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Strategies to establish the link between biosynthetic gene clusters and secondary metabolites.

Kjærbølling I, Mortensen UH, Vesth T, Andersen MR.

Fungal Genet Biol. 2019 Jun 10;130:107-121. doi: 10.1016/j.fgb.2019.06.001. [Epub ahead of print] Review.


Cpf1 enables fast and efficient genome editing in Aspergilli.

Vanegas KG, Jarczynska ZD, Strucko T, Mortensen UH.

Fungal Biol Biotechnol. 2019 May 1;6:6. doi: 10.1186/s40694-019-0069-6. eCollection 2019.


Investigation of inter- and intraspecies variation through genome sequencing of Aspergillus section Nigri.

Vesth TC, Nybo JL, Theobald S, Frisvad JC, Larsen TO, Nielsen KF, Hoof JB, Brandl J, Salamov A, Riley R, Gladden JM, Phatale P, Nielsen MT, Lyhne EK, Kogle ME, Strasser K, McDonnell E, Barry K, Clum A, Chen C, LaButti K, Haridas S, Nolan M, Sandor L, Kuo A, Lipzen A, Hainaut M, Drula E, Tsang A, Magnuson JK, Henrissat B, Wiebenga A, Simmons BA, Mäkelä MR, de Vries RP, Grigoriev IV, Mortensen UH, Baker SE, Andersen MR.

Nat Genet. 2018 Dec;50(12):1688-1695. doi: 10.1038/s41588-018-0246-1. Epub 2018 Oct 22.


Heterologous production of the widely used natural food colorant carminic acid in Aspergillus nidulans.

Frandsen RJN, Khorsand-Jamal P, Kongstad KT, Nafisi M, Kannangara RM, Staerk D, Okkels FT, Binderup K, Madsen B, Møller BL, Thrane U, Mortensen UH.

Sci Rep. 2018 Aug 27;8(1):12853. doi: 10.1038/s41598-018-30816-9.


Correction to: Indirect and direct routes to C-glycosylated flavones in Saccharomyces cerevisiae.

Vanegas KG, Larsen AB, Eichenberger M, Fischer D, Mortensen UH, Naesby M.

Microb Cell Fact. 2018 Jul 28;17(1):119. doi: 10.1186/s12934-018-0967-y.


Indirect and direct routes to C-glycosylated flavones in Saccharomyces cerevisiae.

Vanegas KG, Larsen AB, Eichenberger M, Fischer D, Mortensen UH, Naesby M.

Microb Cell Fact. 2018 Jul 9;17(1):107. doi: 10.1186/s12934-018-0952-5. Erratum in: Microb Cell Fact. 2018 Jul 28;17(1):119.


Novofumigatonin biosynthesis involves a non-heme iron-dependent endoperoxide isomerase for orthoester formation.

Matsuda Y, Bai T, Phippen CBW, Nødvig CS, Kjærbølling I, Vesth TC, Andersen MR, Mortensen UH, Gotfredsen CH, Abe I, Larsen TO.

Nat Commun. 2018 Jul 3;9(1):2587. doi: 10.1038/s41467-018-04983-2.


Genome Editing: CRISPR-Cas9.

Hoof JB, Nødvig CS, Mortensen UH.

Methods Mol Biol. 2018;1775:119-132. doi: 10.1007/978-1-4939-7804-5_11.


On the biosynthetic origin of carminic acid.

Rasmussen SA, Kongstad KT, Khorsand-Jamal P, Kannangara RM, Nafisi M, Van Dam A, Bennedsen M, Madsen B, Okkels F, Gotfredsen CH, Staerk D, Thrane U, Mortensen UH, Larsen TO, Frandsen RJN.

Insect Biochem Mol Biol. 2018 May;96:51-61. doi: 10.1016/j.ibmb.2018.03.002. Epub 2018 Mar 16.


Efficient oligo nucleotide mediated CRISPR-Cas9 gene editing in Aspergilli.

Nødvig CS, Hoof JB, Kogle ME, Jarczynska ZD, Lehmbeck J, Klitgaard DK, Mortensen UH.

Fungal Genet Biol. 2018 Jun;115:78-89. doi: 10.1016/j.fgb.2018.01.004. Epub 2018 Jan 8.


Linking secondary metabolites to gene clusters through genome sequencing of six diverse Aspergillus species.

Kjærbølling I, Vesth TC, Frisvad JC, Nybo JL, Theobald S, Kuo A, Bowyer P, Matsuda Y, Mondo S, Lyhne EK, Kogle ME, Clum A, Lipzen A, Salamov A, Ngan CY, Daum C, Chiniquy J, Barry K, LaButti K, Haridas S, Simmons BA, Magnuson JK, Mortensen UH, Larsen TO, Grigoriev IV, Baker SE, Andersen MR.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E753-E761. doi: 10.1073/pnas.1715954115. Epub 2018 Jan 9.


