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Needs and challenges among physicians and researchers in thrombosis and hemostasis: Results from an international study.

Murray S, McLintock C, Lazure P, Peniuta M, Schulman S, Rezende SM, Morrissey JH, Reiser T, Pabinger I.

Res Pract Thromb Haemost. 2019 Jun 28;3(4):626-638. doi: 10.1002/rth2.12237. eCollection 2019 Oct.


Genomic momentum for hemostasis and thrombosis.

Lillicrap D, Morrissey JH.

J Thromb Haemost. 2019 Sep;17(9):1411. doi: 10.1111/jth.14582. No abstract available.


Polyphosphate, Zn2+ and high molecular weight kininogen modulate individual reactions of the contact pathway of blood clotting.

Wang Y, Ivanov I, Smith SA, Gailani D, Morrissey JH.

J Thromb Haemost. 2019 Aug 17. doi: 10.1111/jth.14612. [Epub ahead of print]


Nomenclature of factor XI and the contact system.

Schmaier AH, Emsley J, Feener EP, Gailani D, Govers-Riemslag JWP, Kaplan AP, Maas C, Morrissey JH, Renné T, Sidelmann JJ, Meijers JCM.

J Thromb Haemost. 2019 Jul 30. doi: 10.1111/jth.14595. [Epub ahead of print] No abstract available.


27th ISTH Congress - July in Melbourne.

Lillicrap D, Morrissey JH.

J Thromb Haemost. 2019 Jun;17(6):847. doi: 10.1111/jth.14463. No abstract available. Erratum in: J Thromb Haemost. 2019 Sep;17(9):1577.


Simplify, simplify.

Morrissey JH, Lillicrap D.

J Thromb Haemost. 2019 May;17(5):711. doi: 10.1111/jth.14436. No abstract available.


Polyphosphate in thrombosis, hemostasis, and inflammation.

Baker CJ, Smith SA, Morrissey JH.

Res Pract Thromb Haemost. 2018 Nov 15;3(1):18-25. doi: 10.1002/rth2.12162. eCollection 2019 Jan. Review.


Fifty years new.

Lillicrap D, Morrissey JH.

J Thromb Haemost. 2019 Jan;17(1):1. doi: 10.1111/jth.14351. Epub 2018 Dec 16. No abstract available.


Calcium-Induced Lipid Nanocluster Structures: Sculpturing of the Plasma Membrane.

Hallock MJ, Greenwood AI, Wang Y, Morrissey JH, Tajkhorshid E, Rienstra CM, Pogorelov TV.

Biochemistry. 2018 Dec 18;57(50):6897-6905. doi: 10.1021/acs.biochem.8b01069. Epub 2018 Dec 4.


Factor XII Activation Promotes Platelet Consumption in the Presence of Bacterial-Type Long-Chain Polyphosphate In Vitro and In Vivo.

Zilberman-Rudenko J, Reitsma SE, Puy C, Rigg RA, Smith SA, Tucker EI, Silasi R, Merkulova A, McCrae KR, Maas C, Urbanus RT, Gailani D, Morrissey JH, Gruber A, Lupu F, Schmaier AH, McCarty OJT.

Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1748-1760. doi: 10.1161/ATVBAHA.118.311193.


Inorganic polyphosphate interacts with nucleolar and glycosomal proteins in trypanosomatids.

Negreiros RS, Lander N, Huang G, Cordeiro CD, Smith SA, Morrissey JH, Docampo R.

Mol Microbiol. 2018 Dec;110(6):973-994. doi: 10.1111/mmi.14131. Epub 2018 Oct 18.


DNA ladders can be used to size polyphosphate resolved by polyacrylamide gel electrophoresis.

Smith SA, Wang Y, Morrissey JH.

Electrophoresis. 2018 Oct;39(19):2454-2459. doi: 10.1002/elps.201800227. Epub 2018 Jul 26.


Ability of Polyphosphate and Nucleic Acids to Trigger Blood Clotting: Some Observations and Caveats.

Smith SA, Gajsiewicz JM, Morrissey JH.

Front Med (Lausanne). 2018 Apr 17;5:107. doi: 10.3389/fmed.2018.00107. eCollection 2018.


Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies.

