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Items: 1 to 50 of 254

1.

Advances in the molecular regulation of endothelial BMP9 signalling complexes and implications for cardiovascular disease.

Wood JH, Guo J, Morrell NW, Li W.

Biochem Soc Trans. 2019 May 24. pii: BST20180137. doi: 10.1042/BST20180137. [Epub ahead of print] Review.

PMID:
31127068
2.

Germline selection shapes human mitochondrial DNA diversity.

Wei W, Tuna S, Keogh MJ, Smith KR, Aitman TJ, Beales PL, Bennett DL, Gale DP, Bitner-Glindzicz MAK, Black GC, Brennan P, Elliott P, Flinter FA, Floto RA, Houlden H, Irving M, Koziell A, Maher ER, Markus HS, Morrell NW, Newman WG, Roberts I, Sayer JA, Smith KGC, Taylor JC, Watkins H, Webster AR, Wilkie AOM, Williamson C; NIHR BioResource–Rare Diseases; 100,000 Genomes Project–Rare Diseases Pilot, Ashford S, Penkett CJ, Stirrups KE, Rendon A, Ouwehand WH, Bradley JR, Raymond FL, Caulfield M, Turro E, Chinnery PF.

Science. 2019 May 24;364(6442). pii: eaau6520. doi: 10.1126/science.aau6520. Epub 2019 May 23.

PMID:
31123110
3.

Letter by Morrell et al Regarding Article, "Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension".

Morrell NW, Upton PD, Li W, Yu PB.

Circ Res. 2019 Apr 26;124(9):e81. doi: 10.1161/CIRCRESAHA.119.314962. No abstract available.

PMID:
31021722
4.

Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension: a UK cohort study analysis.

Sofianopoulou E, Kaptoge S, Gräf S, Hadinnapola C, Treacy CM, Church C, Coghlan G, Gibbs JSR, Haimel M, Howard LS, Johnson M, Kiely DG, Lawrie A, Lordan J, MacKenzie Ross RV, Martin JM, Moledina S, Newnham M, Peacock AJ, Price LC, Rhodes CJ, Suntharalingam J, Swietlik EM, Toshner MR, Wharton J, Wilkins MR, Wort SJ, Pepke-Zaba J, Condliffe R, Corris PA, Di Angelantonio E, Provencher S, Morrell NW.

Eur Respir J. 2019 May 30;53(5). pii: 1801429. doi: 10.1183/13993003.01429-2018. Print 2019 May.

PMID:
30923185
5.

Finding the needle in the haystack: BMP9 and 10 emerge from the genome in pulmonary arterial hypertension.

Morrell NW.

Eur Respir J. 2019 Mar 14;53(3). pii: 1900078. doi: 10.1183/13993003.00078-2019. Print 2019 Mar. No abstract available.

PMID:
30872557
6.

BMPRII deficiency impairs apoptosis via the BMPRII-ALK1-BclX-mediated pathway in pulmonary arterial hypertension (PAH).

Chowdhury HM, Sharmin N, Baran MY, Long L, Morrell NW, Trembath RC, Nasim MT.

Hum Mol Genet. 2019 Feb 27. pii: ddz047. doi: 10.1093/hmg/ddz047. [Epub ahead of print]

PMID:
30809644
7.

A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension.

Yang P, Read C, Kuc RE, Nyimanu D, Williams TL, Crosby A, Buonincontri G, Southwood M, Sawiak SJ, Glen RC, Morrell NW, Davenport AP, Maguire JJ.

Br J Pharmacol. 2019 May;176(9):1206-1221. doi: 10.1111/bph.14603. Epub 2019 Apr 1.

8.

The ADAMTS13-VWF axis is dysregulated in chronic thromboembolic pulmonary hypertension.

Newnham M, South K, Bleda M, Auger WR, Barberà JA, Bogaard H, Bunclark K, Cannon JE, Delcroix M, Hadinnapola C, Howard LS, Jenkins D, Mayer E, Ng C, Rhodes CJ, Screaton N, Sheares K, Simpson MA, Southwood M, Su L, Taboada D, Traylor M, Trembath RC, Villar SS, Wilkins MR, Wharton J, Gräf S, Pepke-Zaba J, Laffan M, Lane DA, Morrell NW, Toshner M.

Eur Respir J. 2019 Mar 28;53(3). pii: 1801805. doi: 10.1183/13993003.01805-2018. Print 2019 Mar.

9.

