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Intestinal non-canonical NFκB signaling shapes the local and systemic immune response.

Ramakrishnan SK, Zhang H, Ma X, Jung I, Schwartz AJ, Triner D, Devenport SN, Das NK, Xue X, Zeng MY, Hu Y, Mortensen RM, Greenson JK, Cascalho M, Wobus CE, Colacino JA, Nunez G, Rui L, Shah YM.

Nat Commun. 2019 Feb 8;10(1):660. doi: 10.1038/s41467-019-08581-8.


Neutrophils Restrict Tumor-Associated Microbiota to Reduce Growth and Invasion of Colon Tumors in Mice.

Triner D, Devenport SN, Ramakrishnan SK, Ma X, Frieler RA, Greenson JK, Inohara N, Nunez G, Colacino JA, Mortensen RM, Shah YM.

Gastroenterology. 2019 Apr;156(5):1467-1482. doi: 10.1053/j.gastro.2018.12.003. Epub 2018 Dec 11.


Genetic neutrophil deficiency ameliorates cerebral ischemia-reperfusion injury.

Frieler RA, Chung Y, Ahlers CG, Gheordunescu G, Song J, Vigil TM, Shah YM, Mortensen RM.

Exp Neurol. 2017 Dec;298(Pt A):104-111. doi: 10.1016/j.expneurol.2017.08.016. Epub 2017 Aug 31.


Lipodystrophy, Diabetes and Normal Serum Insulin in PPARγ-Deficient Neonatal Mice.

O'Donnell PE, Ye XZ, DeChellis MA, Davis VM, Duan SZ, Mortensen RM, Milstone DS.

PLoS One. 2016 Aug 9;11(8):e0160636. doi: 10.1371/journal.pone.0160636. eCollection 2016.


Analysis of Drug Design for a Selection of G Protein-Coupled Neuro- Receptors Using Neural Network Techniques.

Agerskov C, Mortensen RM, Bohr HG.

Curr Comput Aided Drug Des. 2015;11(3):202-11.


Depletion of macrophages in CD11b diphtheria toxin receptor mice induces brain inflammation and enhances inflammatory signaling during traumatic brain injury.

Frieler RA, Nadimpalli S, Boland LK, Xie A, Kooistra LJ, Song J, Chung Y, Cho KW, Lumeng CN, Wang MM, Mortensen RM.

Brain Res. 2015 Oct 22;1624:103-112. doi: 10.1016/j.brainres.2015.07.011. Epub 2015 Jul 21.


Immune cell and other noncardiomyocyte regulation of cardiac hypertrophy and remodeling.

Frieler RA, Mortensen RM.

Circulation. 2015 Mar 17;131(11):1019-30. doi: 10.1161/CIRCULATIONAHA.114.008788. Review. No abstract available.


Myeloid mineralocorticoid receptor deficiency inhibits aortic constriction-induced cardiac hypertrophy in mice.

Li C, Zhang YY, Frieler RA, Zheng XJ, Zhang WC, Sun XN, Yang QZ, Ma SM, Huang B, Berger S, Wang W, Wu Y, Yu Y, Duan SZ, Mortensen RM.

PLoS One. 2014 Oct 29;9(10):e110950. doi: 10.1371/journal.pone.0110950. eCollection 2014.


Rosiglitazone causes cardiotoxicity via peroxisome proliferator-activated receptor γ-independent mitochondrial oxidative stress in mouse hearts.

He H, Tao H, Xiong H, Duan SZ, McGowan FX Jr, Mortensen RM, Balschi JA.

Toxicol Sci. 2014 Apr;138(2):468-81. doi: 10.1093/toxsci/kfu015. Epub 2014 Jan 21.


Myeloid mineralocorticoid receptor during experimental ischemic stroke: effects of model and sex.

Frieler RA, Ray JJ, Meng H, Ramnarayanan SP, Usher MG, Su EJ, Berger S, Pinsky DJ, Lawrence DA, Wang MM, Mortensen RM.

J Am Heart Assoc. 2012 Oct;1(5):e002584. doi: 10.1161/JAHA.112.002584. Epub 2012 Oct 25.


Systemic PPARγ deletion impairs circadian rhythms of behavior and metabolism.

Yang G, Jia Z, Aoyagi T, McClain D, Mortensen RM, Yang T.

PLoS One. 2012;7(8):e38117. doi: 10.1371/journal.pone.0038117. Epub 2012 Aug 10.


Smooth muscle protein 22 alpha-Cre is expressed in myeloid cells in mice.

Shen Z, Li C, Frieler RA, Gerasimova AS, Lee SJ, Wu J, Wang MM, Lumeng CN, Brosius FC 3rd, Duan SZ, Mortensen RM.

Biochem Biophys Res Commun. 2012 Jun 15;422(4):639-42. doi: 10.1016/j.bbrc.2012.05.041. Epub 2012 May 16.


Effects of PPARs agonists on cardiac metabolism in littermate and cardiomyocyte-specific PPAR-γ-knockout (CM-PGKO) mice.

