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CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan.

Vennin C, Mélénec P, Rouet R, Nobis M, Cazet AS, Murphy KJ, Herrmann D, Reed DA, Lucas MC, Warren SC, Elgundi Z, Pinese M, Kalna G, Roden D, Samuel M, Zaratzian A, Grey ST, Da Silva A, Leung W; Australian Pancreatic Genome Initiative (APGI), Mathivanan S, Wang Y, Braithwaite AW, Christ D, Benda A, Parkin A, Phillips PA, Whitelock JM, Gill AJ, Sansom OJ, Croucher DR, Parker BL, Pajic M, Morton JP, Cox TR, Timpson P.

Nat Commun. 2019 Aug 12;10(1):3637. doi: 10.1038/s41467-019-10968-6.


Post-exercise carbohydrate and energy availability induce independent effects on skeletal muscle cell signalling and bone turnover: implications for training adaptation.

Hammond KM, Sale C, Fraser W, Tang J, Shepherd SO, Strauss JA, Close GL, Cocks M, Louis J, Pugh J, Stewart C, Sharples AP, Morton JP.

J Physiol. 2019 Jul 31. doi: 10.1113/JP278209. [Epub ahead of print]


Performance Nutrition in the digital era - An exploratory study into the use of social media by sports nutritionists.

Dunne DM, Lefevre C, Cunniffe B, Tod D, Close GL, Morton JP, Murphy R.

J Sports Sci. 2019 Jul 26:1-8. doi: 10.1080/02640414.2019.1642052. [Epub ahead of print]


The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy.

Reader CS, Vallath S, Steele CW, Haider S, Brentnall A, Desai A, Moore KM, Jamieson NB, Chang D, Bailey P, Scarpa A, Lawlor R, Chelala C, Keyse SM, Biankin A, Morton JP, Evans TJ, Barry ST, Sansom OJ, Kocher HM, Marshall JF.

J Pathol. 2019 Jul 1. doi: 10.1002/path.5320. [Epub ahead of print]


The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype.

Hari P, Millar FR, Tarrats N, Birch J, Quintanilla A, Rink CJ, Fernández-Duran I, Muir M, Finch AJ, Brunton VG, Passos JF, Morton JP, Boulter L, Acosta JC.

Sci Adv. 2019 Jun 5;5(6):eaaw0254. doi: 10.1126/sciadv.aaw0254. eCollection 2019 Jun.


Ultrasound Does Not Detect Acute Changes in Glycogen in Vastus Lateralis of Man.

Routledge HE, Bradley WJ, Shepherd SO, Cocks M, Erskine RM, Close GL, Morton JP.

Med Sci Sports Exerc. 2019 May 31. doi: 10.1249/MSS.0000000000002052. [Epub ahead of print]


Low pre-exercise muscle glycogen availability offsets the effect of post-exercise cold water immersion in augmenting PGC-1α gene expression.

Allan R, Sharples AP, Cocks M, Drust B, Dutton J, Dugdale HF, Mawhinney C, Clucas A, Hawkins W, Morton JP, Gregson W.

Physiol Rep. 2019 Jun;7(11):e14082. doi: 10.14814/phy2.14082.


Carbohydrate Restriction in Type 1 Diabetes: A Realistic Therapy for Improved Glycaemic Control and Athletic Performance?

Scott SN, Anderson L, Morton JP, Wagenmakers AJM, Riddell MC.

Nutrients. 2019 May 7;11(5). pii: E1022. doi: 10.3390/nu11051022. Review.


Graded reductions in preexercise muscle glycogen impair exercise capacity but do not augment skeletal muscle cell signaling: implications for CHO periodization.

Hearris MA, Hammond KM, Seaborne RA, Stocks B, Shepherd SO, Philp A, Sharples AP, Morton JP, Louis JB.

J Appl Physiol (1985). 2019 Jun 1;126(6):1587-1597. doi: 10.1152/japplphysiol.00913.2018. Epub 2019 May 2.


Case Study: Muscle Atrophy, Hypertrophy, and Energy Expenditure of a Premier League Soccer Player During Rehabilitation From Anterior Cruciate Ligament Injury.

Anderson L, Close GL, Konopinski M, Rydings D, Milsom J, Hambly C, Speakman JR, Drust B, Morton JP.

