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Items: 1 to 50 of 152

1.

Mesenchyme-free expansion and transplantation of adult alveolar progenitor cells: steps toward cell-based regenerative therapies.

Weiner AI, Jackson SR, Zhao G, Quansah KK, Farshchian JN, Neupauer KM, Littauer EQ, Paris AJ, Liberti DC, Scott Worthen G, Morrisey EE, Vaughan AE.

NPJ Regen Med. 2019 Aug 20;4:17. doi: 10.1038/s41536-019-0080-9. eCollection 2019.

2.

Hedgehog and WNT Signaling: Signaling Hubs in Tracheal Morphogenesis.

Frank DB, Morrisey EE.

Am J Respir Crit Care Med. 2019 Jul 10. doi: 10.1164/rccm.201907-1285ED. [Epub ahead of print] No abstract available.

PMID:
31291547
3.

Dnmt1 is required for proximal-distal patterning of the lung endoderm and for restraining alveolar type 2 cell fate.

Liberti DC, Zepp JA, Bartoni CA, Liberti KH, Zhou S, Lu M, Morley MP, Morrisey EE.

Dev Biol. 2019 Oct 15;454(2):108-117. doi: 10.1016/j.ydbio.2019.06.019. Epub 2019 Jun 23.

PMID:
31242446
4.

Cellular crosstalk in the development and regeneration of the respiratory system.

Zepp JA, Morrisey EE.

Nat Rev Mol Cell Biol. 2019 Sep;20(9):551-566. doi: 10.1038/s41580-019-0141-3. Epub 2019 Jun 19. Review.

PMID:
31217577
5.

BASC-ing in the glow: bronchioalveolar stem cells get their place in the lung.

Basil MC, Morrisey EE.

EMBO J. 2019 Jun 17;38(12). pii: e102344. doi: 10.15252/embj.2019102344. Epub 2019 May 28. No abstract available.

PMID:
31138607
6.

In utero gene editing for monogenic lung disease.

Alapati D, Zacharias WJ, Hartman HA, Rossidis AC, Stratigis JD, Ahn NJ, Coons B, Zhou S, Li H, Singh K, Katzen J, Tomer Y, Chadwick AC, Musunuru K, Beers MF, Morrisey EE, Peranteau WH.

Sci Transl Med. 2019 Apr 17;11(488). pii: eaav8375. doi: 10.1126/scitranslmed.aav8375.

PMID:
30996081
7.

Yap/Taz regulate alveolar regeneration and resolution of lung inflammation.

LaCanna R, Liccardo D, Zhang P, Tragesser L, Wang Y, Cao T, Chapman HA, Morrisey EE, Shen H, Koch WJ, Kosmider B, Wolfson MR, Tian Y.

J Clin Invest. 2019 Apr 15;129(5):2107-2122. doi: 10.1172/JCI125014. eCollection 2019 Apr 15.

8.

The long noncoding RNA Falcor regulates Foxa2 expression to maintain lung epithelial homeostasis and promote regeneration.

Swarr DT, Herriges M, Li S, Morley M, Fernandes S, Sridharan A, Zhou S, Garcia BA, Stewart K, Morrisey EE.

Genes Dev. 2019 Jun 1;33(11-12):656-668. doi: 10.1101/gad.320523.118. Epub 2019 Mar 28.

PMID:
30923168
9.

Early lineage specification defines alveolar epithelial ontogeny in the murine lung.

Frank DB, Penkala IJ, Zepp JA, Sivakumar A, Linares-Saldana R, Zacharias WJ, Stolz KG, Pankin J, Lu M, Wang Q, Babu A, Li L, Zhou S, Morley MP, Jain R, Morrisey EE.

Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4362-4371. doi: 10.1073/pnas.1813952116. Epub 2019 Feb 19.

10.

Repairing the lungs one breath at a time: How dedicated or facultative are you?

Leach JP, Morrisey EE.

Genes Dev. 2018 Dec 1;32(23-24):1461-1471. doi: 10.1101/gad.319418.118. Review.

11.

In utero CRISPR-mediated therapeutic editing of metabolic genes.

