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Items: 1 to 50 of 416

1.

Transcription factors IRF8 and PU.1 are required for follicular B cell development and BCL6-driven germinal center responses.

Wang H, Jain S, Li P, Lin JX, Oh J, Qi C, Gao Y, Sun J, Sakai T, Naghashfar Z, Abbasi S, Kovalchuk AL, Bolland S, Nutt SL, Leonard WJ, Morse HC 3rd.

Proc Natl Acad Sci U S A. 2019 May 7;116(19):9511-9520. doi: 10.1073/pnas.1901258116. Epub 2019 Apr 18.

PMID:
31000603
2.

Epigenetic control of early dendritic cell lineage specification by the transcription factor IRF8 in mice.

Kurotaki D, Kawase W, Sasaki H, Nakabayashi J, Nishiyama A, Morse HC 3rd, Ozato K, Suzuki Y, Tamura T.

Blood. 2019 Apr 25;133(17):1803-1813. doi: 10.1182/blood-2018-06-857789. Epub 2019 Feb 22.

PMID:
30796024
3.

Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis.

Ibrahim ML, Klement JD, Lu C, Redd PS, Xiao W, Yang D, Browning DD, Savage NM, Buckhaults PJ, Morse HC 3rd, Liu K.

Cell Rep. 2018 Dec 11;25(11):3036-3046.e6. doi: 10.1016/j.celrep.2018.11.050.

4.

3'Igh enhancers hs3b/hs4 are dispensable for Myc deregulation in mouse plasmacytomas with T(12;15) translocations.

Kovalchuk AL, Sakai T, Qi CF, Du Bois W, Dunnick WA, Cogné M, Morse HC 3rd.

Oncotarget. 2018 Oct 2;9(77):34528-34542. doi: 10.18632/oncotarget.26160. eCollection 2018 Oct 2.

5.

T follicular helper cells restricted by IRF8 contribute to T cell-mediated inflammation.

Zhang R, Qi CF, Hu Y, Shan Y, Hsieh YP, Xu F, Lu G, Dai J, Gupta M, Cui M, Peng L, Yang J, Xue Q, Chen-Liang R, Chen K, Zhang Y, Fung-Leung WP, Mora JR, Li L, Morse HC 3rd, Ozato K, Heeger PS, Xiong H.

J Autoimmun. 2019 Jan;96:113-122. doi: 10.1016/j.jaut.2018.09.001. Epub 2018 Sep 19.

PMID:
30241692
6.

Early Generated B-1-Derived B Cells Have the Capacity To Progress To Become Mantle Cell Lymphoma-like Neoplasia in Aged Mice.

Hayakawa K, Formica AM, Nakao Y, Ichikawa D, Shinton SA, Brill-Dashoff J, Smith MR, Morse HC 3rd, Hardy RR.

J Immunol. 2018 Jul 15;201(2):804-813. doi: 10.4049/jimmunol.1800400. Epub 2018 Jun 13.

7.

Plasma Cell Alloantigen 1 and IL-10 Secretion Define Two Distinct Peritoneal B1a B Cell Subsets With Opposite Functions, PC1high Cells Being Protective and PC1low Cells Harmful for the Growing Fetus.

Schumacher A, Ehrentraut S, Scharm M, Wang H, Hartig R, Morse HC 3rd, Zenclussen AC.

Front Immunol. 2018 May 15;9:1045. doi: 10.3389/fimmu.2018.01045. eCollection 2018.

8.

Relative Contributions of B Cells and Dendritic Cells from Lupus-Prone Mice to CD4+ T Cell Polarization.

Choi SC, Xu Z, Li W, Yang H, Roopenian DC, Morse HC 3rd, Morel L.

J Immunol. 2018 May 1;200(9):3087-3099. doi: 10.4049/jimmunol.1701179. Epub 2018 Mar 21.

9.

ATP-degrading ENPP1 is required for survival (or persistence) of long-lived plasma cells.

Wang H, Gonzalez-Garcia I, Traba J, Jain S, Conteh S, Shin DM, Qi C, Gao Y, Sun J, Kang S, Abbasi S, Naghashfar Z, Yoon J, DuBois W, Kovalchuk AL, Sack MN, Duffy P, Morse HC 3rd.

Sci Rep. 2017 Dec 19;7(1):17867. doi: 10.1038/s41598-017-18028-z.

