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Items: 49

1.

A Wars2 Mutant Mouse Model Displays OXPHOS Deficiencies and Activation of Tissue-Specific Stress Response Pathways.

Agnew T, Goldsworthy M, Aguilar C, Morgan A, Simon M, Hilton H, Esapa C, Wu Y, Cater H, Bentley L, Scudamore C, Poulton J, Morten KJ, Thompson K, He L, Brown SDM, Taylor RW, Bowl MR, Cox RD.

Cell Rep. 2018 Dec 18;25(12):3315-3328.e6. doi: 10.1016/j.celrep.2018.11.080.

2.

Validating the RedMIT/GFP-LC3 Mouse Model by Studying Mitophagy in Autosomal Dominant Optic Atrophy Due to the OPA1Q285STOP Mutation.

Diot A, Agnew T, Sanderson J, Liao C, Carver J, Neves RPD, Gupta R, Guo Y, Waters C, Seto S, Daniels MJ, Dombi E, Lodge T, Morten K, Williams SA, Enver T, Iborra FJ, Votruba M, Poulton J.

Front Cell Dev Biol. 2018 Sep 19;6:103. doi: 10.3389/fcell.2018.00103. eCollection 2018.

3.

A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy.

Xu J, Potter M, Tomas C, Elson JL, Morten KJ, Poulton J, Wang N, Jin H, Hou Z, Huang WE.

Analyst. 2018 Sep 12. doi: 10.1039/c8an01437j. [Epub ahead of print]

PMID:
30207334
4.

Mechanisms driving the lactate switch in Chinese hamster ovary cells.

Hartley F, Walker T, Chung V, Morten K.

Biotechnol Bioeng. 2018 Aug;115(8):1890-1903. doi: 10.1002/bit.26603. Epub 2018 Apr 10. Review.

PMID:
29603726
5.

Acute nutritional stress during pregnancy affects placental efficiency, fetal growth and adult glucose homeostasis.

Malik S, Diot A, Morten K, Dombi E, Vatish M, Boyd CAR, Poulton J.

Oncotarget. 2017 Nov 25;8(65):109478-109486. doi: 10.18632/oncotarget.22695. eCollection 2017 Dec 12.

6.

The isolation of primary hepatocytes from human tissue: optimising the use of small non-encapsulated liver resection surplus.

Green CJ, Charlton CA, Wang LM, Silva M, Morten KJ, Hodson L.

Cell Tissue Bank. 2017 Dec;18(4):597-604. doi: 10.1007/s10561-017-9641-6. Epub 2017 Jul 17.

7.

Correction: Is Placental Mitochondrial Function a Regulator that Matches Fetal and Placental Growth to Maternal Nutrient Intake in the Mouse?

Chiaratti MR, Malik S, Diot A, Rapa E, Macleod L, Morten K, Vatish M, Boyd R, Poulton J.

PLoS One. 2017 Feb 3;12(2):e0171795. doi: 10.1371/journal.pone.0171795. eCollection 2017.

8.

Dysregulated mitophagy and mitochondrial organization in optic atrophy due to OPA1 mutations.

Liao C, Ashley N, Diot A, Morten K, Phadwal K, Williams A, Fearnley I, Rosser L, Lowndes J, Fratter C, Ferguson DJ, Vay L, Quaghebeur G, Moroni I, Bianchi S, Lamperti C, Downes SM, Sitarz KS, Flannery PJ, Carver J, Dombi E, East D, Laura M, Reilly MM, Mortiboys H, Prevo R, Campanella M, Daniels MJ, Zeviani M, Yu-Wai-Man P, Simon AK, Votruba M, Poulton J.

Neurology. 2017 Jan 10;88(2):131-142. doi: 10.1212/WNL.0000000000003491. Epub 2016 Dec 14.

9.

The Warburg effect: 80 years on.

Potter M, Newport E, Morten KJ.

Biochem Soc Trans. 2016 Oct 15;44(5):1499-1505. Review.

10.

Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children.

Diot A, Dombi E, Lodge T, Liao C, Morten K, Carver J, Wells D, Child T, Johnston IG, Williams S, Poulton J.

