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Impact of Stiffer Arteries on the Response to Antihypertensive Treatment: A Longitudinal Study of the SardiNIA Cohort.

Lakatta EG, AlunniFegatelli D, Morrell CH, Fiorillo E, Orru M, Delitala A, Marongiu M, Schlessinger D, Cucca F, Scuteri A.

J Am Med Dir Assoc. 2019 Dec 26. pii: S1525-8610(19)30823-0. doi: 10.1016/j.jamda.2019.11.014. [Epub ahead of print]


Platelet-derived β2m regulates age related monocyte/macrophage functions.

Hilt ZT, Ture SK, Mohan A, Arne A, Morrell CN.

Aging (Albany NY). 2019 Dec 18;11(24):11955-11974. doi: 10.18632/aging.102520. Epub 2019 Dec 18.


PAD4 and von Willebrand Factor Link Inflammation and Thrombosis.

Morrell CN, Hilt ZT, Pariser DN, Maurya P.

Circ Res. 2019 Aug 16;125(5):520-522. doi: 10.1161/CIRCRESAHA.119.315601. Epub 2019 Aug 15. No abstract available.


Subclinical Longitudinal Change in Ankle-Brachial Index With Aging in a Community-Dwelling Population Is Associated With Central Arterial Stiffening.

Oberdier MT, Morrell CH, Lakatta EG, Ferrucci L, AlGhatrif M.

J Am Heart Assoc. 2019 Aug 6;8(15):e011650. doi: 10.1161/JAHA.118.011650. Epub 2019 Aug 5.


Arterial stiffness and multiple organ damage: a longitudinal study in population.

Scuteri A, Morrell CH, Fegatelli DA, Fiorillo E, Delitala A, Orru' M, Marongiu M, Schlessinger D, Cucca F.

Aging Clin Exp Res. 2019 Jul 13. doi: 10.1007/s40520-019-01260-0. [Epub ahead of print]


Overexpression of a Neuronal Type Adenylyl Cyclase (Type 8) in Sinoatrial Node Markedly Impacts Heart Rate and Rhythm.

Moen JM, Matt MG, Ramirez C, Tarasov KV, Chakir K, Tarasova YS, Lukyanenko Y, Tsutsui K, Monfredi O, Morrell CH, Tagirova S, Yaniv Y, Huynh T, Pacak K, Ahmet I, Lakatta EG.

Front Neurosci. 2019 Jun 18;13:615. doi: 10.3389/fnins.2019.00615. eCollection 2019.


The Protective Role of Natriuretic Peptide Receptor 2 against High Salt Injury in the Renal Papilla.

Dugbartey GJ, Quinn B, Luo L, Mickelsen DM, Ture SK, Morrell CN, Czyzyk J, Doyley MM, Yan C, Berk BC, Korshunov VA.

Am J Pathol. 2019 Sep;189(9):1721-1731. doi: 10.1016/j.ajpath.2019.05.020. Epub 2019 Jun 18.


Acetylcholine Inhibits Platelet Activation.

Bennett JA, Ture SK, Schmidt RA, Mastrangelo MA, Cameron SJ, Terry LE, Yule DI, Morrell CN, Lowenstein CJ.

J Pharmacol Exp Ther. 2019 May;369(2):182-187. doi: 10.1124/jpet.118.253583. Epub 2019 Feb 14.


Platelet-derived β2M regulates monocyte inflammatory responses.

Hilt ZT, Pariser DN, Ture SK, Mohan A, Quijada P, Asante AA, Cameron SJ, Sterling JA, Merkel AR, Johanson AL, Jenkins JL, Small EM, McGrath KE, Palis J, Elliott MR, Morrell CN.

JCI Insight. 2019 Mar 7;4(5). pii: 122943. doi: 10.1172/jci.insight.122943. eCollection 2019 Mar 7.


The Platelet Napoleon Complex-Small Cells, but Big Immune Regulatory Functions.

Morrell CN, Pariser DN, Hilt ZT, Vega Ocasio D.

Annu Rev Immunol. 2019 Apr 26;37:125-144. doi: 10.1146/annurev-immunol-042718-041607. Epub 2018 Nov 28.


Platelet CD36 signaling through ERK5 promotes caspase-dependent procoagulant activity and fibrin deposition in vivo.

Yang M, Kholmukhamedov A, Schulte ML, Cooley BC, Scoggins NO, Wood JP, Cameron SJ, Morrell CN, Jobe SM, Silverstein RL.

Blood Adv. 2018 Nov 13;2(21):2848-2861. doi: 10.1182/bloodadvances.2018025411.


Cost-effectiveness of PoNDER health visitor training for mothers at lower risk of depression: findings on prevention of postnatal depression from a cluster-randomised controlled trial.

Henderson C, Dixon S, Bauer A, Knapp M, Morrell CJ, Slade P, Walters SJ, Brugha T.

Psychol Med. 2019 Jun;49(8):1324-1334. doi: 10.1017/S0033291718001940. Epub 2018 Aug 30.


Prostate-Specific Antigen Trends Predict the Probability of Prostate Cancer in a Very Large U.S. Veterans Affairs Cohort.

Karnes RJ, MacKintosh FR, Morrell CH, Rawson L, Sprenkle PC, Kattan MW, Colicchia M, Neville TB.

Front Oncol. 2018 Aug 6;8:296. doi: 10.3389/fonc.2018.00296. eCollection 2018.


Hypoxia and Ischemia Promote a Maladaptive Platelet Phenotype.

