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Items: 1 to 50 of 118

1.

Zika Virus Associated Pathology and Antigen Presence in the Testicle in the Absence of Sexual Transmission During Subacute to Chronic Infection in a Mouse Model.

Clancy CS, Van Wettere AJ, Morrey JD, Julander JG.

Sci Rep. 2019 Jun 6;9(1):8325. doi: 10.1038/s41598-019-44582-9.

2.

Human Polyclonal Antibodies Produced from Transchromosomal Bovine Provides Prophylactic and Therapeutic Protections Against Zika Virus Infection in STAT2 KO Syrian Hamsters.

Siddharthan V, Miao J, Van Wettere AJ, Li R, Wu H, Sullivan E, Jiao J, Hooper JW, Safronetz D, Morrey JD, Julander JG, Wang Z.

Viruses. 2019 Jan 22;11(2). pii: E92. doi: 10.3390/v11020092.

3.

Coitus-Free Sexual Transmission of Zika Virus in a Mouse Model.

Clancy CS, Van Wettere AJ, Morrey JD, Julander JG.

Sci Rep. 2018 Oct 18;8(1):15379. doi: 10.1038/s41598-018-33528-2.

4.

Consequences of in utero exposure to Zika virus in offspring of AG129 mice.

Julander JG, Siddharthan V, Park AH, Preston E, Mathur P, Bertolio M, Wang H, Zukor K, Van Wettere AJ, Sinex DG, Morrey JD.

Sci Rep. 2018 Jun 20;8(1):9384. doi: 10.1038/s41598-018-27611-x.

5.

Zika virus-induced acute myelitis and motor deficits in adult interferon αβ/γ receptor knockout mice.

Zukor K, Wang H, Siddharthan V, Julander JG, Morrey JD.

J Neurovirol. 2018 Jun;24(3):273-290. doi: 10.1007/s13365-017-0595-z. Epub 2018 Feb 23.

6.

Comparative Histopathologic Lesions of the Male Reproductive Tract during Acute Infection of Zika Virus in AG129 and Ifnar-/- Mice.

Clancy CS, Van Wettere AJ, Siddharthan V, Morrey JD, Julander JG.

Am J Pathol. 2018 Apr;188(4):904-915. doi: 10.1016/j.ajpath.2017.12.019. Epub 2018 Jan 31.

7.

Causation of Acute Flaccid Paralysis by Myelitis and Myositis in Enterovirus-D68 Infected Mice Deficient in Interferon αβ/γ Receptor Deficient Mice.

Morrey JD, Wang H, Hurst BL, Zukor K, Siddharthan V, Van Wettere AJ, Sinex DG, Tarbet EB.

Viruses. 2018 Jan 12;10(1). pii: E33. doi: 10.3390/v10010033.

8.

Activity of nucleic acid polymers in rodent models of HBV infection.

Schöneweis K, Motter N, Roppert PL, Lu M, Wang B, Roehl I, Glebe D, Yang D, Morrey JD, Roggendorf M, Vaillant A.

Antiviral Res. 2018 Jan;149:26-33. doi: 10.1016/j.antiviral.2017.10.022. Epub 2017 Nov 8.

9.

Zika virus infection of adult and fetal STAT2 knock-out hamsters.

Siddharthan V, Van Wettere AJ, Li R, Miao J, Wang Z, Morrey JD, Julander JG.

Virology. 2017 Jul;507:89-95. doi: 10.1016/j.virol.2017.04.013. Epub 2017 Apr 18.

10.

Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model.

Julander JG, Siddharthan V, Evans J, Taylor R, Tolbert K, Apuli C, Stewart J, Collins P, Gebre M, Neilson S, Van Wettere A, Lee YM, Sheridan WP, Morrey JD, Babu YS.

Antiviral Res. 2017 Jan;137:14-22. doi: 10.1016/j.antiviral.2016.11.003. Epub 2016 Nov 10.

11.

Phrenic nerve deficits and neurological immunopathology associated with acute West Nile virus infection in mice and hamsters.

Zukor K, Wang H, Hurst BL, Siddharthan V, Van Wettere A, Pilowsky PM, Morrey JD.

J Neurovirol. 2017 Apr;23(2):186-204. doi: 10.1007/s13365-016-0488-6. Epub 2016 Oct 19.

12.

The Synthetic Antiviral Drug Arbidol Inhibits Globally Prevalent Pathogenic Viruses.