Biochem Soc Trans. 2016 Aug 15;44(4):1091-100. doi: 10.1042/BST20160095.

11.

Mitophagy plays a central role in mitochondrial ageing.

Diot A, Morten K, Poulton J.

Mamm Genome. 2016 Aug;27(7-8):381-95. doi: 10.1007/s00335-016-9651-x. Epub 2016 Jun 28. Review.

12.

The m.13051G>A mitochondrial DNA mutation results in variable neurology and activated mitophagy.

Dombi E, Diot A, Morten K, Carver J, Lodge T, Fratter C, Ng YS, Liao C, Muir R, Blakely EL, Hargreaves I, Al-Dosary M, Sarkar G, Hickman SJ, Downes SM, Jayawant S, Yu-Wai-Man P, Taylor RW, Poulton J.

Neurology. 2016 May 17;86(20):1921-3. doi: 10.1212/WNL.0000000000002688. Epub 2016 Apr 22. No abstract available.

13.

Monitoring Intracellular Oxygen Concentration: Implications for Hypoxia Studies and Real-Time Oxygen Monitoring.

Potter M, Badder L, Hoade Y, Johnston IG, Morten KJ.

Adv Exp Med Biol. 2016;876:257-263. doi: 10.1007/978-1-4939-3023-4_32.

PMID:
26782220
14.

Using an Integrated -Omics Approach to Identify Key Cellular Processes That Are Disturbed in the Kidney After Brain Death.

Akhtar MZ, Huang H, Kaisar M, Lo Faro ML, Rebolledo R, Morten K, Heather LC, Dona A, Leuvenink HG, Fuggle SV, Kessler BM, Pugh CW, Ploeg RJ.

Am J Transplant. 2016 May;16(5):1421-40. doi: 10.1111/ajt.13626. Epub 2016 Mar 10.

15.

A novel quantitative assay of mitophagy: Combining high content fluorescence microscopy and mitochondrial DNA load to quantify mitophagy and identify novel pharmacological tools against pathogenic heteroplasmic mtDNA.

Diot A, Hinks-Roberts A, Lodge T, Liao C, Dombi E, Morten K, Brady S, Fratter C, Carver J, Muir R, Davis R, Green CJ, Johnston I, Hilton-Jones D, Sue C, Mortiboys H, Poulton J.

Pharmacol Res. 2015 Oct;100:24-35. doi: 10.1016/j.phrs.2015.07.014. Epub 2015 Jul 18.

PMID:
26196248
16.

Is Placental Mitochondrial Function a Regulator that Matches Fetal and Placental Growth to Maternal Nutrient Intake in the Mouse?

Chiaratti MR, Malik S, Diot A, Rapa E, Macleod L, Morten K, Vatish M, Boyd R, Poulton J.

PLoS One. 2015 Jul 1;10(7):e0130631. doi: 10.1371/journal.pone.0130631. eCollection 2015. Erratum in: PLoS One. 2017 Feb 3;12 (2):e0171795.

17.

Characterization of lipid metabolism in a novel immortalized human hepatocyte cell line.

Green CJ, Johnson D, Amin HD, Sivathondan P, Silva MA, Wang LM, Stevanato L, McNeil CA, Miljan EA, Sinden JD, Morten KJ, Hodson L.

Am J Physiol Endocrinol Metab. 2015 Sep 15;309(6):E511-22. doi: 10.1152/ajpendo.00594.2014. Epub 2015 Jun 30.

18.

Sodium valproate induces mitochondrial respiration dysfunction in HepG2 in vitro cell model.

Komulainen T, Lodge T, Hinttala R, Bolszak M, Pietilä M, Koivunen P, Hakkola J, Poulton J, Morten KJ, Uusimaa J.

Toxicology. 2015 May 4;331:47-56. doi: 10.1016/j.tox.2015.03.001. Epub 2015 Mar 5.

PMID:
25745980
19.

Oxygen-sensing scaffolds for 3-dimensional cell and tissue culture.

Jenkins J, Dmitriev RI, Morten K, McDermott KW, Papkovsky DB.

