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Effects of Liraglutide and Fenretinide treatments on the diabetic phenotype of neuronal human BACE1 knock-in mice.

Dekeryte R, Hull C, Plucińska K, Khan S, Kamli-Salino S, Mody N, Morrice N, McLaughlin C, Gault V, Platt B, Delibegovic M.

Biochem Pharmacol. 2019 Aug;166:222-230. doi: 10.1016/j.bcp.2019.05.020. Epub 2019 May 16.


Deciphering the Dark Proteome: Use of the Testis and Characterization of Two Dark Proteins.

Melaine N, Com E, Bellaud P, Guillot L, Lagarrigue M, Morrice NA, Guével B, Lavigne R, Velez de la Calle JF, Dojahn J, Pineau C.

J Proteome Res. 2018 Dec 7;17(12):4197-4210. doi: 10.1021/acs.jproteome.8b00387. Epub 2018 Aug 31.


Corrigendum to "Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR" [DNA Repair 6 (2007) 1536-1544].

Jowsey P, Morrice NA, Hastie CJ, MacLauchlan H, Toth R, Rouse J.

DNA Repair (Amst). 2018 May;65:80. doi: 10.1016/j.dnarep.2017.10.012. Epub 2018 Feb 12. No abstract available.


Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer.

Unbekandt M, Belshaw S, Bower J, Clarke M, Cordes J, Crighton D, Croft DR, Drysdale MJ, Garnett MJ, Gill K, Gray C, Greenhalgh DA, Hall JAM, Konczal J, Lilla S, McArthur D, McConnell P, McDonald L, McGarry L, McKinnon H, McMenemy C, Mezna M, Morrice NA, Munro J, Naylor G, Rath N, Schüttelkopf AW, Sime M, Olson MF.

Cancer Res. 2018 Apr 15;78(8):2096-2114. doi: 10.1158/0008-5472.CAN-17-2870. Epub 2018 Jan 30.


Response to comment by Moxon et al.

Thompson D, Morrice N, Grant L, Le Sommer S, Lees EK, Mody N, Wilson HM, Delibegovic M.

Clin Sci (Lond). 2018 Jan 2;132(1):39-41. doi: 10.1042/CS20171555. Print 2018 Jan 16. No abstract available.


Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia.

Le Sommer S, Morrice N, Pesaresi M, Thompson D, Vickers MA, Murray GI, Mody N, Neel BG, Bence KK, Wilson HM, Delibegović M.

Cancer Res. 2018 Jan 1;78(1):75-87. doi: 10.1158/0008-5472.CAN-17-0946. Epub 2017 Nov 9.


Depletion of Myofibril-Associated Proteins Using Selective Protein Extraction as a Tool in Cardiac Proteomics.

Treumann A, Palmowski P, Tong WC, Taggart J, Morrice N, Nicholas Europe-Finner G, Taggart MJ.

Methods Mol Biol. 2018;1788:1-9. doi: 10.1007/7651_2017_73.


Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR-/- mouse model of atherosclerosis.

Thompson D, Morrice N, Grant L, Le Sommer S, Lees EK, Mody N, Wilson HM, Delibegovic M.

Clin Sci (Lond). 2017 Sep 28;131(20):2489-2501. doi: 10.1042/CS20171066. Print 2017 Oct 1.


LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells.

Susanto O, Koh YWH, Morrice N, Tumanov S, Thomason PA, Nielson M, Tweedy L, Muinonen-Martin AJ, Kamphorst JJ, Mackay GM, Insall RH.

J Cell Sci. 2017 Oct 15;130(20):3455-3466. doi: 10.1242/jcs.207514. Epub 2017 Sep 4.


Direct comparison of methionine restriction with leucine restriction on the metabolic health of C57BL/6J mice.

Lees EK, Banks R, Cook C, Hill S, Morrice N, Grant L, Mody N, Delibegovic M.

Sci Rep. 2017 Aug 30;7(1):9977. doi: 10.1038/s41598-017-10381-3.


Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE-/- mouse model of atherosclerosis with alterations in IL10/AMPKα pathway.

Thompson D, Morrice N, Grant L, Le Sommer S, Ziegler K, Whitfield P, Mody N, Wilson HM, Delibegović M.

Mol Metab. 2017 Jun 13;6(8):845-853. doi: 10.1016/j.molmet.2017.06.003. eCollection 2017 Aug.


Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice.

Morrice N, Mcilroy GD, Tammireddy SR, Reekie J, Shearer KD, Doherty MK, Delibegović M, Whitfield PD, Mody N.