Slatter DA, Percy CL, Allen-Redpath K, Gajsiewicz JM, Brooks NJ, Clayton A, Tyrrell VJ, Rosas M, Lauder SN, Watson A, Dul M, Garcia-Diaz Y, Aldrovandi M, Heurich M, Hall J, Morrissey JH, Lacroix-Desmazes S, Delignat S, Jenkins PV, Collins PW, O'Donnell VB.

JCI Insight. 2018 Mar 22;3(6). pii: 98459. doi: 10.1172/jci.insight.98459.


Design of Polyphosphate Inhibitors: A Molecular Dynamics Investigation on Polyethylene Glycol-Linked Cationic Binding Groups.

Mafi A, Abbina S, Kalathottukaren MT, Morrissey JH, Haynes C, Kizhakkedathu JN, Pfaendtner J, Chou KC.

Biomacromolecules. 2018 Apr 9;19(4):1358-1367. doi: 10.1021/acs.biomac.8b00327. Epub 2018 Mar 23.


Multiplexed silicon photonic sensor arrays enable facile characterization of coagulation protein binding to nanodiscs with variable lipid content.

Muehl EM, Gajsiewicz JM, Medfisch SM, Wiersma ZSB, Morrissey JH, Bailey RC.

J Biol Chem. 2017 Sep 29;292(39):16249-16256. doi: 10.1074/jbc.M117.800938. Epub 2017 Aug 11.


Lipid specificity of the membrane binding domain of coagulation factor X.

Muller MP, Wang Y, Morrissey JH, Tajkhorshid E.

J Thromb Haemost. 2017 Oct;15(10):2005-2016. doi: 10.1111/jth.13788. Epub 2017 Sep 1.


Silica particles contribute to the procoagulant activity of DNA and polyphosphate isolated using commercial kits.

Smith SA, Baker CJ, Gajsiewicz JM, Morrissey JH.

Blood. 2017 Jul 6;130(1):88-91. doi: 10.1182/blood-2017-03-772848. Epub 2017 May 22. No abstract available.


Localization of Short-Chain Polyphosphate Enhances its Ability to Clot Flowing Blood Plasma.

Yeon JH, Mazinani N, Schlappi TS, Chan KY, Baylis JR, Smith SA, Donovan AJ, Kudela D, Stucky GD, Liu Y, Morrissey JH, Kastrup CJ.

Sci Rep. 2017 Feb 10;7:42119. doi: 10.1038/srep42119.


Alteration of blood clotting and lung damage by protamine are avoided using the heparin and polyphosphate inhibitor UHRA.

Kalathottukaren MT, Abraham L, Kapopara PR, Lai BF, Shenoi RA, Rosell FI, Conway EM, Pryzdial EL, Morrissey JH, Haynes CA, Kizhakkedathu JN.

Blood. 2017 Mar 9;129(10):1368-1379. doi: 10.1182/blood-2016-10-747915. Epub 2016 Dec 29.


Polyphosphate and RNA Differentially Modulate the Contact Pathway of Blood Clotting.

Gajsiewicz JM, Smith SA, Morrissey JH.

J Biol Chem. 2017 Feb 3;292(5):1808-1814. doi: 10.1074/jbc.M116.754325. Epub 2016 Dec 22.


Differential Roles for the Coagulation Factors XI and XII in Regulating the Physical Biology of Fibrin.

Sylman JL, Daalkhaijav U, Zhang Y, Gray EM, Farhang PA, Chu TT, Zilberman-Rudenko J, Puy C, Tucker EI, Smith SA, Morrissey JH, Walker TW, Nan XL, Gruber A, McCarty OJT.

Ann Biomed Eng. 2017 May;45(5):1328-1340. doi: 10.1007/s10439-016-1771-7. Epub 2016 Dec 8.


Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia.

Cines DB, Yarovoi SV, Zaitsev SV, Lebedeva T, Rauova L, Poncz M, Arepally GM, Khandelwal S, Stepanova V, Rux AH, Cuker A, Guo C, Ocariza LM, Travers RJ, Smith SA, Kim H, Morrissey JH, Conway EM.

Blood Adv. 2016 Nov 22;1(1):62-74. doi: 10.1182/bloodadvances.2016000877. eCollection 2016 Nov 29.


Platelet-Derived Short-Chain Polyphosphates Enhance the Inactivation of Tissue Factor Pathway Inhibitor by Activated Coagulation Factor XI.

Puy C, Tucker EI, Ivanov IS, Gailani D, Smith SA, Morrissey JH, Gruber A, McCarty OJ.

