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An epigenome-wide association study of sex-specific chronological ageing.

McCartney DL, Zhang F, Hillary RF, Zhang Q, Stevenson AJ, Walker RM, Bermingham ML, Boutin T, Morris SW, Campbell A, Murray AD, Whalley HC, Porteous DJ, Hayward C, Evans KL, Chandra T, Deary IJ, McIntosh AM, Yang J, Visscher PM, McRae AF, Marioni RE.

Genome Med. 2019 Dec 31;12(1):1. doi: 10.1186/s13073-019-0693-z.


A meta-analysis of genome-wide association studies of epigenetic age acceleration.

Gibson J, Russ TC, Clarke TK, Howard DM, Hillary RF, Evans KL, Walker RM, Bermingham ML, Morris SW, Campbell A, Hayward C, Murray AD, Porteous DJ, Horvath S, Lu AT, McIntosh AM, Whalley HC, Marioni RE.

PLoS Genet. 2019 Nov 18;15(11):e1008104. doi: 10.1371/journal.pgen.1008104. eCollection 2019 Nov.


A β2-Integrin/MRTF-A/SRF Pathway Regulates Dendritic Cell Gene Expression, Adhesion, and Traction Force Generation.

Guenther C, Faisal I, Uotila LM, Asens ML, Harjunpää H, Savinko T, Öhman T, Yao S, Moser M, Morris SW, Tojkander S, Fagerholm SC.

Front Immunol. 2019 May 28;10:1138. doi: 10.3389/fimmu.2019.01138. eCollection 2019.


Publisher Correction: Parent of origin genetic effects on methylation in humans are common and influence complex trait variation.

Zeng Y, Amador C, Xia C, Marioni R, Sproul D, Walker RM, Morris SW, Bretherick A, Canela-Xandri O, Boutin TS, Clark DW, Campbell A, Rawlik K, Hayward C, Nagy R, Tenesa A, Porteous DJ, Wilson JF, Deary IJ, Evans KL, McIntosh AM, Navarro P, Haley CS.

Nat Commun. 2019 May 1;10(1):2069. doi: 10.1038/s41467-019-10155-7.


Assessment of dried blood spots for DNA methylation profiling.

Walker RM, MacGillivray L, McCafferty S, Wrobel N, Murphy L, Kerr SM, Morris SW, Campbell A, McIntosh AM, Porteous DJ, Evans KL.

Wellcome Open Res. 2019 Mar 6;4:44. doi: 10.12688/wellcomeopenres.15136.1. eCollection 2019.


Identification of novel differentially methylated sites with potential as clinical predictors of impaired respiratory function and COPD.

Bermingham ML, Walker RM, Marioni RE, Morris SW, Rawlik K, Zeng Y, Campbell A, Redmond P, Whalley HC, Adams MJ, Hayward C, Deary IJ, Porteous DJ, McIntosh AM, Evans KL.

EBioMedicine. 2019 May;43:576-586. doi: 10.1016/j.ebiom.2019.03.072. Epub 2019 Mar 29.


Parent of origin genetic effects on methylation in humans are common and influence complex trait variation.

Zeng Y, Amador C, Xia C, Marioni R, Sproul D, Walker RM, Morris SW, Bretherick A, Canela-Xandri O, Boutin TS, Clark DW, Campbell A, Rawlik K, Hayward C, Nagy R, Tenesa A, Porteous DJ, Wilson JF, Deary IJ, Evans KL, McIntosh AM, Navarro P, Haley CS.

Nat Commun. 2019 Mar 27;10(1):1383. doi: 10.1038/s41467-019-09301-y. Erratum in: Nat Commun. 2019 May 1;10(1):2069.


An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort.

Hamilton OKL, Zhang Q, McRae AF, Walker RM, Morris SW, Redmond P, Campbell A, Murray AD, Porteous DJ, Evans KL, McIntosh AM, Deary IJ, Marioni RE.

Int J Obes (Lond). 2019 Sep;43(9):1795-1802. doi: 10.1038/s41366-018-0262-3. Epub 2019 Mar 6.