10.

Precocious Interleukin 21 Expression in Naive Mice Identifies a Natural Helper Cell Population in Autoimmune Disease.

Marnik EA, Wang X, Sproule TJ, Park G, Christianson GJ, Lane-Reticker SK, Jain S, Duffy T, Wang H, Carter GW, Morse HC 3rd, Roopenian DC.

Cell Rep. 2017 Oct 3;21(1):208-221. doi: 10.1016/j.celrep.2017.09.036.

11.

The tumor suppressive role of inhibin βA in diffuse large B-cell lymphoma.

Jiang L, Si T, Yu M, Zeng X, Morse HC 3rd, Lu Y, Ouyang G, Zhou JX.

Leuk Lymphoma. 2018 May;59(5):1202-1212. doi: 10.1080/10428194.2017.1372574. Epub 2017 Sep 7.

PMID:
28877610
12.

Associations of Autoimmunity, Immunodeficiency, Lymphomagenesis, and Gut Microbiota in Mice with Knockins for a Pathogenic Autoantibody.

Jain S, Ward JM, Shin DM, Wang H, Naghashfar Z, Kovalchuk AL, Morse HC 3rd.

Am J Pathol. 2017 Sep;187(9):2020-2033. doi: 10.1016/j.ajpath.2017.05.017. Epub 2017 Jul 17.

13.

Correction: Suppression of CD300A inhibits the growth of diffuse large B-cell lymphoma.

Jiang L, Xu Y, Zeng X, Fang J, Morse HC III, Zhou JX.

Oncotarget. 2017 May 9;8(19):32380. doi: 10.18632/oncotarget.17684. No abstract available.

14.

DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice.

Sakai T, Miyazaki T, Shin DM, Kim YS, Qi CF, Fariss R, Munasinghe J, Wang H, Kovalchuk AL, Kothari PH, Fermaintt CS, Atkinson JP, Perrino FW, Yan N, Morse HC 3rd.

J Autoimmun. 2017 Jul;81:13-23. doi: 10.1016/j.jaut.2017.03.001. Epub 2017 Mar 18.

15.

EBI2 overexpression in mice leads to B1 B-cell expansion and chronic lymphocytic leukemia-like B-cell malignancies.

Niss Arfelt K, Barington L, Benned-Jensen T, Kubale V, Kovalchuk AL, Daugvilaite V, Christensen JP, Thomsen AR, Egerod KL, Bassi MR, Spiess K, Schwartz TW, Wang H, Morse HC 3rd, Holst PJ, Rosenkilde MM.

Blood. 2017 Feb 16;129(7):866-878. doi: 10.1182/blood-2016-02-697185. Epub 2016 Dec 21.

16.

Early generated B1 B cells with restricted BCRs become chronic lymphocytic leukemia with continued c-Myc and low Bmf expression.

Hayakawa K, Formica AM, Brill-Dashoff J, Shinton SA, Ichikawa D, Zhou Y, Morse HC 3rd, Hardy RR.

J Exp Med. 2016 Dec 12;213(13):3007-3024. Epub 2016 Nov 29.

17.

Transgenic mouse model of IgM+ lymphoproliferative disease mimicking Waldenström macroglobulinemia.

Tompkins VS, Sompallae R, Rosean TR, Walsh S, Acevedo M, Kovalchuk AL, Han SS, Jing X, Holman C, Rehg JE, Herms S, Sunderland JS, Morse HC, Janz S.

Blood Cancer J. 2016 Nov 4;6(11):e488. doi: 10.1038/bcj.2016.95.

18.

Decreased Expression of Retinoid X Receptors During Human and Azoxymethane-induced Colorectal Carcinogenesis in the Rat.

Hao X, Xiao H, Ju J, Hewitt SM, Morse HC 3rd.

Anticancer Res. 2016 Jun;36(6):2659-64.

PMID:
27272774
19.

Interferon Regulator Factor 8 (IRF8) Limits Ocular Pathology during HSV-1 Infection by Restraining the Activation and Expansion of CD8+ T Cells.

Sun L, St Leger AJ, Yu CR, He C, Mahdi RM, Chan CC, Wang H, Morse HC 3rd, Egwuagu CE.

PLoS One. 2016 May 12;11(5):e0155420. doi: 10.1371/journal.pone.0155420. eCollection 2016.

20.

