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TAFI deficiency causes maladaptive vascular remodeling after hemophilic joint bleeding.

Wyseure T, Yang T, Zhou JY, Cooke EJ, Wanko B, Olmer M, Agashe R, Morodomi Y, Behrendt N, Lotz M, Morser J, von Drygalski A, Mosnier LO.

JCI Insight. 2019 Oct 3;4(19). pii: 128379. doi: 10.1172/jci.insight.128379.


Antibody-mediated targeting of cleavage-specific OPN-T cell interactions.

Wanko B, Tardelli M, Jürets A, Neuhofer A, Prager G, Morser J, Leung LL, Staffler G, Zeyda M, Stulnig TM.

PLoS One. 2019 Apr 5;14(4):e0214938. doi: 10.1371/journal.pone.0214938. eCollection 2019.


Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis.

Islam I, Yuan S, West CW, Adler M, Bothe U, Bryant J, Chang Z, Chu K, Emayan K, Gualtieri G, Ho E, Light D, Mallari C, Morser J, Phillips G, Schaefer C, Sukovich D, Whitlow M, Chen D, Buckman BO.

Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375. doi: 10.1016/j.bmcl.2018.09.001. Epub 2018 Sep 5.


Dynamic and tissue-specific proteolytic processing of chemerin in obese mice.

Zhao L, Yamaguchi Y, Shen WJ, Morser J, Leung LLK.

PLoS One. 2018 Aug 30;13(8):e0202780. doi: 10.1371/journal.pone.0202780. eCollection 2018.


Chemerin 156F, generated by chymase cleavage of prochemerin, is elevated in joint fluids of arthritis patients.

Zhao L, Yamaguchi Y, Ge X, Robinson WH, Morser J, Leung LLK.

Arthritis Res Ther. 2018 Jul 4;20(1):132. doi: 10.1186/s13075-018-1615-y.


Carboxypeptidase B2 and carboxypeptidase N in the crosstalk between coagulation, thrombosis, inflammation, and innate immunity.

Leung LLK, Morser J.

J Thromb Haemost. 2018 Jun 8. doi: 10.1111/jth.14199. [Epub ahead of print] Review.


Carboxypeptidase B2 and N play different roles in regulation of activated complements C3a and C5a in mice.

Morser J, Shao Z, Nishimura T, Zhou Q, Zhao L, Higgins J, Leung LLK.

J Thromb Haemost. 2018 May;16(5):991-1002. doi: 10.1111/jth.13964. Epub 2018 Apr 6.


Anti-apoptotic activity of human matrix metalloproteinase-2 attenuates diabetes mellitus.

Nishihama K, Yasuma T, Yano Y, D' Alessandro-Gabazza CN, Toda M, Hinneh JA, Baffour Tonto P, Takeshita A, Totoki T, Mifuji-Moroka R, Kobayashi T, Iwasa M, Takei Y, Morser J, Cann I, Gabazza EC.

Metabolism. 2018 May;82:88-99. doi: 10.1016/j.metabol.2018.01.016. Epub 2018 Jan 31.


Prochemerin cleavage by factor XIa links coagulation and inflammation.

Ge X, Yamaguchi Y, Zhao L, Bury L, Gresele P, Berube C, Leung LL, Morser J.

Blood. 2018 Jan 18;131(3):353-364. doi: 10.1182/blood-2017-07-792580. Epub 2017 Nov 20.


Activated TAFI Promotes the Development of Chronic Thromboembolic Pulmonary Hypertension: A Possible Novel Therapeutic Target.

Satoh T, Satoh K, Yaoita N, Kikuchi N, Omura J, Kurosawa R, Numano K, Al-Mamun E, Siddique MA, Sunamura S, Nogi M, Suzuki K, Miyata S, Morser J, Shimokawa H.

Circ Res. 2017 Apr 14;120(8):1246-1262. doi: 10.1161/CIRCRESAHA.117.310640. Epub 2017 Mar 13.


Erratum. Amelioration of Diabetes by Protein S. Diabetes 2016;65:1940-1951.

Yasuma T, Yano Y, D'Alessandro-Gabazza CN, Toda M, Gil-Bernabe P, Kobayashi T, Nishihama K, Hinneh JA, Mifuji-Moroka R, Roeen Z, Morser J, Cann I, Motoh I, Takei Y, Gabazza EC.