Rossidis AC, Stratigis JD, Chadwick AC, Hartman HA, Ahn NJ, Li H, Singh K, Coons BE, Li L, Lv W, Zoltick PW, Alapati D, Zacharias W, Jain R, Morrisey EE, Musunuru K, Peranteau WH.

Nat Med. 2018 Oct;24(10):1513-1518. doi: 10.1038/s41591-018-0184-6. Epub 2018 Oct 8.

12.

The Lung and Esophagus: Developmental and Regenerative Overlap.

Morrisey EE, Rustgi AK.

Trends Cell Biol. 2018 Sep;28(9):738-748. doi: 10.1016/j.tcb.2018.04.007. Epub 2018 Jun 2. Review.

13.

Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium.

McCauley KB, Alysandratos KD, Jacob A, Hawkins F, Caballero IS, Vedaie M, Yang W, Slovik KJ, Morley M, Carraro G, Kook S, Guttentag SH, Stripp BR, Morrisey EE, Kotton DN.

Stem Cell Reports. 2018 May 8;10(5):1579-1595. doi: 10.1016/j.stemcr.2018.03.013. Epub 2018 Apr 12.

14.

Basal Cells in Lung Development and Repair.

Morrisey EE.

Dev Cell. 2018 Mar 26;44(6):653-654. doi: 10.1016/j.devcel.2018.03.004.

15.

Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor.

Zacharias WJ, Frank DB, Zepp JA, Morley MP, Alkhaleel FA, Kong J, Zhou S, Cantu E, Morrisey EE.

Nature. 2018 Mar 8;555(7695):251-255. doi: 10.1038/nature25786. Epub 2018 Feb 28.

16.

Local and sustained miRNA delivery from an injectable hydrogel promotes cardiomyocyte proliferation and functional regeneration after ischemic injury.

Wang LL, Liu Y, Chung JJ, Wang T, Gaffey AC, Lu M, Cavanaugh CA, Zhou S, Kanade R, Atluri P, Morrisey EE, Burdick JA.

Nat Biomed Eng. 2017;1:983-992. doi: 10.1038/s41551-017-0157-y. Epub 2017 Nov 27.

17.

Novel Molecular and Phenotypic Insights into Congenital Lung Malformations.

Swarr DT, Peranteau WH, Pogoriler J, Frank DB, Adzick NS, Hedrick HL, Morley M, Zhou S, Morrisey EE.

Am J Respir Crit Care Med. 2018 May 15;197(10):1328-1339. doi: 10.1164/rccm.201706-1243OC.

18.

Deep RNA Sequencing Uncovers a Repertoire of Human Macrophage Long Intergenic Noncoding RNAs Modulated by Macrophage Activation and Associated With Cardiometabolic Diseases.

Zhang H, Xue C, Wang Y, Shi J, Zhang X, Li W, Nunez S, Foulkes AS, Lin J, Hinkle CC, Yang W, Morrisey EE, Rader DJ, Li M, Reilly MP.

J Am Heart Assoc. 2017 Nov 13;6(11). pii: e007431. doi: 10.1161/JAHA.117.007431.

19.

Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis.

Goddard LM, Duchemin AL, Ramalingan H, Wu B, Chen M, Bamezai S, Yang J, Li L, Morley MP, Wang T, Scherrer-Crosbie M, Frank DB, Engleka KA, Jameson SC, Morrisey EE, Carroll TJ, Zhou B, Vermot J, Kahn ML.

Dev Cell. 2017 Nov 6;43(3):274-289.e5. doi: 10.1016/j.devcel.2017.09.023. Epub 2017 Oct 19.

20.

Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction.

Poleshko A, Shah PP, Gupta M, Babu A, Morley MP, Manderfield LJ, Ifkovits JL, Calderon D, Aghajanian H, Sierra-Pagán JE, Sun Z, Wang Q, Li L, Dubois NC, Morrisey EE, Lazar MA, Smith CL, Epstein JA, Jain R.

Cell. 2017 Oct 19;171(3):573-587.e14. doi: 10.1016/j.cell.2017.09.018. Epub 2017 Oct 12.

21.

Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells.