Myeloid angiogenic cells exhibit impaired migration, reduced expression of endothelial markers, and increased apoptosis in idiopathic pulmonary arterial hypertension 1.

Zhang Q, Zucco L, Toshner M, Morrell NW, Granton J, Stewart DJ, Kutryk MJB.

Can J Physiol Pharmacol. 2019 Apr;97(4):306-312. doi: 10.1139/cjpp-2018-0424. Epub 2018 Dec 17.

PMID:
30557040
10.

Growth/differentiation factor 15 causes TGFβ-activated kinase 1-dependent muscle atrophy in pulmonary arterial hypertension.

Garfield BE, Crosby A, Shao D, Yang P, Read C, Sawiak S, Moore S, Parfitt L, Harries C, Rice M, Paul R, Ormiston ML, Morrell NW, Polkey MI, Wort SJ, Kemp PR.

Thorax. 2019 Feb;74(2):164-176. doi: 10.1136/thoraxjnl-2017-211440. Epub 2018 Dec 15.

11.

Genetics and genomics of pulmonary arterial hypertension.

Morrell NW, Aldred MA, Chung WK, Elliott CG, Nichols WC, Soubrier F, Trembath RC, Loyd JE.

Eur Respir J. 2019 Jan 24;53(1). pii: 1801899. doi: 10.1183/13993003.01899-2018. Print 2019 Jan.

12.

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.

Rhodes CJ, Batai K, Bleda M, Haimel M, Southgate L, Germain M, Pauciulo MW, Hadinnapola C, Aman J, Girerd B, Arora A, Knight J, Hanscombe KB, Karnes JH, Kaakinen M, Gall H, Ulrich A, Harbaum L, Cebola I, Ferrer J, Lutz K, Swietlik EM, Ahmad F, Amouyel P, Archer SL, Argula R, Austin ED, Badesch D, Bakshi S, Barnett C, Benza R, Bhatt N, Bogaard HJ, Burger CD, Chakinala M, Church C, Coghlan JG, Condliffe R, Corris PA, Danesino C, Debette S, Elliott CG, Elwing J, Eyries M, Fortin T, Franke A, Frantz RP, Frost A, Garcia JGN, Ghio S, Ghofrani HA, Gibbs JSR, Harley J, He H, Hill NS, Hirsch R, Houweling AC, Howard LS, Ivy D, Kiely DG, Klinger J, Kovacs G, Lahm T, Laudes M, Machado RD, MacKenzie Ross RV, Marsolo K, Martin LJ, Moledina S, Montani D, Nathan SD, Newnham M, Olschewski A, Olschewski H, Oudiz RJ, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Rehman Z, Robbins I, Roden DM, Rosenzweig EB, Saydain G, Scelsi L, Schilz R, Seeger W, Shaffer CM, Simms RW, Simon M, Sitbon O, Suntharalingam J, Tang H, Tchourbanov AY, Thenappan T, Torres F, Toshner MR, Treacy CM, Vonk Noordegraaf A, Waisfisz Q, Walsworth AK, Walter RE, Wharton J, White RJ, Wilt J, Wort SJ, Yung D, Lawrie A, Humbert M, Soubrier F, Trégouët DA, Prokopenko I, Kittles R, Gräf S, Nichols WC, Trembath RC, Desai AA, Morrell NW, Wilkins MR; UK NIHR BioResource Rare Diseases Consortium; UK PAH Cohort Study Consortium; US PAH Biobank Consortium.

Lancet Respir Med. 2019 Mar;7(3):227-238. doi: 10.1016/S2213-2600(18)30409-0. Epub 2018 Dec 5.

13.

Increased Antielastase Activity in Idiopathic Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension.

Guo J, Lodge K, Newnham M, Bunclark K, Toshner M, Morrell NW, Li W.

Am J Respir Cell Mol Biol. 2018 Nov;59(5):652-655. doi: 10.1165/rcmb.2018-0060LE. No abstract available.

14.

Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension.

Bohnen MS, Ma L, Zhu N, Qi H, McClenaghan C, Gonzaga-Jauregui C, Dewey FE, Overton JD, Reid JG, Shuldiner AR, Baras A, Sampson KJ, Bleda M, Hadinnapola C, Haimel M, Bogaard HJ, Church C, Coghlan G, Corris PA, Eyries M, Gibbs JSR, Girerd B, Houweling AC, Humbert M, Guignabert C, Kiely DG, Lawrie A, MacKenzie Ross RV, Martin JM, Montani D, Peacock AJ, Pepke-Zaba J, Soubrier F, Suntharalingam J, Toshner M, Treacy CM, Trembath RC, Vonk Noordegraaf A, Wharton J, Wilkins MR, Wort SJ, Yates K, Gräf S, Morrell NW, Krishnan U, Rosenzweig EB, Shen Y, Nichols CG, Kass RS, Chung WK.