Diabetes. 2016 Dec;65(12):3812. Epub 2016 Nov 1. No abstract available.


Chemerin activation in human obesity.

Chang SS, Eisenberg D, Zhao L, Adams C, Leib R, Morser J, Leung L.

Obesity (Silver Spring). 2016 Jul;24(7):1522-9. doi: 10.1002/oby.21534. Epub 2016 May 25.


Patterns of expression of factor VIII and von Willebrand factor by endothelial cell subsets in vivo.

Pan J, Dinh TT, Rajaraman A, Lee M, Scholz A, Czupalla CJ, Kiefel H, Zhu L, Xia L, Morser J, Jiang H, Santambrogio L, Butcher EC.

Blood. 2016 Jul 7;128(1):104-9. doi: 10.1182/blood-2015-12-684688. Epub 2016 May 12.


Amelioration of Diabetes by Protein S.

Yasuma T, Yano Y, D'Alessandro-Gabazza CN, Toda M, Gil-Bernabe P, Kobayashi T, Nishihama K, Hinneh JA, Mifuji-Moroka R, Roeen Z, Morser J, Cann I, Motoh I, Takei Y, Gabazza EC.

Diabetes. 2016 Jul;65(7):1940-51. doi: 10.2337/db15-1404. Epub 2016 May 9. Erratum in: Diabetes. 2016 Nov 1;:.


Plasmin as a complement C5 convertase.

Leung LL, Morser J.

EBioMedicine. 2016 Mar 11;5:20-1. doi: 10.1016/j.ebiom.2016.03.015. eCollection 2016 Mar. No abstract available.


Evaluation of and recommendation for the nomenclature of the CPB2 gene product (also known as TAFI and proCPU): communication from the SSC of the ISTH.

Foley JH, Kim PY, Hendriks D, Morser J, Gils A, Mutch NJ; Subcommittee on Fibrinolysis.

J Thromb Haemost. 2015 Dec;13(12):2277-8. doi: 10.1111/jth.13168. Epub 2015 Nov 24. No abstract available.


Carboxypeptidase B2 deficiency reveals opposite effects of complement C3a and C5a in a murine polymicrobial sepsis model.

Shao Z, Nishimura T, Leung LL, Morser J.

J Thromb Haemost. 2015 Jun;13(6):1090-102. doi: 10.1111/jth.12956. Epub 2015 May 10.


Thrombomodulin modulates dendritic cells via both antagonism of high mobility group protein B1 and an independent mechanism.

Toda M, D'Alessandro-Gabazza CN, Takagi T, Chelakkot-Govindalayathila AL, Taguchi O, Roeen Z, Munesue S, Yamamoto Y, Yamamoto H, Gabazza EC, Morser J.

Allergol Int. 2014 Mar;63(1):57-66. doi: 10.2332/allergolint.13-OA-0595. Epub 2013 Dec 25.


Differential gene expression in thrombomodulin (TM; CD141)(+) and TM(-) dendritic cell subsets.

Toda M, Shao Z, Yamaguchi KD, Takagi T, D'Alessandro-Gabazza CN, Taguchi O, Salamon H, Leung LL, Gabazza EC, Morser J.

PLoS One. 2013 Aug 23;8(8):e72392. doi: 10.1371/journal.pone.0072392. eCollection 2013.


Dose-dependent differential effects of thrombin in allergic bronchial asthma.

Miyake Y, D'Alessandro-Gabazza CN, Takagi T, Naito M, Hataji O, Nakahara H, Yuda H, Fujimoto H, Kobayashi H, Yasuma T, Toda M, Kobayashi T, Yano Y, Morser J, Taguchi O, Gabazza EC.

J Thromb Haemost. 2013 Oct;11(10):1903-15. doi: 10.1111/jth.12392.


Thrombin-activatable fibrinolysis inhibitor protects against acute lung injury by inhibiting the complement system.

Naito M, Taguchi O, Kobayashi T, Takagi T, D'Alessandro-Gabazza CN, Matsushima Y, Boveda-Ruiz D, Gil-Bernabe P, Matsumoto T, Chelakkot-Govindalayathil AL, Toda M, Yasukawa A, Hataji O, Morser J, Takei Y, Gabazza EC.