Acta Biomater. 2015 Apr;16:126-35. doi: 10.1016/j.actbio.2015.01.032. Epub 2015 Jan 31.

PMID:
25653216
20.

From whole body to cellular models of hepatic triglyceride metabolism: man has got to know his limitations.

Green CJ, Pramfalk C, Morten KJ, Hodson L.

Am J Physiol Endocrinol Metab. 2015 Jan 1;308(1):E1-20. doi: 10.1152/ajpendo.00192.2014. Epub 2014 Oct 28. Review.

21.
22.

The over-expression of cell migratory genes in alveolar rhabdomyosarcoma could contribute to metastatic spread.

Rapa E, Hill SK, Morten KJ, Potter M, Mitchell C.

Clin Exp Metastasis. 2012 Jun;29(5):419-29. doi: 10.1007/s10585-012-9460-x. Epub 2012 Mar 14.

PMID:
22415709
23.

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo.

Mortensen M, Ferguson DJ, Edelmann M, Kessler B, Morten KJ, Komatsu M, Simon AK.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):832-7. doi: 10.1073/pnas.0913170107. Epub 2009 Dec 22.

24.

Critical role of complex III in the early metabolic changes following myocardial infarction.

Heather LC, Carr CA, Stuckey DJ, Pope S, Morten KJ, Carter EE, Edwards LM, Clarke K.

Cardiovasc Res. 2010 Jan 1;85(1):127-36. doi: 10.1093/cvr/cvp276.

PMID:
19666902
25.

Liver mtDNA content increases during development: a comparison of methods and the importance of age- and tissue-specific controls for the diagnosis of mtDNA depletion.

Morten KJ, Ashley N, Wijburg F, Hadzic N, Parr J, Jayawant S, Adams S, Bindoff L, Bakker HD, Mieli-Vergani G, Zeviani M, Poulton J.

Mitochondrion. 2007 Dec;7(6):386-95. Epub 2007 Sep 21.

PMID:
17981517
26.

Mitochondrial oxidative stress causes hyperphosphorylation of tau.

Melov S, Adlard PA, Morten K, Johnson F, Golden TR, Hinerfeld D, Schilling B, Mavros C, Masters CL, Volitakis I, Li QX, Laughton K, Hubbard A, Cherny RA, Gibson B, Bush AI.

PLoS One. 2007 Jun 20;2(6):e536.

27.

Mitochondrial reactive oxygen species in mice lacking superoxide dismutase 2: attenuation via antioxidant treatment.

Morten KJ, Ackrell BA, Melov S.

J Biol Chem. 2006 Feb 10;281(6):3354-9. Epub 2005 Dec 2.

28.
29.

Fetal and neonatal exposure to AZT and low-protein diet affects glucose homeostasis: a model with implications for AIDS prevention.

Morten K, Field P, Ashley N, Williams KA, Harris D, Hartley M, Clark A, Poulton J.

Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E1115-8. Epub 2005 Jul 12.

30.

Pharmacogenomic profiling of an oxidative stress-mediated spongiform encephalopathy.

Golden TR, Hubbard A, Morten KJ, Hinerfeld D, Melov S.

Free Radic Biol Med. 2005 Jul 15;39(2):152-63. Epub 2005 Mar 30.

PMID:
15964507
31.

Mapping of autosomal dominant progressive external ophthalmoplegia to a 7-cM critical region on 10q24.

Li FY, Tariq M, Croxen R, Morten K, Squier W, Newsom-Davis J, Beeson D, Larsson C.

Neurology. 1999 Oct 12;53(6):1265-71.

PMID:
10522883
32.

Dichloroacetate stabilizes the mutant E1alpha subunit in pyruvate dehydrogenase deficiency.

Morten KJ, Beattie P, Brown GK, Matthews PM.

Neurology. 1999 Aug 11;53(3):612-6.

PMID:
10449128
33.

Stabilization of the pyruvate dehydrogenase E1alpha subunit by dichloroacetate.

Morten KJ, Caky M, Matthews PM.

Neurology. 1998 Nov;51(5):1331-5.

PMID:
9818855
34.

