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Items: 1 to 50 of 58

1.

Mouse Idh3a mutations cause retinal degeneration and reduced mitochondrial function.

Findlay AS, Carter RN, Starbuck B, McKie L, Nováková K, Budd PS, Keighren MA, Marsh JA, Cross SH, Simon MM, Potter PK, Morton NM, Jackson IJ.

Dis Model Mech. 2018 Dec 18;11(12). pii: dmm036426. doi: 10.1242/dmm.036426.

2.

Corrigendum: Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness.

Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MTG, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipilä P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S.

Nat Med. 2018 Apr 10;24(4):525. doi: 10.1038/nm0418-525e.

PMID:
29634685
3.

Editorial: Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases?

Even PC, Virtue S, Morton NM, Fromentin G, Semple RK.

Front Nutr. 2017 Dec 1;4:58. doi: 10.3389/fnut.2017.00058. eCollection 2017. No abstract available.

4.

Complement Factor B Is a Determinant of Both Metabolic and Cardiovascular Features of Metabolic Syndrome.

Coan PM, Barrier M, Alfazema N, Carter RN, Marion de Procé S, Dopico XC, Garcia Diaz A, Thomson A, Jackson-Jones LH, Moyon B, Webster Z, Ross D, Moss J, Arends MJ, Morton NM, Aitman TJ.

Hypertension. 2017 Jul 24. pii: HYPERTENSIONAHA.117.09242. doi: 10.1161/HYPERTENSIONAHA.117.09242. [Epub ahead of print]

5.

Skeletal energy homeostasis: a paradigm of endocrine discovery.

Suchacki KJ, Roberts F, Lovdel A, Farquharson C, Morton NM, MacRae VE, Cawthorn WP.

J Endocrinol. 2017 Jul;234(1):R67-R79. doi: 10.1530/JOE-17-0147. Epub 2017 Apr 28. Review.

PMID:
28455432
6.

Bioenergetic status modulates motor neuron vulnerability and pathogenesis in a zebrafish model of spinal muscular atrophy.

Boyd PJ, Tu WY, Shorrock HK, Groen EJN, Carter RN, Powis RA, Thomson SR, Thomson D, Graham LC, Motyl AAL, Wishart TM, Highley JR, Morton NM, Becker T, Becker CG, Heath PR, Gillingwater TH.

PLoS Genet. 2017 Apr 20;13(4):e1006744. doi: 10.1371/journal.pgen.1006744. eCollection 2017 Apr.

7.

MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation.

Ho GT, Aird RE, Liu B, Boyapati RK, Kennedy NA, Dorward DA, Noble CL, Shimizu T, Carter RN, Chew ETS, Morton NM, Rossi AG, Sartor RB, Iredale JP, Satsangi J.

Mucosal Immunol. 2018 Jan;11(1):120-130. doi: 10.1038/mi.2017.31. Epub 2017 Apr 12.

8.

Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism.

Thompson AA, Dickinson RS, Murphy F, Thomson JP, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Mirchandani A, Dos Santos Coelho P, Doherty C, Ryan E, Watts E, Morton NM, Forbes S, Stimson RH, Hameed AG, Arnold N, Preston JA, Lawrie A, Finisguerra V, Mazzone M, Sadiku P, Goveia J, Taverna F, Carmeliet P, Foster SJ, Chilvers ER, Cowburn AS, Dockrell DH, Johnson RS, Meehan RR, Whyte MK, Walmsley SR.

Sci Immunol. 2017 Feb 10;2(8). pii: eaal2861. doi: 10.1126/sciimmunol.aal2861.

9.

Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions.

Guitart AV, Panagopoulou TI, Villacreces A, Vukovic M, Sepulveda C, Allen L, Carter RN, van de Lagemaat LN, Morgan M, Giles P, Sas Z, Gonzalez MV, Lawson H, Paris J, Edwards-Hicks J, Schaak K, Subramani C, Gezer D, Armesilla-Diaz A, Wills J, Easterbrook A, Coman D, So CW, O'Carroll D, Vernimmen D, Rodrigues NP, Pollard PJ, Morton NM, Finch A, Kranc KR.

J Exp Med. 2017 Mar 6;214(3):719-735. doi: 10.1084/jem.20161087. Epub 2017 Feb 15.

10.

Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology.

Amorim IS, Graham LC, Carter RN, Morton NM, Hammachi F, Kunath T, Pennetta G, Carpanini SM, Manson JC, Lamont DJ, Wishart TM, Gillingwater TH.

J Cell Sci. 2017 Jan 15;130(2):325-331. doi: 10.1242/jcs.194241. Epub 2017 Jan 3.

11.