Current challenges of research on filamentous fungi in relation to human welfare and a sustainable bio-economy: a white paper.

Meyer V, Andersen MR, Brakhage AA, Braus GH, Caddick MX, Cairns TC, de Vries RP, Haarmann T, Hansen K, Hertz-Fowler C, Krappmann S, Mortensen UH, Peñalva MA, Ram AFJ, Head RM.

Fungal Biol Biotechnol. 2016 Aug 31;3:6. doi: 10.1186/s40694-016-0024-8. eCollection 2016.


Synthesis of C-Glucosylated Octaketide Anthraquinones in Nicotiana benthamiana by Using a Multispecies-Based Biosynthetic Pathway.

Andersen-Ranberg J, Kongstad KT, Nafisi M, Staerk D, Okkels FT, Mortensen UH, Lindberg Møller B, Frandsen RJN, Kannangara R.

Chembiochem. 2017 Oct 5;18(19):1893-1897. doi: 10.1002/cbic.201700331. Epub 2017 Aug 21.


Gene expression plasticity across hosts of an invasive scale insect species.

Christodoulides N, Van Dam AR, Peterson DA, Frandsen RJN, Mortensen UH, Petersen B, Rasmussen S, Normark BB, Hardy NB.

PLoS One. 2017 May 4;12(5):e0176956. doi: 10.1371/journal.pone.0176956. eCollection 2017.


Effects of dissolved oxygen concentration and iron addition on immediate-early gene expression of Magnetospirillum gryphiswaldense MSR-1.

Zhuang S, Anyaogu DC, Kasama T, Workman M, Mortensen UH, Hobley TJ.

FEMS Microbiol Lett. 2017 Jun 15;364(11). doi: 10.1093/femsle/fnx079.


Erratum to: SWITCH: a dynamic CRISPR tool for genome engineering and metabolic pathway control for cell factory construction in Saccharomyces cerevisiae.

Vanegas KG, Lehka BJ, Mortensen UH.

Microb Cell Fact. 2017 Mar 28;16(1):53. doi: 10.1186/s12934-017-0668-y. No abstract available.


Genome Sequence of Talaromyces atroroseus, Which Produces Red Colorants for the Food Industry.

Thrane U, Rasmussen KB, Petersen B, Rasmussen S, Sicheritz-Pontén T, Mortensen UH.

Genome Announc. 2017 Mar 2;5(9). pii: e01736-16. doi: 10.1128/genomeA.01736-16.


CASCADE, a platform for controlled gene amplification for high, tunable and selection-free gene expression in yeast.

Strucko T, Buron LD, Jarczynska ZD, Nødvig CS, Mølgaard L, Halkier BA, Mortensen UH.

Sci Rep. 2017 Jan 30;7:41431. doi: 10.1038/srep41431.


Editorial: 3Rs tightly intertwined to maintain genome stability.

Lisby M, Mortensen UH.

FEMS Yeast Res. 2017 Jan 1;17(1). doi: 10.1093/femsyr/fox003. No abstract available.


Genes Linked to Production of Secondary Metabolites in Talaromyces atroroseus Revealed Using CRISPR-Cas9.

Nielsen ML, Isbrandt T, Rasmussen KB, Thrane U, Hoof JB, Larsen TO, Mortensen UH.

PLoS One. 2017 Jan 5;12(1):e0169712. doi: 10.1371/journal.pone.0169712. eCollection 2017.


High-resolution kinetics and modeling of hydrogen peroxide degradation in live cells.

Altıntaş A, Davidsen K, Garde C, Mortensen UH, Brasen JC, Sams T, Workman CT.

Free Radic Biol Med. 2016 Dec;101:143-153. doi: 10.1016/j.freeradbiomed.2016.10.006. Epub 2016 Oct 11.


Functional Reconstitution of a Fungal Natural Product Gene Cluster by Advanced Genome Editing.

Weber J, Valiante V, Nødvig CS, Mattern DJ, Slotkowski RA, Mortensen UH, Brakhage AA.

ACS Synth Biol. 2017 Jan 20;6(1):62-68. doi: 10.1021/acssynbio.6b00203. Epub 2016 Sep 13.


Linker Flexibility Facilitates Module Exchange in Fungal Hybrid PKS-NRPS Engineering.

Nielsen ML, Isbrandt T, Petersen LM, Mortensen UH, Andersen MR, Hoof JB, Larsen TO.

PLoS One. 2016 Aug 23;11(8):e0161199. doi: 10.1371/journal.pone.0161199. eCollection 2016.


SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination.

Silva S, Altmannova V, Eckert-Boulet N, Kolesar P, Gallina I, Hang L, Chung I, Arneric M, Zhao X, Buron LD, Mortensen UH, Krejci L, Lisby M.