Int J Sport Nutr Exerc Metab. 2019 Jun 13:1-8. doi: 10.1123/ijsnem.2018-0391. [Epub ahead of print]


Four weeks of probiotic supplementation reduces GI symptoms during a marathon race.

Pugh JN, Sparks AS, Doran DA, Fleming SC, Langan-Evans C, Kirk B, Fearn R, Morton JP, Close GL.

Eur J Appl Physiol. 2019 Jul;119(7):1491-1501. doi: 10.1007/s00421-019-04136-3. Epub 2019 Apr 13.


Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas.

Liko D, Mitchell L, Campbell KJ, Ridgway RA, Jones C, Dudek K, King A, Bryson S, Stevenson D, Blyth K, Strathdee D, Morton JP, Bird TG, Knight JRP, Willis AE, Sansom OJ.

Cell Death Differ. 2019 Mar 11. doi: 10.1038/s41418-019-0316-7. [Epub ahead of print]


A Stromal Lysolipid-Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression.

Auciello FR, Bulusu V, Oon C, Tait-Mulder J, Berry M, Bhattacharyya S, Tumanov S, Allen-Petersen BL, Link J, Kendsersky ND, Vringer E, Schug M, Novo D, Hwang RF, Evans RM, Nixon C, Dorrell C, Morton JP, Norman JC, Sears RC, Kamphorst JJ, Sherman MH.

Cancer Discov. 2019 May;9(5):617-627. doi: 10.1158/2159-8290.CD-18-1212. Epub 2019 Mar 5.


Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.

Halbrook CJ, Pontious C, Kovalenko I, Lapienyte L, Dreyer S, Lee HJ, Thurston G, Zhang Y, Lazarus J, Sajjakulnukit P, Hong HS, Kremer DM, Nelson BS, Kemp S, Zhang L, Chang D, Biankin A, Shi J, Frankel TL, Crawford HC, Morton JP, Pasca di Magliano M, Lyssiotis CA.

Cell Metab. 2019 Jun 4;29(6):1390-1399.e6. doi: 10.1016/j.cmet.2019.02.001. Epub 2019 Feb 28.


From Paper to Podium: Quantifying the Translational Potential of Performance Nutrition Research.

Close GL, Kasper AM, Morton JP.

Sports Med. 2019 Feb;49(Suppl 1):25-37. doi: 10.1007/s40279-018-1005-2. Review.


A Framework for Periodized Nutrition for Athletics.

Stellingwerff T, Morton JP, Burke LM.

Int J Sport Nutr Exerc Metab. 2019 Mar 1;29(2):141-151. doi: 10.1123/ijsnem.2018-0305. Epub 2019 Apr 3. Review.


Assessment of Energy Expenditure of a Professional Goalkeeper From the English Premier League Using the Doubly Labeled Water Method.

Anderson L, Close GL, Morgans R, Hambly C, Speakman JR, Drust B, Morton JP.

Int J Sports Physiol Perform. 2019 May 1;14(5):681-684. doi: 10.1123/ijspp.2018-0520. Epub 2019 Apr 16.


Combating pancreatic cancer with PI3K pathway inhibitors in the era of personalised medicine.

Conway JR, Herrmann D, Evans TJ, Morton JP, Timpson P.

Gut. 2019 Apr;68(4):742-758. doi: 10.1136/gutjnl-2018-316822. Epub 2018 Nov 5. Review.


Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma.

Allen-Petersen BL, Risom T, Feng Z, Wang Z, Jenny ZP, Thoma MC, Pelz KR, Morton JP, Sansom OJ, Lopez CD, Sheppard B, Christensen DJ, Ohlmeyer M, Narla G, Sears RC.

Cancer Res. 2019 Jan 1;79(1):209-219. doi: 10.1158/0008-5472.CAN-18-0717. Epub 2018 Nov 2.


Methylome of human skeletal muscle after acute & chronic resistance exercise training, detraining & retraining.

Seaborne RA, Strauss J, Cocks M, Shepherd S, O'Brien TD, Someren KAV, Bell PG, Murgatroyd C, Morton JP, Stewart CE, Mein CA, Sharples AP.

