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Items: 17


The Landscape of Actionable Genomic Alterations in Cell-Free Circulating Tumor DNA from 21,807 Advanced Cancer Patients.

Zill OA, Banks KC, Fairclough SR, Mortimer SA, Vowles JV, Mokhtari R, Gandara DR, Mack PC, Odegaard JI, Nagy RJ, Baca AM, Eltoukhy H, Chudova DI, Lanman RB, Talasaz A.

Clin Cancer Res. 2018 Aug 1;24(15):3528-3538. doi: 10.1158/1078-0432.CCR-17-3837. Epub 2018 May 18.


Analytical and Clinical Validation of a Digital Sequencing Panel for Quantitative, Highly Accurate Evaluation of Cell-Free Circulating Tumor DNA.

Lanman RB, Mortimer SA, Zill OA, Sebisanovic D, Lopez R, Blau S, Collisson EA, Divers SG, Hoon DS, Kopetz ES, Lee J, Nikolinakos PG, Baca AM, Kermani BG, Eltoukhy H, Talasaz A.

PLoS One. 2015 Oct 16;10(10):e0140712. doi: 10.1371/journal.pone.0140712. eCollection 2015.


Insights into RNA structure and function from genome-wide studies.

Mortimer SA, Kidwell MA, Doudna JA.

Nat Rev Genet. 2014 Jul;15(7):469-79. doi: 10.1038/nrg3681. Epub 2014 May 13. Review.


Enhancement of hepatitis C viral RNA abundance by precursor miR-122 molecules.

Cox EM, Sagan SM, Mortimer SA, Doudna JA, Sarnow P.

RNA. 2013 Dec;19(12):1825-32. doi: 10.1261/rna.040865.113. Epub 2013 Oct 8.


SHAPE-Seq: High-Throughput RNA Structure Analysis.

Mortimer SA, Trapnell C, Aviran S, Pachter L, Lucks JB.

Curr Protoc Chem Biol. 2012 Dec 1;4(4):275-97. doi: 10.1002/9780470559277.ch120019.


Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation.

Sun C, Querol-Audí J, Mortimer SA, Arias-Palomo E, Doudna JA, Nogales E, Cate JH.

Nucleic Acids Res. 2013 Aug;41(15):7512-21. doi: 10.1093/nar/gkt510. Epub 2013 Jun 13.


Unconventional miR-122 binding stabilizes the HCV genome by forming a trimolecular RNA structure.

Mortimer SA, Doudna JA.

Nucleic Acids Res. 2013 Apr;41(7):4230-40. doi: 10.1093/nar/gkt075. Epub 2013 Feb 14.


Crystal structure of the HCV IRES central domain reveals strategy for start-codon positioning.

Berry KE, Waghray S, Mortimer SA, Bai Y, Doudna JA.

Structure. 2011 Oct 12;19(10):1456-66. doi: 10.1016/j.str.2011.08.002.


Modeling and automation of sequencing-based characterization of RNA structure.

Aviran S, Trapnell C, Lucks JB, Mortimer SA, Luo S, Schroth GP, Doudna JA, Arkin AP, Pachter L.

Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11069-74. doi: 10.1073/pnas.1106541108. Epub 2011 Jun 3.


Multiplexed RNA structure characterization with selective 2'-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq).

Lucks JB, Mortimer SA, Trapnell C, Luo S, Aviran S, Schroth GP, Pachter L, Doudna JA, Arkin AP.

Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11063-8. doi: 10.1073/pnas.1106501108. Epub 2011 Jun 3.


Time-resolved RNA SHAPE chemistry: quantitative RNA structure analysis in one-second snapshots and at single-nucleotide resolution.

Mortimer SA, Weeks KM.

Nat Protoc. 2009;4(10):1413-21. doi: 10.1038/nprot.2009.126. Epub 2009 Sep 10.


C2'-endo nucleotides as molecular timers suggested by the folding of an RNA domain.

Mortimer SA, Weeks KM.

Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15622-7. doi: 10.1073/pnas.0901319106. Epub 2009 Aug 26.


Influence of nucleotide identity on ribose 2'-hydroxyl reactivity in RNA.

Wilkinson KA, Vasa SM, Deigan KE, Mortimer SA, Giddings MC, Weeks KM.

RNA. 2009 Jul;15(7):1314-21. doi: 10.1261/rna.1536209. Epub 2009 May 20.


Quantitative analysis of RNA solvent accessibility by N-silylation of guanosine.

Mortimer SA, Johnson JS, Weeks KM.

Biochemistry. 2009 Mar 17;48(10):2109-14. doi: 10.1021/bi801939g.


Time-resolved RNA SHAPE chemistry.

Mortimer SA, Weeks KM.

J Am Chem Soc. 2008 Dec 3;130(48):16178-80. doi: 10.1021/ja8061216.


Slow conformational dynamics at C2'-endo nucleotides in RNA.

Gherghe CM, Mortimer SA, Krahn JM, Thompson NL, Weeks KM.

J Am Chem Soc. 2008 Jul 16;130(28):8884-5. doi: 10.1021/ja802691e. Epub 2008 Jun 18.


A fast-acting reagent for accurate analysis of RNA secondary and tertiary structure by SHAPE chemistry.

Mortimer SA, Weeks KM.

J Am Chem Soc. 2007 Apr 11;129(14):4144-5. Epub 2007 Mar 17. No abstract available.


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