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Items: 35

1.

Profiling of hepatic clearance pathways of Pittsburgh compound B and human liver cytochrome p450 phenotyping.

Van Vlaslaer A, Mortishire-Smith RJ, Mackie C, Langlois X, Schmidt ME.

EJNMMI Res. 2013 Feb 14;3(1):10. doi: 10.1186/2191-219X-3-10.

2.

Identifying metabolite ions of peptide drugs in the presence of an in vivo matrix background.

Cuyckens F, Dillen L, Cools W, Bockx M, Vereyken L, de Vries R, Mortishire-Smith RJ.

Bioanalysis. 2012 Mar;4(5):595-604. doi: 10.4155/bio.11.333.

PMID:
22409556
3.

Product ion mobility as a promising tool for assignment of positional isomers of drug metabolites.

Cuyckens F, Wassvik C, Mortishire-Smith RJ, Tresadern G, Campuzano I, Claereboudt J.

Rapid Commun Mass Spectrom. 2011 Dec 15;25(23):3497-503. doi: 10.1002/rcm.5258.

PMID:
22095497
4.

Evaluation of three state-of-the-art metabolite prediction software packages (Meteor, MetaSite, and StarDrop) through independent and synergistic use.

T'jollyn H, Boussery K, Mortishire-Smith RJ, Coe K, De Boeck B, Van Bocxlaer JF, Mannens G.

Drug Metab Dispos. 2011 Nov;39(11):2066-75. doi: 10.1124/dmd.111.039982. Epub 2011 Aug 10.

PMID:
21832003
5.

A metabolomic comparison of mouse models of the Neuronal Ceroid Lipofuscinoses.

Salek RM, Pears MR, Cooper JD, Mitchison HM, Pearce DA, Mortishire-Smith RJ, Griffin JL.

J Biomol NMR. 2011 Apr;49(3-4):175-84. doi: 10.1007/s10858-011-9491-7. Epub 2011 Apr 3.

6.

Deletion of btn1, an orthologue of CLN3, increases glycolysis and perturbs amino acid metabolism in the fission yeast model of Batten disease.

Pears MR, Codlin S, Haines RL, White IJ, Mortishire-Smith RJ, Mole SE, Griffin JL.

Mol Biosyst. 2010 Jun;6(6):1093-102. doi: 10.1039/b915670d. Epub 2010 Mar 17.

PMID:
20485751
7.

Generic dealkylation: a tool for increasing the hit-rate of metabolite rationalization, and automatic customization of mass defect filters.

Mortishire-Smith RJ, Castro-Perez JM, Yu K, Shockcor JP, Goshawk J, Hartshorn MJ, Hill A.

Rapid Commun Mass Spectrom. 2009 Apr;23(7):939-48. doi: 10.1002/rcm.3951.

PMID:
19241416
8.

Extracting metabolite ions out of a matrix background by combined mass defect, neutral loss and isotope filtration.

Cuyckens F, Hurkmans R, Castro-Perez JM, Leclercq L, Mortishire-Smith RJ.

Rapid Commun Mass Spectrom. 2009 Jan;23(2):327-32. doi: 10.1002/rcm.3881.

PMID:
19089853
9.

IsoScore: automated localization of biotransformations by mass spectrometry using product ion scoring of virtual regioisomers.

Leclercq L, Mortishire-Smith RJ, Huisman M, Cuyckens F, Hartshorn MJ, Hill A.

Rapid Commun Mass Spectrom. 2009 Jan;23(1):39-50. doi: 10.1002/rcm.3854.

PMID:
19051234
10.

Metabolomic investigation of CLN6 neuronal ceroid lipofuscinosis in affected South Hampshire sheep.

Pears MR, Salek RM, Palmer DN, Kay GW, Mortishire-Smith RJ, Griffin JL.

J Neurosci Res. 2007 Nov 15;85(15):3494-504.

PMID:
17510975
11.

High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease.

Pears MR, Cooper JD, Mitchison HM, Mortishire-Smith RJ, Pearce DA, Griffin JL.

J Biol Chem. 2005 Dec 30;280(52):42508-14. Epub 2005 Oct 20.

12.
13.

'All-in-one' analysis for metabolite identification using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry with collision energy switching.

Wrona M, Mauriala T, Bateman KP, Mortishire-Smith RJ, O'Connor D.

Rapid Commun Mass Spectrom. 2005;19(18):2597-602.

PMID:
16106348
14.

1H NMR study of the conformation and absolute stereochemistry of two spirocyclic NK-1 antagonists.

Herbert RH, Gerhard U, Mortishire-Smith RJ, Thomas SR, Hollingworth G.

Magn Reson Chem. 2005 Aug;43(8):658-61.

PMID:
15924294
15.

A functional analysis of mouse models of cardiac disease through metabolic profiling.

Jones GL, Sang E, Goddard C, Mortishire-Smith RJ, Sweatman BC, Haselden JN, Davies K, Grace AA, Clarke K, Griffin JL.

J Biol Chem. 2005 Mar 4;280(9):7530-9. Epub 2004 Nov 16.

16.

Length preferences and periodicity in beta-strands. Antiparallel edge beta-sheets are more likely to finish in non-hydrogen bonded rings.

