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Items: 32


Comparative Analysis of Inflammatory Cytokine Release and Alveolar Epithelial Barrier Invasion in a Transwell® Bilayer Model of Mucormycosis.

Belic S, Page L, Lazariotou M, Waaga-Gasser AM, Dragan M, Springer J, Loeffler J, Morton CO, Einsele H, Ullmann AJ, Wurster S.

Front Microbiol. 2019 Jan 8;9:3204. doi: 10.3389/fmicb.2018.03204. eCollection 2018.


Validation of a simplified in vitro Transwell® model of the alveolar surface to assess host immunity induced by different morphotypes of Aspergillus fumigatus.

Morton CO, Wurster S, Fliesser M, Ebel F, Page L, Hünniger K, Kurzai O, Schmitt AL, Michel D, Springer J, Einsele H, Loeffler J.

Int J Med Microbiol. 2018 Dec;308(8):1009-1017. doi: 10.1016/j.ijmm.2018.09.001. Epub 2018 Sep 3.


First Insights in NK-DC Cross-Talk and the Importance of Soluble Factors During Infection With Aspergillus fumigatus.

Weiss E, Ziegler S, Fliesser M, Schmitt AL, Hünniger K, Kurzai O, Morton CO, Einsele H, Loeffler J.

Front Cell Infect Microbiol. 2018 Aug 20;8:288. doi: 10.3389/fcimb.2018.00288. eCollection 2018.


Human and Murine Innate Immune Cell Populations Display Common and Distinct Response Patterns during Their In Vitro Interaction with the Pathogenic Mold Aspergillus fumigatus.

Hellmann AM, Lother J, Wurster S, Lutz MB, Schmitt AL, Morton CO, Eyrich M, Czakai K, Einsele H, Loeffler J.

Front Immunol. 2017 Dec 6;8:1716. doi: 10.3389/fimmu.2017.01716. eCollection 2017.


Diagnosis of aspergillosis by PCR: Clinical considerations and technical tips.

Barnes RA, White PL, Morton CO, Rogers TR, Cruciani M, Loeffler J, Donnelly JP.

Med Mycol. 2018 Apr 1;56(suppl_1):60-72. doi: 10.1093/mmy/myx091. Review.


The in vitro effects of interferon-gamma, alone or in combination with amphotericin B, tested against the pathogenic fungi Candida albicans and Aspergillus fumigatus.

El-Khoury M, Ligot R, Mahoney S, Stack CM, Perrone GG, Morton CO.

BMC Res Notes. 2017 Aug 1;10(1):364. doi: 10.1186/s13104-017-2696-4.


Clinical evaluation of a Mucorales-specific real-time PCR assay in tissue and serum samples.

Springer J, Lackner M, Ensinger C, Risslegger B, Morton CO, Nachbaur D, Lass-Flörl C, Einsele H, Heinz WJ, Loeffler J.

J Med Microbiol. 2016 Dec;65(12):1414-1421. doi: 10.1099/jmm.0.000375. Epub 2016 Oct 24.


Proteomic Profiling of Serological Responses to Aspergillus fumigatus Antigens in Patients with Invasive Aspergillosis.

Teutschbein J, Simon S, Lother J, Springer J, Hortschansky P, Morton CO, Löffler J, Einsele H, Conneally E, Rogers TR, Guthke R, Brakhage AA, Kniemeyer O.

J Proteome Res. 2016 May 6;15(5):1580-91. doi: 10.1021/acs.jproteome.6b00042. Epub 2016 Mar 24.


Determining the analytical specificity of PCR-based assays for the diagnosis of IA: What is Aspergillus?

Morton CO, White PL, Barnes RA, Klingspor L, Cuenca-Estrella M, Lagrou K, Bretagne S, Melchers W, Mengoli C, Caliendo AM, Cogliati M, Debets-Ossenkopp Y, Gorton R, Hagen F, Halliday C, Hamal P, Harvey-Wood K, Jaton K, Johnson G, Kidd S, Lengerova M, Lass-Florl C, Linton C, Millon L, Morrissey CO, Paholcsek M, Talento AF, Ruhnke M, Willinger B, Donnelly JP, Loeffler J; EAPCRI.

Med Mycol. 2017 Jun 1;55(4):402-413. doi: 10.1093/mmy/myw093.