Interleukin 6 Accelerates Mortality by Promoting the Progression of the Systemic Lupus Erythematosus-Like Disease of BXSB.Yaa Mice.

Jain S, Park G, Sproule TJ, Christianson GJ, Leeth CM, Wang H, Roopenian DC, Morse HC 3rd.

PLoS One. 2016 Apr 6;11(4):e0153059. doi: 10.1371/journal.pone.0153059. eCollection 2016.

21.

Emerging Functions of Natural IgM and Its Fc Receptor FCMR in Immune Homeostasis.

Wang H, Coligan JE, Morse HC 3rd.

Front Immunol. 2016 Mar 15;7:99. doi: 10.3389/fimmu.2016.00099. eCollection 2016. Review.

22.

Cutting Edge: Expression of IRF8 in Gastric Epithelial Cells Confers Protective Innate Immunity against Helicobacter pylori Infection.

Yan M, Wang H, Sun J, Liao W, Li P, Zhu Y, Xu C, Joo J, Sun Y, Abbasi S, Kovalchuk A, Lv N, Leonard WJ, Morse HC 3rd.

J Immunol. 2016 Mar 1;196(5):1999-2003. doi: 10.4049/jimmunol.1500766. Epub 2016 Feb 3.

23.

Hematopoietic neoplasms in Prkar2a-deficient mice.

Saloustros E, Salpea P, Qi CF, Gugliotti LA, Tsang K, Liu S, Starost MF, Morse HC 3rd, Stratakis CA.

J Exp Clin Cancer Res. 2015 Nov 25;34:143. doi: 10.1186/s13046-015-0257-z.

24.

Suppression of CD300A inhibits the growth of diffuse large B-cell lymphoma.

Jiang L, Xu Y, Zeng X, Fang J, Morse HC 3rd, Zhou JX.

Oncotarget. 2015 Oct 13;6(31):31191-202. doi: 10.18632/oncotarget.5152. Erratum in: Oncotarget. 2017 May 9;8(19):32380.

25.

ATM deficiency promotes development of murine B-cell lymphomas that resemble diffuse large B-cell lymphoma in humans.

Hathcock KS, Padilla-Nash HM, Camps J, Shin DM, Triner D, Shaffer AL 3rd, Maul RW, Steinberg SM, Gearhart PJ, Staudt LM, Morse HC 3rd, Ried T, Hodes RJ.

Blood. 2015 Nov 12;126(20):2291-301. doi: 10.1182/blood-2015-06-654749. Epub 2015 Sep 23.

26.

IL-21-driven neoplasms in SJL mice mimic some key features of human angioimmunoblastic T-cell lymphoma.

Jain S, Chen J, Nicolae A, Wang H, Shin DM, Adkins EB, Sproule TJ, Leeth CM, Sakai T, Kovalchuk AL, Raffeld M, Ward JM, Rehg JE, Waldmann TA, Jaffe ES, Roopenian DC, Morse HC 3rd.

Am J Pathol. 2015 Nov;185(11):3102-14. doi: 10.1016/j.ajpath.2015.07.021. Epub 2015 Sep 9.

27.

Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation.

Hasan M, Fermaintt CS, Gao N, Sakai T, Miyazaki T, Jiang S, Li QZ, Atkinson JP, Morse HC 3rd, Lehrman MA, Yan N.

Immunity. 2015 Sep 15;43(3):463-74. doi: 10.1016/j.immuni.2015.07.022. Epub 2015 Aug 25.

28.

Loss of IRF8 Inhibits the Growth of Diffuse Large B-cell Lymphoma.

Xu Y, Jiang L, Fang J, Fang R, Morse HC 3rd, Ouyang G, Zhou JX.

J Cancer. 2015 Aug 7;6(10):953-61. doi: 10.7150/jca.12067. eCollection 2015.

29.

Finding mouse models of human lymphomas and leukemia's using the Jackson laboratory mouse tumor biology database.

Begley DA, Sundberg JP, Krupke DM, Neuhauser SB, Bult CJ, Eppig JT, Morse HC 3rd, Ward JM.

Exp Mol Pathol. 2015 Dec;99(3):533-6. doi: 10.1016/j.yexmp.2015.07.004. Epub 2015 Aug 21.

30.

Dual Function of the IRF8 Transcription Factor in Autoimmune Uveitis: Loss of IRF8 in T Cells Exacerbates Uveitis, Whereas Irf8 Deletion in the Retina Confers Protection.

