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Items: 34


Noninvasive localization of cardiac arrhythmias using electromechanical wave imaging.

Grubb CS, Melki L, Wang DY, Peacock J, Dizon J, Iyer V, Sorbera C, Biviano A, Rubin DA, Morrow JP, Saluja D, Tieu A, Nauleau P, Weber R, Chaudhary S, Khurram I, Waase M, Garan H, Konofagou EE, Wan EY.

Sci Transl Med. 2020 Mar 25;12(536). pii: eaax6111. doi: 10.1126/scitranslmed.aax6111.


PKCδ causes sepsis-induced cardiomyopathy by inducing mitochondrial dysfunction.

Joseph LC, Reyes MV, Lakkadi KR, Gowen BH, Hasko G, Drosatos K, Morrow JP.

Am J Physiol Heart Circ Physiol. 2020 Apr 1;318(4):H778-H786. doi: 10.1152/ajpheart.00749.2019. Epub 2020 Mar 6.


ERK1/2 Phosphorylation of FHOD Connects Signaling and Nuclear Positioning Alternations in Cardiac Laminopathy.

Antoku S, Wu W, Joseph LC, Morrow JP, Worman HJ, Gundersen GG.

Dev Cell. 2019 Dec 2;51(5):602-616.e12. doi: 10.1016/j.devcel.2019.10.023.


Dietary Saturated Fat Promotes Arrhythmia by Activating NOX2 (NADPH Oxidase 2).

Joseph LC, Avula UMR, Wan EY, Reyes MV, Lakkadi KR, Subramanyam P, Nakanishi K, Homma S, Muchir A, Pajvani UB, Thorp EB, Reiken SR, Marks AR, Colecraft HM, Morrow JP.

Circ Arrhythm Electrophysiol. 2019 Nov;12(11):e007573. doi: 10.1161/CIRCEP.119.007573. Epub 2019 Oct 31.


Editorial: Arrhythmogenic Substrates in Diabetes and Obesity.

Morrow JP, Akar FG, Aromolaran AS.

Front Physiol. 2019 May 10;10:549. doi: 10.3389/fphys.2019.00549. eCollection 2019. No abstract available.


Postnatal Development of Mice with Combined Genetic Depletions of Lamin A/C, Emerin and Lamina-associated Polypeptide 1.

Wang Y, Shin JY, Nakanishi K, Homma S, Kim GJ, Tanji K, Joseph LC, Morrow JP, Stewart CL, Dauer WT, Worman HJ.

Hum Mol Genet. 2019 Apr 22. pii: ddz082. doi: 10.1093/hmg/ddz082. [Epub ahead of print]


Secretoneurin to the Rescue?: Maybe or Maybe Not.

Morrow JP, Marx SO.

Circ Arrhythm Electrophysiol. 2019 Apr;12(4):e007298. doi: 10.1161/CIRCEP.119.007298. No abstract available.


Clinical Overview of Obesity and Diabetes Mellitus as Risk Factors for Atrial Fibrillation and Sudden Cardiac Death.

Homan EA, Reyes MV, Hickey KT, Morrow JP.

Front Physiol. 2019 Jan 7;9:1847. doi: 10.3389/fphys.2018.01847. eCollection 2018. Review.


Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair.

Zhang S, Yeap XY, DeBerge M, Naresh NK, Wang K, Jiang Z, Wilcox JE, White SM, Morrow JP, Burridge PW, Procissi D, Scott EA, Frazier W, Thorp EB.

JACC Basic Transl Sci. 2017 Aug;2(4):386-397. doi: 10.1016/j.jacbts.2017.03.013.


Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function.

Joseph LC, Kokkinaki D, Valenti MC, Kim GJ, Barca E, Tomar D, Hoffman NE, Subramanyam P, Colecraft HM, Hirano M, Ratner AJ, Madesh M, Drosatos K, Morrow JP.

JCI Insight. 2017 Sep 7;2(17). pii: 94248. doi: 10.1172/jci.insight.94248. eCollection 2017 Sep 7.


Correction: Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes.

Joseph LC, Barca E, Subramanyam P, Komrowski M, Pajvani U, Colecraft HM, Hirano M, Morrow JP.

PLoS One. 2017 Mar 20;12(3):e0174525. doi: 10.1371/journal.pone.0174525. eCollection 2017.


Decreased WNT/β-catenin signalling contributes to the pathogenesis of dilated cardiomyopathy caused by mutations in the lamin a/C gene.

Le Dour C, Macquart C, Sera F, Homma S, Bonne G, Morrow JP, Worman HJ, Muchir A.

Hum Mol Genet. 2017 Jan 15;26(2):333-343. doi: 10.1093/hmg/ddw389.


ERK1/2 directly acts on CTGF/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A/C gene.

Chatzifrangkeskou M, Le Dour C, Wu W, Morrow JP, Joseph LC, Beuvin M, Sera F, Homma S, Vignier N, Mougenot N, Bonne G, Lipson KE, Worman HJ, Muchir A.

Hum Mol Genet. 2016 Jun 1;25(11):2220-2233. Epub 2016 Apr 30.


Mitochondrial oxidative stress during cardiac lipid overload causes intracellular calcium leak and arrhythmia.

Joseph LC, Subramanyam P, Radlicz C, Trent CM, Iyer V, Colecraft HM, Morrow JP.

Heart Rhythm. 2016 Aug;13(8):1699-706. doi: 10.1016/j.hrthm.2016.05.002. Epub 2016 May 3.


Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes.

Joseph LC, Barca E, Subramanyam P, Komrowski M, Pajvani U, Colecraft HM, Hirano M, Morrow JP.

