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Correction for Yang et al., "Granzyme B Is an Essential Mediator in CD8+ T Cell Killing of Theileria parva-Infected Cells".

Yang J, Pemberton A, Morrison WI, Connelley T.

Infect Immun. 2019 Sep 19;87(10). pii: e00548-19. doi: 10.1128/IAI.00548-19. Print 2019 Oct. No abstract available.


Molecular and Antigenic Properties of Mammalian Cell-Expressed Theileria parva Antigen Tp9.

Bastos RG, Franceschi V, Tebaldi G, Connelley T, Morrison WI, Knowles DP, Donofrio G, Fry LM.

Front Immunol. 2019 Apr 29;10:897. doi: 10.3389/fimmu.2019.00897. eCollection 2019.


Similar levels of diversity in the gene encoding the p67 sporozoite surface protein of Theileria parva are observed in blood samples from buffalo and cattle naturally infected from buffalo.

Sitt T, Henson S, Morrison WI, Toye P.

Vet Parasitol. 2019 May;269:21-27. doi: 10.1016/j.vetpar.2019.04.006. Epub 2019 Apr 13.


Granzyme B Is an Essential Mediator in CD8+ T Cell Killing of Theileria parva-Infected Cells.

Yang J, Pemberton A, Morrison WI, Connelley T.

Infect Immun. 2018 Dec 19;87(1). pii: e00386-18. doi: 10.1128/IAI.00386-18. Print 2019 Jan. Erratum in: Infect Immun. 2019 Sep 19;87(10):.


Bovine Staphylococcus aureus Superantigens Stimulate the Entire T Cell Repertoire of Cattle.

Wilson GJ, Tuffs SW, Wee BA, Seo KS, Park N, Connelley T, Guinane CM, Morrison WI, Fitzgerald JR.

Infect Immun. 2018 Oct 25;86(11). pii: e00505-18. doi: 10.1128/IAI.00505-18. Print 2018 Nov.


Corrigendum to "Exposure of vaccinated and naive cattle to natural challenge from buffalo-derived Theileria parva" [Int. J. Parasitol. Parasites Wildl. 4(2) (2015) 244-251].

Sitt T, Poole EJ, Ndambuki G, Mwaura S, Njoroge T, Omondi GP, Mutinda M, Mathenge J, Prettejohn G, Morrison WI, Toye P.

Int J Parasitol Parasites Wildl. 2017 Aug 4;6(3):219. doi: 10.1016/j.ijppaw.2017.07.007. eCollection 2017 Dec.


Identification and annotation of bovine granzyme genes reveals a novel granzyme encoded within the trypsin-like locus.

Yang J, Vrettou C, Connelley T, Morrison WI.

Immunogenetics. 2018 Sep;70(9):585-597. doi: 10.1007/s00251-018-1062-6. Epub 2018 Jun 8.


Theileria parva antigens recognized by CD8+ T cells show varying degrees of diversity in buffalo-derived infected cell lines.

Sitt T, Pelle R, Chepkwony M, Morrison WI, Toye P.

Parasitology. 2018 Sep;145(11):1430-1439. doi: 10.1017/S0031182018000264. Epub 2018 May 6.


Ancient diversity and geographical sub-structuring in African buffalo Theileria parva populations revealed through metagenetic analysis of antigen-encoding loci.

Hemmink JD, Sitt T, Pelle R, de Klerk-Lorist LM, Shiels B, Toye PG, Morrison WI, Weir W.

Int J Parasitol. 2018 Mar;48(3-4):287-296. doi: 10.1016/j.ijpara.2017.10.006. Epub 2018 Feb 3.


Identification of immediate early gene products of bovine herpes virus 1 (BHV-1) as dominant antigens recognized by CD8 T cells in immune cattle.

Hart J, MacHugh ND, Sheldrake T, Nielsen M, Morrison WI.

J Gen Virol. 2017 Jul;98(7):1843-1854. doi: 10.1099/jgv.0.000823. Epub 2017 Jul 3.


Development of vaccines for parasitic diseases of animals: Challenges and opportunities.

Morrison WI, Tomley F.

Parasite Immunol. 2016 Dec;38(12):707-708. doi: 10.1111/pim.12398. No abstract available.


Approaches to vaccination against Theileria parva and Theileria annulata.

Nene V, Morrison WI.

Parasite Immunol. 2016 Dec;38(12):724-734. doi: 10.1111/pim.12388. Review.


Identification of Theileria lestoquardi Antigens Recognized by CD8+ T Cells.

Goh S, Ngugi D, Lizundia R, Hostettler I, Woods K, Ballingall K, MacHugh ND, Morrison WI, Weir W, Shiels B, Werling D.