Kim SH, Burton J, Yu CR, Sun L, He C, Wang H, Morse HC 3rd, Egwuagu CE.

J Immunol. 2015 Aug 15;195(4):1480-8. doi: 10.4049/jimmunol.1500653. Epub 2015 Jul 10.

31.

New insights into heterogeneity of peritoneal B-1a cells.

Wang H, Lin JX, Li P, Skinner J, Leonard WJ, Morse HC 3rd.

Ann N Y Acad Sci. 2015 Dec;1362:68-76. doi: 10.1111/nyas.12791. Epub 2015 May 18. Review.

32.

LKB1 inhibition of NF-κB in B cells prevents T follicular helper cell differentiation and germinal center formation.

Walsh NC, Waters LR, Fowler JA, Lin M, Cunningham CR, Brooks DG, Rehg JE, Morse HC 3rd, Teitell MA.

EMBO Rep. 2015 Jun;16(6):753-68. doi: 10.15252/embr.201439505. Epub 2015 Apr 26.

33.

Nomenclature of Toso, Fas apoptosis inhibitory molecule 3, and IgM FcR.

Kubagawa H, Carroll MC, Jacob CO, Lang KS, Lee KH, Mak T, McAndrews M, Morse HC 3rd, Nolan GP, Ohno H, Richter GH, Seal R, Wang JY, Wiestner A, Coligan JE.

J Immunol. 2015 May 1;194(9):4055-7. doi: 10.4049/jimmunol.1500222.

34.

IRF8 directs stress-induced autophagy in macrophages and promotes clearance of Listeria monocytogenes.

Gupta M, Shin DM, Ramakrishna L, Goussetis DJ, Platanias LC, Xiong H, Morse HC 3rd, Ozato K.

Nat Commun. 2015 Mar 16;6:6379. doi: 10.1038/ncomms7379.

35.

IFN regulatory factor 8 represses GM-CSF expression in T cells to affect myeloid cell lineage differentiation.

Paschall AV, Zhang R, Qi CF, Bardhan K, Peng L, Lu G, Yang J, Merad M, McGaha T, Zhou G, Mellor A, Abrams SI, Morse HC 3rd, Ozato K, Xiong H, Liu K.

J Immunol. 2015 Mar 1;194(5):2369-79. doi: 10.4049/jimmunol.1402412. Epub 2015 Feb 2.

36.

Myeloid cell TRAF3 regulates immune responses and inhibits inflammation and tumor development in mice.

Lalani AI, Moore CR, Luo C, Kreider BZ, Liu Y, Morse HC 3rd, Xie P.

J Immunol. 2015 Jan 1;194(1):334-48. doi: 10.4049/jimmunol.1401548. Epub 2014 Nov 24.

37.

Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells.

Sasaki H, Kurotaki D, Osato N, Sato H, Sasaki I, Koizumi S, Wang H, Kaneda C, Nishiyama A, Kaisho T, Aburatani H, Morse HC 3rd, Ozato K, Tamura T.

Blood. 2015 Jan 8;125(2):358-69. doi: 10.1182/blood-2014-02-557983. Epub 2014 Nov 14.

38.

Interferon regulatory factor 8 (IRF8) interacts with the B cell lymphoma 6 (BCL6) corepressor BCOR.

Yoon J, Feng X, Kim YS, Shin DM, Hatzi K, Wang H, Morse HC 3rd.

J Biol Chem. 2014 Dec 5;289(49):34250-7. doi: 10.1074/jbc.M114.571182. Epub 2014 Oct 20.

39.

The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation.

Carotta S, Willis SN, Hasbold J, Inouye M, Pang SH, Emslie D, Light A, Chopin M, Shi W, Wang H, Morse HC 3rd, Tarlinton DM, Corcoran LM, Hodgkin PD, Nutt SL.

J Exp Med. 2014 Oct 20;211(11):2169-81. doi: 10.1084/jem.20140425. Epub 2014 Oct 6.

40.

The 3'-5' DNA exonuclease TREX1 directly interacts with poly(ADP-ribose) polymerase-1 (PARP1) during the DNA damage response.

Miyazaki T, Kim YS, Yoon J, Wang H, Suzuki T, Morse HC 3rd.