Glucocorticoids Acutely Increase Brown Adipose Tissue Activity in Humans, Revealing Species-Specific Differences in UCP-1 Regulation.

Ramage LE, Akyol M, Fletcher AM, Forsythe J, Nixon M, Carter RN, van Beek EJ, Morton NM, Walker BR, Stimson RH.

Cell Metab. 2016 Jul 12;24(1):130-41. doi: 10.1016/j.cmet.2016.06.011.

12.

Construction of an integrative regulatory element and variation map of the murine Tst locus.

Beltram J, Morton NM, Kunej T, Horvat S.

BMC Genet. 2016 Jun 11;17(1):77. doi: 10.1186/s12863-016-0381-6.

13.

Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness.

Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MT, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipilä P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S.

Nat Med. 2016 Jul;22(7):771-9. doi: 10.1038/nm.4115. Epub 2016 Jun 6. Erratum in: Nat Med. 2018 Apr 10;24(4):525.

14.

Cysteine and hydrogen sulphide in the regulation of metabolism: insights from genetics and pharmacology.

Carter RN, Morton NM.

J Pathol. 2016 Jan;238(2):321-32. doi: 10.1002/path.4659. Epub 2015 Nov 13. Review.

15.

Adipocyte pseudohypoxia suppresses lipolysis and facilitates benign adipose tissue expansion.

Michailidou Z, Morton NM, Moreno Navarrete JM, West CC, Stewart KJ, Fernández-Real JM, Schofield CJ, Seckl JR, Ratcliffe PJ.

Diabetes. 2015 Mar;64(3):733-45. doi: 10.2337/db14-0233. Epub 2014 Nov 5.

16.

Deficiency of the bone mineralization inhibitor NPP1 protects mice against obesity and diabetes.

Huesa C, Zhu D, Glover JD, Ferron M, Karsenty G, Milne EM, Millan JL, Ahmed SF, Farquharson C, Morton NM, MacRae VE.

Dis Model Mech. 2014 Dec;7(12):1341-50. doi: 10.1242/dmm.017905. Epub 2014 Oct 31.

17.

β-Cell-Specific Glucocorticoid Reactivation Attenuates Inflammatory β-Cell Destruction.

Liu X, Turban S, Carter RN, Ahmad S, Ramage L, Webster SP, Walker BR, Seckl JR, Morton NM.

Front Endocrinol (Lausanne). 2014 Oct 14;5:165. doi: 10.3389/fendo.2014.00165. eCollection 2014.

18.

Pregnancy in obese mice protects selectively against visceral adiposity and is associated with increased adipocyte estrogen signalling.

Pedroni SM, Turban S, Kipari T, Dunbar DR, McInnes K, Saunders PT, Morton NM, Norman JE.

PLoS One. 2014 Apr 14;9(4):e94680. doi: 10.1371/journal.pone.0094680. eCollection 2014.

19.

Administration of heme arginate ameliorates murine type 2 diabetes independently of heme oxygenase activity.

Choudhary AK, Rennie J, Cairns C, Borthwick G, Hughes J, Morton NM, Kluth D, Conway BR.

PLoS One. 2013 Oct 30;8(10):e78209. doi: 10.1371/journal.pone.0078209. eCollection 2013.

20.

Regulation of adipocyte 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) by CCAAT/enhancer-binding protein (C/EBP) β isoforms, LIP and LAP.

Esteves CL, Kelly V, Bégay V, Man TY, Morton NM, Leutz A, Seckl JR, Chapman KE.

PLoS One. 2012;7(5):e37953. doi: 10.1371/journal.pone.0037953. Epub 2012 May 25.

21.

Optimal elevation of β-cell 11β-hydroxysteroid dehydrogenase type 1 is a compensatory mechanism that prevents high-fat diet-induced β-cell failure.

Turban S, Liu X, Ramage L, Webster SP, Walker BR, Dunbar DR, Mullins JJ, Seckl JR, Morton NM.

Diabetes. 2012 Mar;61(3):642-52. doi: 10.2337/db11-1054. Epub 2012 Feb 7.

22.

Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11β-hydroxysteroid dehydrogenase type 1 (HSD1)-deficient mice.

Michailidou Z, Turban S, Miller E, Zou X, Schrader J, Ratcliffe PJ, Hadoke PW, Walker BR, Iredale JP, Morton NM, Seckl JR.

J Biol Chem. 2012 Feb 3;287(6):4188-97. doi: 10.1074/jbc.M111.259325. Epub 2011 Dec 12.

23.

A stratified transcriptomics analysis of polygenic fat and lean mouse adipose tissues identifies novel candidate obesity genes.

