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Items: 41


Immunotherapy Targeting HPV16/18 Generates Potent Immune Responses in HPV-Associated Head and Neck Cancer.

Aggarwal C, Cohen RB, Morrow MP, Kraynyak KA, Sylvester AJ, Knoblock DM, Bauml JM, Weinstein GS, Lin A, Boyer J, Sakata L, Tan S, Anton A, Dickerson K, Mangrolia D, Vang R, Dallas M, Oyola S, Duff S, Esser M, Kumar R, Weiner D, Csiki I, Bagarazzi ML.

Clin Cancer Res. 2019 Jan 1;25(1):110-124. doi: 10.1158/1078-0432.CCR-18-1763. Epub 2018 Sep 21.


In vivo protection against ZIKV infection and pathogenesis through passive antibody transfer and active immunisation with a prMEnv DNA vaccine.

Muthumani K, Griffin BD, Agarwal S, Kudchodkar SB, Reuschel EL, Choi H, Kraynyak KA, Duperret EK, Keaton AA, Chung C, Kim YK, Booth SA, Racine T, Yan J, Morrow MP, Jiang J, Lee B, Ramos S, Broderick KE, Reed CC, Khan AS, Humeau L, Ugen KE, Park YK, Maslow JN, Sardesai NY, Joseph Kim J, Kobinger GP, Weiner DB.

NPJ Vaccines. 2016 Nov 10;1:16021. doi: 10.1038/npjvaccines.2016.21. eCollection 2016.


Broad cross-protective anti-hemagglutination responses elicited by influenza microconsensus DNA vaccine.

Yan J, Morrow MP, Chu JS, Racine T, Reed CC, Khan AS, Broderick KE, Kim JJ, Kobinger GP, Sardesai NY, Weiner DB.

Vaccine. 2018 May 24;36(22):3079-3089. doi: 10.1016/j.vaccine.2017.09.086.


Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy.

Morrow MP, Kraynyak KA, Sylvester AJ, Dallas M, Knoblock D, Boyer JD, Yan J, Vang R, Khan AS, Humeau L, Sardesai NY, Kim JJ, Plotkin S, Weiner DB, Trimble CL, Bagarazzi ML.

Clin Cancer Res. 2018 Jan 15;24(2):276-294. doi: 10.1158/1078-0432.CCR-17-2335. Epub 2017 Oct 30.


Development of an intradermal DNA vaccine delivery strategy to achieve single-dose immunity against respiratory syncytial virus.

Smith TRF, Schultheis K, Morrow MP, Kraynyak KA, McCoy JR, Yim KC, Muthumani K, Humeau L, Weiner DB, Sardesai NY, Broderick KE.

Vaccine. 2017 May 15;35(21):2840-2847. doi: 10.1016/j.vaccine.2017.04.008. Epub 2017 Apr 14.


Augmentation of cellular and humoral immune responses to HPV16 and HPV18 E6 and E7 antigens by VGX-3100.

Morrow MP, Kraynyak KA, Sylvester AJ, Shen X, Amante D, Sakata L, Parker L, Yan J, Boyer J, Roh C, Humeau L, Khan AS, Broderick K, Marcozzi-Pierce K, Giffear M, Lee J, Trimble CL, Kim JJ, Sardesai NY, Weiner DB, Bagarazzi ML.

Mol Ther Oncolytics. 2016 Nov 30;3:16025. doi: 10.1038/mto.2016.25. eCollection 2016.


Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial.

Trimble CL, Morrow MP, Kraynyak KA, Shen X, Dallas M, Yan J, Edwards L, Parker RL, Denny L, Giffear M, Brown AS, Marcozzi-Pierce K, Shah D, Slager AM, Sylvester AJ, Khan A, Broderick KE, Juba RJ, Herring TA, Boyer J, Lee J, Sardesai NY, Weiner DB, Bagarazzi ML.

Lancet. 2015 Nov 21;386(10008):2078-2088. doi: 10.1016/S0140-6736(15)00239-1. Epub 2015 Sep 17.


Molecular adjuvant IL-33 enhances the potency of a DNA vaccine in a lethal challenge model.

Villarreal DO, Svoronos N, Wise MC, Shedlock DJ, Morrow MP, Conejo-Garcia JR, Weiner DB.

