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Items: 27

1.

TIGAR inclusion pathology is specific for Lewy body diseases.

Robles López KL, Simpson JE, Watson LC, Mortiboys H, Hautbergue GM, Bandmann O, Highley JR.

Brain Res. 2018 Sep 26. pii: S0006-8993(18)30497-9. doi: 10.1016/j.brainres.2018.09.032. [Epub ahead of print]

PMID:
30267647
2.

Ursodeoxycholic Acid Improves Mitochondrial Function and Redistributes Drp1 in Fibroblasts from Patients with Either Sporadic or Familial Alzheimer's Disease.

Bell SM, Barnes K, Clemmens H, Al-Rafiah AR, Al-Ofi EA, Leech V, Bandmann O, Shaw PJ, Blackburn DJ, Ferraiuolo L, Mortiboys H.

J Mol Biol. 2018 Oct 19;430(21):3942-3953. doi: 10.1016/j.jmb.2018.08.019. Epub 2018 Aug 29.

3.

Loss of IGF1R in Human Astrocytes Alters Complex I Activity and Support for Neurons.

Ratcliffe LE, Vázquez Villaseñor I, Jennings L, Heath PR, Mortiboys H, Schwartzentruber A, Karyka E, Simpson JE, Ince PG, Garwood CJ, Wharton SB.

Neuroscience. 2018 Oct 15;390:46-59. doi: 10.1016/j.neuroscience.2018.07.029. Epub 2018 Jul 27.

4.

Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?

Macdonald R, Barnes K, Hastings C, Mortiboys H.

Biochem Soc Trans. 2018 Aug 20;46(4):891-909. doi: 10.1042/BST20170501. Epub 2018 Jul 19. Review.

PMID:
30026371
5.

Translational approaches to restoring mitochondrial function in Parkinson's disease.

Mortiboys H, Macdonald R, Payne T, Sassani M, Jenkins T, Bandmann O.

FEBS Lett. 2018 Mar;592(5):776-792. doi: 10.1002/1873-3468.12920. Epub 2017 Dec 17. Review.

PMID:
29178330
6.

Modulating mitophagy in mitochondrial disease.

Dombi E, Mortiboys H, Poulton J.

Curr Med Chem. 2017 Jun 16. doi: 10.2174/0929867324666170616101741. [Epub ahead of print]

7.

Dysregulated mitophagy and mitochondrial organization in optic atrophy due to OPA1 mutations.

Liao C, Ashley N, Diot A, Morten K, Phadwal K, Williams A, Fearnley I, Rosser L, Lowndes J, Fratter C, Ferguson DJ, Vay L, Quaghebeur G, Moroni I, Bianchi S, Lamperti C, Downes SM, Sitarz KS, Flannery PJ, Carver J, Dombi E, East D, Laura M, Reilly MM, Mortiboys H, Prevo R, Campanella M, Daniels MJ, Zeviani M, Yu-Wai-Man P, Simon AK, Votruba M, Poulton J.

Neurology. 2017 Jan 10;88(2):131-142. doi: 10.1212/WNL.0000000000003491. Epub 2016 Dec 14.

8.

Screening for chemical modulators for LRRK2.

Mortiboys H.

Biochem Soc Trans. 2016 Dec 15;44(6):1617-1623. Review.

9.

Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons in pink1-/- zebrafish.

Soman S, Keatinge M, Moein M, Da Costa M, Mortiboys H, Skupin A, Sugunan S, Bazala M, Kuznicki J, Bandmann O.

Eur J Neurosci. 2017 Feb;45(4):528-535. doi: 10.1111/ejn.13473. Epub 2016 Dec 28.

10.

Rescue of mitochondrial function in parkin-mutant fibroblasts using drug loaded PMPC-PDPA polymersomes and tubular polymersomes.

Yealland G, Battaglia G, Bandmann O, Mortiboys H.

Neurosci Lett. 2016 Sep 6;630:23-29. doi: 10.1016/j.neulet.2016.06.065. Epub 2016 Jul 10.

11.

Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death.

Keatinge M, Bui H, Menke A, Chen YC, Sokol AM, Bai Q, Ellett F, Da Costa M, Burke D, Gegg M, Trollope L, Payne T, McTighe A, Mortiboys H, de Jager S, Nuthall H, Kuo MS, Fleming A, Schapira AH, Renshaw SA, Highley JR, Chacinska A, Panula P, Burton EA, O'Neill MJ, Bandmann O.

Hum Mol Genet. 2015 Dec 1;24(23):6640-52. doi: 10.1093/hmg/ddv369. Epub 2015 Sep 16.

12.

UDCA exerts beneficial effect on mitochondrial dysfunction in LRRK2(G2019S) carriers and in vivo.

Mortiboys H, Furmston R, Bronstad G, Aasly J, Elliott C, Bandmann O.

Neurology. 2015 Sep 8;85(10):846-52. doi: 10.1212/WNL.0000000000001905. Epub 2015 Aug 7.

13.

A novel quantitative assay of mitophagy: Combining high content fluorescence microscopy and mitochondrial DNA load to quantify mitophagy and identify novel pharmacological tools against pathogenic heteroplasmic mtDNA.