Sci Data. 2018 Oct 30;5:180213. doi: 10.1038/sdata.2018.213.


Toward a Common Understanding of Diet-Exercise Strategies to Manipulate Fuel Availability for Training and Competition Preparation in Endurance Sport.

Burke LM, Hawley JA, Jeukendrup A, Morton JP, Stellingwerff T, Maughan RJ.

Int J Sport Nutr Exerc Metab. 2018 Sep 1;28(5):451-463. doi: 10.1123/ijsnem.2018-0289. Epub 2018 Sep 25.


Publisher Correction: Genomic instability in mutant p53 cancer cells upon entotic engulfment.

Mackay HL, Moore D, Hall C, Birkbak NJ, Jamal-Hanjani M, Karim SA, Phatak VM, Piñon L, Morton JP, Swanton C, Le Quesne J, Muller PAJ.

Nat Commun. 2018 Aug 28;9(1):3540. doi: 10.1038/s41467-018-06026-2.


Genomic instability in mutant p53 cancer cells upon entotic engulfment.

Mackay HL, Moore D, Hall C, Birkbak NJ, Jamal-Hanjani M, Karim SA, Phatak VM, Piñon L, Morton JP, Swanton C, Le Quesne J, Muller PAJ.

Nat Commun. 2018 Aug 3;9(1):3070. doi: 10.1038/s41467-018-05368-1. Erratum in: Nat Commun. 2018 Aug 28;9(1):3540.


Relative Energy Deficiency in Sport in Male Athletes: A Commentary on Its Presentation Among Selected Groups of Male Athletes.

Burke LM, Close GL, Lundy B, Mooses M, Morton JP, Tenforde AS.

Int J Sport Nutr Exerc Metab. 2018 Jul 1;28(4):364-374. doi: 10.1123/ijsnem.2018-0182. Epub 2018 Jul 24.


Case Study: Extreme Weight Making Causes Relative Energy Deficiency, Dehydration, and Acute Kidney Injury in a Male Mixed Martial Arts Athlete.

Kasper AM, Crighton B, Langan-Evans C, Riley P, Sharma A, Close GL, Morton JP.

Int J Sport Nutr Exerc Metab. 2019 May 1;29(3):331-338. doi: 10.1123/ijsnem.2018-0029. Epub 2019 Jan 15.


Removing physiological motion from intravital and clinical functional imaging data.

Warren SC, Nobis M, Magenau A, Mohammed YH, Herrmann D, Moran I, Vennin C, Conway JR, Mélénec P, Cox TR, Wang Y, Morton JP, Welch HC, Strathdee D, Anderson KI, Phan TG, Roberts MS, Timpson P.

Elife. 2018 Jul 9;7. pii: e35800. doi: 10.7554/eLife.35800.


Prevalence, Severity and Potential Nutritional Causes of Gastrointestinal Symptoms during a Marathon in Recreational Runners.

Pugh JN, Kirk B, Fearn R, Morton JP, Close GL.

Nutrients. 2018 Jun 24;10(7). pii: E811. doi: 10.3390/nu10070811.


Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer.

Conway JRW, Warren SC, Herrmann D, Murphy KJ, Cazet AS, Vennin C, Shearer RF, Killen MJ, Magenau A, Mélénec P, Pinese M, Nobis M, Zaratzian A, Boulghourjian A, Da Silva AM, Del Monte-Nieto G, Adam ASA, Harvey RP, Haigh JJ, Wang Y, Croucher DR, Sansom OJ, Pajic M, Caldon CE, Morton JP, Timpson P.

Cell Rep. 2018 Jun 12;23(11):3312-3326. doi: 10.1016/j.celrep.2018.05.038.


Muscle Glycogen Utilisation during an Australian Rules Football Game.

Routledge HE, Leckey JJ, Lee MJ, Garnham A, Graham S, Burgess D, Burke LM, Erskine RM, Close GL, Morton JP.

Int J Sports Physiol Perform. 2018 Jun 12:1-13. doi: 10.1123/ijspp.2018-0106. [Epub ahead of print]


MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus.

Godfrey JD, Morton JP, Wilczynska A, Sansom OJ, Bushell MD.

Cell Death Dis. 2018 May 29;9(6):644. doi: 10.1038/s41419-018-0628-4.