Morton NM, Nelson YB, Michailidou Z, Di Rollo EM, Ramage L, Hadoke PW, Seckl JR, Bunger L, Horvat S, Kenyon CJ, Dunbar DR.

PLoS One. 2011;6(9):e23944. doi: 10.1371/journal.pone.0023944. Epub 2011 Sep 7.

24.

Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet.

Jamieson PM, Cleasby ME, Kuperman Y, Morton NM, Kelly PA, Brownstein DG, Mustard KJ, Vaughan JM, Carter RN, Hahn CN, Hardie DG, Seckl JR, Chen A, Vale WW.

Diabetologia. 2011 Sep;54(9):2392-403. doi: 10.1007/s00125-011-2205-6. Epub 2011 Jun 11.

25.

Dietary manipulation reveals an unexpected inverse relationship between fat mass and adipose 11β-hydroxysteroid dehydrogenase type 1.

Man TY, Michailidou Z, Gokcel A, Ramage L, Chapman KE, Kenyon CJ, Seckl JR, Morton NM.

Am J Physiol Endocrinol Metab. 2011 Jun;300(6):E1076-84. doi: 10.1152/ajpendo.00531.2010. Epub 2011 Mar 15.

26.

Novel fat depot-specific mechanisms underlie resistance to visceral obesity and inflammation in 11 β-hydroxysteroid dehydrogenase type 1-deficient mice.

Wamil M, Battle JH, Turban S, Kipari T, Seguret D, de Sousa Peixoto R, Nelson YB, Nowakowska D, Ferenbach D, Ramage L, Chapman KE, Hughes J, Dunbar DR, Seckl JR, Morton NM.

Diabetes. 2011 Apr;60(4):1158-67. doi: 10.2337/db10-0830. Epub 2011 Feb 24.

27.

Metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency: implications for the pathogenesis of steatohepatitis.

Macfarlane DP, Zou X, Andrew R, Morton NM, Livingstone DE, Aucott RL, Nyirenda MJ, Iredale JP, Walker BR.

Am J Physiol Endocrinol Metab. 2011 Feb;300(2):E402-9. doi: 10.1152/ajpendo.00331.2010. Epub 2010 Nov 30.

28.

Effects of proportions of dietary macronutrients on glucocorticoid metabolism in diet-induced obesity in rats.

Stimson RH, Lobley GE, Maraki I, Morton NM, Andrew R, Walker BR.

PLoS One. 2010 Jan 19;5(1):e8779. doi: 10.1371/journal.pone.0008779.

29.

Obesity and corticosteroids: 11beta-hydroxysteroid type 1 as a cause and therapeutic target in metabolic disease.

Morton NM.

Mol Cell Endocrinol. 2010 Mar 25;316(2):154-64. doi: 10.1016/j.mce.2009.09.024. Epub 2009 Oct 3. Review.

PMID:
19804814
30.

7-oxysterols modulate glucocorticoid activity in adipocytes through competition for 11beta-hydroxysteroid dehydrogenase type.

Wamil M, Andrew R, Chapman KE, Street J, Morton NM, Seckl JR.

Endocrinology. 2008 Dec;149(12):5909-18. doi: 10.1210/en.2008-0420. Epub 2008 Aug 28.

PMID:
18755798
31.

Glucocorticoid receptor haploinsufficiency causes hypertension and attenuates hypothalamic-pituitary-adrenal axis and blood pressure adaptions to high-fat diet.

Michailidou Z, Carter RN, Marshall E, Sutherland HG, Brownstein DG, Owen E, Cockett K, Kelly V, Ramage L, Al-Dujaili EA, Ross M, Maraki I, Newton K, Holmes MC, Seckl JR, Morton NM, Kenyon CJ, Chapman KE.

FASEB J. 2008 Nov;22(11):3896-907. doi: 10.1096/fj.08-111914. Epub 2008 Aug 12.

32.

Divergent physical activity and novel alternative responses to high fat feeding in polygenic fat and lean mice.

Simoncic M, Horvat S, Stevenson PL, Bünger L, Holmes MC, Kenyon CJ, Speakman JR, Morton NM.

Behav Genet. 2008 May;38(3):292-300. doi: 10.1007/s10519-008-9199-y. Epub 2008 Mar 18.

PMID:
18347969
33.

11beta-hydroxysteroid dehydrogenase type 1 and obesity.

Morton NM, Seckl JR.

Front Horm Res. 2008;36:146-64. doi: 10.1159/0000115363. Review.

PMID:
18230901
34.

Preadipocyte 11beta-hydroxysteroid dehydrogenase type 1 is a keto-reductase and contributes to diet-induced visceral obesity in vivo.

De Sousa Peixoto RA, Turban S, Battle JH, Chapman KE, Seckl JR, Morton NM.