DNA Repair (Amst). 2016 Jun;42:11-25. doi: 10.1016/j.dnarep.2016.04.001. Epub 2016 Apr 16.


Quantification of oxidative stress phenotypes based on high-throughput growth profiling of protein kinase and phosphatase knockouts.

Altıntaş A, Martini J, Mortensen UH, Workman CT.

FEMS Yeast Res. 2016 Feb;16(1):fov101. doi: 10.1093/femsyr/fov101. Epub 2015 Nov 11.


Investigation of a 6-MSA Synthase Gene Cluster in Aspergillus aculeatus Reveals 6-MSA-derived Aculinic Acid, Aculins A-B and Epi-Aculin A.

Petersen LM, Holm DK, Gotfredsen CH, Mortensen UH, Larsen TO.

Chembiochem. 2015 Oct 12;16(15):2200-4. doi: 10.1002/cbic.201500210. Epub 2015 Sep 16.


Manipulating the glycosylation pathway in bacterial and lower eukaryotes for production of therapeutic proteins.

Anyaogu DC, Mortensen UH.

Curr Opin Biotechnol. 2015 Dec;36:122-8. doi: 10.1016/j.copbio.2015.08.012. Epub 2015 Sep 1. Review.


A CRISPR-Cas9 System for Genetic Engineering of Filamentous Fungi.

Nødvig CS, Nielsen JB, Kogle ME, Mortensen UH.

PLoS One. 2015 Jul 15;10(7):e0133085. doi: 10.1371/journal.pone.0133085. eCollection 2015.


Heterologous production of fungal secondary metabolites in Aspergilli.

Anyaogu DC, Mortensen UH.

Front Microbiol. 2015 Feb 10;6:77. doi: 10.3389/fmicb.2015.00077. eCollection 2015. Review.


Characterization of four new antifungal yanuthones from Aspergillus niger.

Petersen LM, Holm DK, Knudsen PB, Nielsen KF, Gotfredsen CH, Mortensen UH, Larsen TO.

J Antibiot (Tokyo). 2015 Mar;68(3):201-5. doi: 10.1038/ja.2014.130. Epub 2014 Oct 8.


A versatile system for USER cloning-based assembly of expression vectors for mammalian cell engineering.

Lund AM, Kildegaard HF, Petersen MB, Rank J, Hansen BG, Andersen MR, Mortensen UH.

PLoS One. 2014 May 30;9(5):e96693. doi: 10.1371/journal.pone.0096693. eCollection 2014.


Molecular and chemical characterization of the biosynthesis of the 6-MSA-derived meroterpenoid yanuthone D in Aspergillus niger.

Holm DK, Petersen LM, Klitgaard A, Knudsen PB, Jarczynska ZD, Nielsen KF, Gotfredsen CH, Larsen TO, Mortensen UH.

Chem Biol. 2014 Apr 24;21(4):519-529. doi: 10.1016/j.chembiol.2014.01.013. Epub 2014 Mar 27.


A novel platform for heterologous gene expression in Trichoderma reesei (Teleomorph Hypocrea jecorina).

Jørgensen MS, Skovlund DA, Johannesen PF, Mortensen UH.

Microb Cell Fact. 2014 Mar 6;13(1):33. doi: 10.1186/1475-2859-13-33.


USER-derived cloning methods and their primer design.

Salomonsen B, Mortensen UH, Halkier BA.

Methods Mol Biol. 2014;1116:59-72. doi: 10.1007/978-1-62703-764-8_5.


Supercluster takes a walk on the wild side.

Nielsen JB, Andersen MR, Mortensen UH.

Trends Microbiol. 2013 Dec;21(12):617-8. doi: 10.1016/j.tim.2013.11.002. Epub 2013 Nov 14.


EasyClone: method for iterative chromosomal integration of multiple genes in Saccharomyces cerevisiae.

Jensen NB, Strucko T, Kildegaard KR, David F, Maury J, Mortensen UH, Forster J, Nielsen J, Borodina I.

FEMS Yeast Res. 2014 Mar;14(2):238-48. doi: 10.1111/1567-1364.12118. Epub 2013 Nov 18.


Heterologous reconstitution of the intact geodin gene cluster in Aspergillus nidulans through a simple and versatile PCR based approach.

Nielsen MT, Nielsen JB, Anyaogu DC, Holm DK, Nielsen KF, Larsen TO, Mortensen UH.

PLoS One. 2013 Aug 23;8(8):e72871. doi: 10.1371/journal.pone.0072871. eCollection 2013. Erratum in: PLoS One. 2013;8(11). doi:10.1371/annotation/c05c3fd1-dd00-4840-891d-693c614aaaf9. Anyaogu, Dianna Chinyere [corrected to Anyaogu, Diana Chinyere].