Whey Protein Augments Leucinemia and Postexercise p70S6K1 Activity Compared With a Hydrolyzed Collagen Blend When in Recovery From Training With Low Carbohydrate Availability.

Impey SG, Hammond KM, Naughton R, Langan-Evans C, Shepherd SO, Sharples AP, Cegielski J, Smith K, Jeromson S, Hamilton DL, Close GL, Morton JP.

Int J Sport Nutr Exerc Metab. 2018 Nov 1;28(6):651-659. doi: 10.1123/ijsnem.2018-0054. Epub 2018 Oct 1.


CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype.

Candido JB, Morton JP, Bailey P, Campbell AD, Karim SA, Jamieson T, Lapienyte L, Gopinathan A, Clark W, McGhee EJ, Wang J, Escorcio-Correia M, Zollinger R, Roshani R, Drew L, Rishi L, Arkell R, Evans TRJ, Nixon C, Jodrell DI, Wilkinson RW, Biankin AV, Barry ST, Balkwill FR, Sansom OJ.

Cell Rep. 2018 May 1;23(5):1448-1460. doi: 10.1016/j.celrep.2018.03.131.


Increased formate overflow is a hallmark of oxidative cancer.

Meiser J, Schuster A, Pietzke M, Vande Voorde J, Athineos D, Oizel K, Burgos-Barragan G, Wit N, Dhayade S, Morton JP, Dornier E, Sumpton D, Mackay GM, Blyth K, Patel KJ, Niclou SP, Vazquez A.

Nat Commun. 2018 Apr 10;9(1):1368. doi: 10.1038/s41467-018-03777-w.


Infection by Parorchis acanthus (Trematoda) decreases grazing by the keystone gastropod, Littoraria irrorata.

Morton JP.

PeerJ. 2018 Mar 27;6:e4544. doi: 10.7717/peerj.4544. eCollection 2018.


Regulation of Muscle Glycogen Metabolism during Exercise: Implications for Endurance Performance and Training Adaptations.

Hearris MA, Hammond KM, Fell JM, Morton JP.

Nutrients. 2018 Mar 2;10(3). pii: E298. doi: 10.3390/nu10030298. Review.


Fuel for the Work Required: A Theoretical Framework for Carbohydrate Periodization and the Glycogen Threshold Hypothesis.

Impey SG, Hearris MA, Hammond KM, Bartlett JD, Louis J, Close GL, Morton JP.

Sports Med. 2018 May;48(5):1031-1048. doi: 10.1007/s40279-018-0867-7.


Male Flat Jockeys Do Not Display Deteriorations in Bone Density or Resting Metabolic Rate in Accordance With Race Riding Experience: Implications for RED-S.

Wilson G, Martin D, Morton JP, Close GL.

Int J Sport Nutr Exerc Metab. 2018 Jul 1;28(4):434-439. doi: 10.1123/ijsnem.2017-0371. Epub 2018 Jun 22.


High dietary fat intake increases fat oxidation and reduces skeletal muscle mitochondrial respiration in trained humans.

Leckey JJ, Hoffman NJ, Parr EB, Devlin BL, Trewin AJ, Stepto NK, Morton JP, Burke LM, Hawley JA.

FASEB J. 2018 Jun;32(6):2979-2991. doi: 10.1096/fj.201700993R. Epub 2018 Jan 17.


Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy.

Seaborne RA, Strauss J, Cocks M, Shepherd S, O'Brien TD, van Someren KA, Bell PG, Murgatroyd C, Morton JP, Stewart CE, Sharples AP.

Sci Rep. 2018 Jan 30;8(1):1898. doi: 10.1038/s41598-018-20287-3.


Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma.

Schofield HK, Zeller J, Espinoza C, Halbrook CJ, Del Vecchio A, Magnuson B, Fabo T, Daylan AEC, Kovalenko I, Lee HJ, Yan W, Feng Y, Karim SA, Kremer DM, Kumar-Sinha C, Lyssiotis CA, Ljungman M, Morton JP, Galbán S, Fearon ER, Pasca di Magliano M.

JCI Insight. 2018 Jan 25;3(2). pii: 97422. doi: 10.1172/jci.insight.97422. eCollection 2018 Jan 25.


Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule.

Marchetti C, Zyner KG, Ohnmacht SA, Robson M, Haider SM, Morton JP, Marsico G, Vo T, Laughlin-Toth S, Ahmed AA, Di Vita G, Pazitna I, Gunaratnam M, Besser RJ, Andrade ACG, Diocou S, Pike JA, Tannahill D, Pedley RB, Evans TRJ, Wilson WD, Balasubramanian S, Neidle S.

J Med Chem. 2018 Mar 22;61(6):2500-2517. doi: 10.1021/acs.jmedchem.7b01781. Epub 2018 Feb 7.


Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer.

Vennin C, Murphy KJ, Morton JP, Cox TR, Pajic M, Timpson P.

Gastroenterology. 2018 Mar;154(4):820-838. doi: 10.1053/j.gastro.2017.11.280. Epub 2017 Dec 26. Review.


Neutrophils: Homing in on the myeloid mechanisms of metastasis.

Leach J, Morton JP, Sansom OJ.

Mol Immunol. 2019 Jun;110:69-76. doi: 10.1016/j.molimm.2017.12.013.


Energy expenditure in professional flat jockeys using doubly labelled water during the racing season: Implications for body weight management.

Wilson G, Lucas D, Hambly C, Speakman JR, Morton JP, Close GL.

Eur J Sport Sci. 2018 Mar;18(2):235-242. doi: 10.1080/17461391.2017.1406996. Epub 2017 Dec 7.


Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology.

Conway JRW, Vennin C, Cazet AS, Herrmann D, Murphy KJ, Warren SC, Wullkopf L, Boulghourjian A, Zaratzian A, Da Silva AM, Pajic M, Morton JP, Cox TR, Timpson P.

Sci Rep. 2017 Dec 4;7(1):16887. doi: 10.1038/s41598-017-17177-5.


The role of resveratrol on skeletal muscle cell differentiation and myotube hypertrophy during glucose restriction.

Dugdale HF, Hughes DC, Allan R, Deane CS, Coxon CR, Morton JP, Stewart CE, Sharples AP.

Mol Cell Biochem. 2018 Jul;444(1-2):109-123. doi: 10.1007/s11010-017-3236-1. Epub 2017 Nov 30.


MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance.

Farrell AS, Joly MM, Allen-Petersen BL, Worth PJ, Lanciault C, Sauer D, Link J, Pelz C, Heiser LM, Morton JP, Muthalagu N, Hoffman MT, Manning SL, Pratt ED, Kendsersky ND, Egbukichi N, Amery TS, Thoma MC, Jenny ZP, Rhim AD, Murphy DJ, Sansom OJ, Crawford HC, Sheppard BC, Sears RC.

Nat Commun. 2017 Nov 23;8(1):1728. doi: 10.1038/s41467-017-01967-6.


Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer.

Chou A, Froio D, Nagrial AM, Parkin A, Murphy KJ, Chin VT, Wohl D, Steinmann A, Stark R, Drury A, Walters SN, Vennin C, Burgess A, Pinese M, Chantrill LA, Cowley MJ, Molloy TJ; Australian Pancreatic Cancer Genome Initiative (APGI), Waddell N, Johns A, Grimmond SM, Chang DK, Biankin AV, Sansom OJ, Morton JP, Grey ST, Cox TR, Turchini J, Samra J, Clarke SJ, Timpson P, Gill AJ, Pajic M.

Gut. 2018 Dec;67(12):2142-2155. doi: 10.1136/gutjnl-2017-315144. Epub 2017 Oct 28.


Glutamine supplementation reduces markers of intestinal permeability during running in the heat in a dose-dependent manner.

Pugh JN, Sage S, Hutson M, Doran DA, Fleming SC, Highton J, Morton JP, Close GL.

Eur J Appl Physiol. 2017 Dec;117(12):2569-2577. doi: 10.1007/s00421-017-3744-4. Epub 2017 Oct 20.


Gastrointestinal symptoms in elite athletes: time to recognise the problem?

Pugh JN, Fearn R, Morton JP, Close GL.

Br J Sports Med. 2018 Apr;52(8):487-488. doi: 10.1136/bjsports-2017-098376. Epub 2017 Oct 10. No abstract available.


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