Pécheur EI, Borisevich V, Halfmann P, Morrey JD, Smee DF, Prichard M, Mire CE, Kawaoka Y, Geisbert TW, Polyak SJ.

J Virol. 2016 Jan 6;90(6):3086-92. doi: 10.1128/JVI.02077-15.

13.

Inhibition of West Nile virus by calbindin-D28k.

Siddharthan V, Wang H, Davies CJ, Hall JO, Morrey JD.

PLoS One. 2014 Sep 2;9(9):e106535. doi: 10.1371/journal.pone.0106535. eCollection 2014.

14.

BCX4430, a novel nucleoside analog, effectively treats yellow fever in a Hamster model.

Julander JG, Bantia S, Taubenheim BR, Minning DM, Kotian P, Morrey JD, Smee DF, Sheridan WP, Babu YS.

Antimicrob Agents Chemother. 2014 Nov;58(11):6607-14. doi: 10.1128/AAC.03368-14. Epub 2014 Aug 25.

15.

A molecularly cloned, live-attenuated japanese encephalitis vaccine SA14-14-2 virus: a conserved single amino acid in the ij Hairpin of the Viral E glycoprotein determines neurovirulence in mice.

Yun SI, Song BH, Kim JK, Yun GN, Lee EY, Li L, Kuhn RJ, Rossmann MG, Morrey JD, Lee YM.

PLoS Pathog. 2014 Jul 31;10(7):e1004290. doi: 10.1371/journal.ppat.1004290. eCollection 2014 Jul. Erratum in: PLoS Pathog. 2014 Sep;10(9):e1004465.

16.

The use of plethysmography in determining the severity of lung pathology in a mouse model of minimally lethal influenza virus infection.

Julander JG, Kesler K, Van Wettere AJ, Morrey JD, Smee DF.

Antiviral Res. 2014 Aug;108:10-3. doi: 10.1016/j.antiviral.2014.05.002. Epub 2014 May 14.

PMID:
24837607
17.
18.

Humanized monoclonal antibody 2C9-cIgG has enhanced efficacy for yellow fever prophylaxis and therapy in an immunocompetent animal model.

Julander JG, Thibodeaux BA, Morrey JD, Roehrig JT, Blair CD.

Antiviral Res. 2014 Mar;103:32-8. doi: 10.1016/j.antiviral.2013.12.011. Epub 2014 Jan 3.

19.

Autonomic deficit not the cause of death in West Nile virus neurological disease.

Wang H, Siddharthan V, Hall JO, Morrey JD.

Clin Auton Res. 2014 Feb;24(1):15-23. doi: 10.1007/s10286-013-0213-y. Epub 2013 Oct 25.

20.

Neurological approaches for investigating West Nile virus disease and its treatment in rodents.

Morrey JD, Siddharthan V, Wang H.

Antiviral Res. 2013 Nov;100(2):535-45. doi: 10.1016/j.antiviral.2013.09.010. Epub 2013 Sep 19. Review.

21.

Deletion of the D domain of the human parainfluenza virus type 3 (HPIV3) PD protein results in decreased viral RNA synthesis and beta interferon (IFN-β) expression.

Roth JP, Li JK, Morrey JD, Barnard DL, Vollmer AH.

Virus Genes. 2013 Aug;47(1):10-9. doi: 10.1007/s11262-013-0919-x. Epub 2013 May 18.

PMID:
23686695
22.

Fatal neurological respiratory insufficiency is common among viral encephalitides.

Wang H, Siddharthan V, Kesler KK, Hall JO, Motter NE, Julander JG, Morrey JD.

J Infect Dis. 2013 Aug 15;208(4):573-83. doi: 10.1093/infdis/jit186. Epub 2013 May 2.

23.
24.

Respiratory insufficiency correlated strongly with mortality of rodents infected with West Nile virus.

Morrey JD, Siddharthan V, Wang H, Hall JO.

PLoS One. 2012;7(6):e38672. doi: 10.1371/journal.pone.0038672. Epub 2012 Jun 14.

25.

Combinations of favipiravir and peramivir for the treatment of pandemic influenza A/California/04/2009 (H1N1) virus infections in mice.

Tarbet EB, Maekawa M, Furuta Y, Babu YS, Morrey JD, Smee DF.

Antiviral Res. 2012 Apr;94(1):103-10. doi: 10.1016/j.antiviral.2012.03.001. Epub 2012 Mar 10.

26.

In vitro and in vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic H1N1 virus infections.

Kumaki Y, Day CW, Smee DF, Morrey JD, Barnard DL.