Am J Respir Cell Mol Biol. 2013 Oct;49(4):646-53. doi: 10.1165/rcmb.2012-0454OC.


Targeting complement component 5a promotes vascular integrity and limits airway remodeling.

Khan MA, Maasch C, Vater A, Klussmann S, Morser J, Leung LL, Atkinson C, Tomlinson S, Heeger PS, Nicolls MR.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6061-6. doi: 10.1073/pnas.1217991110. Epub 2013 Mar 25.


Microfluidic impedance cytometer for platelet analysis.

Evander M, Ricco AJ, Morser J, Kovacs GT, Leung LL, Giovangrandi L.

Lab Chip. 2013 Feb 21;13(4):722-9. doi: 10.1039/c2lc40896a.


Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage.

Yamaguchi Y, Shao Z, Sharif S, Du XY, Myles T, Merchant M, Harsh G, Glantz M, Recht L, Morser J, Leung LL.

J Biol Chem. 2013 Feb 1;288(5):3097-111. doi: 10.1074/jbc.M112.362954. Epub 2012 Nov 30.


Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) levels are decreased in patients with trauma-induced coagulopathy.

Lustenberger T, Relja B, Puttkammer B, Gabazza EC, Geiger E, Takei Y, Morser J, Marzi I.

Thromb Res. 2013 Jan;131(1):e26-30. doi: 10.1016/j.thromres.2012.11.005. Epub 2012 Nov 20.


Efficacy of a novel class of RNA interference therapeutic agents.

Hamasaki T, Suzuki H, Shirohzu H, Matsumoto T, D'Alessandro-Gabazza CN, Gil-Bernabe P, Boveda-Ruiz D, Naito M, Kobayashi T, Toda M, Mizutani T, Taguchi O, Morser J, Eguchi Y, Kuroda M, Ochiya T, Hayashi H, Gabazza EC, Ohgi T.

PLoS One. 2012;7(8):e42655. doi: 10.1371/journal.pone.0042655. Epub 2012 Aug 15.


Thrombin-activatable fibrinolysis inhibitor (TAFI) is enhanced in major trauma patients without infectious complications.

Relja B, Lustenberger T, Puttkammer B, Jakob H, Morser J, Gabazza EC, Takei Y, Marzi I.

Immunobiology. 2013 Apr;218(4):470-6. doi: 10.1016/j.imbio.2012.06.002. Epub 2012 Jun 9.


Differential role of regulatory T cells in early and late stages of pulmonary fibrosis.

Boveda-Ruiz D, D'Alessandro-Gabazza CN, Toda M, Takagi T, Naito M, Matsushima Y, Matsumoto T, Kobayashi T, Gil-Bernabe P, Chelakkot-Govindalayathil AL, Miyake Y, Yasukawa A, Morser J, Taguchi O, Gabazza EC.

Immunobiology. 2013 Feb;218(2):245-54. doi: 10.1016/j.imbio.2012.05.020. Epub 2012 May 23.


Exogenous activated protein C inhibits the progression of diabetic nephropathy.

Gil-Bernabe P, D'Alessandro-Gabazza CN, Toda M, Boveda Ruiz D, Miyake Y, Suzuki T, Onishi Y, Morser J, Gabazza EC, Takei Y, Yano Y.

J Thromb Haemost. 2012 Mar;10(3):337-46. doi: 10.1111/j.1538-7836.2012.04621.x.


Thrombomodulin links coagulation to inflammation and immunity.

Morser J.

Curr Drug Targets. 2012 Mar;13(3):421-31. Review.


Role of thrombin-activatable fibrinolysis inhibitor in allergic bronchial asthma.

Fujiwara A, Taguchi O, Takagi T, D'Alessandro-Gabazza CN, Boveda-Ruiz D, Toda M, Yasukawa A, Matsushima Y, Miyake Y, Kobayashi H, Kobayashi T, Gil-Bernabe P, Naito M, Yoshida M, Morser J, Takei Y, Gabazza EC.

Lung. 2012 Apr;190(2):189-98. doi: 10.1007/s00408-011-9337-9. Epub 2011 Oct 25.


Development and preclinical efficacy of novel transforming growth factor-β1 short interfering RNAs for pulmonary fibrosis.

