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Items: 1 to 50 of 190

1.

Expression and Localization of Kcne2 in the Vertebrate Retina.

Lindner M, Gilhooley MJ, Palumaa T, Morton AJ, Hughes S, Hankins MW.

Invest Ophthalmol Vis Sci. 2020 Mar 9;61(3):33. doi: 10.1167/iovs.61.3.33.

PMID:
32191288
2.

Characterizing Sleep Spindles in Sheep.

Schneider WT, Vas S, Nicol AU, Morton AJ.

eNeuro. 2020 Mar 18;7(2). pii: ENEURO.0410-19.2020. doi: 10.1523/ENEURO.0410-19.2020. Print 2020 Mar/Apr.

3.

Recommendations for measuring whisker movements and locomotion in mice with sensory, motor and cognitive deficits.

Simanaviciute U, Ahmed J, Brown RE, Connor-Robson N, Farr TD, Fertan E, Gambles N, Garland H, Morton AJ, Staiger JF, Skillings EA, Trueman RC, Wade-Martins R, Wood NI, Wong AA, Grant RA.

J Neurosci Methods. 2020 Feb 1;331:108532. doi: 10.1016/j.jneumeth.2019.108532. Epub 2019 Nov 28. Review.

PMID:
31785300
4.

Abnormal Photic Entrainment to Phase-Delaying Stimuli in the R6/2 Mouse Model of Huntington's Disease, despite Retinal Responsiveness to Light.

Ouk K, Aungier J, Ware M, Morton AJ.

eNeuro. 2019 Dec 10;6(6). pii: ENEURO.0088-19.2019. doi: 10.1523/ENEURO.0088-19.2019. Print 2019 Nov/Dec.

5.

Increased plasma melatonin in presymptomatic Huntington disease sheep (Ovis aries): Compensatory neuroprotection in a neurodegenerative disease?

Morton AJ, Middleton B, Rudiger S, Bawden CS, Kuchel TR, Skene DJ.

J Pineal Res. 2020 Mar;68(2):e12624. doi: 10.1111/jpi.12624. Epub 2019 Dec 6.

PMID:
31742766
6.

Frailty Factors and Outcomes in Vascular Surgery Patients: A Systematic Review and Meta-analysis.

Houghton JSM, Nickinson ATO, Morton AJ, Nduwayo S, Pepper CJ, Rayt HS, Gray LJ, Conroy SP, Haunton VJ, Sayers RD.

Ann Surg. 2019 Oct 22. doi: 10.1097/SLA.0000000000003642. [Epub ahead of print]

PMID:
31651536
7.

Pegylated interferon-2α invokes graft-versus-leukemia effects in patients relapsing after allogeneic stem cell transplantation.

Henden AS, Varelias A, Leach J, Sturgeon E, Avery J, Kelly J, Olver S, Samson L, Hartel G, Durrant S, Butler J, Morton AJ, Misra A, Tey SK, Subramoniapillai E, Curley C, Kennedy G, Hill GR.

Blood Adv. 2019 Oct 22;3(20):3013-3019. doi: 10.1182/bloodadvances.2019000453.

8.

Phase I Trial of Inducible Caspase 9 T Cells in Adult Stem Cell Transplant Demonstrates Massive Clonotypic Proliferative Potential and Long-term Persistence of Transgenic T Cells.

Zhang P, Raju J, Ullah MA, Au R, Varelias A, Gartlan KH, Olver SD, Samson LD, Sturgeon E, Zomerdijk N, Avery J, Gargett T, Brown MP, Coin LJ, Ganesamoorthy D, Hutchins C, Pratt GR, Kennedy GA, Morton AJ, Curley CI, Hill GR, Tey SK.

Clin Cancer Res. 2019 Mar 15;25(6):1749-1755. doi: 10.1158/1078-0432.CCR-18-3069. Epub 2019 Feb 14.

9.

