Duncanson KW, Yoder F.

Science. 2018 Oct 26;362(6413):410-411. doi: 10.1126/science.aav5002. No abstract available.


Overcoming Carrier Concentration Limits in Polycrystalline CdTe Thin Films with In Situ Doping.

McCandless BE, Buchanan WA, Thompson CP, Sriramagiri G, Lovelett RJ, Duenow J, Albin D, Jensen S, Colegrove E, Moseley J, Moutinho H, Harvey S, Al-Jassim M, Metzger WK.

Sci Rep. 2018 Sep 28;8(1):14519. doi: 10.1038/s41598-018-32746-y.



Moseley JB.

Curr Biol. 2018 Apr 23;28(8):R376-R378. doi: 10.1016/j.cub.2017.11.073. Review.


Cell size-dependent regulation of Wee1 localization by Cdr2 cortical nodes.

Allard CAH, Opalko HE, Liu KW, Medoh U, Moseley JB.

J Cell Biol. 2018 May 7;217(5):1589-1599. doi: 10.1083/jcb.201709171. Epub 2018 Mar 7.


The impact of parallel regulatory-health technology assessment scientific advice on clinical development. Assessing the uptake of regulatory and health technology assessment recommendations.

Tafuri G, Lucas I, Estevão S, Moseley J, d'Andon A, Bruehl H, Gajraj E, Garcia S, Hedberg N, Massari M, Molina A, Obach M, Osipenko L, Petavy F, Petschulies M, Pontes C, Russo P, Schiel A, Van de Casteele M, Zebedin-Brandl EM, Rasi G, Vamvakas S.

Br J Clin Pharmacol. 2018 May;84(5):1013-1019. doi: 10.1111/bcp.13524. Epub 2018 Mar 5.


Mechanisms Connecting the Conserved Protein Kinases Ssp1, Kin1, and Pom1 in Fission Yeast Cell Polarity and Division.

Lee ME, Rusin SF, Jenkins N, Kettenbach AN, Moseley JB.

Curr Biol. 2018 Jan 8;28(1):84-92.e4. doi: 10.1016/j.cub.2017.11.034. Epub 2017 Dec 14.


Dynamic regulation of Cdr1 kinase localization and phosphorylation during osmotic stress.

Opalko HE, Moseley JB.

J Biol Chem. 2017 Nov 10;292(45):18457-18468. doi: 10.1074/jbc.M117.793034. Epub 2017 Sep 18.


Phase 1 safety, pharmacokinetic and pharmacodynamic study of the cyclin-dependent kinase inhibitor dinaciclib administered every three weeks in patients with advanced malignancies.

Mita MM, Mita AC, Moseley JL, Poon J, Small KA, Jou YM, Kirschmeier P, Zhang D, Zhu Y, Statkevich P, Sankhala KK, Sarantopoulos J, Cleary JM, Chirieac LR, Rodig SJ, Bannerji R, Shapiro GI.

Br J Cancer. 2017 Oct 24;117(9):1258-1268. doi: 10.1038/bjc.2017.288. Epub 2017 Aug 31.


Feasibility of 4D perfusion CT imaging for the assessment of liver treatment response following SBRT and sorafenib.

Coolens C, Driscoll B, Moseley J, Brock KK, Dawson LA.

Adv Radiat Oncol. 2016 Jul 1;1(3):194-203. doi: 10.1016/j.adro.2016.06.004. eCollection 2016 Jul-Sep.


From the Memphis Model to the North Carolina Way: Lessons Learned from Emerging Health System and Faith Community Partnerships.

Cutts T, Gunderson G, Carter D, Childers M, Long P, Marisiddaiah L, Milleson H, Stamper D, Archie A, Moseley J, Viverette E, Baker B.

N C Med J. 2017 Jul-Aug;78(4):267-272. doi: 10.18043/ncm.78.4.267.


The role of biomechanical anatomical modeling via computed tomography for identification of restrictive allograft syndrome.

Horie M, Saito T, Moseley J, D'Errico L, Salazar P, Nakajima D, Brock K, Yasufuku K, Binnie M, Keshavjee S, Paul N.

Clin Transplant. 2017 Aug;31(8). doi: 10.1111/ctr.13027. Epub 2017 Jul 25.


Transient activation of fission yeast AMPK is required for cell proliferation during osmotic stress.

Schutt KL, Moseley JB.

Mol Biol Cell. 2017 Jul 1;28(13):1804-1814. doi: 10.1091/mbc.E17-04-0235. Epub 2017 May 17.


