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M-Ras/Shoc2 signaling modulates E-cadherin turnover and cell-cell adhesion during collective cell migration.

Kota P, Terrell EM, Ritt DA, Insinna C, Westlake CJ, Morrison DK.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3536-3545. doi: 10.1073/pnas.1805919116. Epub 2019 Feb 11.


A data-driven study of Chinese participants' social judgments of Chinese faces.

Wang H, Han C, Hahn AC, Fasolt V, Morrison DK, Holzleitner IJ, DeBruine LM, Jones BC.

PLoS One. 2019 Jan 4;14(1):e0210315. doi: 10.1371/journal.pone.0210315. eCollection 2019.


Synthesis and Biological Evaluation of New Madecassic Acid Derivatives Targeting ERK Cascade Signaling.

Valdeira ASC, Ritt DA, Morrison DK, McMahon JB, Gustafson KR, Salvador JAR.

Front Chem. 2018 Sep 28;6:434. doi: 10.3389/fchem.2018.00434. eCollection 2018.


Oncogenic RAS isoforms show a hierarchical requirement for the guanine nucleotide exchange factor SOS2 to mediate cell transformation.

Sheffels E, Sealover NE, Wang C, Kim DH, Vazirani IA, Lee E, M Terrell E, Morrison DK, Luo J, Kortum RL.

Sci Signal. 2018 Sep 4;11(546). pii: eaar8371. doi: 10.1126/scisignal.aar8371.


Macrophilones from the Marine Hydroid Macrorhynchia philippina Can Inhibit ERK Cascade Signaling.

Yan P, Ritt DA, Zlotkowski K, Bokesch HR, Reinhold WC, Schneekloth JS Jr, Morrison DK, Gustafson KR.

J Nat Prod. 2018 Jul 27;81(7):1666-1672. doi: 10.1021/acs.jnatprod.8b00343. Epub 2018 Jul 6.


Ras-Mediated Activation of the Raf Family Kinases.

Terrell EM, Morrison DK.

Cold Spring Harb Perspect Med. 2019 Jan 2;9(1). pii: a033746. doi: 10.1101/cshperspect.a033746. Review.


Oncogenic RAS-Induced Perinuclear Signaling Complexes Requiring KSR1 Regulate Signal Transmission to Downstream Targets.

Basu SK, Lee S, Salotti J, Basu S, Sakchaisri K, Xiao Z, Walia V, Westlake CJ, Morrison DK, Johnson PF.

Cancer Res. 2018 Feb 15;78(4):891-908. doi: 10.1158/0008-5472.CAN-17-2353. Epub 2017 Dec 19.


Targeting the Raf kinases in human cancer: the Raf dimer dilemma.

Durrant DE, Morrison DK.

Br J Cancer. 2018 Jan;118(1):3-8. doi: 10.1038/bjc.2017.399. Epub 2017 Dec 14. Review.


MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.

Sandí MJ, Marshall CB, Balan M, Coyaud É, Zhou M, Monson DM, Ishiyama N, Chandrakumar AA, La Rose J, Couzens AL, Gingras AC, Raught B, Xu W, Ikura M, Morrison DK, Rottapel R.

Sci Signal. 2017 Oct 31;10(503). pii: eaan3286. doi: 10.1126/scisignal.aan3286.


Survival of BRCA2-Deficient Cells Is Promoted by GIPC3, a Novel Genetic Interactor of BRCA2.

Ding X, Philip S, Martin BK, Pang Y, Burkett S, Swing DA, Pamala C, Ritt DA, Zhou M, Morrison DK, Ji X, Sharan SK.

Genetics. 2017 Dec;207(4):1335-1345. doi: 10.1534/genetics.117.300357. Epub 2017 Oct 11.


KIT Suppresses BRAFV600E-Mutant Melanoma by Attenuating Oncogenic RAS/MAPK Signaling.

Neiswender JV, Kortum RL, Bourque C, Kasheta M, Zon LI, Morrison DK, Ceol CJ.

Cancer Res. 2017 Nov 1;77(21):5820-5830. doi: 10.1158/0008-5472.CAN-17-0473. Epub 2017 Sep 25.


RAS signaling: Divide and conquer.

Holderfield M, Morrison DK.

Nat Chem Biol. 2016 Dec 16;13(1):7-8. doi: 10.1038/nchembio.2264. No abstract available.


Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit.

Ritt DA, Abreu-Blanco MT, Bindu L, Durrant DE, Zhou M, Specht SI, Stephen AG, Holderfield M, Morrison DK.

Mol Cell. 2016 Dec 1;64(5):875-887. doi: 10.1016/j.molcel.2016.10.029. Epub 2016 Nov 23.


Path Forward for RAF Therapies: Inhibition of Monomers and Dimers.

Kortum RL, Morrison DK.

