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Items: 28


Processive DNA synthesis is associated with localized decompaction of constitutive heterochromatin at the sites of DNA replication and repair.

Chagin VO, Reinhart B, Becker A, Mortusewicz O, Jost KL, Rapp A, Leonhardt H, Cardoso MC.

Nucleus. 2019 Dec;10(1):231-253. doi: 10.1080/19491034.2019.1688932.


Restriction of AID activity and somatic hypermutation by PARP-1.

Tepper S, Mortusewicz O, Członka E, Bello A, Schmidt A, Jeschke J, Fischbach A, Pfeil I, Petersen-Mahrt SK, Mangerich A, Helleday T, Leonhardt H, Jungnickel B.

Nucleic Acids Res. 2019 Aug 22;47(14):7418-7429. doi: 10.1093/nar/gkz466.


Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.

Visnes T, Cázares-Körner A, Hao W, Wallner O, Masuyer G, Loseva O, Mortusewicz O, Wiita E, Sarno A, Manoilov A, Astorga-Wells J, Jemth AS, Pan L, Sanjiv K, Karsten S, Gokturk C, Grube M, Homan EJ, Hanna BMF, Paulin CBJ, Pham T, Rasti A, Berglund UW, von Nicolai C, Benitez-Buelga C, Koolmeister T, Ivanic D, Iliev P, Scobie M, Krokan HE, Baranczewski P, Artursson P, Altun M, Jensen AJ, Kalderén C, Ba X, Zubarev RA, Stenmark P, Boldogh I, Helleday T.

Science. 2018 Nov 16;362(6416):834-839. doi: 10.1126/science.aar8048.


dUTPase inhibition augments replication defects of 5-Fluorouracil.

Hagenkort A, Paulin CBJ, Desroses M, Sarno A, Wiita E, Mortusewicz O, Koolmeister T, Loseva O, Jemth AS, Almlöf I, Homan E, Lundbäck T, Gustavsson AL, Scobie M, Helleday T.

Oncotarget. 2017 Apr 4;8(14):23713-23726. doi: 10.18632/oncotarget.15785.


Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities.

Sanjiv K, Hagenkort A, Calderón-Montaño JM, Koolmeister T, Reaper PM, Mortusewicz O, Jacques SA, Kuiper RV, Schultz N, Scobie M, Charlton PA, Pollard JR, Berglund UW, Altun M, Helleday T.

Cell Rep. 2016 Dec 20;17(12):3407-3416. doi: 10.1016/j.celrep.2016.12.031. No abstract available.


The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing.

Tanikawa M, Sanjiv K, Helleday T, Herr P, Mortusewicz O.

Oncogenesis. 2016 Dec 19;5(12):e280. doi: 10.1038/oncsis.2016.70.


Genome-wide screen of cell-cycle regulators in normal and tumor cells identifies a differential response to nucleosome depletion.

Sokolova M, Turunen M, Mortusewicz O, Kivioja T, Herr P, Vähärautio A, Björklund M, Taipale M, Helleday T, Taipale J.

Cell Cycle. 2017 Jan 17;16(2):189-199. doi: 10.1080/15384101.2016.1261765. Epub 2016 Dec 8.


Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities.

Sanjiv K, Hagenkort A, Calderón-Montaño JM, Koolmeister T, Reaper PM, Mortusewicz O, Jacques SA, Kuiper RV, Schultz N, Scobie M, Charlton PA, Pollard JR, Berglund UW, Altun M, Helleday T.

Cell Rep. 2016 Jan 12;14(2):298-309. doi: 10.1016/j.celrep.2015.12.032. Epub 2015 Dec 31. Erratum in: Cell Rep. 2016 Dec 20;17 (12 ):3407-3416.


DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair.

Ying S, Chen Z, Medhurst AL, Neal JA, Bao Z, Mortusewicz O, McGouran J, Song X, Shen H, Hamdy FC, Kessler BM, Meek K, Helleday T.

Cancer Res. 2016 Mar 1;76(5):1078-88. doi: 10.1158/0008-5472.CAN-15-0608. Epub 2015 Nov 24.


Generation of an alpaca-derived nanobody recognizing γ-H2AX.

Rajan M, Mortusewicz O, Rothbauer U, Hastert FD, Schmidthals K, Rapp A, Leonhardt H, Cardoso MC.

FEBS Open Bio. 2015 Sep 21;5:779-88. doi: 10.1016/j.fob.2015.09.005. eCollection 2015.


Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair.

Xie S, Mortusewicz O, Ma HT, Herr P, Poon RY, Helleday T, Qian C.

Mol Cell. 2015 Oct 1;60(1):163-76. doi: 10.1016/j.molcel.2015.07.031. Epub 2015 Sep 3. Erratum in: Mol Cell. 2016 Jan 7;61(1):181. Poon, Randy R Y [Corrected to Poon, Randy Y C].