Mechanisms of expression of pyruvate dehydrogenase deficiency caused by an E1alpha subunit mutation.

Morten KJ, Caky M, Matthews PM.

Neurology. 1998 Nov;51(5):1324-30.

PMID:
9818854
35.

Diagnosis of mitochondrial disorders using the PCR.

Morten KJ.

Methods Mol Med. 1998;16:171-87. doi: 10.1385/0-89603-499-2:171.

PMID:
21390785
36.
37.

Functional mtDNA replication defect in a fibroblast line from a patient with mtDNA depletion.

Morten KJ, Freeman Emmerson C, Poulton J.

J Inherit Metab Dis. 1996;19(2):123-6. No abstract available.

PMID:
8739945
38.

Multiple independent occurrence of the 3243 mutation in mitochondrial tRNA(leuUUR) in patients with the MELAS phenotype.

Morten KJ, Poulton J, Sykes B.

Hum Mol Genet. 1995 Sep;4(9):1689-91. No abstract available.

PMID:
8541865
39.
40.

Mitochondrial DNA, diabetes and pancreatic pathology in Kearns-Sayre syndrome.

Poulton J, O'Rahilly S, Morten KJ, Clark A.

Diabetologia. 1995 Jul;38(7):868-71.

PMID:
7556992
41.

Variation in mitochondrial DNA levels in muscle from normal controls. Is depletion of mtDNA in patients with mitochondrial myopathy a distinct clinical syndrome.

Poulton J, Sewry C, Potter CG, Bougeron T, Chretien D, Wijburg FA, Morten KJ, Brown G.

J Inherit Metab Dis. 1995;18(1):4-20.

PMID:
7623440
42.

Duplications of mitochondrial DNA in Kearns-Sayre syndrome.

Poulton J, Morten KJ, Marchington D, Weber K, Brown GK, Rötig A, Bindoff L.

Muscle Nerve Suppl. 1995;3:S154-8.

PMID:
7603518
43.

Leber's hereditary optic neuropathy: implications of the sex ratio for linkage studies in families with the 3460 ND1 mutation.

Black GC, Craig IW, Oostra RJ, Norby S, Rosenberg T, Morten K, Laborde A, Poulton J.

Eye (Lond). 1995;9 ( Pt 4):513-6.

PMID:
7498577
44.

Deficiency of the human mitochondrial transcription factor h-mtTFA in infantile mitochondrial myopathy is associated with mtDNA depletion.

Poulton J, Morten K, Freeman-Emmerson C, Potter C, Sewry C, Dubowitz V, Kidd H, Stephenson J, Whitehouse W, Hansen FJ, et al.

Hum Mol Genet. 1994 Oct;3(10):1763-9.

PMID:
7849699
45.

Are duplications of mitochondrial DNA characteristic of Kearns-Sayre syndrome?

Poulton J, Morten KJ, Weber K, Brown GK, Bindoff L.

Hum Mol Genet. 1994 Jun;3(6):947-51.

PMID:
7951243
46.

A new point mutation associated with mitochondrial encephalomyopathy.

Morten KJ, Cooper JM, Brown GK, Lake BD, Pike D, Poulton J.

Hum Mol Genet. 1993 Dec;2(12):2081-7.

PMID:
8111377
47.

Abnormal RNA processing associated with a novel tRNA mutation in mitochondrial DNA. A potential disease mechanism.

Bindoff LA, Howell N, Poulton J, McCullough DA, Morten KJ, Lightowlers RN, Turnbull DM, Weber K.

J Biol Chem. 1993 Sep 15;268(26):19559-64.

48.

Noninvasive diagnosis of the MELAS syndrome from blood DNA.

Poulton J, Morten K.

Ann Neurol. 1993 Jul;34(1):116. No abstract available.

PMID:
8517674
49.

Families of mtDNA re-arrangements can be detected in patients with mtDNA deletions: duplications may be a transient intermediate form.

Poulton J, Deadman ME, Bindoff L, Morten K, Land J, Brown G.

Hum Mol Genet. 1993 Jan;2(1):23-30.

PMID:
8490619

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