PLoS One. 2016 Sep 9;11(9):e0162571. doi: 10.1371/journal.pone.0162571. eCollection 2016.


Rapid identification of bovine MHCI haplotypes in genetically divergent cattle populations using next-generation sequencing.

Vasoya D, Law A, Motta P, Yu M, Muwonge A, Cook E, Li X, Bryson K, MacCallam A, Sitt T, Toye P, Bronsvoort B, Watson M, Morrison WI, Connelley T.

Immunogenetics. 2016 Nov;68(10):765-781. Epub 2016 Aug 11.


Protection associated with a TB vaccine is linked to increased frequency of Ag85A-specific CD4(+) T cells but no increase in avidity for Ag85A.

Metcalfe HJ, Steinbach S, Jones GJ, Connelley T, Morrison WI, Vordermeier M, Villarreal-Ramos B.

Vaccine. 2016 Aug 31;34(38):4520-4525. doi: 10.1016/j.vaccine.2016.07.055. Epub 2016 Aug 4.


CD8 T-cell responses against the immunodominant Theileria parva peptide Tp249-59 are composed of two distinct populations specific for overlapping 11-mer and 10-mer epitopes.

Connelley TK, Li X, MacHugh N, Colau D, Graham SP, van der Bruggen P, Taracha EL, Gill A, Morrison WI.

Immunology. 2016 Oct;149(2):172-85. doi: 10.1111/imm.12637. Epub 2016 Jul 25.


East Coast Fever Caused by Theileria parva Is Characterized by Macrophage Activation Associated with Vasculitis and Respiratory Failure.

Fry LM, Schneider DA, Frevert CW, Nelson DD, Morrison WI, Knowles DP.

PLoS One. 2016 May 19;11(5):e0156004. doi: 10.1371/journal.pone.0156004. eCollection 2016.


Limited genetic and antigenic diversity within parasite isolates used in a live vaccine against Theileria parva.

Hemmink JD, Weir W, MacHugh ND, Graham SP, Patel E, Paxton E, Shiels B, Toye PG, Morrison WI, Pelle R.

Int J Parasitol. 2016 Jul;46(8):495-506. doi: 10.1016/j.ijpara.2016.02.007. Epub 2016 Apr 11.


The aetiology, pathogenesis and control of theileriosis in domestic animals.

Morrison WI.

Rev Sci Tech. 2015 Aug;34(2):599-611. Review.


Co-infections determine patterns of mortality in a population exposed to parasite infection.

Woolhouse ME, Thumbi SM, Jennings A, Chase-Topping M, Callaby R, Kiara H, Oosthuizen MC, Mbole-Kariuki MN, Conradie I, Handel IG, Poole EJ, Njiiri E, Collins NE, Murray G, Tapio M, Auguet OT, Weir W, Morrison WI, Kruuk LE, Bronsvoort BM, Hanotte O, Coetzer K, Toye PG.

Sci Adv. 2015 Mar 20;1(2):e1400026. doi: 10.1126/sciadv.1400026. eCollection 2015 Mar.


The African buffalo parasite Theileria. sp. (buffalo) can infect and immortalize cattle leukocytes and encodes divergent orthologues of Theileria parva antigen genes.

Bishop RP, Hemmink JD, Morrison WI, Weir W, Toye PG, Sitt T, Spooner PR, Musoke AJ, Skilton RA, Odongo DO.

Int J Parasitol Parasites Wildl. 2015 Aug 29;4(3):333-42. doi: 10.1016/j.ijppaw.2015.08.006. eCollection 2015 Dec.


Haematopoietic depletion in vaccine-induced neonatal pancytopenia depends on both the titre and specificity of alloantibody and levels of MHC I expression.

Bell CR, MacHugh ND, Connelley TK, Degnan K, Morrison WI.

Vaccine. 2015 Jul 9;33(30):3488-96. doi: 10.1016/j.vaccine.2015.05.069. Epub 2015 Jun 11.


Exposure of vaccinated and naive cattle to natural challenge from buffalo-derived Theileria parva.

Sitt T, Poole EJ, Ndambuki G, Mwaura S, Njoroge T, Omondi GP, Mutinda M, Mathenge J, Prettejohn G, Morrison WI, Toye P.

Int J Parasitol Parasites Wildl. 2015 May 8;4(2):244-51. doi: 10.1016/j.ijppaw.2015.04.006. eCollection 2015 Aug. Erratum in: Int J Parasitol Parasites Wildl. 2017 Aug 04;6(3):219.


Understanding the basis of parasite strain-restricted immunity to Theileria parva.

Morrison WI, Connelley T, Hemmink JD, MacHugh ND.

Annu Rev Anim Biosci. 2015;3:397-418. doi: 10.1146/annurev-animal-022513-114152. Epub 2014 Nov 12. Review.