Barbieri M, Di Filippo C, Esposito A, Marfella R, Rizzo MR, D'Amico M, Ferraraccio F, Di Ronza C, Duan SZ, Mortensen RM, Rossi F, Paolisso G.

PLoS One. 2012;7(4):e35999. doi: 10.1371/journal.pone.0035999. Epub 2012 Apr 26.


Immune cell modulation of cardiac remodeling.

Mortensen RM.

Circulation. 2012 Apr 3;125(13):1597-600. doi: 10.1161/CIRCULATIONAHA.112.097832. Epub 2012 Mar 2. No abstract available.


Nuclear receptor control of opposing macrophage phenotypes in cardiovascular disease.

Frieler RA, Ramnarayanan S, Mortensen RM.

Front Biosci (Landmark Ed). 2012 Jan 1;17:1917-30. Review.


μ-Opioid receptor coupling to Gα(o) plays an important role in opioid antinociception.

Lamberts JT, Jutkiewicz EM, Mortensen RM, Traynor JR.

Neuropsychopharmacology. 2011 Sep;36(10):2041-53. doi: 10.1038/npp.2011.91. Epub 2011 Jun 8.


Myeloid-specific deletion of the mineralocorticoid receptor reduces infarct volume and alters inflammation during cerebral ischemia.

Frieler RA, Meng H, Duan SZ, Berger S, Schütz G, He Y, Xi G, Wang MM, Mortensen RM.

Stroke. 2011 Jan;42(1):179-85. doi: 10.1161/STROKEAHA.110.598441. Epub 2010 Nov 24.


Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice.

Usher MG, Duan SZ, Ivaschenko CY, Frieler RA, Berger S, Schütz G, Lumeng CN, Mortensen RM.

J Clin Invest. 2010 Sep;120(9):3350-64. doi: 10.1172/JCI41080. Epub 2010 Aug 9.


RGS inhibition at G(alpha)i2 selectively potentiates 5-HT1A-mediated antidepressant effects.

Talbot JN, Jutkiewicz EM, Graves SM, Clemans CF, Nicol MR, Mortensen RM, Huang X, Neubig RR, Traynor JR.

Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11086-91. doi: 10.1073/pnas.1000003107. Epub 2010 Jun 2.


Sex dimorphic actions of rosiglitazone in generalised peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-deficient mice.

Duan SZ, Usher MG, Foley EL 4th, Milstone DS, Brosius FC 3rd, Mortensen RM.

Diabetologia. 2010 Jul;53(7):1493-505. doi: 10.1007/s00125-010-1748-2. Epub 2010 Apr 17. Erratum in: Diabetologia. 2012 Jan;55(1):270-1.


PPARs: the vasculature, inflammation and hypertension.

Duan SZ, Usher MG, Mortensen RM.

Curr Opin Nephrol Hypertens. 2009 Mar;18(2):128-33. doi: 10.1097/MNH.0b013e328325803b. Review.


Selection of transfected mammalian cells.

Mortensen RM, Kingston RE.

Curr Protoc Mol Biol. 2009 Apr;Chapter 9:Unit9.5. doi: 10.1002/0471142727.mb0905s86.


In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor gamma response element in the mouse pdx-1 promoter.

Gupta D, Jetton TL, Mortensen RM, Duan SZ, Peshavaria M, Leahy JL.

J Biol Chem. 2008 Nov 21;283(47):32462-70. doi: 10.1074/jbc.M801813200. Epub 2008 Aug 21.


PPAR-gamma in the Cardiovascular System.

Duan SZ, Ivashchenko CY, Usher MG, Mortensen RM.

PPAR Res. 2008;2008:745804. doi: 10.1155/2008/745804.


Peroxisome proliferator-activated receptor-gamma-mediated effects in the vasculature.

Duan SZ, Usher MG, Mortensen RM.

Circ Res. 2008 Feb 15;102(3):283-94. doi: 10.1161/CIRCRESAHA.107.164384. Review.


G(o) controls the hyperpolarization-activated current in embryonic stem cell-derived cardiocytes.

Ye CP, Duan SZ, Milstone DS, Mortensen RM.

Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H979-85. Epub 2007 Dec 21.


Direct monitoring pressure overload predicts cardiac hypertrophy in mice.

Duan SZ, Ivashchenko CY, Whitesall SE, D'Alecy LG, Mortensen RM.

Physiol Meas. 2007 Nov;28(11):1329-39. Epub 2007 Oct 5.


PPAR-gamma knockout in pancreatic epithelial cells abolishes the inhibitory effect of rosiglitazone on caerulein-induced acute pancreatitis.

Ivashchenko CY, Duan SZ, Usher MG, Mortensen RM.

Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G319-26. Epub 2007 Apr 26.


Go but not Gi2 or Gi3 is required for muscarinic regulation of heart rate and heart rate variability in mice.

Duan SZ, Christe M, Milstone DS, Mortensen RM.

Biochem Biophys Res Commun. 2007 May 25;357(1):139-43. Epub 2007 Mar 30.


Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality.