Vaccine. 2015 Aug 20;33(35):4313-20. doi: 10.1016/j.vaccine.2015.03.086. Epub 2015 Apr 14.


Activated CD4+CCR5+ T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus macaques.

Carnathan DG, Wetzel KS, Yu J, Lee ST, Johnson BA, Paiardini M, Yan J, Morrow MP, Sardesai NY, Weiner DB, Ertl HC, Silvestri G.

Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):518-23. doi: 10.1073/pnas.1407466112. Epub 2014 Dec 30.


Synthetic consensus HIV-1 DNA induces potent cellular immune responses and synthesis of granzyme B, perforin in HIV infected individuals.

Morrow MP, Tebas P, Yan J, Ramirez L, Slager A, Kraynyak K, Diehl M, Shah D, Khan A, Lee J, Boyer J, Kim JJ, Sardesai NY, Weiner DB, Bagarazzi ML.

Mol Ther. 2015 Mar;23(3):591-601. doi: 10.1038/mt.2014.245. Epub 2014 Dec 22.


Strong HCV NS3/4a, NS4b, NS5a, NS5b-specific cellular immune responses induced in Rhesus macaques by a novel HCV genotype 1a/1b consensus DNA vaccine.

Latimer B, Toporovski R, Yan J, Pankhong P, Morrow MP, Khan AS, Sardesai NY, Welles SL, Jacobson JM, Weiner DB, Kutzler MA.

Hum Vaccin Immunother. 2014;10(8):2357-65. doi: 10.4161/hv.29590.


Highly optimized DNA vaccine targeting human telomerase reverse transcriptase stimulates potent antitumor immunity.

Yan J, Pankhong P, Shin TH, Obeng-Adjei N, Morrow MP, Walters JN, Khan AS, Sardesai NY, Weiner DB.

Cancer Immunol Res. 2013 Sep;1(3):179-189. doi: 10.1158/2326-6066.CIR-13-0001. Epub 2013 Jul 17.


Protective immunity to H7N9 influenza viruses elicited by synthetic DNA vaccine.

Yan J, Villarreal DO, Racine T, Chu JS, Walters JN, Morrow MP, Khan AS, Sardesai NY, Kim JJ, Kobinger GP, Weiner DB.

Vaccine. 2014 May 19;32(24):2833-42. doi: 10.1016/j.vaccine.2014.02.038. Epub 2014 Mar 12.


Intramuscular therapeutic vaccination targeting HPV16 induces T cell responses that localize in mucosal lesions.

Maldonado L, Teague JE, Morrow MP, Jotova I, Wu TC, Wang C, Desmarais C, Boyer JD, Tycko B, Robins HS, Clark RA, Trimble CL.

Sci Transl Med. 2014 Jan 29;6(221):221ra13. doi: 10.1126/scitranslmed.3007323.


Alarmin IL-33 acts as an immunoadjuvant to enhance antigen-specific tumor immunity.

Villarreal DO, Wise MC, Walters JN, Reuschel EL, Choi MJ, Obeng-Adjei N, Yan J, Morrow MP, Weiner DB.

Cancer Res. 2014 Mar 15;74(6):1789-800. doi: 10.1158/0008-5472.CAN-13-2729. Epub 2014 Jan 21.


DNA vaccine cocktail expressing genotype A and C HBV surface and consensus core antigens generates robust cytotoxic and antibody responses in mice and Rhesus macaques.

Obeng-Adjei N, Hutnick NA, Yan J, Chu JS, Myles DJ, Morrow MP, Sardesai NY, Weiner DB.

Cancer Gene Ther. 2013 Dec;20(12):652-62. doi: 10.1038/cgt.2013.65. Epub 2013 Dec 6.


Inducing humoral and cellular responses to multiple sporozoite and liver-stage malaria antigens using exogenous plasmid DNA.

Ferraro B, Talbott KT, Balakrishnan A, Cisper N, Morrow MP, Hutnick NA, Myles DJ, Shedlock DJ, Obeng-Adjei N, Yan J, Kayatani AK, Richie N, Cabrera W, Shiver R, Khan AS, Brown AS, Yang M, Wille-Reece U, Birkett AJ, Sardesai NY, Weiner DB.

Infect Immun. 2013 Oct;81(10):3709-20. doi: 10.1128/IAI.00180-13. Epub 2013 Jul 29.