Circ Genom Precis Med. 2018 Oct;11(10):e002087. doi: 10.1161/CIRCGEN.118.002087.

15.

Bone Morphogenetic Protein 9 Is a Mechanistic Biomarker of Portopulmonary Hypertension.

Nikolic I, Yung LM, Yang P, Malhotra R, Paskin-Flerlage SD, Dinter T, Bocobo GA, Tumelty KE, Faugno AJ, Troncone L, McNeil ME, Huang X, Coser KR, Lai CSC, Upton PD, Goumans MJ, Zamanian RT, Elliott CG, Lee A, Zheng W, Berasi SP, Huard C, Morrell NW, Chung RT, Channick RW, Roberts KE, Yu PB.

Am J Respir Crit Care Med. 2019 Apr 1;199(7):891-902. doi: 10.1164/rccm.201807-1236OC.

PMID:
30312106
16.

Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells.

Vattulainen-Collanus S, Southwood M, Yang XD, Moore S, Ghatpande P, Morrell NW, Lagna G, Hata A.

Commun Biol. 2018 Sep 24;1:149. doi: 10.1038/s42003-018-0152-1. eCollection 2018.

17.

Spontaneous pulmonary hypertension in genetic mouse models of natural killer cell deficiency.

Rätsep MT, Moore SD, Jafri S, Mitchell M, Brady HJM, Mandelboim O, Southwood M, Morrell NW, Colucci F, Ormiston ML.

Am J Physiol Lung Cell Mol Physiol. 2018 Dec 1;315(6):L977-L990. doi: 10.1152/ajplung.00477.2017. Epub 2018 Sep 20.

18.

Hematopoietic stem cell transplantation alters susceptibility to pulmonary hypertension in Bmpr2-deficient mice.

Crosby A, Toshner MR, Southwood MR, Soon E, Dunmore BJ, Groves E, Moore S, Wright P, Ottersbach K, Bennett C, Guerrero J, Ghevaert C, Morrell NW.

Pulm Circ. 2018 Oct-Dec;8(4):2045894018801642. doi: 10.1177/2045894018801642. Epub 2018 Aug 30.

19.

Reply to "Letter to the Editor: Is Id3 proliferative or antiproliferative?"

Li X, Morrell NW, Yang J.

Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L336-L337. doi: 10.1152/ajplung.00315.2018. No abstract available.

PMID:
30088800
20.

A pro-con debate: current controversies in PAH pathogenesis at the American Thoracic Society International Conference in 2017.

Kuebler WM, Nicolls MR, Olschewski A, Abe K, Rabinovitch M, Stewart D, Chan SY, Morrell NW, Archer SL, Spiekerkoetter E.

Am J Physiol Lung Cell Mol Physiol. 2018 Oct 1;315(4):L502-L516. doi: 10.1152/ajplung.00150.2018. Epub 2018 Jun 7.

PMID:
29877097
21.

Genomic atlas of the human plasma proteome.

Sun BB, Maranville JC, Peters JE, Stacey D, Staley JR, Blackshaw J, Burgess S, Jiang T, Paige E, Surendran P, Oliver-Williams C, Kamat MA, Prins BP, Wilcox SK, Zimmerman ES, Chi A, Bansal N, Spain SL, Wood AM, Morrell NW, Bradley JR, Janjic N, Roberts DJ, Ouwehand WH, Todd JA, Soranzo N, Suhre K, Paul DS, Fox CS, Plenge RM, Danesh J, Runz H, Butterworth AS.

Nature. 2018 Jun;558(7708):73-79. doi: 10.1038/s41586-018-0175-2. Epub 2018 Jun 6.

PMID:
29875488
22.

Response by Hadinnapola et al to Letter Regarding Article, "Phenotypic Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension".

Hadinnapola C, Gräf S, Morrell NW.

Circulation. 2018 May 29;137(22):2413-2414. doi: 10.1161/CIRCULATIONAHA.118.033970. No abstract available.

PMID:
29844075
23.

A Potential Role for Exosomal Translationally Controlled Tumor Protein Export in Vascular Remodeling in Pulmonary Arterial Hypertension.