PC4 promotes genome stability and DNA repair through binding of ssDNA at DNA damage sites.

Mortusewicz O, Evers B, Helleday T.

Oncogene. 2016 Feb 11;35(6):761-70. doi: 10.1038/onc.2015.135. Epub 2015 May 11.


A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair.

Herr P, Lundin C, Evers B, Ebner D, Bauerschmidt C, Kingham G, Palmai-Pallag T, Mortusewicz O, Frings O, Sonnhammer E, Helleday T.

Cell Discov. 2015 Dec 1;1:15034. doi: 10.1038/celldisc.2015.34. eCollection 2015.


Early replication fragile sites: where replication-transcription collisions cause genetic instability.

Mortusewicz O, Herr P, Helleday T.

EMBO J. 2013 Feb 20;32(4):493-5. doi: 10.1038/emboj.2013.20. Epub 2013 Feb 1. Review. No abstract available.


Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress.

Jones RM, Mortusewicz O, Afzal I, Lorvellec M, García P, Helleday T, Petermann E.

Oncogene. 2013 Aug 8;32(32):3744-53. doi: 10.1038/onc.2012.387. Epub 2012 Sep 3.


CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair.

Ström CE, Mortusewicz O, Finch D, Parsons JL, Lagerqvist A, Johansson F, Schultz N, Erixon K, Dianov GL, Helleday T.

DNA Repair (Amst). 2011 Sep 5;10(9):961-9. doi: 10.1016/j.dnarep.2011.07.004. Epub 2011 Aug 15.


Role for hACF1 in the G2/M damage checkpoint.

Sánchez-Molina S, Mortusewicz O, Bieber B, Auer S, Eckey M, Leonhardt H, Friedl AA, Becker PB.

Nucleic Acids Res. 2011 Oct;39(19):8445-56. doi: 10.1093/nar/gkr435. Epub 2011 Jul 11.


PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms.

Mortusewicz O, Fouquerel E, Amé JC, Leonhardt H, Schreiber V.

Nucleic Acids Res. 2011 Jul;39(12):5045-56. doi: 10.1093/nar/gkr099. Epub 2011 Mar 11.


Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression.

Boehler C, Gauthier LR, Mortusewicz O, Biard DS, Saliou JM, Bresson A, Sanglier-Cianferani S, Smith S, Schreiber V, Boussin F, Dantzer F.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2783-8. doi: 10.1073/pnas.1016574108. Epub 2011 Jan 26.


MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos.

Ruzov A, Shorning B, Mortusewicz O, Dunican DS, Leonhardt H, Meehan RR.

Development. 2009 Jul;136(13):2277-86. doi: 10.1242/dev.032227.


Recruitment of RNA polymerase II cofactor PC4 to DNA damage sites.

Mortusewicz O, Roth W, Li N, Cardoso MC, Meisterernst M, Leonhardt H.

J Cell Biol. 2008 Dec 1;183(5):769-76. doi: 10.1083/jcb.200808097.


A fluorescent two-hybrid assay for direct visualization of protein interactions in living cells.

Zolghadr K, Mortusewicz O, Rothbauer U, Kleinhans R, Goehler H, Wanker EE, Cardoso MC, Leonhardt H.

Mol Cell Proteomics. 2008 Nov;7(11):2279-87. doi: 10.1074/mcp.M700548-MCP200. Epub 2008 Jul 12.


Spatiotemporal dynamics of regulatory protein recruitment at DNA damage sites.

Mortusewicz O, Leonhardt H, Cardoso MC.

J Cell Biochem. 2008 Aug 1;104(5):1562-9. doi: 10.1002/jcb.21751. Review.


Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells.

Mortusewicz O, Amé JC, Schreiber V, Leonhardt H.

Nucleic Acids Res. 2007;35(22):7665-75. Epub 2007 Nov 3.


Differential recruitment of DNA Ligase I and III to DNA repair sites.

Mortusewicz O, Rothbauer U, Cardoso MC, Leonhardt H.

Nucleic Acids Res. 2006 Jul 19;34(12):3523-32. Print 2006.


Spatiotemporal dynamics of p21CDKN1A protein recruitment to DNA-damage sites and interaction with proliferating cell nuclear antigen.

Perucca P, Cazzalini O, Mortusewicz O, Necchi D, Savio M, Nardo T, Stivala LA, Leonhardt H, Cardoso MC, Prosperi E.

J Cell Sci. 2006 Apr 15;119(Pt 8):1517-27. Epub 2006 Mar 21.


Recruitment of DNA methyltransferase I to DNA repair sites.

Mortusewicz O, Schermelleh L, Walter J, Cardoso MC, Leonhardt H.

Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8905-9. Epub 2005 Jun 13.

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