PLoS One. 2016 Oct 20;11(10):e0165172. doi: 10.1371/journal.pone.0165172. eCollection 2016.


High-Resolution NMR Studies of Human Tissue Factor.

Nuzzio KM, Watt ED, Boettcher JM, Gajsiewicz JM, Morrissey JH, Rienstra CM.

PLoS One. 2016 Sep 22;11(9):e0163206. doi: 10.1371/journal.pone.0163206. eCollection 2016.


Artificial Dense Granules: A Procoagulant Liposomal Formulation Modeled after Platelet Polyphosphate Storage Pools.

Donovan AJ, Kalkowski J, Szymusiak M, Wang C, Smith SA, Klie RF, Morrissey JH, Liu Y.

Biomacromolecules. 2016 Aug 8;17(8):2572-81. doi: 10.1021/acs.biomac.6b00577. Epub 2016 Jul 27.


Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor.

Wijeyewickrema LC, Lameignere E, Hor L, Duncan RC, Shiba T, Travers RJ, Kapopara PR, Lei V, Smith SA, Kim H, Morrissey JH, Pike RN, Conway EM.

Blood. 2016 Sep 29;128(13):1766-76. doi: 10.1182/blood-2016-02-699561. Epub 2016 Jun 23.


Deeper understanding of carboxylase.

Morrissey JH.

Blood. 2016 Apr 14;127(15):1841-2. doi: 10.1182/blood-2016-02-694927.


Colloidal Confinement of Polyphosphate on Gold Nanoparticles Robustly Activates the Contact Pathway of Blood Coagulation.

Szymusiak M, Donovan AJ, Smith SA, Ransom R, Shen H, Kalkowski J, Morrissey JH, Liu Y.

Bioconjug Chem. 2016 Jan 20;27(1):102-9. doi: 10.1021/acs.bioconjchem.5b00524. Epub 2015 Dec 15.


Structure-Function Relationship of the Interaction between Tissue Factor and Factor VIIa.

Gajsiewicz JM, Morrissey JH.

Semin Thromb Hemost. 2015 Oct;41(7):682-90. doi: 10.1055/s-0035-1564044. Epub 2015 Sep 26. Review.


Experimental Protein Structure Verification by Scoring with a Single, Unassigned NMR Spectrum.

Courtney JM, Ye Q, Nesbitt AE, Tang M, Tuttle MD, Watt ED, Nuzzio KM, Sperling LJ, Comellas G, Peterson JR, Morrissey JH, Rienstra CM.

Structure. 2015 Oct 6;23(10):1958-1966. doi: 10.1016/j.str.2015.07.019. Epub 2015 Sep 10.


Tissue Factor Residues That Modulate Magnesium-Dependent Rate Enhancements of the Tissue Factor/Factor VIIa Complex.

Gajsiewicz JM, Nuzzio KM, Rienstra CM, Morrissey JH.

Biochemistry. 2015 Aug 4;54(30):4665-71. doi: 10.1021/acs.biochem.5b00608. Epub 2015 Jul 27.


Polyphosphate as modulator of hemostasis, thrombosis, and inflammation.

Morrissey JH, Smith SA.

J Thromb Haemost. 2015 Jun;13 Suppl 1:S92-7. doi: 10.1111/jth.12896. Review.


FXIa and platelet polyphosphate as therapeutic targets during human blood clotting on collagen/tissue factor surfaces under flow.

Zhu S, Travers RJ, Morrissey JH, Diamond SL.

Blood. 2015 Sep 17;126(12):1494-502. doi: 10.1182/blood-2015-04-641472. Epub 2015 Jul 1.


How it all starts: Initiation of the clotting cascade.

Smith SA, Travers RJ, Morrissey JH.

Crit Rev Biochem Mol Biol. 2015;50(4):326-36. doi: 10.3109/10409238.2015.1050550. Epub 2015 May 28. Review.


Polyphosphate, platelets, and coagulation.

Travers RJ, Smith SA, Morrissey JH.

Int J Lab Hematol. 2015 May;37 Suppl 1:31-5. doi: 10.1111/ijlh.12349. Review.


2013 scientific sessions Sol Sherry distinguished lecture in thrombosis: polyphosphate: a novel modulator of hemostasis and thrombosis.

Smith SA, Morrissey JH.

Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1298-305. doi: 10.1161/ATVBAHA.115.301927. Epub 2015 Apr 23.


