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Items: 1 to 50 of 245

1.

Novel inhibitors of protein arginine deiminase with potential activity in multiple sclerosis animal model.

Wei L, Wasilewski E, Chakka SK, Bello AM, Moscarello MA, Kotra LP.

J Med Chem. 2013 Feb 28;56(4):1715-22. doi: 10.1021/jm301755q. Epub 2013 Feb 19.

PMID:
23421315
2.

Interrogation of the Active Sites of Protein Arginine Deiminases (PAD1, -2, and -4) Using Designer Probes.

Bello AM, Wasilewski E, Wei L, Moscarello MA, Kotra LP.

ACS Med Chem Lett. 2013 Jan 15;4(2):249-53. doi: 10.1021/ml300377d. eCollection 2013 Feb 14.

3.

Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis.

Moscarello MA, Lei H, Mastronardi FG, Winer S, Tsui H, Li Z, Ackerley C, Zhang L, Raijmakers R, Wood DD.

Dis Model Mech. 2013 Mar;6(2):467-78. doi: 10.1242/dmm.010520. Epub 2012 Nov 1.

4.

Myelin basic protein undergoes a broader range of modifications in mammals than in lower vertebrates.

Zhang C, Walker AK, Zand R, Moscarello MA, Yan JM, Andrews PC.

J Proteome Res. 2012 Oct 5;11(10):4791-802. doi: 10.1021/pr201196e. Epub 2012 Sep 21.

5.

NMDA receptor encephalitis mimicking seronegative neuromyelitis optica.

Kruer MC, Koch TK, Bourdette DN, Chabas D, Waubant E, Mueller S, Moscarello MA, Dalmau J, Woltjer RL, Adamus G.

Neurology. 2010 May 4;74(18):1473-5. doi: 10.1212/WNL.0b013e3181dc1a7f. No abstract available.

6.

Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system.

Musse AA, Li Z, Ackerley CA, Bienzle D, Lei H, Poma R, Harauz G, Moscarello MA, Mastronardi FG.

Dis Model Mech. 2008 Nov-Dec;1(4-5):229-40. doi: 10.1242/dmm.000729. Epub 2008 Nov 6.

7.

Myelin localization of peptidylarginine deiminases 2 and 4: comparison of PAD2 and PAD4 activities.

Wood DD, Ackerley CA, Brand Bv, Zhang L, Raijmakers R, Mastronardi FG, Moscarello MA.

Lab Invest. 2008 Apr;88(4):354-64. doi: 10.1038/labinvest.3700748. Epub 2008 Jan 28.

8.

Synergy between paclitaxel plus an exogenous methyl donor in the suppression of murine demyelinating diseases.

Mastronardi FG, Tsui H, Winer S, Wood DD, Selvanantham T, Galligan C, Fish EN, Dosch HM, Moscarello MA.

Mult Scler. 2007 Jun;13(5):596-609. Epub 2007 Feb 9.

PMID:
17548438
9.

Peptidyl argininedeiminase 2 CpG island in multiple sclerosis white matter is hypomethylated.

Mastronardi FG, Noor A, Wood DD, Paton T, Moscarello MA.

J Neurosci Res. 2007 Jul;85(9):2006-16.

PMID:
17469138
10.

Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination: a role for tumor necrosis factor-induced peptidylarginine deiminase 4 translocation.

Mastronardi FG, Wood DD, Mei J, Raijmakers R, Tseveleki V, Dosch HM, Probert L, Casaccia-Bonnefil P, Moscarello MA.

J Neurosci. 2006 Nov 1;26(44):11387-96.

11.

The role of citrullinated proteins suggests a novel mechanism in the pathogenesis of multiple sclerosis.

Moscarello MA, Mastronardi FG, Wood DD.

Neurochem Res. 2007 Feb;32(2):251-6. Epub 2006 Sep 22. Review.

12.

Differences in susceptibility of MBP charge isomers to digestion by stromelysin-1 (MMP-3) and release of an immunodominant epitope.

D'Souza CA, Moscarello MA.

Neurochem Res. 2006 Aug;31(8):1045-54. Epub 2006 Jul 27.

PMID:
16871440
13.

Autocatalytic cleavage of myelin basic protein: an alternative to molecular mimicry.

D'Souza CA, Wood DD, She YM, Moscarello MA.

Biochemistry. 2005 Sep 27;44(38):12905-13.

PMID:
16171406
14.

Molecules affecting myelin stability: a novel hypothesis regarding the pathogenesis of multiple sclerosis.

Mastronardi FG, Moscarello MA.

J Neurosci Res. 2005 May 1;80(3):301-8. Review.

PMID:
15704220
15.
16.