Diot A, Hinks-Roberts A, Lodge T, Liao C, Dombi E, Morten K, Brady S, Fratter C, Carver J, Muir R, Davis R, Green CJ, Johnston I, Hilton-Jones D, Sue C, Mortiboys H, Poulton J.

Pharmacol Res. 2015 Oct;100:24-35. doi: 10.1016/j.phrs.2015.07.014. Epub 2015 Jul 18.

PMID:
26196248
14.

The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy.

Pogson JH, Ivatt RM, Sanchez-Martinez A, Tufi R, Wilson E, Mortiboys H, Whitworth AJ.

PLoS Genet. 2014 Nov 20;10(11):e1004815. doi: 10.1371/journal.pgen.1004815. eCollection 2014 Nov.

15.

IHG-1 increases mitochondrial fusion and bioenergetic function.

Hickey FB, Corcoran JB, Griffin B, Bhreathnach U, Mortiboys H, Reid HM, Andrews D, Byrne S, Furlong F, Martin F, Godson C, Murphy M.

Diabetes. 2014 Dec;63(12):4314-25. doi: 10.2337/db13-1256. Epub 2014 Jul 9.

16.

Superoxide dismutase 1 mutation in a cellular model of amyotrophic lateral sclerosis shifts energy generation from oxidative phosphorylation to glycolysis.

Allen SP, Rajan S, Duffy L, Mortiboys H, Higginbottom A, Grierson AJ, Shaw PJ.

Neurobiol Aging. 2014 Jun;35(6):1499-509. doi: 10.1016/j.neurobiolaging.2013.11.025. Epub 2013 Dec 3.

PMID:
24439480
17.

TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency.

Flinn LJ, Keatinge M, Bretaud S, Mortiboys H, Matsui H, De Felice E, Woodroof HI, Brown L, McTighe A, Soellner R, Allen CE, Heath PR, Milo M, Muqit MM, Reichert AS, Köster RW, Ingham PW, Bandmann O.

Ann Neurol. 2013 Dec;74(6):837-47. doi: 10.1002/ana.23999.

18.

Ursocholanic acid rescues mitochondrial function in common forms of familial Parkinson's disease.

Mortiboys H, Aasly J, Bandmann O.

Brain. 2013 Oct;136(Pt 10):3038-50. doi: 10.1093/brain/awt224. Epub 2013 Sep 2.

PMID:
24000005
19.

The effect of SOD1 mutation on cellular bioenergetic profile and viability in response to oxidative stress and influence of mutation-type.

Richardson K, Allen SP, Mortiboys H, Grierson AJ, Wharton SB, Ince PG, Shaw PJ, Heath PR.

PLoS One. 2013 Jun 28;8(6):e68256. doi: 10.1371/journal.pone.0068256. Print 2013.

20.

The common PARK8 mutation LRRK2G²⁰¹⁹S is not a risk factor for breast cancer in the absence of Parkinson's disease.

Mortiboys H, Cox A, Brock IW, Bandmann O.

J Neurol. 2013 Aug;260(8):2177-8. doi: 10.1007/s00415-013-7027-7. Epub 2013 Jul 4. No abstract available.

PMID:
23824357
21.

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.

Mortiboys H, Johansen KK, Aasly JO, Bandmann O.

Neurology. 2010 Nov 30;75(22):2017-20. doi: 10.1212/WNL.0b013e3181ff9685.

PMID:
21115957
22.

Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS).

Cox LE, Ferraiuolo L, Goodall EF, Heath PR, Higginbottom A, Mortiboys H, Hollinger HC, Hartley JA, Brockington A, Burness CE, Morrison KE, Wharton SB, Grierson AJ, Ince PG, Kirby J, Shaw PJ.

PLoS One. 2010 Mar 24;5(3):e9872. doi: 10.1371/journal.pone.0009872.

23.

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.

Tain LS, Mortiboys H, Tao RN, Ziviani E, Bandmann O, Whitworth AJ.

Nat Neurosci. 2009 Sep;12(9):1129-35. doi: 10.1038/nn.2372. Epub 2009 Aug 16.

24.

Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio).

Flinn L, Mortiboys H, Volkmann K, Köster RW, Ingham PW, Bandmann O.

Brain. 2009 Jun;132(Pt 6):1613-23. doi: 10.1093/brain/awp108. Epub 2009 May 12.

PMID:
19439422
25.

Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts.

Mortiboys H, Thomas KJ, Koopman WJ, Klaffke S, Abou-Sleiman P, Olpin S, Wood NW, Willems PH, Smeitink JA, Cookson MR, Bandmann O.

Ann Neurol. 2008 Nov;64(5):555-65. doi: 10.1002/ana.21492.

26.

Light affects mitochondria to cause apoptosis to cultured cells: possible relevance to ganglion cell death in certain optic neuropathies.

Osborne NN, Li GY, Ji D, Mortiboys HJ, Jackson S.

J Neurochem. 2008 Jun;105(5):2013-28. doi: 10.1111/j.1471-4159.2008.05320.x. Epub 2008 Feb 28.

27.

Mitochondrial dysfunction in Parkinson's disease--revisited.

Mortiboys HJ, Schaefer J, Reichmann H, Jackson S.

Neurol Neurochir Pol. 2007 Mar-Apr;41(2):150-9. Review.

PMID:
17530578

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