Antagonistic pleiotropy in mice carrying a CAG repeat expansion in the range causing Huntington's disease.

Morton AJ, Skillings EA, Wood NI, Zheng Z.

Sci Rep. 2019 Jan 10;9(1):37. doi: 10.1038/s41598-018-37102-8.

10.

Lentiviral-based reporter constructs for profiling chondrogenic activity in primary equine cell populations.

Martin-Pena A, Porter RM, Plumton G, McCarrel TM, Morton AJ, Guijarro MV, Ghivizzani SC, Sharma B, Palmer GD.

Eur Cell Mater. 2018 Oct 12;36:156-170. doi: 10.22203/eCM.v036a12.

11.

Indices of comparative cognition: assessing animal models of human brain function.

McBride SD, Morton AJ.

Exp Brain Res. 2018 Dec;236(12):3379-3390. doi: 10.1007/s00221-018-5370-8. Epub 2018 Sep 28.

12.

mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington's Disease.

Ast A, Buntru A, Schindler F, Hasenkopf R, Schulz A, Brusendorf L, Klockmeier K, Grelle G, McMahon B, Niederlechner H, Jansen I, Diez L, Edel J, Boeddrich A, Franklin SA, Baldo B, Schnoegl S, Kunz S, Purfürst B, Gaertner A, Kampinga HH, Morton AJ, Petersén Å, Kirstein J, Bates GP, Wanker EE.

Mol Cell. 2018 Sep 6;71(5):675-688.e6. doi: 10.1016/j.molcel.2018.07.032.

13.

Erratum to: Large-Brained Animal Models of Huntington's Disease: Sheep.

Morton AJ.

Methods Mol Biol. 2018;1780:E1. doi: 10.1007/978-1-4939-7825-0_29.

PMID:
30051251
14.

Gene Therapy for Osteoarthritis: Pharmacokinetics of Intra-Articular Self-Complementary Adeno-Associated Virus Interleukin-1 Receptor Antagonist Delivery in an Equine Model.

Watson Levings RS, Broome TA, Smith AD, Rice BL, Gibbs EP, Myara DA, Hyddmark EV, Nasri E, Zarezadeh A, Levings PP, Lu Y, White ME, Dacanay EA, Foremny GB, Evans CH, Morton AJ, Winter M, Dark MJ, Nickerson DM, Colahan PT, Ghivizzani SC.

Hum Gene Ther Clin Dev. 2018 Jun;29(2):90-100. doi: 10.1089/humc.2017.142.

15.

Self-Complementary Adeno-Associated Virus-Mediated Interleukin-1 Receptor Antagonist Gene Delivery for the Treatment of Osteoarthritis: Test of Efficacy in an Equine Model.

Watson Levings RS, Smith AD, Broome TA, Rice BL, Gibbs EP, Myara DA, Hyddmark EV, Nasri E, Zarezadeh A, Levings PP, Lu Y, White ME, Dacanay EA, Foremny GB, Evans CH, Morton AJ, Winter M, Dark MJ, Nickerson DM, Colahan PT, Ghivizzani SC.

Hum Gene Ther Clin Dev. 2018 Jun;29(2):101-112. doi: 10.1089/humc.2017.143.

16.

Large-Brained Animal Models of Huntington's Disease: Sheep.

Morton AJ.

Methods Mol Biol. 2018;1780:221-239. doi: 10.1007/978-1-4939-7825-0_12. Erratum in: Methods Mol Biol. 2018;1780:E1.

PMID:
29856022
17.

XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington's disease is age- and sex- dependent.

Polyzos AA, Wood NI, Williams P, Wipf P, Morton AJ, McMurray CT.

PLoS One. 2018 Apr 9;13(4):e0194580. doi: 10.1371/journal.pone.0194580. eCollection 2018.

18.

Single-Cell RNA-Seq of Mouse Dopaminergic Neurons Informs Candidate Gene Selection for Sporadic Parkinson Disease.