Antiviral Res. 2011 Nov;92(2):329-40. doi: 10.1016/j.antiviral.2011.09.001. Epub 2011 Sep 8.

27.

Use of plethysmography in assessing the efficacy of antivirals in a mouse model of pandemic influenza A virus.

Julander JG, Hagloch J, Latimer S, Motter N, Dagley A, Barnard DL, Smee DF, Morrey JD.

Antiviral Res. 2011 Nov;92(2):228-36. doi: 10.1016/j.antiviral.2011.08.011. Epub 2011 Aug 17.

PMID:
21867731
28.

Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion.

Yu W, Goddard C, Clearfield E, Mills C, Xiao T, Guo H, Morrey JD, Motter NE, Zhao K, Block TM, Cuconati A, Xu X.

J Med Chem. 2011 Aug 25;54(16):5660-70. doi: 10.1021/jm200696v. Epub 2011 Aug 2.

29.

Autonomic nervous dysfunction in hamsters infected with West Nile virus.

Wang H, Siddharthan V, Hall JO, Morrey JD.

PLoS One. 2011 May 9;6(5):e19575. doi: 10.1371/journal.pone.0019575.

30.

Treatment of spatial memory impairment in hamsters infected with West Nile virus using a humanized monoclonal antibody MGAWN1.

Smeraski CA, Siddharthan V, Morrey JD.

Antiviral Res. 2011 Jul;91(1):43-9. doi: 10.1016/j.antiviral.2011.04.011. Epub 2011 Apr 30.

31.

Breaking B and T cell tolerance using cationic lipid--DNA complexes (CLDC) as a vaccine adjuvant with hepatitis B virus (HBV) surface antigen in transgenic mice expressing HBV.

Morrey JD, Motter NE, Chang S, Fairman J.

Antiviral Res. 2011 Jun;90(3):227-30. doi: 10.1016/j.antiviral.2011.04.006. Epub 2011 Apr 23.

32.

Treatment of yellow fever virus with an adenovirus-vectored interferon, DEF201, in a hamster model.

Julander JG, Ennis J, Turner J, Morrey JD.

Antimicrob Agents Chemother. 2011 May;55(5):2067-73. doi: 10.1128/AAC.01635-10. Epub 2011 Feb 7.

33.

Development of a new tacaribe arenavirus infection model and its use to explore antiviral activity of a novel aristeromycin analog.

Gowen BB, Wong MH, Larson D, Ye W, Jung KH, Sefing EJ, Skirpstunas R, Smee DF, Morrey JD, Schneller SW.

PLoS One. 2010 Sep 16;5(9). pii: e12760. doi: 10.1371/journal.pone.0012760.

34.

Assessing changes in vascular permeability in a hamster model of viral hemorrhagic fever.

Gowen BB, Julander JG, London NR, Wong MH, Larson D, Morrey JD, Li DY, Bray M.

Virol J. 2010 Sep 16;7:240. doi: 10.1186/1743-422X-7-240.

35.

Combinations of oseltamivir and peramivir for the treatment of influenza A (H1N1) virus infections in cell culture and in mice.

Smee DF, Hurst BL, Wong MH, Tarbet EB, Babu YS, Klumpp K, Morrey JD.

Antiviral Res. 2010 Oct;88(1):38-44. doi: 10.1016/j.antiviral.2010.07.003. Epub 2010 Jul 13.

36.

Neurological suppression of diaphragm electromyographs in hamsters infected with West Nile virus.

Morrey JD, Siddharthan V, Wang H, Hall JO, Motter NE, Skinner RD, Skirpstunas RT.

J Neurovirol. 2010 Jul;16(4):318-29. doi: 10.3109/13550284.2010.501847.

37.

PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.

Lam AM, Murakami E, Espiritu C, Steuer HM, Niu C, Keilman M, Bao H, Zennou V, Bourne N, Julander JG, Morrey JD, Smee DF, Frick DN, Heck JA, Wang P, Nagarathnam D, Ross BS, Sofia MJ, Otto MJ, Furman PA.

Antimicrob Agents Chemother. 2010 Aug;54(8):3187-96. doi: 10.1128/AAC.00399-10. Epub 2010 Jun 1.

38.

Efficacy of 2'-C-methylcytidine against yellow fever virus in cell culture and in a hamster model.

Julander JG, Jha AK, Choi JA, Jung KH, Smee DF, Morrey JD, Chu CK.