Epigenetic signatures of starting and stopping smoking.

McCartney DL, Stevenson AJ, Hillary RF, Walker RM, Bermingham ML, Morris SW, Clarke TK, Campbell A, Murray AD, Whalley HC, Porteous DJ, Visscher PM, McIntosh AM, Evans KL, Deary IJ, Marioni RE.

EBioMedicine. 2018 Nov;37:214-220. doi: 10.1016/j.ebiom.2018.10.051. Epub 2018 Oct 30.


Rates of immune cell infiltration in patients with triple-negative breast cancer by molecular subtype.

Harano K, Wang Y, Lim B, Seitz RS, Morris SW, Bailey DB, Hout DR, Skelton RL, Ring BZ, Masuda H, Rao AUK, Laere SV, Bertucci F, Woodward WA, Reuben JM, Krishnamurthy S, Ueno NT.

PLoS One. 2018 Oct 12;13(10):e0204513. doi: 10.1371/journal.pone.0204513. eCollection 2018.


Epigenetic prediction of complex traits and death.

McCartney DL, Hillary RF, Stevenson AJ, Ritchie SJ, Walker RM, Zhang Q, Morris SW, Bermingham ML, Campbell A, Murray AD, Whalley HC, Gale CR, Porteous DJ, Haley CS, McRae AF, Wray NR, Visscher PM, McIntosh AM, Evans KL, Deary IJ, Marioni RE.

Genome Biol. 2018 Sep 27;19(1):136. doi: 10.1186/s13059-018-1514-1.


Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer's disease.

McCartney DL, Stevenson AJ, Walker RM, Gibson J, Morris SW, Campbell A, Murray AD, Whalley HC, Porteous DJ, McIntosh AM, Evans KL, Deary IJ, Marioni RE.

Alzheimers Dement (Amst). 2018 Jun 21;10:429-437. doi: 10.1016/j.dadm.2018.05.006. eCollection 2018.


DNA sequence-level analyses reveal potential phenotypic modifiers in a large family with psychiatric disorders.

Ryan NM, Lihm J, Kramer M, McCarthy S, Morris SW, Arnau-Soler A, Davies G, Duff B, Ghiban E, Hayward C, Deary IJ, Blackwood DHR, Lawrie SM, McIntosh AM, Evans KL, Porteous DJ, McCombie WR, Thomson PA.

Mol Psychiatry. 2018 Dec;23(12):2254-2265. doi: 10.1038/s41380-018-0087-4. Epub 2018 Jun 7.


Altered DNA methylation associated with a translocation linked to major mental illness.

McCartney DL, Walker RM, Morris SW, Anderson SM, Duff BJ, Marioni RE, Millar JK, McCarthy SE, Ryan NM, Lawrie SM, Watson AR, Blackwood DHR, Thomson PA, McIntosh AM, McCombie WR, Porteous DJ, Evans KL.

NPJ Schizophr. 2018 Mar 19;4(1):5. doi: 10.1038/s41537-018-0047-7.


Performance of a RT-PCR Assay in Comparison to FISH and Immunohistochemistry for the Detection of ALK in Non-Small Cell Lung Cancer.

Hout DR, Schweitzer BL, Lawrence K, Morris SW, Tucker T, Mazzola R, Skelton R, McMahon F, Handshoe J, Lesperance M, Karsan A, Saltman DL.

Cancers (Basel). 2017 Aug 1;9(8). pii: E99. doi: 10.3390/cancers9080099.


Comparison of triple-negative breast cancer molecular subtyping using RNA from matched fresh-frozen versus formalin-fixed paraffin-embedded tissue.

Jovanović B, Sheng Q, Seitz RS, Lawrence KD, Morris SW, Thomas LR, Hout DR, Schweitzer BL, Guo Y, Pietenpol JA, Lehmann BD.

BMC Cancer. 2017 Apr 4;17(1):241. doi: 10.1186/s12885-017-3237-1.


MLF1 is a proapoptotic antagonist of HOP complex-mediated survival.

Sun Y, Chao JR, Xu W, Pourpak A, Boyd K, Moshiach S, Qi GY, Fu A, Shao HR, Pounds S, Morris SW.