Biomarkers and Surrogate Endpoints in Drug Development: A European Regulatory View.

Wickström K, Moseley J.

Invest Ophthalmol Vis Sci. 2017 May 1;58(6):BIO27-BIO33. doi: 10.1167/iovs.17-21778. Review.


Validation of biomechanical deformable image registration in the abdomen, thorax, and pelvis in a commercial radiotherapy treatment planning system.

Velec M, Moseley JL, Svensson S, Hårdemark B, Jaffray DA, Brock KK.

Med Phys. 2017 Jul;44(7):3407-3417. doi: 10.1002/mp.12307. Epub 2017 Jun 1.


A phase II study of REOLYSIN® (pelareorep) in combination with carboplatin and paclitaxel for patients with advanced malignant melanoma.

Mahalingam D, Fountzilas C, Moseley J, Noronha N, Tran H, Chakrabarty R, Selvaggi G, Coffey M, Thompson B, Sarantopoulos J.

Cancer Chemother Pharmacol. 2017 Apr;79(4):697-703. doi: 10.1007/s00280-017-3260-6. Epub 2017 Mar 13.


Wee1 and Cdc25: Tools, pathways, mechanisms, questions.

Moseley JB.

Cell Cycle. 2017 Apr 3;16(7):599-600. doi: 10.1080/15384101.2017.1302229. No abstract available.


Phosphatases Generate Signal Specificity Downstream of Ssp1 Kinase in Fission Yeast.

Deng L, Lee ME, Schutt KL, Moseley JB.

Mol Cell Biol. 2017 May 2;37(10). pii: e00494-16. doi: 10.1128/MCB.00494-16. Print 2017 May 15.


Open access phone triage for veterans with suspected malignant pleural mesothelioma.

Siegert CJ, Fisichella PM, Moseley JM, Shoni M, Lebenthal A.

J Surg Res. 2017 Jan;207:108-114. doi: 10.1016/j.jss.2016.08.031. Epub 2016 Aug 19.


Concise Xanthine Synthesis through a Double-Amidination Reaction of a 6-Chlorouracil with Amidines using Base-Metal Catalysis.

Morel B, Franck P, Bidange J, Sergeyev S, Smith DA, Moseley JD, Maes BU.

ChemSusChem. 2017 Feb 8;10(3):624-628. doi: 10.1002/cssc.201601483. Epub 2017 Jan 12.


CAG Expansions Are Genetically Stable and Form Nontoxic Aggregates in Cells Lacking Endogenous Polyglutamine Proteins.

Zurawel AA, Kabeche R, DiGregorio SE, Deng L, Menon KM, Opalko H, Duennwald ML, Moseley JB, Supattapone S.

MBio. 2016 Sep 27;7(5). pii: e01367-16. doi: 10.1128/mBio.01367-16.


How aligned are the perspectives of EU regulators and HTA bodies? A comparative analysis of regulatory-HTA parallel scientific advice.

Tafuri G, Pagnini M, Moseley J, Massari M, Petavy F, Behring A, Catalan A, Gajraj E, Hedberg N, Obach M, Osipenko L, Russo P, Van De Casteele M, Zebedin EM, Rasi G, Vamvakas S.

Br J Clin Pharmacol. 2016 Oct;82(4):965-73. doi: 10.1111/bcp.13023. Epub 2016 Jul 1.


Sideline Management of Joint Dislocations.

Schupp CM, Rand SE, Hanson TW, Lee BM, Jafarnia K, Jia Y, Moseley JB, Seaberg JP, Seelhoefer GM.

Curr Sports Med Rep. 2016 May-Jun;15(3):140-53. doi: 10.1249/JSR.0000000000000266.


Planned versus 'delivered' bladder dose reconstructed using solid and hollow organ models during prostate cancer IMRT.

Rosewall T, Wheat J, Currie G, Kong V, Bayley AJ, Moseley J, Chung P, Catton C, Craig T, Milosevic M.

Radiother Oncol. 2016 Jun;119(3):417-22. doi: 10.1016/j.radonc.2016.03.022. Epub 2016 Apr 9.


Impact of image registration surrogates on the planning target volume geometry for bladder radiation therapy.

Kong V, Kwan M, Chen S, Moseley J, Craig T, Chung P, Rosewall T.

Pract Radiat Oncol. 2016 Sep-Oct;6(5):e187-e194. doi: 10.1016/j.prro.2015.12.007. Epub 2015 Dec 29.


Pil1 cytoplasmic rods contain bundles of crosslinked tubules.

Kabeche R, Howard L, Moseley JB.