Jacob A, Morley M, Hawkins F, McCauley KB, Jean JC, Heins H, Na CL, Weaver TE, Vedaie M, Hurley K, Hinds A, Russo SJ, Kook S, Zacharias W, Ochs M, Traber K, Quinton LJ, Crane A, Davis BR, White FV, Wambach J, Whitsett JA, Cole FS, Morrisey EE, Guttentag SH, Beers MF, Kotton DN.

Cell Stem Cell. 2017 Oct 5;21(4):472-488.e10. doi: 10.1016/j.stem.2017.08.014. Epub 2017 Sep 28.

22.

Distinct Mesenchymal Lineages and Niches Promote Epithelial Self-Renewal and Myofibrogenesis in the Lung.

Zepp JA, Zacharias WJ, Frank DB, Cavanaugh CA, Zhou S, Morley MP, Morrisey EE.

Cell. 2017 Sep 7;170(6):1134-1148.e10. doi: 10.1016/j.cell.2017.07.034.

23.

WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation.

Xu M, Horrell J, Snitow M, Cui J, Gochnauer H, Syrett CM, Kallish S, Seykora JT, Liu F, Gaillard D, Katz JP, Kaestner KH, Levin B, Mansfield C, Douglas JE, Cowart BJ, Tordoff M, Liu F, Zhu X, Barlow LA, Rubin AI, McGrath JA, Morrisey EE, Chu EY, Millar SE.

Nat Commun. 2017 Jun 7;8:15397. doi: 10.1038/ncomms15397.

24.

The NANCI-Nkx2.1 gene duplex buffers Nkx2.1 expression to maintain lung development and homeostasis.

Herriges MJ, Tischfield DJ, Cui Z, Morley MP, Han Y, Babu A, Li S, Lu M, Cendan I, Garcia BA, Anderson SA, Morrisey EE.

Genes Dev. 2017 May 1;31(9):889-903. doi: 10.1101/gad.298018.117. Epub 2017 May 25.

25.

Lack of MTTP Activity in Pluripotent Stem Cell-Derived Hepatocytes and Cardiomyocytes Abolishes apoB Secretion and Increases Cell Stress.

Liu Y, Conlon DM, Bi X, Slovik KJ, Shi J, Edelstein HI, Millar JS, Javaheri A, Cuchel M, Pashos EE, Iqbal J, Hussain MM, Hegele RA, Yang W, Duncan SA, Rader DJ, Morrisey EE.

Cell Rep. 2017 May 16;19(7):1456-1466. doi: 10.1016/j.celrep.2017.04.064.

26.

Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci.

Pashos EE, Park Y, Wang X, Raghavan A, Yang W, Abbey D, Peters DT, Arbelaez J, Hernandez M, Kuperwasser N, Li W, Lian Z, Liu Y, Lv W, Lytle-Gabbin SL, Marchadier DH, Rogov P, Shi J, Slovik KJ, Stylianou IM, Wang L, Yan R, Zhang X, Kathiresan S, Duncan SA, Mikkelsen TS, Morrisey EE, Rader DJ, Brown CD, Musunuru K.

Cell Stem Cell. 2017 Apr 6;20(4):558-570.e10. doi: 10.1016/j.stem.2017.03.017.

27.

A Drug Screen using Human iPSC-Derived Hepatocyte-like Cells Reveals Cardiac Glycosides as a Potential Treatment for Hypercholesterolemia.

Cayo MA, Mallanna SK, Di Furio F, Jing R, Tolliver LB, Bures M, Urick A, Noto FK, Pashos EE, Greseth MD, Czarnecki M, Traktman P, Yang W, Morrisey EE, Grompe M, Rader DJ, Duncan SA.

Cell Stem Cell. 2017 Apr 6;20(4):478-489.e5. doi: 10.1016/j.stem.2017.01.011.

28.

ATP-Binding Cassette Transporter A1 Deficiency in Human Induced Pluripotent Stem Cell-Derived Hepatocytes Abrogates HDL Biogenesis and Enhances Triglyceride Secretion.

Bi X, Pashos EE, Cuchel M, Lyssenko NN, Hernandez M, Picataggi A, McParland J, Yang W, Liu Y, Yan R, Yu C, DerOhannessian SL, Phillips MC, Morrisey EE, Duncan SA, Rader DJ.