Ferrer E, Dunmore BJ, Hassan D, Ormiston ML, Moore S, Deighton J, Long L, Yang XD, Stewart DJ, Morrell NW.

Am J Respir Cell Mol Biol. 2018 Oct;59(4):467-478. doi: 10.1165/rcmb.2017-0129OC.

24.

Identification of rare sequence variation underlying heritable pulmonary arterial hypertension.

Gräf S, Haimel M, Bleda M, Hadinnapola C, Southgate L, Li W, Hodgson J, Liu B, Salmon RM, Southwood M, Machado RD, Martin JM, Treacy CM, Yates K, Daugherty LC, Shamardina O, Whitehorn D, Holden S, Aldred M, Bogaard HJ, Church C, Coghlan G, Condliffe R, Corris PA, Danesino C, Eyries M, Gall H, Ghio S, Ghofrani HA, Gibbs JSR, Girerd B, Houweling AC, Howard L, Humbert M, Kiely DG, Kovacs G, MacKenzie Ross RV, Moledina S, Montani D, Newnham M, Olschewski A, Olschewski H, Peacock AJ, Pepke-Zaba J, Prokopenko I, Rhodes CJ, Scelsi L, Seeger W, Soubrier F, Stein DF, Suntharalingam J, Swietlik EM, Toshner MR, van Heel DA, Vonk Noordegraaf A, Waisfisz Q, Wharton J, Wort SJ, Ouwehand WH, Soranzo N, Lawrie A, Upton PD, Wilkins MR, Trembath RC, Morrell NW.

Nat Commun. 2018 Apr 12;9(1):1416. doi: 10.1038/s41467-018-03672-4.

25.

Contributions of BMPR2 Mutations and Extrinsic Factors to Cellular Phenotypes of Pulmonary Arterial Hypertension Revealed by Induced Pluripotent Stem Cell Modeling.

Kiskin FN, Chang CH, Huang CJZ, Kwieder B, Cheung C, Dunmore BJ, Serrano F, Sinha S, Morrell NW, Rana AA.

Am J Respir Crit Care Med. 2018 Jul 15;198(2):271-275. doi: 10.1164/rccm.201801-0049LE. No abstract available.

26.

miR-322-5p targets IGF-1 and is suppressed in the heart of rats with pulmonary hypertension.

Connolly M, Garfield BE, Crosby A, Morrell NW, Wort SJ, Kemp PR.

FEBS Open Bio. 2018 Jan 24;8(3):339-348. doi: 10.1002/2211-5463.12369. eCollection 2018 Mar.

27.

A novel piperidine identified by stem cell-based screening attenuates pulmonary arterial hypertension by regulating BMP2 and PTGS2 levels.

Xing Y, Zhao S, Wei Q, Gong S, Zhao X, Zhou F, Ai-Lamki R, Ortmann D, Du M, Pedersen R, Shang G, Si S, Morrell NW, Yang J.

Eur Respir J. 2018 Apr 4;51(4). pii: 1702229. doi: 10.1183/13993003.02229-2017. Print 2018 Apr.

PMID:
29449428
28.

Loss of SMAD3 Promotes Vascular Remodeling in Pulmonary Arterial Hypertension via MRTF Disinhibition.

Zabini D, Granton E, Hu Y, Miranda MZ, Weichelt U, Breuils Bonnet S, Bonnet S, Morrell NW, Connelly KA, Provencher S, Ghanim B, Klepetko W, Olschewski A, Kapus A, Kuebler WM.

Am J Respir Crit Care Med. 2018 Jan 15;197(2):244-260. doi: 10.1164/rccm.201702-0386OC. Erratum in: Am J Respir Crit Care Med. 2019 Apr 1;199(7):932.

PMID:
29095649
29.

Phenotypic Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension.

Hadinnapola C, Bleda M, Haimel M, Screaton N, Swift A, Dorfmüller P, Preston SD, Southwood M, Hernandez-Sanchez J, Martin J, Treacy C, Yates K, Bogaard H, Church C, Coghlan G, Condliffe R, Corris PA, Gibbs S, Girerd B, Holden S, Humbert M, Kiely DG, Lawrie A, Machado R, MacKenzie Ross R, Moledina S, Montani D, Newnham M, Peacock A, Pepke-Zaba J, Rayner-Matthews P, Shamardina O, Soubrier F, Southgate L, Suntharalingam J, Toshner M, Trembath R, Vonk Noordegraaf A, Wilkins MR, Wort SJ, Wharton J; NIHR BioResource–Rare Diseases Consortium; UK National Cohort Study of Idiopathic and Heritable PAH, Gräf S, Morrell NW.