Biochim Biophys Acta Mol Cell Res. 2017 Apr;1864(4):719-727. doi: 10.1016/j.bbamcr.2017.01.016. Epub 2017 Jan 27.


Balanced translocation linked to psychiatric disorder, glutamate, and cortical structure/function.

Thomson PA, Duff B, Blackwood DH, Romaniuk L, Watson A, Whalley HC, Li X, Dauvermann MR, Moorhead TW, Bois C, Ryan NM, Redpath H, Hall L, Morris SW, van Beek EJ, Roberts N, Porteous DJ, St Clair D, Whitcher B, Dunlop J, Brandon NJ, Hughes ZA, Hall J, McIntosh A, Lawrie SM.

NPJ Schizophr. 2016 Aug 10;2:16024. doi: 10.1038/npjschz.2016.24. eCollection 2016.


Identification of polymorphic and off-target probe binding sites on the Illumina Infinium MethylationEPIC BeadChip.

McCartney DL, Walker RM, Morris SW, McIntosh AM, Porteous DJ, Evans KL.

Genom Data. 2016 May 26;9:22-4. doi: 10.1016/j.gdata.2016.05.012. eCollection 2016 Sep.


Erratum to: Generation of an algorithm based on minimal gene sets to clinically subtype triple negative breast cancer patients.

Ring BZ, Hout DR, Morris SW, Lawrence K, Schweitzer BL, Bailey DB, Lehmann BD, Pietenpol JA, Seitz RS.

BMC Cancer. 2016 Apr 18;16:275. doi: 10.1186/s12885-016-2307-0. No abstract available.


Successful treatment of hepatic oligometastases with stereotactic ablative radiotherapy and radiofrequency ablation in an anaplastic lymphoma kinase fusion-positive lung cancer patient.

Weber B, Liu M, Sobkin P, Morris SW, Hout D, van der Westhuizen N, Tonseth RP, Saltman DL.

J Med Radiat Sci. 2016 Mar;63(1):67-70. doi: 10.1002/jmrs.144. Epub 2015 Oct 3.


Generation of an algorithm based on minimal gene sets to clinically subtype triple negative breast cancer patients.

Ring BZ, Hout DR, Morris SW, Lawrence K, Schweitzer BL, Bailey DB, Lehmann BD, Pietenpol JA, Seitz RS.

BMC Cancer. 2016 Feb 23;16:143. doi: 10.1186/s12885-016-2198-0. Erratum in: BMC Cancer. 2016;16(1):275.


DNA methylation in a Scottish family multiply affected by bipolar disorder and major depressive disorder.

Walker RM, Christoforou AN, McCartney DL, Morris SW, Kennedy NA, Morten P, Anderson SM, Torrance HS, Macdonald A, Sussmann JE, Whalley HC, Blackwood DH, McIntosh AM, Porteous DJ, Evans KL.

Clin Epigenetics. 2016 Jan 20;8:5. doi: 10.1186/s13148-016-0171-z. eCollection 2016.


Myeloid leukemia factor 1 interfered with Bcl-XL to promote apoptosis and its function was regulated by 14-3-3.

Sun Y, Fu A, Xu W, Chao JR, Moshiach S, Morris SW.

J Physiol Biochem. 2015 Dec;71(4):807-21. doi: 10.1007/s13105-015-0445-5. Epub 2015 Nov 12.


Detection of a TRAF1-ALK fusion in an anaplastic large cell lymphoma patient with chemotherapy and ALK inhibitor-resistant disease.

Lawrence K, Berry B, Handshoe J, Hout D, Mazzola R, Morris SW, Saltman DL.

BMC Res Notes. 2015 Jul 18;8:308. doi: 10.1186/s13104-015-1277-7.


SuRFing the genomics wave: an R package for prioritising SNPs by functionality.

Ryan NM, Morris SW, Porteous DJ, Taylor MS, Evans KL.

Genome Med. 2014 Oct 14;6(10):79. doi: 10.1186/s13073-014-0079-1. eCollection 2014.