Cancer Cell. 2015 Sep 14;28(3):279-81. doi: 10.1016/j.ccell.2015.08.006.


Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma.

Maity TK, Venugopalan A, Linnoila I, Cultraro CM, Giannakou A, Nemati R, Zhang X, Webster JD, Ritt D, Ghosal S, Hoschuetzky H, Simpson RM, Biswas R, Politi K, Morrison DK, Varmus HE, Guha U.

Cancer Discov. 2015 May;5(5):534-49. doi: 10.1158/2159-8290.CD-14-0750. Epub 2015 Mar 3.


EphrinB1 interacts with CNK1 and promotes cell migration through c-Jun N-terminal kinase (JNK) activation.

Cho HJ, Hwang YS, Mood K, Ji YJ, Lim J, Morrison DK, Daar IO.

J Biol Chem. 2014 Jun 27;289(26):18556-68. doi: 10.1074/jbc.M114.558809. Epub 2014 May 13.


The CNK2 scaffold interacts with vilse and modulates Rac cycling during spine morphogenesis in hippocampal neurons.

Lim J, Ritt DA, Zhou M, Morrison DK.

Curr Biol. 2014 Mar 31;24(7):786-92. doi: 10.1016/j.cub.2014.02.036. Epub 2014 Mar 20.


The importance of Raf dimerization in cell signaling.

Freeman AK, Ritt DA, Morrison DK.

Small GTPases. 2013 Jul-Sep;4(3):180-5. doi: 10.4161/sgtp.26117. Epub 2013 Aug 28.


FBXW7α attenuates inflammatory signalling by downregulating C/EBPδ and its target gene Tlr4.

Balamurugan K, Sharan S, Klarmann KD, Zhang Y, Coppola V, Summers GH, Roger T, Morrison DK, Keller JR, Sterneck E.

Nat Commun. 2013;4:1662. doi: 10.1038/ncomms2677.


Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling.

Freeman AK, Ritt DA, Morrison DK.

Mol Cell. 2013 Feb 21;49(4):751-8. doi: 10.1016/j.molcel.2012.12.018. Epub 2013 Jan 24.


A CC-SAM, for coiled coil-sterile α motif, domain targets the scaffold KSR-1 to specific sites in the plasma membrane.

Koveal D, Schuh-Nuhfer N, Ritt D, Page R, Morrison DK, Peti W.

Sci Signal. 2012 Dec 18;5(255):ra94. doi: 10.1126/scisignal.2003289.


MAP kinase pathways.

Morrison DK.

Cold Spring Harb Perspect Biol. 2012 Nov 1;4(11). pii: a011254. doi: 10.1101/cshperspect.a011254. Review. No abstract available.


LAT-independent Erk activation via Bam32-PLC-γ1-Pak1 complexes: GTPase-independent Pak1 activation.

Rouquette-Jazdanian AK, Sommers CL, Kortum RL, Morrison DK, Samelson LE.

Mol Cell. 2012 Oct 26;48(2):298-312. doi: 10.1016/j.molcel.2012.08.011. Epub 2012 Sep 13.


Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapy.

Logue JS, Morrison DK.

Genes Dev. 2012 Apr 1;26(7):641-50. doi: 10.1101/gad.186965.112. Review.


Complexity in KSR function revealed by Raf inhibitor and KSR structure studies.

McKay MM, Freeman AK, Morrison DK.

Small GTPases. 2011 Sep;2(5):276-281. Epub 2011 Sep 1.


Identification of a Src tyrosine kinase/SIAH2 E3 ubiquitin ligase pathway that regulates C/EBPδ expression and contributes to transformation of breast tumor cells.

Sarkar TR, Sharan S, Wang J, Pawar SA, Cantwell CA, Johnson PF, Morrison DK, Wang JM, Sterneck E.

Mol Cell Biol. 2012 Jan;32(2):320-32. doi: 10.1128/MCB.05790-11. Epub 2011 Oct 28.


14-3-3 Proteins: diverse functions in cell proliferation and cancer progression.

Freeman AK, Morrison DK.

Semin Cell Dev Biol. 2011 Sep;22(7):681-7. doi: 10.1016/j.semcdb.2011.08.009. Epub 2011 Aug 22. Review.


RAF inhibitor-induced KSR1/B-RAF binding and its effects on ERK cascade signaling.

McKay MM, Ritt DA, Morrison DK.

Curr Biol. 2011 Apr 12;21(7):563-8. doi: 10.1016/j.cub.2011.02.033. Epub 2011 Mar 31.


AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade.

Smith FD, Langeberg LK, Cellurale C, Pawson T, Morrison DK, Davis RJ, Scott JD.

Nat Cell Biol. 2010 Dec;12(12):1242-9. doi: 10.1038/ncb2130. Epub 2010 Nov 21.


Proteomic analysis of scaffold proteins in the ERK cascade.