Penel S, Morrison RG, Dobson PD, Mortishire-Smith RJ, Doig AJ.

Protein Eng. 2003 Dec;16(12):957-61.

PMID:
14983075
17.

Use of metabonomics to identify impaired fatty acid metabolism as the mechanism of a drug-induced toxicity.

Mortishire-Smith RJ, Skiles GL, Lawrence JW, Spence S, Nicholls AW, Johnson BA, Nicholson JK.

Chem Res Toxicol. 2004 Feb;17(2):165-73.

PMID:
14967004
18.

NMR spectroscopic-based metabonomic studies of urinary metabolite variation in acclimatizing germ-free rats.

Nicholls AW, Mortishire-Smith RJ, Nicholson JK.

Chem Res Toxicol. 2003 Nov;16(11):1395-404.

PMID:
14615964
19.

Metabolite identification in drug discovery.

Watt AP, Mortishire-Smith RJ, Gerhard U, Thomas SR.

Curr Opin Drug Discov Devel. 2003 Jan;6(1):57-65. Review.

PMID:
12613277
20.

Enantiomeric separation of substituted 2-arylindoles on derivatised polysaccharide chiral stationary phases.

Watt AP, Hitzel L, Mortishire-Smith RJ.

J Biochem Biophys Methods. 2002 Dec 31;54(1-3):275-86.

PMID:
12543504
21.

Synthesis and conformational dynamics of tricyclic pyridones containing a fused seven-membered ring.

Gibson KR, Hitzel L, Mortishire-Smith RJ, Gerhard U, Jelley RA, Reeve AJ, Rowley M, Nadin A, Owens AP.

J Org Chem. 2002 Dec 27;67(26):9354-60.

PMID:
12492338
22.

Metabolic profiling of rodent biological fluids via 1H NMR spectroscopy using a 1 mm microlitre probe.

Griffin JL, Nicholls AW, Keun HC, Mortishire-Smith RJ, Nicholson JK, Kuehn T.

Analyst. 2002 May;127(5):582-4.

PMID:
12081031
24.

Structural studies on phospholamban and implications for regulation of the Ca(2+)-ATPase.

Mortishire-Smith RJ, Broughton H, Garsky VM, Mayer EJ, Johnson RG Jr.

Ann N Y Acad Sci. 1998 Sep 16;853:63-78.

PMID:
10603937
25.

Periodicity in alpha-helix lengths and C-capping preferences.

Penel S, Morrison RG, Mortishire-Smith RJ, Doig AJ.

J Mol Biol. 1999 Nov 12;293(5):1211-9.

PMID:
10547296
26.

2,7-diazabicyclo[3.3.0]octanes as novel h5-HT receptor agonists.

Russell MG, Beer MS, Stanton JA, Sohal B, Mortishire-Smith RJ, Castro JL.

Bioorg Med Chem Lett. 1999 Sep 6;9(17):2491-6.

PMID:
10498195
27.

Delineation of the structural determinants of the N-methyl-D-aspartate receptor glycine binding site.

Sandhu S, Grimwood S, Mortishire-Smith RJ, Whiting PJ, le Bourdell├Ęs B.

J Neurochem. 1999 Apr;72(4):1694-8.

28.

The toxicity in vitro of beta-amyloid protein.

Iversen LL, Mortishire-Smith RJ, Pollack SJ, Shearman MS.

Biochem J. 1995 Oct 1;311 ( Pt 1):1-16. Review. No abstract available.

29.

Solution structure of the cytoplasmic domain of phopholamban: phosphorylation leads to a local perturbation in secondary structure.

Mortishire-Smith RJ, Pitzenberger SM, Burke CJ, Middaugh CR, Garsky VM, Johnson RG.

Biochemistry. 1995 Jun 13;34(23):7603-13.

PMID:
7779806
30.

The solution structure of the Oct-1 POU-specific domain reveals a striking similarity to the bacteriophage lambda repressor DNA-binding domain.

Assa-Munt N, Mortishire-Smith RJ, Aurora R, Herr W, Wright PE.

Cell. 1993 Apr 9;73(1):193-205.

PMID:
8462099
31.

The zinc finger motif. Conservation of chemical shifts and correlation with structure.

Lee MS, Mortishire-Smith RJ, Wright PE.

FEBS Lett. 1992 Aug 31;309(1):29-32.

32.

Structural determinants of Cys2His2 zinc fingers.

Mortishire-Smith RJ, Lee MS, Bolinger L, Wright PE.

FEBS Lett. 1992 Jan 13;296(1):11-5.

33.

Conserved positioning of proline residues in membrane-spanning helices of ion-channel proteins.

Woolfson DN, Mortishire-Smith RJ, Williams DH.

Biochem Biophys Res Commun. 1991 Mar 29;175(3):733-7.

PMID:
1709011
34.

Left handed alpha-helix formation by a bacterial peptide.

Mortishire-Smith RJ, Drake AF, Nutkins JC, Williams DH.

FEBS Lett. 1991 Jan 28;278(2):244-6.

35.

Molecular recognition by secondary metabolites.

Williams DH, Stone MJ, Mortishire-Smith RJ, Hauck PR.

Biochem Pharmacol. 1990 Jul 1;40(1):27-34.

PMID:
2372307

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