Genomic analysis offers insights into the evolution of the bovine TRA/TRD locus.

Connelley TK, Degnan K, Longhi CW, Morrison WI.

BMC Genomics. 2014 Nov 19;15:994. doi: 10.1186/1471-2164-15-994.


Evidence of a high incidence of subclinically affected calves in a herd of cattle with fatal cases of Bovine Neonatal Pancytopenia (BNP).

Bell CR, Kerr MG, Scott PR, Morrison WI, Brown H.

BMC Vet Res. 2014 Oct 8;10:245. doi: 10.1186/s12917-014-0245-0.


NKp46+ CD3+ cells: a novel nonconventional T cell subset in cattle exhibiting both NK cell and T cell features.

Connelley TK, Longhi C, Burrells A, Degnan K, Hope J, Allan AJ, Hammond JA, Storset AK, Morrison WI.

J Immunol. 2014 Apr 15;192(8):3868-80. doi: 10.4049/jimmunol.1302464. Epub 2014 Mar 17.


Escape from CD8+ T cell response by natural variants of an immunodominant epitope from Theileria parva is predominantly due to loss of TCR recognition.

Connelley TK, MacHugh ND, Pelle R, Weir W, Morrison WI.

J Immunol. 2011 Dec 1;187(11):5910-20. doi: 10.4049/jimmunol.1102009. Epub 2011 Nov 4.


A novel core genome-encoded superantigen contributes to lethality of community-associated MRSA necrotizing pneumonia.

Wilson GJ, Seo KS, Cartwright RA, Connelley T, Chuang-Smith ON, Merriman JA, Guinane CM, Park JY, Bohach GA, Schlievert PM, Morrison WI, Fitzgerald JR.

PLoS Pathog. 2011 Oct;7(10):e1002271. doi: 10.1371/journal.ppat.1002271. Epub 2011 Oct 13.


Herd-level risk factors of bovine tuberculosis in England and Wales after the 2001 foot-and-mouth disease epidemic.

Johnston WT, Vial F, Gettinby G, Bourne FJ, Clifton-Hadley RS, Cox DR, Crea P, Donnelly CA, McInerney JP, Mitchell AP, Morrison WI, Woodroffe R.

Int J Infect Dis. 2011 Dec;15(12):e833-40. doi: 10.1016/j.ijid.2011.08.004. Epub 2011 Sep 28.


Two Theileria parva CD8 T cell antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity.

Pelle R, Graham SP, Njahira MN, Osaso J, Saya RM, Odongo DO, Toye PG, Spooner PR, Musoke AJ, Mwangi DM, Taracha EL, Morrison WI, Weir W, Silva JC, Bishop RP.

PLoS One. 2011 Apr 29;6(4):e19015. doi: 10.1371/journal.pone.0019015.


Extensive polymorphism and evidence of immune selection in a highly dominant antigen recognized by bovine CD8 T cells specific for Theileria annulata.

MacHugh ND, Weir W, Burrells A, Lizundia R, Graham SP, Taracha EL, Shiels BR, Langsley G, Morrison WI.

Infect Immun. 2011 May;79(5):2059-69. doi: 10.1128/IAI.01285-10. Epub 2011 Feb 7.


MHC class I bound to an immunodominant Theileria parva epitope demonstrates unconventional presentation to T cell receptors.

Macdonald IK, Harkiolaki M, Hunt L, Connelley T, Carroll AV, MacHugh ND, Graham SP, Jones EY, Morrison WI, Flower DR, Ellis SA.

PLoS Pathog. 2010 Oct 14;6(10):e1001149. doi: 10.1371/journal.ppat.1001149.


Progress towards understanding the immunobiology of Theileria parasites.

Morrison WI.

Parasitology. 2009 Oct;136(12):1415-26. doi: 10.1017/S0031182009990916. Epub 2009 Aug 20. Review.


CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen: Implications for parasite strain-specific immunity.

MacHugh ND, Connelley T, Graham SP, Pelle R, Formisano P, Taracha EL, Ellis SA, McKeever DJ, Burrells A, Morrison WI.

Eur J Immunol. 2009 Sep;39(9):2459-69. doi: 10.1002/eji.200939227.


Kinetics of the local cellular response in the gastric lymph of immune and susceptible sheep to infection with Teladorsagia circumcincta.

Halliday AM, Morrison WI, Smith WD.

Parasite Immunol. 2009 Jul;31(7):402-11. doi: 10.1111/j.1365-3024.2009.01119.x.


Social group size affects Mycobacterium bovis infection in European badgers (Meles meles).

Woodroffe R, Donnelly CA, Wei G, Cox DR, Bourne FJ, Burke T, Butlin RK, Cheeseman CL, Gettinby G, Gilks P, Hedges S, Jenkins HE, Johnston WT, McInerney JP, Morrison WI, Pope LC.