Human papillomavirus therapeutic vaccines: targeting viral antigens as immunotherapy for precancerous disease and cancer.

Morrow MP, Yan J, Sardesai NY.

Expert Rev Vaccines. 2013 Mar;12(3):271-83. doi: 10.1586/erv.13.23. Review.


Immunotherapy against HPV16/18 generates potent TH1 and cytotoxic cellular immune responses.

Bagarazzi ML, Yan J, Morrow MP, Shen X, Parker RL, Lee JC, Giffear M, Pankhong P, Khan AS, Broderick KE, Knott C, Lin F, Boyer JD, Draghia-Akli R, White CJ, Kim JJ, Weiner DB, Sardesai NY.

Sci Transl Med. 2012 Oct 10;4(155):155ra138. doi: 10.1126/scitranslmed.3004414.


Peripheral immunization induces functional intrahepatic hepatitis C specific immunity following selective retention of vaccine-specific CD8 T cells by the liver.

Lang Kuhs KA, Toporovski R, Ginsberg AA, Olsen AL, Shedlock DJ, Morrow MP, Yan J, Wells RG, Weiner DB.

Hum Vaccin. 2011 Dec;7(12):1326-35. doi: 10.4161/hv.7.12.18279. Epub 2011 Dec 1.


Immune modulation through 4-1BB enhances SIV vaccine protection in non-human primates against SIVmac251 challenge.

Hirao LA, Hokey DA, Morrow MP, Jure-Kunkel MN, Weiner DB.

PLoS One. 2011;6(9):e24250. doi: 10.1371/journal.pone.0024250. Epub 2011 Sep 15.


Clinical applications of DNA vaccines: current progress.

Ferraro B, Morrow MP, Hutnick NA, Shin TH, Lucke CE, Weiner DB.

Clin Infect Dis. 2011 Aug 1;53(3):296-302. doi: 10.1093/cid/cir334. Review.


Molecular adjuvant HMGB1 enhances anti-influenza immunity during DNA vaccination.

Fagone P, Shedlock DJ, Bao H, Kawalekar OU, Yan J, Gupta D, Morrow MP, Patel A, Kobinger GP, Muthumani K, Weiner DB.

Gene Ther. 2011 Nov;18(11):1070-7. doi: 10.1038/gt.2011.59. Epub 2011 May 5.


A highly optimized DNA vaccine confers complete protective immunity against high-dose lethal lymphocytic choriomeningitis virus challenge.

Shedlock DJ, Talbott KT, Cress C, Ferraro B, Tuyishme S, Mallilankaraman K, Cisper NJ, Morrow MP, Wu SJ, Kawalekar OU, Khan AS, Sardesai NY, Muthumani K, Shen H, Weiner DB.

Vaccine. 2011 Sep 9;29(39):6755-62. doi: 10.1016/j.vaccine.2010.12.064. Epub 2011 Jan 14.


Prototype development and preclinical immunogenicity analysis of a novel minimally invasive electroporation device.

Broderick KE, Shen X, Soderholm J, Lin F, McCoy J, Khan AS, Yan J, Morrow MP, Patel A, Kobinger GP, Kemmerrer S, Weiner DB, Sardesai NY.

Gene Ther. 2011 Mar;18(3):258-65. doi: 10.1038/gt.2010.137. Epub 2010 Oct 21.


Interferons as potential adjuvants in prophylactic vaccines.

Toporovski R, Morrow MP, Weiner DB.

Expert Opin Biol Ther. 2010 Oct;10(10):1489-500. doi: 10.1517/14712598.2010.521495. Review.


Unique Th1/Th2 phenotypes induced during priming and memory phases by use of interleukin-12 (IL-12) or IL-28B vaccine adjuvants in rhesus macaques.

Morrow MP, Yan J, Pankhong P, Ferraro B, Lewis MG, Khan AS, Sardesai NY, Weiner DB.

Clin Vaccine Immunol. 2010 Oct;17(10):1493-9. doi: 10.1128/CVI.00181-10. Epub 2010 Aug 4.


Circulating Nef induces dyslipidemia in simian immunodeficiency virus-infected macaques by suppressing cholesterol efflux.

Asztalos BF, Mujawar Z, Morrow MP, Grant A, Pushkarsky T, Wanke C, Shannon R, Geyer M, Kirchhoff F, Sviridov D, Fitzgerald ML, Bukrinsky M, Mansfield KG.