Clotting activity of polyphosphate-functionalized silica nanoparticles.

Kudela D, Smith SA, May-Masnou A, Braun GB, Pallaoro A, Nguyen CK, Chuong TT, Nownes S, Allen R, Parker NR, Rashidi HH, Morrissey JH, Stucky GD.

Angew Chem Int Ed Engl. 2015 Mar 23;54(13):4018-22. doi: 10.1002/anie.201409639. Epub 2015 Feb 4.


Affinity-based design of a synthetic universal reversal agent for heparin anticoagulants.

Shenoi RA, Kalathottukaren MT, Travers RJ, Lai BF, Creagh AL, Lange D, Yu K, Weinhart M, Chew BH, Du C, Brooks DE, Carter CJ, Morrissey JH, Haynes CA, Kizhakkedathu JN.

Sci Transl Med. 2014 Oct 29;6(260):260ra150. doi: 10.1126/scitranslmed.3009427. Epub 2014 Oct 29.


Polyphosphate accelerates factor V activation by factor XIa.

Choi SH, Smith SA, Morrissey JH.

Thromb Haemost. 2015 Mar;113(3):599-604. doi: 10.1160/TH14-06-0515. Epub 2014 Oct 23.


Size-controlled synthesis of granular polyphosphate nanoparticles at physiologic salt concentrations for blood clotting.

Donovan AJ, Kalkowski J, Smith SA, Morrissey JH, Liu Y.

Biomacromolecules. 2014 Nov 10;15(11):3976-84. doi: 10.1021/bm501046t. Epub 2014 Oct 7.


Nontoxic polyphosphate inhibitors reduce thrombosis while sparing hemostasis.

Travers RJ, Shenoi RA, Kalathottukaren MT, Kizhakkedathu JN, Morrissey JH.

Blood. 2014 Nov 20;124(22):3183-90. doi: 10.1182/blood-2014-05-577932. Epub 2014 Sep 8.


Polyphosphate: a new player in the field of hemostasis.

Smith SA, Morrissey JH.

Curr Opin Hematol. 2014 Sep;21(5):388-94. doi: 10.1097/MOH.0000000000000069. Review.


Synthesis and evaluation of chromogenic and fluorogenic substrates for high-throughput detection of enzymes that hydrolyze inorganic polyphosphate.

Hebbard CF, Wang Y, Baker CJ, Morrissey JH.

Biomacromolecules. 2014 Aug 11;15(8):3190-6. doi: 10.1021/bm500872g. Epub 2014 Jul 15.


Tissue factor residues that putatively interact with membrane phospholipids.

Ke K, Yuan J, Morrissey JH.

PLoS One. 2014 Feb 6;9(2):e88675. doi: 10.1371/journal.pone.0088675. eCollection 2014.


Factor XII inhibition reduces thrombus formation in a primate thrombosis model.

Matafonov A, Leung PY, Gailani AE, Grach SL, Puy C, Cheng Q, Sun MF, McCarty OJ, Tucker EI, Kataoka H, Renné T, Morrissey JH, Gruber A, Gailani D.

Blood. 2014 Mar 13;123(11):1739-46. doi: 10.1182/blood-2013-04-499111. Epub 2014 Jan 9.


Polyphosphate suppresses complement via the terminal pathway.

Wat JM, Foley JH, Krisinger MJ, Ocariza LM, Lei V, Wasney GA, Lameignere E, Strynadka NC, Smith SA, Morrissey JH, Conway EM.

Blood. 2014 Jan 30;123(5):768-76. doi: 10.1182/blood-2013-07-515726. Epub 2013 Dec 13.


Influence of membrane composition on the enhancement of factor VIIa/tissue factor activity by magnesium ions.

Tavoosi N, Morrissey JH.

Thromb Haemost. 2014 Apr 1;111(4):770-2. doi: 10.1160/TH13-07-0628. Epub 2013 Nov 28. No abstract available.


Factor XI anion-binding sites are required for productive interactions with polyphosphate.

Geng Y, Verhamme IM, Smith SA, Cheng Q, Sun M, Sheehan JP, Morrissey JH, Gailani D.

J Thromb Haemost. 2013 Nov;11(11):2020-8. doi: 10.1111/jth.12414.


One inositol ring to rule thrombosis.

Morrissey JH.

Blood. 2013 Aug 22;122(8):1331-2. doi: 10.1182/blood-2013-07-511006.


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