EBioMedicine. 2017 Apr;18:139-145. doi: 10.1016/j.ebiom.2017.03.018. Epub 2017 Mar 14.

29.

Developmental pathways in lung regeneration.

Stabler CT, Morrisey EE.

Cell Tissue Res. 2017 Mar;367(3):677-685. doi: 10.1007/s00441-016-2537-0. Epub 2016 Dec 13. Review.

30.

Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation.

Frank DB, Peng T, Zepp JA, Snitow M, Vincent TL, Penkala IJ, Cui Z, Herriges MJ, Morley MP, Zhou S, Lu MM, Morrisey EE.

Cell Rep. 2016 Nov 22;17(9):2312-2325. doi: 10.1016/j.celrep.2016.11.001.

31.

Ezh2 restricts the smooth muscle lineage during mouse lung mesothelial development.

Snitow M, Lu M, Cheng L, Zhou S, Morrisey EE.

Development. 2016 Oct 15;143(20):3733-3741. Epub 2016 Aug 30.

32.

Gene Editing and Genetic Lung Disease. Basic Research Meets Therapeutic Application.

Alapati D, Morrisey EE.

Am J Respir Cell Mol Biol. 2017 Mar;56(3):283-290. doi: 10.1165/rcmb.2016-0301PS. Review.

33.

Neutrophils promote alveolar epithelial regeneration by enhancing type II pneumocyte proliferation in a model of acid-induced acute lung injury.

Paris AJ, Liu Y, Mei J, Dai N, Guo L, Spruce LA, Hudock KM, Brenner JS, Zacharias WJ, Mei HD, Slamowitz AR, Bhamidipati K, Beers MF, Seeholzer SH, Morrisey EE, Worthen GS.

Am J Physiol Lung Cell Mol Physiol. 2016 Dec 1;311(6):L1062-L1075. doi: 10.1152/ajplung.00327.2016. Epub 2016 Sep 30.

34.

Foxp transcription factors suppress a non-pulmonary gene expression program to permit proper lung development.

Li S, Morley M, Lu M, Zhou S, Stewart K, French CA, Tucker HO, Fisher SE, Morrisey EE.

Dev Biol. 2016 Aug 15;416(2):338-46. doi: 10.1016/j.ydbio.2016.06.020. Epub 2016 Jun 21.

35.

Heterogeneity in readouts of canonical wnt pathway activity within intestinal crypts.

Li N, Yousefi M, Nakauka-Ddamba A, Tobias JW, Jensen ST, Morrisey EE, Lengner CJ.

Dev Dyn. 2016 Aug;245(8):822-33. doi: 10.1002/dvdy.24423. Epub 2016 Jul 5.

36.

Expression of histone deacetylase 3 instructs alveolar type I cell differentiation by regulating a Wnt signaling niche in the lung.

Wang X, Wang Y, Snitow ME, Stewart KM, Li S, Lu M, Morrisey EE.

Dev Biol. 2016 Jun 15;414(2):161-9. doi: 10.1016/j.ydbio.2016.04.023. Epub 2016 Apr 30.

37.

Epithelium-generated neuropeptide Y induces smooth muscle contraction to promote airway hyperresponsiveness.

Li S, Koziol-White C, Jude J, Jiang M, Zhao H, Cao G, Yoo E, Jester W, Morley MP, Zhou S, Wang Y, Lu MM, Panettieri RA Jr, Morrisey EE.

J Clin Invest. 2016 May 2;126(5):1978-82. doi: 10.1172/JCI81389. Epub 2016 Apr 18.

38.

INFLAMMATION. Modulating pulmonary inflammation.

Whitsett JA, Morrisey EE.

Science. 2016 Feb 12;351(6274):662-3. doi: 10.1126/science.aaf1429. No abstract available.

PMID:
26912844
39.

HDAC3-Dependent Epigenetic Pathway Controls Lung Alveolar Epithelial Cell Remodeling and Spreading via miR-17-92 and TGF-β Signaling Regulation.

Wang Y, Frank DB, Morley MP, Zhou S, Wang X, Lu MM, Lazar MA, Morrisey EE.