J Infect Dis. 2010 Aug 15;202(4):614-23. doi: 10.1086/654817.


DNA drugs come of age.

Morrow MP, Weiner DB.

Sci Am. 2010 Jul;303(1):48-53. No abstract available.


IL-28B/IFN-lambda 3 drives granzyme B loading and significantly increases CTL killing activity in macaques.

Morrow MP, Yan J, Pankhong P, Shedlock DJ, Lewis MG, Talbott K, Toporovski R, Khan AS, Sardesai NY, Weiner DB.

Mol Ther. 2010 Sep;18(9):1714-23. doi: 10.1038/mt.2010.118. Epub 2010 Jun 22.


Stimulation of the liver X receptor pathway inhibits HIV-1 replication via induction of ATP-binding cassette transporter A1.

Morrow MP, Grant A, Mujawar Z, Dubrovsky L, Pushkarsky T, Kiselyeva Y, Jennelle L, Mukhamedova N, Remaley AT, Kashanchi F, Sviridov D, Bukrinsky M.

Mol Pharmacol. 2010 Aug;78(2):215-25. doi: 10.1124/mol.110.065029. Epub 2010 May 17.


Ki-67 staining for determination of rhesus macaque T cell proliferative responses ex vivo.

Shedlock DJ, Talbott KT, Morrow MP, Ferraro B, Hokey DA, Muthumani K, Weiner DB.

Cytometry A. 2010 Mar;77(3):275-84. doi: 10.1002/cyto.a.20857.


Plasmid-encoded interleukin-15 receptor alpha enhances specific immune responses induced by a DNA vaccine in vivo.

Kraynyak KA, Kutzler MA, Cisper NJ, Laddy DJ, Morrow MP, Waldmann TA, Weiner DB.

Hum Gene Ther. 2009 Oct;20(10):1143-56. doi: 10.1089/hum.2009.025.


Comparative ability of IL-12 and IL-28B to regulate Treg populations and enhance adaptive cellular immunity.

Morrow MP, Pankhong P, Laddy DJ, Schoenly KA, Yan J, Cisper N, Weiner DB.

Blood. 2009 Jun 4;113(23):5868-77. doi: 10.1182/blood-2008-11-190520. Epub 2009 Mar 20.


HIV-1 Vpr: regulator of viral survival.

Thieu KP, Morrow MP, Shedlock DJ, Schoenly KA, Mallilankaraman K, Choo AY, Fagone P, Weiner DB, Muthumani K.

Curr HIV Res. 2009 Mar;7(2):153-62. Review.


Novel SIVmac DNA vaccines encoding Env, Pol and Gag consensus proteins elicit strong cellular immune responses in cynomolgus macaques.

Yan J, Hokey DA, Morrow MP, Corbitt N, Harris K, Harris D, Weiner DB.

Vaccine. 2009 May 26;27(25-26):3260-6. doi: 10.1016/j.vaccine.2009.01.065. Epub 2009 Feb 5.


Design and characterization of a plasmid vector system capable of rapid generation of antibodies of multiple isotypes and specificities.

Morrow MP, Pankhong P, Weiner DB.

Biotechnol Lett. 2009 Jan;31(1):13-22. doi: 10.1007/s10529-008-9826-y. Epub 2008 Sep 6.


Mesoporous silica nanoparticles inhibit cellular respiration.

Tao Z, Morrow MP, Asefa T, Sharma KK, Duncan C, Anan A, Penefsky HS, Goodisman J, Souid AK.

Nano Lett. 2008 May;8(5):1517-26. doi: 10.1021/nl080250u. Epub 2008 Apr 1.


Cytokines as adjuvants for improving anti-HIV responses.

Morrow MP, Weiner DB.

AIDS. 2008 Jan 30;22(3):333-8. doi: 10.1097/QAD.0b013e3282f42461. Review. No abstract available.


Human immunodeficiency virus impairs reverse cholesterol transport from macrophages.

Mujawar Z, Rose H, Morrow MP, Pushkarsky T, Dubrovsky L, Mukhamedova N, Fu Y, Dart A, Orenstein JM, Bobryshev YV, Bukrinsky M, Sviridov D.

PLoS Biol. 2006 Oct;4(11):e365.


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