Antiviral Res. 2010 Jun;86(3):261-7. doi: 10.1016/j.antiviral.2010.03.004. Epub 2010 Mar 20.

39.

Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs.

Coughlin JE, Padmanabhan S, Zhang G, Kirk CJ, Govardhan CP, Korba BE, O'Loughlin K, Green CE, Mirsalis J, Morrey JD, Iyer RP.

Bioorg Med Chem Lett. 2010 Mar 1;20(5):1783-6. doi: 10.1016/j.bmcl.2010.01.010. Epub 2010 Jan 11.

40.

Effects of the combination of favipiravir (T-705) and oseltamivir on influenza A virus infections in mice.

Smee DF, Hurst BL, Wong MH, Bailey KW, Tarbet EB, Morrey JD, Furuta Y.

Antimicrob Agents Chemother. 2010 Jan;54(1):126-33. doi: 10.1128/AAC.00933-09. Epub 2009 Nov 9.

41.

Efficacy of favipiravir (T-705) and T-1106 pyrazine derivatives in phlebovirus disease models.

Gowen BB, Wong MH, Jung KH, Smee DF, Morrey JD, Furuta Y.

Antiviral Res. 2010 May;86(2):121-7. doi: 10.1016/j.antiviral.2009.10.015. Epub 2009 Oct 27.

42.

A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo.

Day CW, Baric R, Cai SX, Frieman M, Kumaki Y, Morrey JD, Smee DF, Barnard DL.

Virology. 2009 Dec 20;395(2):210-22. doi: 10.1016/j.virol.2009.09.023. Epub 2009 Oct 22.

43.

Punta Toro virus (Bunyaviridae, Phlebovirus) infection in mice: strain differences in pathogenesis and host interferon response.

Mendenhall M, Wong MH, Skirpstunas R, Morrey JD, Gowen BB.

Virology. 2009 Dec 5;395(1):143-51. doi: 10.1016/j.virol.2009.09.003. Epub 2009 Sep 26.

44.

West Nile virus preferentially transports along motor neuron axons after sciatic nerve injection of hamsters.

Wang H, Siddharthan V, Hall JO, Morrey JD.

J Neurovirol. 2009 Jul;15(4):293-9. doi: 10.1080/13550280902973978.

45.

Effect of T-705 treatment on western equine encephalitis in a mouse model.

Julander JG, Smee DF, Morrey JD, Furuta Y.

Antiviral Res. 2009 Jun;82(3):169-71. doi: 10.1016/j.antiviral.2009.02.201. Epub 2009 Mar 10.

46.

T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections.

Furuta Y, Takahashi K, Shiraki K, Sakamoto K, Smee DF, Barnard DL, Gowen BB, Julander JG, Morrey JD.

Antiviral Res. 2009 Jun;82(3):95-102. doi: 10.1016/j.antiviral.2009.02.198. Epub 2009 Mar 6. Review.

PMID:
19428599
47.

Alkoxyalkyl esters of 9-(s)-(3-hydroxy-2-phosphonomethoxypropyl) adenine are potent and selective inhibitors of hepatitis B virus (HBV) replication in vitro and in HBV transgenic mice in vivo.

Morrey JD, Korba BE, Beadle JR, Wyles DL, Hostetler KY.

Antimicrob Agents Chemother. 2009 Jul;53(7):2865-70. doi: 10.1128/AAC.00114-09. Epub 2009 Apr 27.

48.

Effects of double combinations of amantadine, oseltamivir, and ribavirin on influenza A (H5N1) virus infections in cell culture and in mice.

Smee DF, Hurst BL, Wong MH, Bailey KW, Morrey JD.

Antimicrob Agents Chemother. 2009 May;53(5):2120-8. doi: 10.1128/AAC.01012-08. Epub 2009 Mar 9.

49.

Persistent West Nile virus associated with a neurological sequela in hamsters identified by motor unit number estimation.

Siddharthan V, Wang H, Motter NE, Hall JO, Skinner RD, Skirpstunas RT, Morrey JD.

J Virol. 2009 May;83(9):4251-61. doi: 10.1128/JVI.00017-09. Epub 2009 Feb 18.

50.

A recombinant, infectious human parainfluenza virus type 3 expressing the enhanced green fluorescent protein for use in high-throughput antiviral assays.

Roth JP, Li JK, Smee DF, Morrey JD, Barnard DL.

Antiviral Res. 2009 Apr;82(1):12-21. doi: 10.1016/j.antiviral.2009.01.001. Epub 2009 Feb 2.

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