The amount of sonic hedgehog in multiple sclerosis white matter is decreased and cleavage to the signaling peptide is deficient.

Mastronardi FG, daCruz LA, Wang H, Boggs J, Moscarello MA.

Mult Scler. 2003 Aug;9(4):362-71.

PMID:
12926841
17.

Multiple sclerosis: an important role for post-translational modifications of myelin basic protein in pathogenesis.

Kim JK, Mastronardi FG, Wood DD, Lubman DM, Zand R, Moscarello MA.

Mol Cell Proteomics. 2003 Jul;2(7):453-62. Epub 2003 Jun 25.

18.

Expression and properties of the recombinant murine Golli-myelin basic protein isoform J37.

Kaur J, Libich DS, Campagnoni CW, Wood DD, Moscarello MA, Campagnoni AT, Harauz G.

J Neurosci Res. 2003 Mar 15;71(6):777-84.

PMID:
12605403
19.

Primary structure of equine myelin basic protein by mass spectrometry.

Wood DD, She YM, Freer AD, Harauz G, Moscarello MA.

Arch Biochem Biophys. 2002 Sep 1;405(1):137-46.

PMID:
12176067
20.

An Arg/Lys-->Gln mutant of recombinant murine myelin basic protein as a mimic of the deiminated form implicated in multiple sclerosis.

Bates IR, Libich DS, Wood DD, Moscarello MA, Harauz G.

Protein Expr Purif. 2002 Jul;25(2):330-41.

PMID:
12135568
21.

Peptidylarginine deiminase: a candidate factor in demyelinating disease.

Moscarello MA, Pritzker L, Mastronardi FG, Wood DD.

J Neurochem. 2002 Apr;81(2):335-43.

22.

Paclitaxel (Taxol) attenuates clinical disease in a spontaneously demyelinating transgenic mouse and induces remyelination.

Moscarello MA, Mak B, Nguyen TA, Wood DD, Mastronardi F, Ludwin SK.

Mult Scler. 2002 Apr;8(2):130-8.

PMID:
11990870
23.

A rapid ELISA-based serum assay for myelin basic protein in multiple sclerosis.

Chamczuk AJ, Ursell M, O'Connor P, Jackowski G, Moscarello MA.

J Immunol Methods. 2002 Apr 1;262(1-2):21-7.

PMID:
11983216
24.

The effects of deimination of myelin basic protein on structures formed by its interaction with phosphoinositide-containing lipid monolayers.

Ishiyama N, Bates IR, Hill CM, Wood DD, Matharu P, Viner NJ, Moscarello MA, Harauz G.

J Struct Biol. 2001 Oct;136(1):30-45.

PMID:
11858705
25.

The up-regulation of stromelysin-1 (MMP-3) in a spontaneously demyelinating transgenic mouse precedes onset of disease.

D'Souza CA, Mak B, Moscarello MA.

J Biol Chem. 2002 Apr 19;277(16):13589-96. Epub 2002 Feb 5.

26.

T cells of multiple sclerosis patients target a common environmental peptide that causes encephalitis in mice.

Winer S, Astsaturov I, Cheung RK, Schrade K, Gunaratnam L, Wood DD, Moscarello MA, O'Connor P, McKerlie C, Becker DJ, Dosch HM.

J Immunol. 2001 Apr 1;166(7):4751-6.

27.

Characterization of a recombinant murine 18.5-kDa myelin basic protein.

Bates IR, Matharu P, Ishiyama N, Rochon D, Wood DD, Polverini E, Moscarello MA, Viner NJ, Harauz G.

Protein Expr Purif. 2000 Nov;20(2):285-99.

PMID:
11049752
28.

Inhibition of experimental allergic encephalomyelitis in the Lewis rat by paclitaxel.

Cao L, Sun D, Cruz T, Moscarello MA, Ludwin SK, Whitaker JN.

J Neuroimmunol. 2000 Aug 1;108(1-2):103-11.

PMID:
10900343
29.

Deimination of myelin basic protein. 2. Effect of methylation of MBP on its deimination by peptidylarginine deiminase.

Pritzker LB, Joshi S, Harauz G, Moscarello MA.

Biochemistry. 2000 May 9;39(18):5382-8.

PMID:
10820009
30.
31.

Cryoelectron microscopy of protein-lipid complexes of human myelin basic protein charge isomers differing in degree of citrullination.

Beniac DR, Wood DD, Palaniyar N, Ottensmeyer FP, Moscarello MA, Harauz G.

J Struct Biol. 2000 Feb;129(1):80-95.

PMID:
10675299
32.

The developmental expression and activity of peptidylarginine deiminase in the mouse.

Pritzker LB, Nguyen TA, Moscarello MA.