Commun Integr Biol. 2015 Mar 4;8(1):e990848. doi: 10.4161/19420889.2014.990848. eCollection 2015 Jan-Feb.


Radiation dose response simulation for biomechanical-based deformable image registration of head and neck cancer treatment.

Al-Mayah A, Moseley J, Hunter S, Brock K.

Phys Med Biol. 2015 Nov 7;60(21):8481-9. doi: 10.1088/0031-9155/60/21/8481. Epub 2015 Oct 20.


Eisosomes provide membrane reservoirs for rapid expansion of the yeast plasma membrane.

Kabeche R, Howard L, Moseley JB.

J Cell Sci. 2015 Nov 15;128(22):4057-62. doi: 10.1242/jcs.176867. Epub 2015 Sep 24.


Eisosomes Regulate Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P2) Cortical Clusters and Mitogen-activated Protein (MAP) Kinase Signaling upon Osmotic Stress.

Kabeche R, Madrid M, Cansado J, Moseley JB.

J Biol Chem. 2015 Oct 23;290(43):25960-73. doi: 10.1074/jbc.M115.674192. Epub 2015 Sep 10.


An increased population of regulatory T cells improves the pathophysiology of placental ischemia in a rat model of preeclampsia.

Cornelius DC, Amaral LM, Harmon A, Wallace K, Thomas AJ, Campbell N, Scott J, Herse F, Haase N, Moseley J, Wallukat G, Dechend R, LaMarca B.

Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15;309(8):R884-91. doi: 10.1152/ajpregu.00154.2015. Epub 2015 Aug 19.


IL-10 supplementation increases Tregs and decreases hypertension in the RUPP rat model of preeclampsia.

Harmon A, Cornelius D, Amaral L, Paige A, Herse F, Ibrahim T, Wallukat G, Faulkner J, Moseley J, Dechend R, LaMarca B.

Hypertens Pregnancy. 2015;34(3):291-306. doi: 10.3109/10641955.2015.1032054. Epub 2015 May 21.


Cytokinesis: does Mid1 have an identity crisis?

Moseley JB.

Curr Biol. 2015 May 4;25(9):R364-6. doi: 10.1016/j.cub.2015.03.017.


Utility and validation of biomechanical deformable image registration in low-contrast images.

Velec M, Juang T, Moseley JL, Oldham M, Brock KK.

Pract Radiat Oncol. 2015 Jul-Aug;5(4):e401-8. doi: 10.1016/j.prro.2015.01.011. Epub 2015 Mar 29.


Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN, Deng L, Wu Y, Baldissard S, Adamo ME, Gerber SA, Moseley JB.

Mol Cell Proteomics. 2015 May;14(5):1275-87. doi: 10.1074/mcp.M114.045245. Epub 2015 Feb 26.


Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia.

Johnson AC, Tremble SM, Chan SL, Moseley J, LaMarca B, Nagle KJ, Cipolla MJ.

PLoS One. 2014 Nov 19;9(11):e113670. doi: 10.1371/journal.pone.0113670. eCollection 2014.


17-hydroxyprogesterone caproate significantly improves clinical characteristics of preeclampsia in the reduced uterine perfusion pressure rat model.

Amaral LM, Cornelius DC, Harmon A, Moseley J, Martin JN Jr, LaMarca B.

Hypertension. 2015 Jan;65(1):225-31. doi: 10.1161/HYPERTENSIONAHA.114.04484. Epub 2014 Nov 3.


CD4+ T cells are important mediators of oxidative stress that cause hypertension in response to placental ischemia.

Wallace K, Cornelius DC, Scott J, Heath J, Moseley J, Chatman K, LaMarca B.

Hypertension. 2014 Nov;64(5):1151-8. doi: 10.1161/HYPERTENSIONAHA.114.03590. Epub 2014 Aug 4.


Assessment of nonrespiratory stomach motion in healthy volunteers in fasting and postprandial states.

Wysocka B, Moseley J, Brock K, Lockwood G, Wilson G, Simeonov A, Haider MA, Menard C, Bissonnette JP, Dawson LA, Ringash J.

Pract Radiat Oncol. 2014 Sep-Oct;4(5):288-293. doi: 10.1016/j.prro.2013.10.001. Epub 2013 Nov 18.


Enodthelin 1 is elevated in plasma and explants from patients having uterine leiomyomas.

Wallace K, Chatman K, Porter J, Scott J, Johnson V, Moseley J, LaMarca B.

Reprod Sci. 2014 Sep;21(9):1196-205. doi: 10.1177/1933719114542018.

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