Dev Cell. 2016 Feb 8;36(3):303-15. doi: 10.1016/j.devcel.2015.12.031. Epub 2016 Jan 28.

40.

DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly.

Ajima R, Bisson JA, Helt JC, Nakaya MA, Habas R, Tessarollo L, He X, Morrisey EE, Yamaguchi TP, Cohen ED.

Dev Biol. 2015 Dec 1;408(1):126-39. doi: 10.1016/j.ydbio.2015.10.003. Epub 2015 Oct 23.

41.

Hippo and Cardiac Hypertrophy: A Complex Interaction.

Windmueller R, Morrisey EE.

Circ Res. 2015 Oct 23;117(10):832-4. doi: 10.1161/CIRCRESAHA.115.307546. No abstract available.

42.

Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration.

Peng T, Frank DB, Kadzik RS, Morley MP, Rathi KS, Wang T, Zhou S, Cheng L, Lu MM, Morrisey EE.

Nature. 2015 Oct 22;526(7574):578-82. doi: 10.1038/nature14984. Epub 2015 Oct 5.

43.

Lung endoderm morphogenesis: gasping for form and function.

Swarr DT, Morrisey EE.

Annu Rev Cell Dev Biol. 2015;31:553-73. doi: 10.1146/annurev-cellbio-100814-125249. Epub 2015 Sep 10. Review.

44.

Generation of iPSCs as a Pooled Culture Using Magnetic Activated Cell Sorting of Newly Reprogrammed Cells.

Yang W, Liu Y, Slovik KJ, Wu JC, Duncan SA, Rader DJ, Morrisey EE.

PLoS One. 2015 Aug 17;10(8):e0134995. doi: 10.1371/journal.pone.0134995. eCollection 2015.

45.

HEART DEVELOPMENT. Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts.

Jain R, Li D, Gupta M, Manderfield LJ, Ifkovits JL, Wang Q, Liu F, Liu Y, Poleshko A, Padmanabhan A, Raum JC, Li L, Morrisey EE, Lu MM, Won KJ, Epstein JA.

Science. 2015 Jun 26;348(6242):aaa6071. doi: 10.1126/science.aaa6071.

46.

The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice.

Spaeth JM, Hunter CS, Bonatakis L, Guo M, French CA, Slack I, Hara M, Fisher SE, Ferrer J, Morrisey EE, Stanger BZ, Stein R.

Diabetologia. 2015 Aug;58(8):1836-44. doi: 10.1007/s00125-015-3635-3. Epub 2015 May 29.

47.

Functional analysis and transcriptomic profiling of iPSC-derived macrophages and their application in modeling Mendelian disease.

Zhang H, Xue C, Shah R, Bermingham K, Hinkle CC, Li W, Rodrigues A, Tabita-Martinez J, Millar JS, Cuchel M, Pashos EE, Liu Y, Yan R, Yang W, Gosai SJ, VanDorn D, Chou ST, Gregory BD, Morrisey EE, Li M, Rader DJ, Reilly MP.

Circ Res. 2015 Jun 19;117(1):17-28. doi: 10.1161/CIRCRESAHA.117.305860. Epub 2015 Apr 22.

48.

A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice.

Tian Y, Liu Y, Wang T, Zhou N, Kong J, Chen L, Snitow M, Morley M, Li D, Petrenko N, Zhou S, Lu M, Gao E, Koch WJ, Stewart KM, Morrisey EE.

Sci Transl Med. 2015 Mar 18;7(279):279ra38. doi: 10.1126/scitranslmed.3010841.

49.

Ezh2 represses the basal cell lineage during lung endoderm development.

Snitow ME, Li S, Morley MP, Rathi K, Lu MM, Kadzik RS, Stewart KM, Morrisey EE.

Development. 2015 Jan 1;142(1):108-17. doi: 10.1242/dev.116947.

50.

BRD4 regulates Nanog expression in mouse embryonic stem cells and preimplantation embryos.

Liu W, Stein P, Cheng X, Yang W, Shao NY, Morrisey EE, Schultz RM, You J.

Cell Death Differ. 2014 Dec;21(12):1950-60. doi: 10.1038/cdd.2014.124. Epub 2014 Aug 22.

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