J Biol Chem. 2014 Nov 21;289(47):32548-58. doi: 10.1074/jbc.M114.547331. Epub 2014 Oct 2.

41.

SNP array profiling of mouse cell lines identifies their strains of origin and reveals cross-contamination and widespread aneuploidy.

Didion JP, Buus RJ, Naghashfar Z, Threadgill DW, Morse HC 3rd, de Villena FP.

BMC Genomics. 2014 Oct 3;15:847. doi: 10.1186/1471-2164-15-847.

42.

The tumor microenvironment is the main source of IL-6 for plasma cell tumor development in mice.

Rosean TR, Tompkins VS, Olivier AK, Sompallae R, Norian LA, Morse HC 3rd, Waldschmidt TJ, Janz S.

Leukemia. 2015 Jan;29(1):233-7. doi: 10.1038/leu.2014.260. Epub 2014 Sep 3. No abstract available.

43.

A reporter mouse reveals lineage-specific and heterogeneous expression of IRF8 during lymphoid and myeloid cell differentiation.

Wang H, Yan M, Sun J, Jain S, Yoshimi R, Abolfath SM, Ozato K, Coleman WG Jr, Ng AP, Metcalf D, DiRago L, Nutt SL, Morse HC 3rd.

J Immunol. 2014 Aug 15;193(4):1766-77. doi: 10.4049/jimmunol.1301939. Epub 2014 Jul 14. Erratum in: J Immunol. 2014 Nov 1;193(9):4749.

44.

Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.

May SL, Zhou Q, Lewellen M, Carter CM, Coffey D, Highfill SL, Bucher CM, Matise I, Morse HC 3rd, O'Sullivan MG, Schutten M, Johnson C, Bellgrau D, Blazar BR, Modiano JF.

PLoS One. 2014 Jun 19;9(6):e100629. doi: 10.1371/journal.pone.0100629. eCollection 2014.

45.

Dasatinib targets B-lineage cells but does not provide an effective therapy for myeloproliferative disease in c-Cbl RING finger mutant mice.

Duyvestyn JM, Taylor SJ, Dagger SA, Orandle M, Morse HC 3rd, Thien CB, Langdon WY.

PLoS One. 2014 Apr 9;9(4):e94717. doi: 10.1371/journal.pone.0094717. eCollection 2014.

46.

The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation.

Yoshida Y, Yoshimi R, Yoshii H, Kim D, Dey A, Xiong H, Munasinghe J, Yazawa I, O'Donovan MJ, Maximova OA, Sharma S, Zhu J, Wang H, Morse HC 3rd, Ozato K.

Immunity. 2014 Feb 20;40(2):187-98. doi: 10.1016/j.immuni.2013.11.022. Epub 2014 Jan 30.

47.

p85α recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression.

Tian L, Choi SC, Murakami Y, Allen J, Morse HC 3rd, Qi CF, Krzewski K, Coligan JE.

Nat Commun. 2014;5:3146. doi: 10.1038/ncomms4146.

48.

(18)F-FDG-PET/CT imaging in an IL-6- and MYC-driven mouse model of human multiple myeloma affords objective evaluation of plasma cell tumor progression and therapeutic response to the proteasome inhibitor ixazomib.

Duncan K, Rosean TR, Tompkins VS, Olivier A, Sompallae R, Zhan F, Tricot G, Acevedo MR, Ponto LL, Walsh SA, Tygrett LT, Berger AJ, Waldschmidt T, Morse HC 3rd, Sunderland JJ, Janz S.

Blood Cancer J. 2013 Nov 29;3:e165. doi: 10.1038/bcj.2013.61.

49.

Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks.

Chopin M, Seillet C, Chevrier S, Wu L, Wang H, Morse HC 3rd, Belz GT, Nutt SL.

J Exp Med. 2013 Dec 16;210(13):2967-80. doi: 10.1084/jem.20130930. Epub 2013 Nov 18.

50.

Homeostatic defects in B cells deficient in the E3 ubiquitin ligase ARF-BP1 are restored by enhanced expression of MYC.

Qi CF, Zhang R, Sun J, Li Z, Shin DM, Wang H, Kovalchuk AL, Sakai T, Xiong H, Kon N, Gu W, Morse HC 3rd.

Leuk Res. 2013 Dec;37(12):1680-9. doi: 10.1016/j.leukres.2013.09.009. Epub 2013 Sep 20.

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