Endocrinology. 2008 Apr;149(4):1861-8. doi: 10.1210/en.2007-1028. Epub 2008 Jan 3.

PMID:
18174284
35.

Dietary macronutrient content alters cortisol metabolism independently of body weight changes in obese men.

Stimson RH, Johnstone AM, Homer NZ, Wake DJ, Morton NM, Andrew R, Lobley GE, Walker BR.

J Clin Endocrinol Metab. 2007 Nov;92(11):4480-4. Epub 2007 Sep 4.

PMID:
17785367
36.

Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone.

Michailidou Z, Coll AP, Kenyon CJ, Morton NM, O'Rahilly S, Seckl JR, Chapman KE.

J Endocrinol. 2007 Jul;194(1):161-70.

37.

Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity.

Michailidou Z, Jensen MD, Dumesic DA, Chapman KE, Seckl JR, Walker BR, Morton NM.

Obesity (Silver Spring). 2007 May;15(5):1155-63.

38.

Glucocorticoid metabolism within superficial subcutaneous rather than visceral adipose tissue is associated with features of the metabolic syndrome in South African women.

Goedecke JH, Wake DJ, Levitt NS, Lambert EV, Collins MR, Morton NM, Andrew R, Seckl JR, Walker BR.

Clin Endocrinol (Oxf). 2006 Jul;65(1):81-7.

PMID:
16817824
39.

11 beta-hydroxysteroid dehydrogenase type 1 induction in the arcuate nucleus by high-fat feeding: A novel constraint to hyperphagia?

Densmore VS, Morton NM, Mullins JJ, Seckl JR.

Endocrinology. 2006 Sep;147(9):4486-95. Epub 2006 Jun 8.

PMID:
16763061
40.

A novel promoter for the 11beta-hydroxysteroid dehydrogenase type 1 gene is active in lung and is C/EBPalpha independent.

Bruley C, Lyons V, Worsley AG, Wilde MD, Darlington GD, Morton NM, Seckl JR, Chapman KE.

Endocrinology. 2006 Jun;147(6):2879-85. Epub 2006 Mar 16.

PMID:
16543369
41.

A polygenic model of the metabolic syndrome with reduced circulating and intra-adipose glucocorticoid action.

Morton NM, Densmore V, Wamil M, Ramage L, Nichol K, Bünger L, Seckl JR, Kenyon CJ.

Diabetes. 2005 Dec;54(12):3371-8.

42.

Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity.

Kershaw EE, Morton NM, Dhillon H, Ramage L, Seckl JR, Flier JS.

Diabetes. 2005 Apr;54(4):1023-31.

43.

Reduced adipose glucocorticoid reactivation and increased hepatic glucocorticoid clearance as an early adaptation to high-fat feeding in Wistar rats.

Drake AJ, Livingstone DE, Andrew R, Seckl JR, Morton NM, Walker BR.

Endocrinology. 2005 Feb;146(2):913-9. Epub 2004 Nov 18.

PMID:
15550507
44.

Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice.

Paterson JM, Morton NM, Fievet C, Kenyon CJ, Holmes MC, Staels B, Seckl JR, Mullins JJ.

Proc Natl Acad Sci U S A. 2004 May 4;101(18):7088-93. Epub 2004 Apr 26.

45.

Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice.

Morton NM, Paterson JM, Masuzaki H, Holmes MC, Staels B, Fievet C, Walker BR, Flier JS, Mullins JJ, Seckl JR.

Diabetes. 2004 Apr;53(4):931-8.

46.
47.

Glucocorticoids and 11beta-hydroxysteroid dehydrogenase in adipose tissue.

Seckl JR, Morton NM, Chapman KE, Walker BR.

Recent Prog Horm Res. 2004;59:359-93. Review.

PMID:
14749510
48.

Modulation of susceptibility to weight gain and insulin resistance in low birthweight rats by treatment of their mothers with leptin during pregnancy and lactation.

Stocker C, O'Dowd J, Morton NM, Wargent E, Sennitt MV, Hislop D, Glund S, Seckl JR, Arch JR, Cawthorne MA.

Int J Obes Relat Metab Disord. 2004 Jan;28(1):129-36.

PMID:
14557827
49.

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice.

Masuzaki H, Yamamoto H, Kenyon CJ, Elmquist JK, Morton NM, Paterson JM, Shinyama H, Sharp MG, Fleming S, Mullins JJ, Seckl JR, Flier JS.

J Clin Invest. 2003 Jul;112(1):83-90.

50.

A transgenic model of visceral obesity and the metabolic syndrome.

Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS.

Science. 2001 Dec 7;294(5549):2166-70.

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