Sci Rep. 2017 Mar 3;7:43782. doi: 10.1038/srep43782.


GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis.

Zibrova D, Vandermoere F, Göransson O, Peggie M, Mariño KV, Knierim A, Spengler K, Weigert C, Viollet B, Morrice NA, Sakamoto K, Heller R.

Biochem J. 2017 Mar 7;474(6):983-1001. doi: 10.1042/BCJ20160980.


IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal).

Dunne A, Carpenter S, Brikos C, Gray P, Strelow A, Wesche H, Morrice N, O'Neill LA.

J Biol Chem. 2016 Nov 18;291(47):24802. No abstract available.


Phosphorylation of a splice variant of collapsin response mediator protein 2 in the nucleus of tumour cells links cyclin dependent kinase-5 to oncogenesis.

Grant NJ, Coates PJ, Woods YL, Bray SE, Morrice NA, Hastie CJ, Lamont DJ, Carey FA, Sutherland C.

BMC Cancer. 2015 Nov 10;15:885. doi: 10.1186/s12885-015-1691-1.


Cyclin Y phosphorylation- and 14-3-3-binding-dependent activation of PCTAIRE-1/CDK16.

Shehata SN, Deak M, Morrice NA, Ohta E, Hunter RW, Kalscheuer VM, Sakamoto K.

Biochem J. 2015 Aug 1;469(3):409-20. doi: 10.1042/BJ20150486. Epub 2015 Jun 11.


Fenretinide prevents obesity in aged female mice in association with increased retinoid and estrogen signaling.

Shearer KD, Morrice N, Henderson C, Reekie J, Mcilroy GD, McCaffery PJ, Delibegovic M, Mody N.

Obesity (Silver Spring). 2015 Aug;23(8):1655-62. doi: 10.1002/oby.21164. Epub 2015 Jul 14.


KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage.

Gong EY, Smits VAJ, Fumagallo F, Piscitello D, Morrice N, Freire R, Gillespie DA.

Sci Rep. 2015 Jun 3;5:10856. doi: 10.1038/srep10856.


Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin.

Ross EA, Smallie T, Ding Q, O'Neil JD, Cunliffe HE, Tang T, Rosner DR, Klevernic I, Morrice NA, Monaco C, Cunningham AF, Buckley CD, Saklatvala J, Dean JL, Clark AR.

J Immunol. 2015 Jul 1;195(1):265-76. doi: 10.4049/jimmunol.1402826. Epub 2015 May 22.


Phosphorylation of SAF-A/hnRNP-U Serine 59 by Polo-Like Kinase 1 Is Required for Mitosis.

Douglas P, Ye R, Morrice N, Britton S, Trinkle-Mulcahy L, Lees-Miller SP.

Mol Cell Biol. 2015 Aug;35(15):2699-713. doi: 10.1128/MCB.01312-14. Epub 2015 May 18.


K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin.

Kristariyanto YA, Abdul Rehman SA, Campbell DG, Morrice NA, Johnson C, Toth R, Kulathu Y.

Mol Cell. 2015 Apr 2;58(1):83-94. doi: 10.1016/j.molcel.2015.01.041. Epub 2015 Mar 5.


Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.

Kristariyanto YA, Choi SY, Rehman SA, Ritorto MS, Campbell DG, Morrice NA, Toth R, Kulathu Y.

Biochem J. 2015 Apr 15;467(2):345-52. doi: 10.1042/BJ20141502.


Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: identification of mitochondrial fission factor as a new AMPK substrate.

Ducommun S, Deak M, Sumpton D, Ford RJ, Núñez Galindo A, Kussmann M, Viollet B, Steinberg GR, Foretz M, Dayon L, Morrice NA, Sakamoto K.

Cell Signal. 2015 May;27(5):978-88. doi: 10.1016/j.cellsig.2015.02.008. Epub 2015 Feb 13.


Fumarate induces redox-dependent senescence by modifying glutathione metabolism.

Zheng L, Cardaci S, Jerby L, MacKenzie ED, Sciacovelli M, Johnson TI, Gaude E, King A, Leach JD, Edrada-Ebel R, Hedley A, Morrice NA, Kalna G, Blyth K, Ruppin E, Frezza C, Gottlieb E.

Nat Commun. 2015 Jan 23;6:6001. doi: 10.1038/ncomms7001.


Expression and purification of functional human glycogen synthase-1:glycogenin-1 complex in insect cells.

Hunter RW, Zeqiraj E, Morrice N, Sicheri F, Sakamoto K.