Hypoxia-inducible factor 1α modulates metabolic activity and cytokine release in anti-Aspergillus fumigatus immune responses initiated by human dendritic cells.

Fliesser M, Morton CO, Bonin M, Ebel F, Hünniger K, Kurzai O, Einsele H, Löffler J.

Int J Med Microbiol. 2015 Dec;305(8):865-73. doi: 10.1016/j.ijmm.2015.08.036. Epub 2015 Sep 16.


Clinical Performance of Aspergillus PCR for Testing Serum and Plasma: a Study by the European Aspergillus PCR Initiative.

White PL, Barnes RA, Springer J, Klingspor L, Cuenca-Estrella M, Morton CO, Lagrou K, Bretagne S, Melchers WJ, Mengoli C, Donnelly JP, Heinz WJ, Loeffler J; EAPCRI.

J Clin Microbiol. 2015 Sep;53(9):2832-7. doi: 10.1128/JCM.00905-15. Epub 2015 Jun 17.


Analytical Comparison of In Vitro-Spiked Human Serum and Plasma for PCR-Based Detection of Aspergillus fumigatus DNA: a Study by the European Aspergillus PCR Initiative.

Loeffler J, Mengoli C, Springer J, Bretagne S, Cuenca-Estrella M, Klingspor L, Lagrou K, Melchers WJ, Morton CO, Barnes RA, Donnelly JP, White PL; European Aspergillus PCR Initiative.

J Clin Microbiol. 2015 Sep;53(9):2838-45. doi: 10.1128/JCM.00906-15. Epub 2015 Jun 17.


Human dendritic cell subsets display distinct interactions with the pathogenic mould Aspergillus fumigatus.

Lother J, Breitschopf T, Krappmann S, Morton CO, Bouzani M, Kurzai O, Gunzer M, Hasenberg M, Einsele H, Loeffler J.

Int J Med Microbiol. 2014 Nov;304(8):1160-8. doi: 10.1016/j.ijmm.2014.08.009. Epub 2014 Aug 18.


The polyene antifungals, amphotericin B and nystatin, cause cell death in Saccharomyces cerevisiae by a distinct mechanism to amphibian-derived antimicrobial peptides.

Serhan G, Stack CM, Perrone GG, Morton CO.

Ann Clin Microbiol Antimicrob. 2014 May 12;13:18. doi: 10.1186/1476-0711-13-18.


Gene expression profiles of human dendritic cells interacting with Aspergillus fumigatus in a bilayer model of the alveolar epithelium/endothelium interface.

Morton CO, Fliesser M, Dittrich M, Mueller T, Bauer R, Kneitz S, Hope W, Rogers TR, Einsele H, Loeffler J.

PLoS One. 2014 May 28;9(5):e98279. doi: 10.1371/journal.pone.0098279. eCollection 2014.


Fever-range temperature modulates activation and function of human dendritic cells stimulated with the pathogenic mould Aspergillus fumigatus.

Semmlinger A, Fliesser M, Waaga-Gasser AM, Dragan M, Morton CO, Einsele H, Loeffler J.

Med Mycol. 2014 May;52(4):438-44. doi: 10.1093/mmy/myu005. Epub 2014 Apr 8.


Combined real-time PCR and galactomannan surveillance improves diagnosis of invasive aspergillosis in high risk patients with haematological malignancies.

Rogers TR, Morton CO, Springer J, Conneally E, Heinz W, Kenny C, Frost S, Einsele H, Loeffler J.

Br J Haematol. 2013 May;161(4):517-24. doi: 10.1111/bjh.12285. Epub 2013 Mar 11.


An investigation into the inhibitory effect of ultraviolet radiation on Trichophyton rubrum.

Cronin LJ, Mildren RP, Moffitt M, Lauto A, Morton CO, Stack CM.

Lasers Med Sci. 2014 Jan;29(1):157-63. doi: 10.1007/s10103-013-1287-4. Epub 2013 Mar 23.


Multicenter comparison of serum and whole-blood specimens for detection of Aspergillus DNA in high-risk hematological patients.

Springer J, Morton CO, Perry M, Heinz WJ, Paholcsek M, Alzheimer M, Rogers TR, Barnes RA, Einsele H, Loeffler J, White PL.