Hook PW, McClymont SA, Cannon GH, Law WD, Morton AJ, Goff LA, McCallion AS.

Am J Hum Genet. 2018 Mar 1;102(3):427-446. doi: 10.1016/j.ajhg.2018.02.001.

19.
20.

Sheep recognize familiar and unfamiliar human faces from two-dimensional images.

Knolle F, Goncalves RP, Morton AJ.

R Soc Open Sci. 2017 Nov 8;4(11):171228. doi: 10.1098/rsos.171228. eCollection 2017 Nov.

21.

Chronic paroxetine treatment prevents disruption of methamphetamine-sensitive circadian oscillator in a transgenic mouse model of Huntington's disease.

Ouk K, Aungier J, Cuesta M, Morton AJ.

Neuropharmacology. 2018 Mar 15;131:337-350. doi: 10.1016/j.neuropharm.2017.12.033. Epub 2017 Dec 21.

PMID:
29274752
22.

Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease.

Pfister EL, DiNardo N, Mondo E, Borel F, Conroy F, Fraser C, Gernoux G, Han X, Hu D, Johnson E, Kennington L, Liu P, Reid SJ, Sapp E, Vodicka P, Kuchel T, Morton AJ, Howland D, Moser R, Sena-Esteves M, Gao G, Mueller C, DiFiglia M, Aronin N.

Hum Gene Ther. 2018 Jun;29(6):663-673. doi: 10.1089/hum.2017.199. Epub 2018 Feb 23.

23.

Erratum to: Chronic Paroxetine Treatment Prevents the Emergence of Abnormal Electroencephalogram Oscillations in Huntington's Disease Mice.

Kantor S, Varga J, Kulkarni S, Morton AJ.

Neurotherapeutics. 2017 Oct;14(4):1166. doi: 10.1007/s13311-017-0559-2. No abstract available.

24.

Effect of lidocaine on inflammation in equine jejunum subjected to manipulation only and remote to intestinal segments subjected to ischemia.

Bauck AG, Grosche A, Morton AJ, Graham AS, Vickroy TW, Freeman DE.

Am J Vet Res. 2017 Aug;78(8):977-989. doi: 10.2460/ajvr.78.8.977.

PMID:
28738006
25.

Chronic Paroxetine Treatment Prevents the Emergence of Abnormal Electroencephalogram Oscillations in Huntington's Disease Mice.

Kantor S, Varga J, Kulkarni S, Morton AJ.

Neurotherapeutics. 2017 Oct;14(4):1120-1133. doi: 10.1007/s13311-017-0546-7. Erratum in: Neurotherapeutics. 2017 Jul 25;:.

26.

Response to early repeat celiotomy in horses after a surgical treatment of jejunal strangulation.

Bauck AG, Easley JT, Cleary OB, Graham S, Morton AJ, Rötting AK, Schaeffer DJ, Smith AD, Freeman DE.

Vet Surg. 2017 Aug;46(6):843-850. doi: 10.1111/vsu.12670. Epub 2017 May 29.

PMID:
28556997
27.

Characterisation of progressive motor deficits in whisker movements in R6/2, Q175 and Hdh knock-in mouse models of Huntington's disease.

Garland H, Wood NI, Skillings EA, Detloff PJ, Morton AJ, Grant RA.

J Neurosci Methods. 2018 Apr 15;300:103-111. doi: 10.1016/j.jneumeth.2017.04.020. Epub 2017 May 1.

PMID:
28472678
28.

A stop-signal task for sheep: introduction and validation of a direct measure for the stop-signal reaction time.

Knolle F, McBride SD, Stewart JE, Goncalves RP, Morton AJ.

Anim Cogn. 2017 Jul;20(4):615-626. doi: 10.1007/s10071-017-1085-7. Epub 2017 Apr 7.

29.

Metabolic profiling of presymptomatic Huntington's disease sheep reveals novel biomarkers.