McKay MM, Morrison DK.

Methods Mol Biol. 2010;661:323-34. doi: 10.1007/978-1-60761-795-2_19.


CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage.

Wang J, Sarkar TR, Zhou M, Sharan S, Ritt DA, Veenstra TD, Morrison DK, Huang AM, Sterneck E.

Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16131-6. doi: 10.1073/pnas.1002603107. Epub 2010 Aug 30.


The CNK1 scaffold binds cytohesins and promotes insulin pathway signaling.

Lim J, Zhou M, Veenstra TD, Morrison DK.

Genes Dev. 2010 Jul 15;24(14):1496-506. doi: 10.1101/gad.1904610.


Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling.

Ritt DA, Monson DM, Specht SI, Morrison DK.

Mol Cell Biol. 2010 Feb;30(3):806-19. doi: 10.1128/MCB.00569-09. Epub 2009 Nov 23.


KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity.

Costanzo-Garvey DL, Pfluger PT, Dougherty MK, Stock JL, Boehm M, Chaika O, Fernandez MR, Fisher K, Kortum RL, Hong EG, Jun JY, Ko HJ, Schreiner A, Volle DJ, Treece T, Swift AL, Winer M, Chen D, Wu M, Leon LR, Shaw AS, McNeish J, Kim JK, Morrison DK, Tschöp MH, Lewis RE.

Cell Metab. 2009 Nov;10(5):366-78. doi: 10.1016/j.cmet.2009.09.010.


KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals.

Dougherty MK, Ritt DA, Zhou M, Specht SI, Monson DM, Veenstra TD, Morrison DK.

Mol Cell. 2009 Jun 26;34(6):652-62. doi: 10.1016/j.molcel.2009.06.001.


Signaling dynamics of the KSR1 scaffold complex.

McKay MM, Ritt DA, Morrison DK.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11022-7. doi: 10.1073/pnas.0901590106. Epub 2009 Jun 18.


The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development.

Morrison DK.

Trends Cell Biol. 2009 Jan;19(1):16-23. doi: 10.1016/j.tcb.2008.10.003. Epub 2008 Nov 20. Review.


Caspase-dependent cleavage disrupts the ERK cascade scaffolding function of KSR1.

McKay MM, Morrison DK.

J Biol Chem. 2007 Sep 7;282(36):26225-34. Epub 2007 Jul 5.


Integrating signals from RTKs to ERK/MAPK.

McKay MM, Morrison DK.

Oncogene. 2007 May 14;26(22):3113-21. Review.


CK2 Is a component of the KSR1 scaffold complex that contributes to Raf kinase activation.

Ritt DA, Zhou M, Conrads TP, Veenstra TD, Copeland TD, Morrison DK.

Curr Biol. 2007 Jan 23;17(2):179-84. Epub 2006 Dec 14.


KSR regulation of the Raf-MEK-ERK cascade.

Ritt DA, Daar IO, Morrison DK.

Methods Enzymol. 2006;407:224-37.


Kinase suppressor of Ras1 compartmentalizes hippocampal signal transduction and subserves synaptic plasticity and memory formation.

Shalin SC, Hernandez CM, Dougherty MK, Morrison DK, Sweatt JD.

Neuron. 2006 Jun 1;50(5):765-79.


Regulation of Raf-1 by direct feedback phosphorylation.

Dougherty MK, Müller J, Ritt DA, Zhou M, Zhou XZ, Copeland TD, Conrads TP, Veenstra TD, Lu KP, Morrison DK.

Mol Cell. 2005 Jan 21;17(2):215-24.


Cancer: enzymes play molecular tag.

Morrison DK.

Nature. 2004 Apr 22;428(6985):813-5. No abstract available.


Unlocking the code of 14-3-3.

Dougherty MK, Morrison DK.

J Cell Sci. 2004 Apr 15;117(Pt 10):1875-84. Review.


Signal transduction: implications for Ras-dependent ERK signaling.

Ory S, Morrison DK.

Curr Biol. 2004 Apr 6;14(7):R277-8. Review.


Morphogenesis during Xenopus gastrulation requires Wee1-mediated inhibition of cell proliferation.

Murakami MS, Moody SA, Daar IO, Morrison DK.

Development. 2004 Feb;131(3):571-80. Epub 2004 Jan 7.


Inhibition of lysophosphatidic acid acyltransferase beta disrupts proliferative and survival signals in normal cells and induces apoptosis of tumor cells.

Coon M, Ball A, Pound J, Ap S, Hollenback D, White T, Tulinsky J, Bonham L, Morrison DK, Finney R, Singer JW.

Mol Cancer Ther. 2003 Oct;2(10):1067-78.


Regulation of MAP kinase signaling modules by scaffold proteins in mammals.

Morrison DK, Davis RJ.

Annu Rev Cell Dev Biol. 2003;19:91-118. Review.


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