Circulation. 2017 Nov 21;136(21):2022-2033. doi: 10.1161/CIRCULATIONAHA.117.028351. Epub 2017 Sep 28.

30.

Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis.

Zhang H, Wang D, Li M, Plecitá-Hlavatá L, D'Alessandro A, Tauber J, Riddle S, Kumar S, Flockton A, McKeon BA, Frid MG, Reisz JA, Caruso P, El Kasmi KC, Ježek P, Morrell NW, Hu CJ, Stenmark KR.

Circulation. 2017 Dec 19;136(25):2468-2485. doi: 10.1161/CIRCULATIONAHA.117.028069. Epub 2017 Sep 26.

31.

Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2.

Caruso P, Dunmore BJ, Schlosser K, Schoors S, Dos Santos C, Perez-Iratxeta C, Lavoie JR, Zhang H, Long L, Flockton AR, Frid MG, Upton PD, D'Alessandro A, Hadinnapola C, Kiskin FN, Taha M, Hurst LA, Ormiston ML, Hata A, Stenmark KR, Carmeliet P, Stewart DJ, Morrell NW.

Circulation. 2017 Dec 19;136(25):2451-2467. doi: 10.1161/CIRCULATIONAHA.117.028034. Epub 2017 Sep 26.

32.

Role of the Aryl Hydrocarbon Receptor in Sugen 5416-induced Experimental Pulmonary Hypertension.

Dean A, Gregorc T, Docherty CK, Harvey KY, Nilsen M, Morrell NW, MacLean MR.

Am J Respir Cell Mol Biol. 2018 Mar;58(3):320-330. doi: 10.1165/rcmb.2017-0260OC.

33.

Correction for Bagarova et al., "Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation".

Bagarova J, Vonner AJ, Armstrong KA, Börgermann J, Lai CSC, Deng DY, Beppu H, Alfano I, Filippakopoulos P, Morrell NW, Bullock AN, Knaus P, Mishina Y, Yu PB.

Mol Cell Biol. 2017 Sep 12;37(19). pii: e00284-17. doi: 10.1128/MCB.00284-17. Print 2017 Oct 1. No abstract available.

34.

Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling.

Pickworth J, Rothman A, Iremonger J, Casbolt H, Hopkinson K, Hickey PM, Gladson S, Shay S, Morrell NW, Francis SE, West JD, Lawrie A.

Pulm Circ. 2017 Oct-Dec;7(4):768-776. doi: 10.1177/2045893217729096. Epub 2017 Sep 22.

35.

A 3D tri-culture system reveals that activin receptor-like kinase 5 and connective tissue growth factor drive human glomerulosclerosis.

Waters JP, Richards YC, Skepper JN, Southwood M, Upton PD, Morrell NW, Pober JS, Bradley JR.

J Pathol. 2017 Nov;243(3):390-400. doi: 10.1002/path.4960. Epub 2017 Oct 3.

36.

Bone Morphogenetic Protein 9 Protects against Neonatal Hyperoxia-Induced Impairment of Alveolarization and Pulmonary Inflammation.

Chen X, Orriols M, Walther FJ, Laghmani EH, Hoogeboom AM, Hogen-Esch ACB, Hiemstra PS, Folkerts G, Goumans MTH, Ten Dijke P, Morrell NW, Wagenaar GTM.

Front Physiol. 2017 Jul 13;8:486. doi: 10.3389/fphys.2017.00486. eCollection 2017.

37.

Inhibition of hyaluronan synthesis attenuates pulmonary hypertension associated with lung fibrosis.

Collum SD, Chen NY, Hernandez AM, Hanmandlu A, Sweeney H, Mertens TCJ, Weng T, Luo F, Molina JG, Davies J, Horan IP, Morrell NW, Amione-Guerra J, Al-Jabbari O, Youker K, Sun W, Rajadas J, Bollyky PL, Akkanti BH, Jyothula S, Sinha N, Guha A, Karmouty-Quintana H.

Br J Pharmacol. 2017 Oct;174(19):3284-3301. doi: 10.1111/bph.13947. Epub 2017 Aug 17.

38.

Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2.

Mitrofan CG, Appleby SL, Nash GB, Mallat Z, Chilvers ER, Upton PD, Morrell NW.