Protein Expr Purif. 2015 Apr;108:23-29. doi: 10.1016/j.pep.2014.12.007. Epub 2014 Dec 17.


HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia.

Rai TS, Cole JJ, Nelson DM, Dikovskaya D, Faller WJ, Vizioli MG, Hewitt RN, Anannya O, McBryan T, Manoharan I, van Tuyn J, Morrice N, Pchelintsev NA, Ivanov A, Brock C, Drotar ME, Nixon C, Clark W, Sansom OJ, Anderson KI, King A, Blyth K, Adams PD.

Genes Dev. 2014 Dec 15;28(24):2712-25. doi: 10.1101/gad.247528.114.


SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes.

Henriksson E, Säll J, Gormand A, Wasserstrom S, Morrice NA, Fritzen AM, Foretz M, Campbell DG, Sakamoto K, Ekelund M, Degerman E, Stenkula KG, Göransson O.

J Cell Sci. 2015 Feb 1;128(3):472-86.


Screening of DUB activity and specificity by MALDI-TOF mass spectrometry.

Ritorto MS, Ewan R, Perez-Oliva AB, Knebel A, Buhrlage SJ, Wightman M, Kelly SM, Wood NT, Virdee S, Gray NS, Morrice NA, Alessi DR, Trost M.

Nat Commun. 2014 Aug 27;5:4763. doi: 10.1038/ncomms5763.


Chk1 protects against chromatin bridges by constitutively phosphorylating BLM serine 502 to inhibit BLM degradation.

Petsalaki E, Dandoulaki M, Morrice N, Zachos G.

J Cell Sci. 2014 Sep 15;127(Pt 18):3902-8. doi: 10.1242/jcs.155176. Epub 2014 Jul 11.


Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis.

Douglas P, Ye R, Trinkle-Mulcahy L, Neal JA, De Wever V, Morrice NA, Meek K, Lees-Miller SP.

Biosci Rep. 2014 Jun 25;34(3). pii: e00113. doi: 10.1042/BSR20140051.


Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae.

Makrantoni V, Corbishley SJ, Rachidi N, Morrice NA, Robinson DA, Stark MJ.

PLoS One. 2014 Feb 18;9(2):e89399. doi: 10.1371/journal.pone.0089399. eCollection 2014.


Cucurbitacin covalent bonding to cysteine thiols: the filamentous-actin severing protein Cofilin1 as an exemplary target.

Gabrielsen M, Schuldt M, Munro J, Borucka D, Cameron J, Baugh M, Mleczak A, Lilla S, Morrice N, Olson MF.

Cell Commun Signal. 2013 Aug 14;11:58. doi: 10.1186/1478-811X-11-58.


Blebs produced by actin-myosin contraction during apoptosis release damage-associated molecular pattern proteins before secondary necrosis occurs.

Wickman GR, Julian L, Mardilovich K, Schumacher S, Munro J, Rath N, Zander SA, Mleczak A, Sumpton D, Morrice N, Bienvenut WV, Olson MF.

Cell Death Differ. 2013 Oct;20(10):1293-305. doi: 10.1038/cdd.2013.69. Epub 2013 Jun 21.


Ebola virus VP35 induces high-level production of recombinant TPL-2-ABIN-2-NF-κB1 p105 complex in co-transfected HEK-293 cells.

Gantke T, Boussouf S, Janzen J, Morrice NA, Howell S, Mühlberger E, Ley SC.

Biochem J. 2013 Jun 1;452(2):359-65. doi: 10.1042/BJ20121873.


Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex.

Erazo T, Moreno A, Ruiz-Babot G, Rodríguez-Asiain A, Morrice NA, Espadamala J, Bayascas JR, Gómez N, Lizcano JM.

Mol Cell Biol. 2013 Apr;33(8):1671-86. doi: 10.1128/MCB.01246-12. Epub 2013 Feb 19.


Quantitative fragmentome mapping reveals novel, domain-specific partners for the modular protein RepoMan (recruits PP1 onto mitotic chromatin at anaphase).

Prévost M, Chamousset D, Nasa I, Freele E, Morrice N, Moorhead G, Trinkle-Mulcahy L.

Mol Cell Proteomics. 2013 May;12(5):1468-86. doi: 10.1074/mcp.M112.023291. Epub 2013 Jan 29.


IκB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400.

Roget K, Ben-Addi A, Mambole-Dema A, Gantke T, Yang HT, Janzen J, Morrice N, Abbott D, Ley SC.

Mol Cell Biol. 2012 Nov;32(22):4684-90. doi: 10.1128/MCB.01065-12. Epub 2012 Sep 17.