Neurosci Lett. 1999 May 14;266(3):161-4.

PMID:
10465698
33.

Highly deiminated isoform of myelin basic protein from multiple sclerosis brain causes fragmentation of lipid vesicles.

Boggs JM, Rangaraj G, Koshy KM, Ackerley C, Wood DD, Moscarello MA.

J Neurosci Res. 1999 Aug 15;57(4):529-35.

PMID:
10440902
34.

Rapid release and unusual stability of immunodominant peptide 45-89 from citrullinated myelin basic protein.

Cao L, Goodin R, Wood D, Moscarello MA, Whitaker JN.

Biochemistry. 1999 May 11;38(19):6157-63.

PMID:
10320343
35.

Marburg's variant of multiple sclerosis correlates with a less compact structure of myelin basic protein.

Beniac DR, Wood DD, Palaniyar N, Ottensmeyer FP, Moscarello MA, Harauz G.

Mol Cell Biol Res Commun. 1999 Apr;1(1):48-51.

PMID:
10329477
36.

Human proteolipid protein (PLP) mediates winding and adhesion of phospholipid membranes but prevents their fusion.

Palaniyar N, Semotok JL, Wood DD, Moscarello MA, Harauz G.

Biochim Biophys Acta. 1998 Dec 9;1415(1):85-100.

37.

A novel microtubule independent effect of paclitaxel: the inhibition of peptidylarginine deiminase from bovine brain.

Pritzker LB, Moscarello MA.

Biochim Biophys Acta. 1998 Oct 14;1388(1):154-60.

PMID:
9774721
38.

Mechanism of demyelination in DM20 transgenic mice involves increased fatty acylation.

Barrese N, Mak B, Fisher L, Moscarello MA.

J Neurosci Res. 1998 Jul 15;53(2):143-52.

PMID:
9671971
39.

Increased expression of CD44 on astrocytoma cells induced by binding myelin basic protein.

Owh P, da Cruz LA, Ackerley CA, Moscarello MA.

Eur J Cell Biol. 1997 Oct;74(2):172-80.

PMID:
9352222
40.
41.

Three-dimensional structure of myelin basic protein. II. Molecular modeling and considerations of predicted structures in multiple sclerosis.

Ridsdale RA, Beniac DR, Tompkins TA, Moscarello MA, Harauz G.

J Biol Chem. 1997 Feb 14;272(7):4269-75.

42.

Three-dimensional structure of myelin basic protein. I. Reconstruction via angular reconstitution of randomly oriented single particles.

Beniac DR, Luckevich MD, Czarnota GJ, Tompkins TA, Ridsdale RA, Ottensmeyer FP, Moscarello MA, Harauz G.

J Biol Chem. 1997 Feb 14;272(7):4261-8.

43.

Acute multiple sclerosis (Marburg type) is associated with developmentally immature myelin basic protein.

Wood DD, Bilbao JM, O'Connors P, Moscarello MA.

Ann Neurol. 1996 Jul;40(1):18-24.

PMID:
8687186
44.

Myelin basic protein in experimental allergic encephalomyelitis is not affected at the posttranslational level: implications for demyelinating disease.

Mastronardi FG, al-Sabbagh A, Nelson PA, Rego J, Roots BI, Moscarello MA.

J Neurosci Res. 1996 May 15;44(4):344-9.

PMID:
8739153
45.

Loss of myelin basic protein cationicity in DM20 transgenic mice is dosage dependent.

Mastronardi FG, Ackerley CA, Roots BI, Moscarello MA.

J Neurosci Res. 1996 May 15;44(4):301-7.

PMID:
8739149
46.

Identification of a mitogen-activated protein kinase site in human myelin basic protein in situ.

Yon M, Ackerley CA, Mastronardi FG, Groome N, Moscarello MA.

J Neuroimmunol. 1996 Mar;65(1):55-9.

PMID:
8642064
47.

Modifications of myelin basic protein in DM20 transgenic mice are similar to those in myelin basic protein from multiple sclerosis.

Mastronardi FG, Mak B, Ackerley CA, Roots BI, Moscarello MA.

J Clin Invest. 1996 Jan 15;97(2):349-58.

48.

ADP-ribosyltransferase activity in myelin membranes isolated from human brain.

Boulias C, Mastronardi FG, Moscarello MA.

Neurochem Res. 1995 Nov;20(11):1269-77.

PMID:
8786812
49.
50.

The isolation and characterization of four myelin basic proteins from the unbound fraction during CM52 chromatography.

Boulias C, Pang H, Mastronardi F, Moscarello MA.

Arch Biochem Biophys. 1995 Sep 10;322(1):174-82.

PMID:
7574672

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