J Anim Ecol. 2009 Jul;78(4):818-27. doi: 10.1111/j.1365-2656.2009.01545.x. Epub 2009 Mar 30.


Genomic analysis reveals extensive gene duplication within the bovine TRB locus.

Connelley T, Aerts J, Law A, Morrison WI.

BMC Genomics. 2009 Apr 24;10:192. doi: 10.1186/1471-2164-10-192.


Bovine tuberculosis in cattle and badgers in localized culling areas.

Woodroffe R, Donnelly CA, Cox DR, Gilks P, Jenkins HE, Johnston WT, Le Fevre AM, Bourne FJ, Cheeseman CL, Clifton-Hadley RS, Gettinby G, Hewinson RG, McInerney JP, Mitchell AP, Morrison WI, Watkins GH.

J Wildl Dis. 2009 Jan;45(1):128-43.


Use of a Pan-Vbeta primer permits the amplification and sequencing of TCRbeta chains expressed by bovine T-cell clones following a single semi-nested PCR reaction.

Connelley T, Burrells A, Machugh ND, Morrison WI.

Vet Immunol Immunopathol. 2008 Nov 15;126(1-2):156-62. doi: 10.1016/j.vetimm.2008.05.025. Epub 2008 Jun 6.


Infection of cattle with Theileria parva induces an early CD8 T cell response lacking appropriate effector function.

Houston EF, Taracha EL, Brackenbury L, MacHugh ND, McKeever DJ, Charleston B, Morrison WI.

Int J Parasitol. 2008 Dec;38(14):1693-704. doi: 10.1016/j.ijpara.2008.05.014. Epub 2008 Jun 12.


Demonstration of strain-specific CD8 T cell responses to Theileria annulata.

Machugh ND, Burrells AC, Morrison WI.

Parasite Immunol. 2008 Aug;30(8):385-93. doi: 10.1111/j.1365-3024.2008.01038.x.


Dissection of the clonal composition of bovine alphabeta T cell responses using T cell receptor Vbeta subfamily-specific PCR and heteroduplex analysis.

Connelley T, MacHugh ND, Burrells A, Morrison WI.

J Immunol Methods. 2008 Jun 1;335(1-2):28-40. doi: 10.1016/j.jim.2008.02.015. Epub 2008 Mar 19.


Characterization of the fine specificity of bovine CD8 T-cell responses to defined antigens from the protozoan parasite Theileria parva.

Graham SP, Pellé R, Yamage M, Mwangi DM, Honda Y, Mwakubambanya RS, de Villiers EP, Abuya E, Awino E, Gachanja J, Mbwika F, Muthiani AM, Muriuki C, Nyanjui JK, Onono FO, Osaso J, Riitho V, Saya RM, Ellis SA, McKeever DJ, MacHugh ND, Gilbert SC, Audonnet JC, Morrison WI, van der Bruggen P, Taracha EL.

Infect Immun. 2008 Feb;76(2):685-94. Epub 2007 Dec 10.


The prevalence, distribution and severity of detectable pathological lesions in badgers naturally infected with Mycobacterium bovis.

Jenkins HE, Morrison WI, Cox DR, Donnelly CA, Johnston WT, Bourne FJ, Clifton-Hadley RS, Gettinby G, McInerney JP, Watkins GH, Woodroffe R.

Epidemiol Infect. 2008 Oct;136(10):1350-61. Epub 2007 Nov 30.


Host cell-specific protein expression in vitro in Ehrlichia ruminantium.

Postigo M, Taoufik A, Bell-Sakyi L, Bekker CP, de Vries E, Morrison WI, Jongejan F.

Vet Microbiol. 2008 Apr 1;128(1-2):136-47. Epub 2007 Oct 6.


Re: TB policy and the ISG's findings.

Bourne FJ, Donnelly CA, Cox DR, Gettinby G, McInerney JP, Morrison WI, Woodroffe R.

Vet Rec. 2007 Nov 3;161(18):633-5. No abstract available.


The biological and practical significance of antigenic variability in protective T cell responses against Theileria parva.

Morrison WI.

Vet Parasitol. 2007 Aug 19;148(1):21-30. Epub 2007 Jun 18. Review.


Impacts of widespread badger culling on cattle tuberculosis: concluding analyses from a large-scale field trial.

Donnelly CA, Wei G, Johnston WT, Cox DR, Woodroffe R, Bourne FJ, Cheeseman CL, Clifton-Hadley RS, Gettinby G, Gilks P, Jenkins HE, Le Fevre AM, McInerney JP, Morrison WI.

Int J Infect Dis. 2007 Jul;11(4):300-8. Epub 2007 Jun 12.

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