Identification of the amino acids 300-600 of IRS-2 as 14-3-3 binding region with the importance of IGF-1/insulin-regulated phosphorylation of Ser-573.

Neukamm SS, Toth R, Morrice N, Campbell DG, Mackintosh C, Lehmann R, Haering HU, Schleicher ED, Weigert C.

PLoS One. 2012;7(8):e43296. doi: 10.1371/journal.pone.0043296. Epub 2012 Aug 17.


Isolation of human mitotic protein phosphatase complexes: identification of a complex between protein phosphatase 1 and the RNA helicase Ddx21.

De Wever V, Lloyd DC, Nasa I, Nimick M, Trinkle-Mulcahy L, Gourlay R, Morrice N, Moorhead GB.

PLoS One. 2012;7(6):e39510. doi: 10.1371/journal.pone.0039510. Epub 2012 Jun 28.


cAMP-elevation mediated by β-adrenergic stimulation inhibits salt-inducible kinase (SIK) 3 activity in adipocytes.

Berggreen C, Henriksson E, Jones HA, Morrice N, Göransson O.

Cell Signal. 2012 Sep;24(9):1863-71. doi: 10.1016/j.cellsig.2012.05.001. Epub 2012 May 12.


The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser358 in adipocytes.

Henriksson E, Jones HA, Patel K, Peggie M, Morrice N, Sakamoto K, Göransson O.

Biochem J. 2012 Jun 15;444(3):503-14. doi: 10.1042/BJ20111932.


Arabidopsis thaliana histone deacetylase 14 (HDA14) is an α-tubulin deacetylase that associates with PP2A and enriches in the microtubule fraction with the putative histone acetyltransferase ELP3.

Tran HT, Nimick M, Uhrig RG, Templeton G, Morrice N, Gourlay R, DeLong A, Moorhead GB.

Plant J. 2012 Jul;71(2):263-72. doi: 10.1111/j.1365-313X.2012.04984.x. Epub 2012 May 2.


Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation.

Ura S, Pollitt AY, Veltman DM, Morrice NA, Machesky LM, Insall RH.

Curr Biol. 2012 Apr 10;22(7):553-61. doi: 10.1016/j.cub.2012.02.020. Epub 2012 Mar 1.


Some supplementary methods for the analysis of the RBANS.

Crawford JR, Garthwaite PH, Morrice N, Duff K.

Psychol Assess. 2012 Jun;24(2):365-74. doi: 10.1037/a0025652. Epub 2011 Sep 26.


Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects.

Marcucci R, Brindle J, Paro S, Casadio A, Hempel S, Morrice N, Bisso A, Keegan LP, Del Sal G, O'Connell MA.

EMBO J. 2011 Aug 16;30(20):4211-22. doi: 10.1038/emboj.2011.303.


Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage.

Zolner AE, Abdou I, Ye R, Mani RS, Fanta M, Yu Y, Douglas P, Tahbaz N, Fang S, Dobbs T, Wang C, Morrice N, Hendzel MJ, Weinfeld M, Lees-Miller SP.

Nucleic Acids Res. 2011 Nov;39(21):9224-37. doi: 10.1093/nar/gkr647. Epub 2011 Aug 8.


Facing challenges in Proteomics today and in the coming decade: Report of Roundtable Discussions at the 4th EuPA Scientific Meeting, Portugal, Estoril 2010.

Cox J, Heeren RM, James P, Jorrin-Novo JV, Kolker E, Levander F, Morrice N, Picotti P, Righetti PG, Sánchez JC, Turck CW, Zubarev R, Alexandre BM, Corrales FJ, Marko-Varga G, O'Donovan S, O'Neil S, Prechl J, Simões T, Weckwerth W, Penque D.

J Proteomics. 2011 Dec 10;75(1):4-17. doi: 10.1016/j.jprot.2011.04.021. Epub 2011 May 3. No abstract available.


Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes.

Navarro MN, Goebel J, Feijoo-Carnero C, Morrice N, Cantrell DA.

Nat Immunol. 2011 Apr;12(4):352-61. doi: 10.1038/ni.2008. Epub 2011 Mar 13.


Identification of the human testis protein phosphatase 1 interactome.

Fardilha M, Esteves SL, Korrodi-Gregório L, Vintém AP, Domingues SC, Rebelo S, Morrice N, Cohen PT, da Cruz e Silva OA, da Cruz e Silva EF.

Biochem Pharmacol. 2011 Nov 15;82(10):1403-15. doi: 10.1016/j.bcp.2011.02.018. Epub 2011 Mar 5.


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