Skene DJ, Middleton B, Fraser CK, Pennings JL, Kuchel TR, Rudiger SR, Bawden CS, Morton AJ.

Sci Rep. 2017 Feb 22;7:43030. doi: 10.1038/srep43030.

30.

Potential molecular consequences of transgene integration: The R6/2 mouse example.

Jacobsen JC, Erdin S, Chiang C, Hanscom C, Handley RR, Barker DD, Stortchevoi A, Blumenthal I, Reid SJ, Snell RG, MacDonald ME, Morton AJ, Ernst C, Gusella JF, Talkowski ME.

Sci Rep. 2017 Jan 25;7:41120. doi: 10.1038/srep41120.

31.

Attenuated pupillary light responses and downregulation of opsin expression parallel decline in circadian disruption in two different mouse models of Huntington's disease.

Ouk K, Hughes S, Pothecary CA, Peirson SN, Morton AJ.

Hum Mol Genet. 2016 Nov 27;25(24). pii: ddw359. doi: 10.1093/hmg/ddw359.

32.

Techniques for chronic monitoring of brain activity in freely moving sheep using wireless EEG recording.

Perentos N, Nicol AU, Martins AQ, Stewart JE, Taylor P, Morton AJ.

J Neurosci Methods. 2017 Mar 1;279:87-100. doi: 10.1016/j.jneumeth.2016.11.010. Epub 2016 Nov 30.

PMID:
27914975
33.

Prolonged day length exposure improves circadian deficits and survival in a transgenic mouse model of Huntington's disease.

Ouk K, Aungier J, Morton AJ.

Neurobiol Sleep Circadian Rhythms. 2016 Nov 30;2:27-38. doi: 10.1016/j.nbscr.2016.11.004. eCollection 2017 Jan.

34.

Progressive gene dose-dependent disruption of the methamphetamine-sensitive circadian oscillator-driven rhythms in a knock-in mouse model of Huntington's disease.

Ouk K, Aungier J, Morton AJ.

Exp Neurol. 2016 Dec;286:69-82. doi: 10.1016/j.expneurol.2016.09.007. Epub 2016 Sep 16.

PMID:
27646506
36.

An EEG Investigation of Sleep Homeostasis in Healthy and CLN5 Batten Disease Affected Sheep.

Perentos N, Martins AQ, Cumming RJ, Mitchell NL, Palmer DN, Sawiak SJ, Morton AJ.

J Neurosci. 2016 Aug 3;36(31):8238-49. doi: 10.1523/JNEUROSCI.4295-15.2016.

37.

Automated detection and characterisation of rumination in sheep using in vivo electrophysiology.

Nicol AU, Perentos N, Martins AQ, Morton AJ.

Physiol Behav. 2016 Sep 1;163:258-266. doi: 10.1016/j.physbeh.2016.05.028. Epub 2016 May 17.

PMID:
27211334
38.

Integrative veterinary medical education and consensus guidelines for an integrative veterinary medicine curriculum within veterinary colleges.

Memon MA, Shmalberg J, Adair HS 3rd, Allweiler S, Bryan JN, Cantwell S, Carr E, Chrisman C, Egger CM, Greene S, Haussler KK, Hershey B, Holyoak GR, Johnson M, Jeune SL, Looney A, McConnico RS, Medina C, Morton AJ, Munsterman A, Nie GJ, Park N, Parsons-Doherty M, Perdrizet JA, Peyton JL, Raditic D, Ramirez HP, Saik J, Robertson S, Sleeper M, Dyke JV, Wakshlag J.

Open Vet J. 2016;6(1):44-56. Epub 2016 Mar 28. Review.

39.

MAGNETIC RESONANCE IMAGING SCORING OF AN EXPERIMENTAL MODEL OF POST-TRAUMATIC OSTEOARTHRITIS IN THE EQUINE CARPUS.

Smith AD, Morton AJ, Winter MD, Colahan PT, Ghivizzani S, Brown MP, Hernandez JA, Nickerson DM.