J Clin Microbiol. 2013 May;51(5):1445-50. doi: 10.1128/JCM.03322-12. Epub 2013 Feb 20.


Direct interaction studies between Aspergillus fumigatus and human immune cells; what have we learned about pathogenicity and host immunity?

Morton CO, Bouzani M, Loeffler J, Rogers TR.

Front Microbiol. 2012 Dec 3;3:413. doi: 10.3389/fmicb.2012.00413. eCollection 2012.


RT-qPCR detection of Aspergillus fumigatus RNA in vitro and in a murine model of invasive aspergillosis utilizing the PAXgene® and Tempus™ RNA stabilization systems.

Morton CO, de Luca A, Romani L, Rogers TR.

Med Mycol. 2012 Aug;50(6):661-6. doi: 10.3109/13693786.2011.652200. Epub 2012 Jan 23.


A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins.

Ryan A, Lynch M, Smith SM, Amu S, Nel HJ, McCoy CE, Dowling JK, Draper E, O'Reilly V, McCarthy C, O'Brien J, Ní Eidhin D, O'Connell MJ, Keogh B, Morton CO, Rogers TR, Fallon PG, O'Neill LA, Kelleher D, Loscher CE.

PLoS Pathog. 2011 Jun;7(6):e1002076. doi: 10.1371/journal.ppat.1002076. Epub 2011 Jun 30.


Human NK cells display important antifungal activity against Aspergillus fumigatus, which is directly mediated by IFN-γ release.

Bouzani M, Ok M, McCormick A, Ebel F, Kurzai O, Morton CO, Einsele H, Loeffler J.

J Immunol. 2011 Aug 1;187(3):1369-76. doi: 10.4049/jimmunol.1003593. Epub 2011 Jun 22.


Real-time PCR and quantitative culture for monitoring of experimental Aspergillus fumigatus intracranial infection in neutropenic mice.

Morton CO, Clemons KV, Springer J, Mueller JG, Rogers TR, Stevens DA, Kurzai O, Einsele H, Loeffler J.

J Med Microbiol. 2011 Jul;60(Pt 7):913-9. doi: 10.1099/jmm.0.028399-0. Epub 2011 Mar 24.


The temporal dynamics of differential gene expression in Aspergillus fumigatus interacting with human immature dendritic cells in vitro.

Morton CO, Varga JJ, Hornbach A, Mezger M, Sennefelder H, Kneitz S, Kurzai O, Krappmann S, Einsele H, Nierman WC, Rogers TR, Loeffler J.

PLoS One. 2011 Jan 14;6(1):e16016. doi: 10.1371/journal.pone.0016016.


Dynamics of extracellular release of Aspergillus fumigatus DNA and galactomannan during growth in blood and serum.

Morton CO, Loeffler J, De Luca A, Frost S, Kenny C, Duval S, Romani L, Rogers TR.

J Med Microbiol. 2010 Apr;59(Pt 4):408-13. doi: 10.1099/jmm.0.017418-0. Epub 2009 Dec 24.


Global phenotype screening and transcript analysis outlines the inhibitory mode(s) of action of two amphibian-derived, alpha-helical, cationic peptides on Saccharomyces cerevisiae.

Morton CO, Hayes A, Wilson M, Rash BM, Oliver SG, Coote P.

Antimicrob Agents Chemother. 2007 Nov;51(11):3948-59. Epub 2007 Sep 10.


Approaches for monitoring the release of Pochonia chlamydosporia var. catenulata, a biocontrol agent of root-knot nematodes.

Atkins SD, Hidalgo-Diaz L, Clark IM, Morton CO, de Oca NM, Gray PA, Kerry BR.

Mycol Res. 2003 Feb;107(Pt 2):206-12.


PCR-based DNA fingerprinting indicates host-related genetic variation in the nematophagous fungus Pochonia chlamydosporia.

Morton CO, Mauchline TH, Kerry BR, Hirsch PR.

Mycol Res. 2003 Feb;107(Pt 2):198-205.


Cloning of and genetic variation in protease VCP1 from the nematophagous fungus Pochonia chlamydosporia.

Morton CO, Hirsch PR, Peberdy JP, Kerry BR.

Mycol Res. 2003 Jan;107(Pt 1):38-46.


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