708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits.

Thomson PA, Parla JS, McRae AF, Kramer M, Ramakrishnan K, Yao J, Soares DC, McCarthy S, Morris SW, Cardone L, Cass S, Ghiban E, Hennah W, Evans KL, Rebolini D, Millar JK, Harris SE, Starr JM, MacIntyre DJ; Generation Scotland, McIntosh AM, Watson JD, Deary IJ, Visscher PM, Blackwood DH, McCombie WR, Porteous DJ.

Mol Psychiatry. 2014 Jun;19(6):668-75. doi: 10.1038/mp.2013.68. Epub 2013 Jun 4.


Bcl10 is an essential regulator for A20 gene expression.

Xu W, Xue L, Sun Y, Henry A, Battle JM, Micault M, Morris SW.

J Physiol Biochem. 2013 Dec;69(4):821-34. doi: 10.1007/s13105-013-0259-2. Epub 2013 May 16.


Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer.

Sang J, Acquaviva J, Friedland JC, Smith DL, Sequeira M, Zhang C, Jiang Q, Xue L, Lovly CM, Jimenez JP, Shaw AT, Doebele RC, He S, Bates RC, Camidge DR, Morris SW, El-Hariry I, Proia DA.

Cancer Discov. 2013 Apr;3(4):430-43. doi: 10.1158/2159-8290.CD-12-0440. Epub 2013 Mar 26.


The heads and tails of buoyant autocatalytic balls.

Rogers MC, Morris SW.

Chaos. 2012 Sep;22(3):037110.


Frequency structure of the nonlinear instability of a dragged viscous thread.

Welch RL, Szeto B, Morris SW.

Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Jun;85(6 Pt 2):066209. Epub 2012 Jun 26.


Targeted inactivation of nuclear interaction partner of ALK disrupts meiotic prophase.

Illert AL, Kawaguchi H, Antinozzi C, Bassermann F, Quintanilla-Martinez L, von Klitzing C, Hiwatari M, Peschel C, de Rooij DG, Morris SW, Barchi M, Duyster J.

Development. 2012 Jul;139(14):2523-34. doi: 10.1242/dev.073072. Epub 2012 Jun 13.


Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction.

Huang X, Yang N, Fiore VF, Barker TH, Sun Y, Morris SW, Ding Q, Thannickal VJ, Zhou Y.

Am J Respir Cell Mol Biol. 2012 Sep;47(3):340-8. doi: 10.1165/rcmb.2012-0050OC. Epub 2012 Mar 29.


Lift and drag forces on an inclined plow moving over a granular surface.

Percier B, Manneville S, McElwaine JN, Morris SW, Taberlet N.

Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Nov;84(5 Pt 1):051302. Epub 2011 Nov 3.


Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis.

Weiss JB, Xue C, Benice T, Xue L, Morris SW, Raber J.

Pharmacol Biochem Behav. 2012 Jan;100(3):566-74. doi: 10.1016/j.pbb.2011.10.024. Epub 2011 Nov 4.


Inhibition of caspase-8 activity caused by overexpression of BCL10 contributes to the pathogenesis of high-grade MALT lymphoma.

Chen Y, Yang Y, Sun M, Yan Z, Wu L, Cui X, Zhang G, Morris SW, Zhang Q.

Pediatr Blood Cancer. 2012 Jun;58(6):865-71. doi: 10.1002/pbc.23331. Epub 2011 Sep 23.


Design, synthesis and initial biological evaluation of a novel pladienolide analog scaffold.

Gundluru MK, Pourpak A, Cui X, Morris SW, Webb TR.

Medchemcomm. 2011 Jan 1;2(9):904-908.


An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol.

Lasek AW, Lim J, Kliethermes CL, Berger KH, Joslyn G, Brush G, Xue L, Robertson M, Moore MS, Vranizan K, Morris SW, Schuckit MA, White RL, Heberlein U.

PLoS One. 2011;6(7):e22636. doi: 10.1371/journal.pone.0022636. Epub 2011 Jul 22.


Synthesis of an aryloxy oxo pyrimidinone library that displays ALK-selective inhibition.