Aspergillus nidulans synthesize insect juvenile hormones upon expression of a heterologous regulatory protein and in response to grazing by Drosophila melanogaster larvae.

Nielsen MT, Klejnstrup ML, Rohlfs M, Anyaogu DC, Nielsen JB, Gotfredsen CH, Andersen MR, Hansen BG, Mortensen UH, Larsen TO.

PLoS One. 2013 Aug 26;8(8):e73369. doi: 10.1371/journal.pone.0073369. eCollection 2013.


Reconstruction of the biosynthetic pathway for the core fungal polyketide scaffold rubrofusarin in Saccharomyces cerevisiae.

Rugbjerg P, Naesby M, Mortensen UH, Frandsen RJ.

Microb Cell Fact. 2013 Apr 4;12:31. doi: 10.1186/1475-2859-12-31.


Expression and functional studies of genes involved in transport and metabolism of glycerol in Pachysolen tannophilus.

Liu X, Mortensen UH, Workman M.

Microb Cell Fact. 2013 Mar 21;12:27. doi: 10.1186/1475-2859-12-27.


Accurate prediction of secondary metabolite gene clusters in filamentous fungi.

Andersen MR, Nielsen JB, Klitgaard A, Petersen LM, Zachariasen M, Hansen TJ, Blicher LH, Gotfredsen CH, Larsen TO, Nielsen KF, Mortensen UH.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):E99-107. doi: 10.1073/pnas.1205532110. Epub 2012 Dec 17.


Involvement of a natural fusion of a cytochrome P450 and a hydrolase in mycophenolic acid biosynthesis.

Hansen BG, Mnich E, Nielsen KF, Nielsen JB, Nielsen MT, Mortensen UH, Larsen TO, Patil KR.

Appl Environ Microbiol. 2012 Jul;78(14):4908-13. doi: 10.1128/AEM.07955-11. Epub 2012 Apr 27.


Microbial production of indolylglucosinolate through engineering of a multi-gene pathway in a versatile yeast expression platform.

Mikkelsen MD, Buron LD, Salomonsen B, Olsen CE, Hansen BG, Mortensen UH, Halkier BA.

Metab Eng. 2012 Mar;14(2):104-11. doi: 10.1016/j.ymben.2012.01.006. Epub 2012 Feb 4.


Genetics of Polyketide Metabolism in Aspergillus nidulans.

Klejnstrup ML, Frandsen RJ, Holm DK, Nielsen MT, Mortensen UH, Larsen TO, Nielsen JB.

Metabolites. 2012 Jan 30;2(1):100-33. doi: 10.3390/metabo2010100.


A new class of IMP dehydrogenase with a role in self-resistance of mycophenolic acid producing fungi.

Hansen BG, Genee HJ, Kaas CS, Nielsen JB, Regueira TB, Mortensen UH, Frisvad JC, Patil KR.

BMC Microbiol. 2011 Sep 16;11:202. doi: 10.1186/1471-2180-11-202.


Adaptive evolution of drug targets in producer and non-producer organisms.

Hansen BG, Sun XE, Genee HJ, Kaas CS, Nielsen JB, Mortensen UH, Frisvad JC, Hedstrom L.

Biochem J. 2012 Jan 1;441(1):219-26. doi: 10.1042/BJ20111278.


A genome-wide polyketide synthase deletion library uncovers novel genetic links to polyketides and meroterpenoids in Aspergillus nidulans.

Nielsen ML, Nielsen JB, Rank C, Klejnstrup ML, Holm DK, Brogaard KH, Hansen BG, Frisvad JC, Larsen TO, Mortensen UH.

FEMS Microbiol Lett. 2011 Aug;321(2):157-66. doi: 10.1111/j.1574-6968.2011.02327.x. Epub 2011 Jun 27.


PHUSER (Primer Help for USER): a novel tool for USER fusion primer design.

Olsen LR, Hansen NB, Bonde MT, Genee HJ, Holm DK, Carlsen S, Hansen BG, Patil KR, Mortensen UH, Wernersson R.

Nucleic Acids Res. 2011 Jul;39(Web Server issue):W61-7. doi: 10.1093/nar/gkr394. Epub 2011 May 26.


Versatile enzyme expression and characterization system for Aspergillus nidulans, with the Penicillium brevicompactum polyketide synthase gene from the mycophenolic acid gene cluster as a test case.

Hansen BG, Salomonsen B, Nielsen MT, Nielsen JB, Hansen NB, Nielsen KF, Regueira TB, Nielsen J, Patil KR, Mortensen UH.

Appl Environ Microbiol. 2011 May;77(9):3044-51. doi: 10.1128/AEM.01768-10. Epub 2011 Mar 11.

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