J Biol Chem. 2017 Aug 18;292(33):13714-13726. doi: 10.1074/jbc.M117.778506. Epub 2017 Jun 23.

39.

A sex-specific reconstitution bias in the competitive CD45.1/CD45.2 congenic bone marrow transplant model.

Jafri S, Moore SD, Morrell NW, Ormiston ML.

Sci Rep. 2017 Jun 14;7(1):3495. doi: 10.1038/s41598-017-03784-9.

40.

The Pulmonary Vascular Research Institute celebrates its first decade.

Yuan JX, Morrell NW, Stenmark KR, Lang IM, Butrous G, Reynolds ME.

Pulm Circ. 2017 Apr-Jun;7(2):283-284. doi: 10.1177/2045893217713107. No abstract available.

41.

Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension.

Yang P, Read C, Kuc RE, Buonincontri G, Southwood M, Torella R, Upton PD, Crosby A, Sawiak SJ, Carpenter TA, Glen RC, Morrell NW, Maguire JJ, Davenport AP.

Circulation. 2017 Mar 21;135(12):1160-1173. doi: 10.1161/CIRCULATIONAHA.116.023218. Epub 2017 Jan 30.

42.

Our readership grows by leaps and bounds.

Yuan JX, Morrell NW, Stenmark KR, Butrous G, Reynolds ME.

Pulm Circ. 2016 Dec;6(4):405-406. doi: 10.1086/688929. No abstract available.

43.

Pulmonary veno-occlusive disease: characterising a rare but important disease.

Hadinnapola C, Morrell NW.

Lancet Respir Med. 2017 Feb;5(2):89-90. doi: 10.1016/S2213-2600(16)30466-0. Epub 2017 Jan 11. No abstract available.

PMID:
28087361
44.

TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling.

Hurst LA, Dunmore BJ, Long L, Crosby A, Al-Lamki R, Deighton J, Southwood M, Yang X, Nikolic MZ, Herrera B, Inman GJ, Bradley JR, Rana AA, Upton PD, Morrell NW.

Nat Commun. 2017 Jan 13;8:14079. doi: 10.1038/ncomms14079.

45.

Plasma Metabolomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial Hypertension.

Rhodes CJ, Ghataorhe P, Wharton J, Rue-Albrecht KC, Hadinnapola C, Watson G, Bleda M, Haimel M, Coghlan G, Corris PA, Howard LS, Kiely DG, Peacock AJ, Pepke-Zaba J, Toshner MR, Wort SJ, Gibbs JS, Lawrie A, Gräf S, Morrell NW, Wilkins MR.

Circulation. 2017 Jan 31;135(5):460-475. doi: 10.1161/CIRCULATIONAHA.116.024602. Epub 2016 Nov 21.

46.

Towards a molecular classification of pulmonary arterial hypertension.

Gräf S, Morrell NW.

Eur Respir J. 2016 Oct;48(4):987-989. doi: 10.1183/13993003.01550-2016. No abstract available.

47.

Bone Morphogenetic Protein 9 Enhances Lipopolysaccharide-Induced Leukocyte Recruitment to the Vascular Endothelium.

Appleby SL, Mitrofan CG, Crosby A, Hoenderdos K, Lodge K, Upton PD, Yates CM, Nash GB, Chilvers ER, Morrell NW.

J Immunol. 2016 Oct 15;197(8):3302-3314. doi: 10.4049/jimmunol.1601219. Epub 2016 Sep 19.

48.

Regulation of the ALK1 ligands, BMP9 and BMP10.

Li W, Salmon RM, Jiang H, Morrell NW.

Biochem Soc Trans. 2016 Aug 15;44(4):1135-41. doi: 10.1042/BST20160083. Review.

PMID:
27528761
49.

HIF2α-arginase axis is essential for the development of pulmonary hypertension.

Cowburn AS, Crosby A, Macias D, Branco C, Colaço RD, Southwood M, Toshner M, Crotty Alexander LE, Morrell NW, Chilvers ER, Johnson RS.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8801-6. doi: 10.1073/pnas.1602978113. Epub 2016 Jul 18.

50.

Disrupted Endothelial Cell Layer and Exposed Extracellular Matrix Proteins Promote Capture of Late Outgrowth Endothelial Progenitor Cells.

Zhao J, Mitrofan CG, Appleby SL, Morrell NW, Lever AM.

Stem Cells Int. 2016;2016:1406304. doi: 10.1155/2016/1406304. Epub 2016 Jun 16.

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