Slavish PJ, Price JE, Jiang Q, Cui X, Morris SW, Webb TR.

Bioorg Med Chem Lett. 2011 Aug 1;21(15):4592-6. doi: 10.1016/j.bmcl.2011.05.103. Epub 2011 Jun 12.


Experiments on the morphology of icicles.

Chen AS, Morris SW.

Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Feb;83(2 Pt 2):026307. Epub 2011 Feb 17.


Autocatalytic plume pinch-off.

Rogers MC, Zebib A, Morris SW.

Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Dec;82(6 Pt 2):066307. Epub 2010 Dec 7.


Association analysis of Neuregulin 1 candidate regions in schizophrenia and bipolar disorder.

Walker RM, Christoforou A, Thomson PA, McGhee KA, Maclean A, Mühleisen TW, Strohmaier J, Nieratschker V, Nöthen MM, Rietschel M, Cichon S, Morris SW, Jilani O, Stclair D, Blackwood DH, Muir WJ, Porteous DJ, Evans KL.

Neurosci Lett. 2010 Jun 30;478(1):9-13. doi: 10.1016/j.neulet.2010.04.056. Epub 2010 May 7.


Convergence of linkage, association and GWAS findings for a candidate region for bipolar disorder and schizophrenia on chromosome 4p.

Christoforou A, McGhee KA, Morris SW, Thomson PA, Anderson S, McLean A, Torrance HS, Le Hellard S, Pickard BS, StClair D, Muir WJ, Blackwood DH, Porteous DJ, Evans KL.

Mol Psychiatry. 2011 Mar;16(3):240-2. doi: 10.1038/mp.2010.25. Epub 2010 Mar 30. No abstract available.


Synthetic mRNA splicing modulator compounds with in vivo antitumor activity.

Lagisetti C, Pourpak A, Goronga T, Jiang Q, Cui X, Hyle J, Lahti JM, Morris SW, Webb TR.

J Med Chem. 2009 Nov 26;52(22):6979-90. doi: 10.1021/jm901215m.


Emu-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-kappaB pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma.

Li Z, Wang H, Xue L, Shin DM, Roopenian D, Xu W, Qi CF, Sangster MY, Orihuela CJ, Tuomanen E, Rehg JE, Cui X, Zhang Q, Morse HC 3rd, Morris SW.

Blood. 2009 Nov 5;114(19):4158-68. doi: 10.1182/blood-2008-12-192583. Epub 2009 Aug 20.


Scaling and dynamics of washboard roads.

Bitbol AF, Taberlet N, Morris SW, McElwaine JN.

Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Jun;79(6 Pt 1):061308. Epub 2009 Jun 26.


Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach.

Li R, Pourpak A, Morris SW.

J Med Chem. 2009 Aug 27;52(16):4981-5004. doi: 10.1021/jm9002395. Review. No abstract available.


Mechanical regulation of the proangiogenic factor CCN1/CYR61 gene requires the combined activities of MRTF-A and CREB-binding protein histone acetyltransferase.

Hanna M, Liu H, Amir J, Sun Y, Morris SW, Siddiqui MA, Lau LF, Chaqour B.

J Biol Chem. 2009 Aug 21;284(34):23125-36. doi: 10.1074/jbc.M109.019059. Epub 2009 Jun 20.


c-Myc is a target of RNA-binding motif protein 15 in the regulation of adult hematopoietic stem cell and megakaryocyte development.

Niu C, Zhang J, Breslin P, Onciu M, Ma Z, Morris SW.

Blood. 2009 Sep 3;114(10):2087-96. doi: 10.1182/blood-2009-01-197921. Epub 2009 Jun 19.


c-Myc-mediated control of cell fate in megakaryocyte-erythrocyte progenitors.

Guo Y, Niu C, Breslin P, Tang M, Zhang S, Wei W, Kini AR, Paner GP, Alkan S, Morris SW, Diaz M, Stiff PJ, Zhang J.

Blood. 2009 Sep 3;114(10):2097-106. doi: 10.1182/blood-2009-01-197947. Epub 2009 Apr 16.

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