PLoS One. 2016 Jan 12;11(1):e0145750. doi: 10.1371/journal.pone.0145750. eCollection 2016. Erratum in: PLoS One. 2017 Mar 20;12 (3):e0174525.


Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice.

Wan E, Abrams J, Weinberg RL, Katchman AN, Bayne J, Zakharov SI, Yang L, Morrow JP, Garan H, Marx SO.

J Clin Invest. 2016 Jan;126(1):112-22. doi: 10.1172/JCI84669. Epub 2015 Nov 23.


Extracellular signal-regulated kinase activation during cardiac hypertrophy reduces sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) transcription.

Huang H, Joseph LC, Gurin MI, Thorp EB, Morrow JP.

J Mol Cell Cardiol. 2014 Oct;75:58-63. doi: 10.1016/j.yjmcc.2014.06.018. Epub 2014 Jul 6.


Depletion of lamina-associated polypeptide 1 from cardiomyocytes causes cardiac dysfunction in mice.

Shin JY, Le Dour C, Sera F, Iwata S, Homma S, Joseph LC, Morrow JP, Dauer WT, Worman HJ.

Nucleus. 2014 May-Jun;5(3):260-459. doi: 10.4161/nucl.29227. Epub 2014 May 23.


High-fat diet, obesity and sudden cardiac death.

Morrow JP.

Acta Physiol (Oxf). 2014 May;211(1):13-6. doi: 10.1111/apha.12276. Epub 2014 Apr 2. No abstract available.


Enhanced efferocytosis of apoptotic cardiomyocytes through myeloid-epithelial-reproductive tyrosine kinase links acute inflammation resolution to cardiac repair after infarction.

Wan E, Yeap XY, Dehn S, Terry R, Novak M, Zhang S, Iwata S, Han X, Homma S, Drosatos K, Lomasney J, Engman DM, Miller SD, Vaughan DE, Morrow JP, Kishore R, Thorp EB.

Circ Res. 2013 Sep 27;113(8):1004-12. doi: 10.1161/CIRCRESAHA.113.301198. Epub 2013 Jul 8.


Ventricular arrhythmias and implantable cardioverter-defibrillator therapy in patients with continuous-flow left ventricular assist devices: need for primary prevention?

Garan AR, Yuzefpolskaya M, Colombo PC, Morrow JP, Te-Frey R, Dano D, Takayama H, Naka Y, Garan H, Jorde UP, Uriel N.

J Am Coll Cardiol. 2013 Jun 25;61(25):2542-50. doi: 10.1016/j.jacc.2013.04.020. Epub 2013 May 2.


Diet-induced obesity causes long QT and reduces transcription of voltage-gated potassium channels.

Huang H, Amin V, Gurin M, Wan E, Thorp E, Homma S, Morrow JP.

J Mol Cell Cardiol. 2013 Jun;59:151-8. doi: 10.1016/j.yjmcc.2013.03.007. Epub 2013 Mar 19.


Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation.

Choi JC, Muchir A, Wu W, Iwata S, Homma S, Morrow JP, Worman HJ.

Sci Transl Med. 2012 Jul 25;4(144):144ra102. doi: 10.1126/scitranslmed.3003875.


Mice with cardiac overexpression of peroxisome proliferator-activated receptor γ have impaired repolarization and spontaneous fatal ventricular arrhythmias.

Morrow JP, Katchman A, Son NH, Trent CM, Khan R, Shiomi T, Huang H, Amin V, Lader JM, Vasquez C, Morley GE, D'Armiento J, Homma S, Goldberg IJ, Marx SO.

Circulation. 2011 Dec 20;124(25):2812-21. doi: 10.1161/CIRCULATIONAHA.111.056309. Epub 2011 Nov 28.


Cardiac L-type calcium channel (Cav1.2) associates with gamma subunits.

Yang L, Katchman A, Morrow JP, Doshi D, Marx SO.

FASEB J. 2011 Mar;25(3):928-36. doi: 10.1096/fj.10-172353. Epub 2010 Dec 2.


Chronic Maintenance of Sinus Rhythm in Patients with Atrial Fibrillation Using Antiarrhythmic Drugs: Update 2010.

Morrow JP, Reiffel JA.

Card Electrophysiol Clin. 2010 Sep;2(3):409-418. doi: 10.1016/j.ccep.2010.06.003.


Drug therapy for atrial fibrillation: what will its role be in the era of increasing use of catheter ablation?

Morrow JP, Reiffel JA.

Pacing Clin Electrophysiol. 2009 Jan;32(1):108-18. doi: 10.1111/j.1540-8159.2009.02184.x. Review.


Potential application of late sodium current blockade in the treatment of heart failure and atrial fibrillation.

Doshi D, Morrow JP.

Rev Cardiovasc Med. 2009;10 Suppl 1:S46-52. Review.


Defining the BK channel domains required for beta1-subunit modulation.

Morrow JP, Zakharov SI, Liu G, Yang L, Sok AJ, Marx SO.

Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5096-101. Epub 2006 Mar 20.


Activation of the BK (SLO1) potassium channel by mallotoxin.

Zakharov SI, Morrow JP, Liu G, Yang L, Marx SO.

J Biol Chem. 2005 Sep 2;280(35):30882-7. Epub 2005 Jul 5.


Ser1928 is a common site for Cav1.2 phosphorylation by protein kinase C isoforms.

Yang L, Liu G, Zakharov SI, Morrow JP, Rybin VO, Steinberg SF, Marx SO.

J Biol Chem. 2005 Jan 7;280(1):207-14. Epub 2004 Oct 27.


"North by west". The story of John A. WYETH, M.D., and his three years on White River.


J Ark Med Soc. 1961 Aug;58:94-101. No abstract available.


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