D'Alessandro-Gabazza CN, Kobayashi T, Boveda-Ruiz D, Takagi T, Toda M, Gil-Bernabe P, Miyake Y, Yasukawa A, Matsuda Y, Suzuki N, Saito H, Yano Y, Fukuda A, Hasegawa T, Toyobuku H, Rennard SI, Wagner PD, Morser J, Takei Y, Taguchi O, Gabazza EC.

Am J Respir Cell Mol Biol. 2012 Mar;46(3):397-406. doi: 10.1165/rcmb.2011-0158OC. Epub 2011 Oct 27.


Proteolytic cleavage of chemerin protein is necessary for activation to the active form, Chem157S, which functions as a signaling molecule in glioblastoma.

Yamaguchi Y, Du XY, Zhao L, Morser J, Leung LL.

J Biol Chem. 2011 Nov 11;286(45):39510-9. doi: 10.1074/jbc.M111.258921. Epub 2011 Sep 23.


Chemerin158K protein is the dominant chemerin isoform in synovial and cerebrospinal fluids but not in plasma.

Zhao L, Yamaguchi Y, Sharif S, Du XY, Song JJ, Lee DM, Recht LD, Robinson WH, Morser J, Leung LL.

J Biol Chem. 2011 Nov 11;286(45):39520-7. doi: 10.1074/jbc.M111.258954. Epub 2011 Sep 19.


Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis.

Song JJ, Hwang I, Cho KH, Garcia MA, Kim AJ, Wang TH, Lindstrom TM, Lee AT, Nishimura T, Zhao L, Morser J, Nesheim M, Goodman SB, Lee DM, Bridges SL Jr; Consortium for the Longitudinal Evaluation of African Americans with Early Rheumatoid Arthritis (CLEAR) Registry, Gregersen PK, Leung LL, Robinson WH.

J Clin Invest. 2011 Sep;121(9):3517-27. doi: 10.1172/JCI46387. Epub 2011 Aug 1.


Atherosclerosis amelioration by moderate alcohol consumption is associated with increased circulating levels of stromal cell-derived factor-1.

Gil-Bernabe P, Boveda-Ruiz D, D'Alessandro-Gabazza C, Toda M, Miyake Y, Mifuji-Moroka R, Iwasa M, Morser J, Gabazza EC, Takei Y.

Circ J. 2011;75(9):2269-79. Epub 2011 Jul 14.


High incidence of tumors in diabetic thrombin activatable fibrinolysis inhibitor and apolipoprotein E double-deficient mice.

Beppu T, Gil-Bernabe P, Boveda-Ruiz D, D'Alessandro-Gabazza C, Matsuda Y, Toda M, Miyake Y, Shiraki K, Murata M, Murata T, Yano Y, Morser J, Gabazza EC, Takei Y.

J Thromb Haemost. 2010 Nov;8(11):2514-22. doi: 10.1111/j.1538-7836.2010.04023.x.


Inhibition of allergic bronchial asthma by thrombomodulin is mediated by dendritic cells.

Takagi T, Taguchi O, Toda M, Ruiz DB, Bernabe PG, D'Alessandro-Gabazza CN, Miyake Y, Kobayashi T, Aoki S, Chiba F, Yano Y, Conway EM, Munesue S, Yamamoto Y, Yamamoto H, Suzuki K, Takei Y, Morser J, Gabazza EC.

Am J Respir Crit Care Med. 2011 Jan 1;183(1):31-42. doi: 10.1164/rccm.201001-0107OC. Epub 2010 Aug 13.


Hyperglycemia modulates plasminogen activator inhibitor-1 expression and aortic diameter in experimental aortic aneurysm disease.

Dua MM, Miyama N, Azuma J, Schultz GM, Sho M, Morser J, Dalman RL.

Surgery. 2010 Aug;148(2):429-35. doi: 10.1016/j.surg.2010.05.014. Epub 2010 Jun 19.


Enhanced abdominal aortic aneurysm formation in thrombin-activatable procarboxypeptidase B-deficient mice.

Schultz G, Tedesco MM, Sho E, Nishimura T, Sharif S, Du X, Myles T, Morser J, Dalman RL, Leung LL.

Arterioscler Thromb Vasc Biol. 2010 Jul;30(7):1363-70. doi: 10.1161/ATVBAHA.109.202259. Epub 2010 Apr 29. Erratum in: Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):e165.