Duan SZ, Ivashchenko CY, Whitesall SE, D'Alecy LG, Duquaine DC, Brosius FC 3rd, Gonzalez FJ, Vinson C, Pierre MA, Milstone DS, Mortensen RM.

J Clin Invest. 2007 Mar;117(3):812-22. Epub 2007 Feb 15.


Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects.

Fu Y, Huang X, Zhong H, Mortensen RM, D'Alecy LG, Neubig RR.

Circ Res. 2006 Mar 17;98(5):659-66. Epub 2006 Feb 2.


Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice.

Duan SZ, Ivashchenko CY, Russell MW, Milstone DS, Mortensen RM.

Circ Res. 2005 Aug 19;97(4):372-9. Epub 2005 Jul 28.


RGS-insensitive G-protein mutations to study the role of endogenous RGS proteins.

Fu Y, Zhong H, Nanamori M, Mortensen RM, Huang X, Lan K, Neubig RR.

Methods Enzymol. 2004;389:229-43. Review.


Genetic determinants of nonmodulating hypertension.

Kosachunhanun N, Hunt SC, Hopkins PN, Williams RR, Jeunemaitre X, Corvol P, Ferri C, Mortensen RM, Hollenberg NK, Williams GH.

Hypertension. 2003 Nov;42(5):901-8. Epub 2003 Oct 6.


Human pancreatic acinar cells do not respond to cholecystokinin.

Ji B, Bi Y, Simeone D, Mortensen RM, Logsdon CD.

Pharmacol Toxicol. 2002 Dec;91(6):327-32. Review.


Identification of P2Y12-dependent and -independent mechanisms of glycoprotein VI-mediated Rap1 activation in platelets.

Larson MK, Chen H, Kahn ML, Taylor AM, Fabre JE, Mortensen RM, Conley PB, Parise LV.

Blood. 2003 Feb 15;101(4):1409-15. Epub 2002 Oct 17.


Cardiac-specific overexpression of GLUT1 prevents the development of heart failure attributable to pressure overload in mice.

Liao R, Jain M, Cui L, D'Agostino J, Aiello F, Luptak I, Ngoy S, Mortensen RM, Tian R.

Circulation. 2002 Oct 15;106(16):2125-31.


PPARgamma-dependent and PPARgamma-independent effects on the development of adipose cells from embryonic stem cells.

Vernochet C, Milstone DS, Iehlé C, Belmonte N, Phillips B, Wdziekonski B, Villageois P, Amri EZ, O'Donnell PE, Mortensen RM, Ailhaud G, Dani C.

FEBS Lett. 2002 Jan 2;510(1-2):94-8.


Human pancreatic acinar cells lack functional responses to cholecystokinin and gastrin.

Ji B, Bi Y, Simeone D, Mortensen RM, Logsdon CD.

Gastroenterology. 2001 Dec;121(6):1380-90.


Angiotensinogen genotype and blood pressure response in the Dietary Approaches to Stop Hypertension (DASH) study.

Svetkey LP, Moore TJ, Simons-Morton DG, Appel LJ, Bray GA, Sacks FM, Ard JD, Mortensen RM, Mitchell SR, Conlin PR, Kesari M; DASH collaborative research group.

J Hypertens. 2001 Nov;19(11):1949-56.


Impaired activation of murine platelets lacking G alpha(i2).

Jantzen HM, Milstone DS, Gousset L, Conley PB, Mortensen RM.

J Clin Invest. 2001 Aug;108(3):477-83.


Targeted inactivation of Galpha(i) does not alter cardiac function or beta-adrenergic sensitivity.

Jain M, Lim CC, Nagata K, Davis VM, Milstone DS, Liao R, Mortensen RM.

Am J Physiol Heart Circ Physiol. 2001 Feb;280(2):H569-75.


The role of PPAR-gamma in macrophage differentiation and cholesterol uptake.

Moore KJ, Rosen ED, Fitzgerald ML, Randow F, Andersson LP, Altshuler D, Milstone DS, Mortensen RM, Spiegelman BM, Freeman MW.

Nat Med. 2001 Jan;7(1):41-7.


Galpha(i2) but not Galpha(i3) is required for muscarinic inhibition of contractility and calcium currents in adult cardiomyocytes.

Nagata K, Ye C, Jain M, Milstone DS, Liao R, Mortensen RM.

Circ Res. 2000 Nov 10;87(10):903-9.


E-selectin expression and stimulation by inflammatory mediators are developmentally regulated during embryogenesis.

Milstone DS, O'Donnell PE, Stavrakis G, Mortensen RM, Davis VM.

Lab Invest. 2000 Jun;80(6):943-54.


PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro.

Rosen ED, Sarraf P, Troy AE, Bradwin G, Moore K, Milstone DS, Spiegelman BM, Mortensen RM.

Mol Cell. 1999 Oct;4(4):611-7.


Enhanced bradykinin-stimulated phospholipase C activity in murine embryonic stem cells lacking the G-protein alphaq-subunit.

Ricupero DA, Polgar P, Taylor L, Sowell MO, Gao Y, Bradwin G, Mortensen RM.

Biochem J. 1997 Nov 1;327 ( Pt 3):803-9.

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