Vet Radiol Ultrasound. 2016 Sep;57(5):502-14. doi: 10.1111/vru.12369. Epub 2016 May 19.

40.

Impaired Nitric Oxide Mediated Vasodilation In The Peripheral Circulation In The R6/2 Mouse Model Of Huntington's Disease.

Kane AD, Niu Y, Herrera EA, Morton AJ, Giussani DA.

Sci Rep. 2016 May 16;6:25979. doi: 10.1038/srep25979.

41.

Pharmacokinetics and immunological outcomes of alemtuzumab-based treatment for steroid-refractory acute GvHD.

Tey SK, Vuckovic S, Varelias A, Martins JP, Olver S, Samson L, Sturgeon E, Leach J, Avery J, Nakagaki M, Butler JP, Curley C, Morton AJ, Durrant ST, Kennedy GA, Hill GR.

Bone Marrow Transplant. 2016 Aug;51(8):1153-5. doi: 10.1038/bmt.2016.83. Epub 2016 Apr 4. No abstract available.

PMID:
27042838
43.

Allelic series of Huntington's disease knock-in mice reveals expression discorrelates.

Kumar A, Zhang J, Tallaksen-Greene S, Crowley MR, Crossman DK, Morton AJ, Van Groen T, Kadish I, Albin RL, Lesort M, Detloff PJ.

Hum Mol Genet. 2016 Apr 15;25(8):1619-36. doi: 10.1093/hmg/ddw040. Epub 2016 Feb 14.

44.

A single dose of hypnotic corrects sleep and EEG abnormalities in symptomatic Huntington's disease mice.

Kantor S, Varga J, Morton AJ.

Neuropharmacology. 2016 Jun;105:298-307. doi: 10.1016/j.neuropharm.2016.01.027. Epub 2016 Jan 22.

PMID:
26805423
45.

Social Behaviour is Impaired in the R6/2 Mouse Model of Huntington’s Disease.

Wood NI, Morton AJ.

J Huntingtons Dis. 2015;4(1):61-73.

PMID:
26333258
46.

A mobile, high-throughput semi-automated system for testing cognition in large non-primate animal models of Huntington disease.

McBride SD, Perentos N, Morton AJ.

J Neurosci Methods. 2016 May 30;265:25-33. doi: 10.1016/j.jneumeth.2015.08.025. Epub 2015 Aug 29.

PMID:
26327320
47.

A comparison of discrimination learning in touchscreen and 2-choice swim tank using an allelic series of Huntington's disease mice.

Glynn D, Skillings EA, Morton AJ.

J Neurosci Methods. 2016 May 30;265:56-71. doi: 10.1016/j.jneumeth.2015.07.016. Epub 2015 Jul 26.

PMID:
26219658
48.

A Significance Test for Inferring Affiliation Networks from Spatio-Temporal Data.

Furmston T, Morton AJ, Hailes S.

PLoS One. 2015 Jul 20;10(7):e0132417. doi: 10.1371/journal.pone.0132417. eCollection 2015.

49.

Rapid and Progressive Regional Brain Atrophy in CLN6 Batten Disease Affected Sheep Measured with Longitudinal Magnetic Resonance Imaging.

Sawiak SJ, Perumal SR, Rudiger SR, Matthews L, Mitchell NL, McLaughlan CJ, Bawden CS, Palmer DN, Kuchel T, Morton AJ.

PLoS One. 2015 Jul 10;10(7):e0132331. doi: 10.1371/journal.pone.0132331. eCollection 2015.

50.

Progression of behavioural despair in R6/2 and Hdh knock-in mouse models recapitulates depression in Huntington's disease.

Ciamei A, Detloff PJ, Morton AJ.

Behav Brain Res. 2015 Sep 15;291:140-146. doi: 10.1016/j.bbr.2015.05.010. Epub 2015 May 16.

PMID:
25986402

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