Efficacy of 23-valent pneumococcal vaccine in preventing pneumonia and improving survival in nursing home residents: double blind, randomised and placebo controlled trial.

Maruyama T, Taguchi O, Niederman MS, Morser J, Kobayashi H, Kobayashi T, D'Alessandro-Gabazza C, Nakayama S, Nishikubo K, Noguchi T, Takei Y, Gabazza EC.

BMJ. 2010 Mar 8;340:c1004. doi: 10.1136/bmj.c1004.


What has been learnt from the thrombin-activatable fibrinolysis inhibitor-deficient mouse?

Morser J, Gabazza EC, Myles T, Leung LL.

J Thromb Haemost. 2010 May;8(5):868-76. doi: 10.1111/j.1538-7836.2010.03787.x. Epub 2010 Jan 30. Review.


Pulmonary hypertension is ameliorated in mice deficient in thrombin-activatable fibrinolysis inhibitor.

Qin L, D'Alessandro-Gabazza CN, Aoki S, Gil-Bernabe P, Yano Y, Takagi T, Boveda-Ruiz D, Ramirez Marmol AY, San Martin Montenegro VT, Toda M, Miyake Y, Taguchi O, Takei Y, Morser J, Gabazza EC.

J Thromb Haemost. 2010 Apr;8(4):808-16. doi: 10.1111/j.1538-7836.2010.03751.x. Epub 2010 Jan 17.


Community-acquired pneumonia and nursing home-acquired pneumonia in the very elderly patients.

Maruyama T, Gabazza EC, Morser J, Takagi T, D'Alessandro-Gabazza C, Hirohata S, Nakayama S, Ramirez AY, Fujiwara A, Naito M, Nishikubo K, Yuda H, Yoshida M, Takei Y, Taguchi O.

Respir Med. 2010 Apr;104(4):584-92. doi: 10.1016/j.rmed.2009.12.008. Epub 2010 Jan 8.


Direct effects of protein S in ameliorating acute lung injury.

Takagi T, Taguchi O, Aoki S, Toda M, Yamaguchi A, Fujimoto H, Boveda-Ruiz D, Gil-Bernabe P, Ramirez AY, Naito M, Yano Y, D'Alessandro-Gabazza CN, Fujiwara A, Takei Y, Morser J, Gabazza EC.

J Thromb Haemost. 2009 Dec;7(12):2053-63. doi: 10.1111/j.1538-7836.2009.03642.x. Epub 2009 Oct 8.


Thrombin-activatable carboxypeptidase B cleavage of osteopontin regulates neutrophil survival and synoviocyte binding in rheumatoid arthritis.

Sharif SA, Du X, Myles T, Song JJ, Price E, Lee DM, Goodman SB, Nagashima M, Morser J, Robinson WH, Leung LL.

Arthritis Rheum. 2009 Oct;60(10):2902-12. doi: 10.1002/art.24814.


Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury.

Scotton CJ, Krupiczojc MA, Königshoff M, Mercer PF, Lee YC, Kaminski N, Morser J, Post JM, Maher TM, Nicholson AG, Moffatt JD, Laurent GJ, Derian CK, Eickelberg O, Chambers RC.

J Clin Invest. 2009 Sep;119(9):2550-63. doi: 10.1172/JCI33288. Epub 2009 Aug 3.


The coagulation and protein C pathways in patients with sleep apnea.

Takagi T, Morser J, Gabazza EC, Qin L, Fujiwara A, Naito M, Yamaguchi A, Kobayashi T, D'Alessandro-Gabazza CN, Boveda Ruiz D, Gil Bernabe P, Iwasaki Y, Takei Y, Taguchi O.

Lung. 2009 Aug;187(4):209-13. doi: 10.1007/s00408-009-9152-8. Epub 2009 Jun 9.


A case of fulminant type 1 diabetes with coxsackie B4 virus infection diagnosed by elevated serum levels of neutralizing antibody.

Akatsuka H, Yano Y, Gabazza EC, Morser J, Sasaki R, Suzuki T, Fujiwara R, Katsuki A, Takei Y, Sumida Y.

Diabetes Res Clin Pract. 2009 Jun;84(3):e50-2. doi: 10.1016/j.diabres.2009.03.009. Epub 2009 Apr 10.


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