Cameron SJ, Mix DS, Ture SK, Schmidt RA, Mohan A, Pariser D, Stoner MC, Shah P, Chen L, Zhang H, Field DJ, Modjeski KL, Toth S, Morrell CN.

Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1594-1606. doi: 10.1161/ATVBAHA.118.311186. Epub 2018 May 3.


Women's views on anxiety in pregnancy and the use of anxiety instruments: a qualitative study.

Evans K, Morrell CJ, Spiby H.

J Reprod Infant Psychol. 2017 Feb;35(1):77-90. doi: 10.1080/02646838.2016.1245413. Epub 2016 Nov 10.


The platelet phenotype in patients with ST-segment elevation myocardial infarction is different from non-ST-segment elevation myocardial infarction.

Schmidt RA, Morrell CN, Ling FS, Simlote P, Fernandez G, Rich DQ, Adler D, Gervase J, Cameron SJ.

Transl Res. 2018 May;195:1-12. doi: 10.1016/j.trsl.2017.11.006. Epub 2017 Dec 2.


Systematic review and meta-analysis of non-pharmacological interventions to reduce the symptoms of mild to moderate anxiety in pregnant women.

Evans K, Morrell CJ, Spiby H.

J Adv Nurs. 2018 Feb;74(2):289-309. doi: 10.1111/jan.13456. Epub 2017 Oct 16. Review.


Platelet factor 4 increases bone marrow B cell development and differentiation.

Field DJ, Aggrey-Amable AA, Blick SK, Ture SK, Johanson A, Cameron SJ, Roy S, Morrell CN.

Immunol Res. 2017 Oct;65(5):1089-1094. doi: 10.1007/s12026-017-8951-x.


miR-451 limits CD4+ T cell proliferative responses to infection in mice.

Chapman LM, Ture SK, Field DJ, Morrell CN.

Immunol Res. 2017 Aug;65(4):828-840. doi: 10.1007/s12026-017-8919-x.


Platelets: killers of parasites or patients?

Morrell CN.

Blood. 2017 Mar 23;129(12):1571-1572. doi: 10.1182/blood-2017-01-764621. No abstract available.


Platelet CD36 promotes thrombosis by activating redox sensor ERK5 in hyperlipidemic conditions.

Yang M, Cooley BC, Li W, Chen Y, Vasquez-Vivar J, Scoggins NO, Cameron SJ, Morrell CN, Silverstein RL.

Blood. 2017 May 25;129(21):2917-2927. doi: 10.1182/blood-2016-11-750133. Epub 2017 Mar 23.


Associations between ambient wood smoke and other particulate pollutants and biomarkers of systemic inflammation, coagulation and thrombosis in cardiac patients.

Croft DP, Cameron SJ, Morrell CN, Lowenstein CJ, Ling F, Zareba W, Hopke PK, Utell MJ, Thurston SW, Thevenet-Morrison K, Evans KA, Chalupa D, Rich DQ.

Environ Res. 2017 Apr;154:352-361. doi: 10.1016/j.envres.2017.01.027. Epub 2017 Feb 4.


Novel Thrombotic Function of a Human SNP in STXBP5 Revealed by CRISPR/Cas9 Gene Editing in Mice.

Zhu QM, Ko KA, Ture S, Mastrangelo MA, Chen MH, Johnson AD, O'Donnell CJ, Morrell CN, Miano JM, Lowenstein CJ.

Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):264-270. doi: 10.1161/ATVBAHA.116.308614. Epub 2016 Dec 29.


Perceptions and experiences of interventions to prevent postnatal depression. A systematic review and qualitative evidence synthesis.

Scope A, Booth A, Morrell CJ, Sutcliffe P, Cantrell A.

J Affect Disord. 2017 Mar 1;210:100-110. doi: 10.1016/j.jad.2016.12.017. Epub 2016 Dec 19. Review.


The relationship between the metabolic syndrome and arterial wall thickness: A mosaic still to be interpreted.

Scuteri A, Franco OH, Majiid A, Jolita B, Sergey B, Cheng HM, Chen CH, Choi SW, Francesco C, De Buyzere ML, Alessandro D, Marcus D, Gunnar E, Albert H, Seul-Ki J, Kweon SS, Michel L, Lee YH, Mattace Raso F, Olle M, Morrell CH, Park KS, Rietzschel ER, Kristina R, Ryliskyte L, Ulf S, David S, Shin MH, Irina S, Shih-Hsien S, Olga T, Völzke H, Lakatta EG, Nilsson P; MARE Consortium.

Atherosclerosis. 2016 Dec;255:11-16. doi: 10.1016/j.atherosclerosis.2016.10.032. Epub 2016 Oct 15.


A novel TRPV4-specific agonist inhibits monocyte adhesion and atherosclerosis.

Xu S, Liu B, Yin M, Koroleva M, Mastrangelo M, Ture S, Morrell CN, Zhang DX, Fisher EA, Jin ZG.

Oncotarget. 2016 Jun 21;7(25):37622-37635. doi: 10.18632/oncotarget.9376.


Glutamate Receptor Interacting Protein 1 Mediates Platelet Adhesion and Thrombus Formation.

Modjeski KL, Ture SK, Field DJ, Cameron SJ, Morrell CN.

PLoS One. 2016 Sep 15;11(9):e0160638. doi: 10.1371/journal.pone.0160638. eCollection 2016.


Age and Prostate-Specific Antigen Level Prior to Diagnosis Predict Risk of Death from Prostate Cancer.

MacKintosh FR, Sprenkle PC, Walter LC, Rawson L, Karnes RJ, Morrell CH, Kattan MW, Nawaf CB, Neville TB.

Front Oncol. 2016 Jun 28;6:157. doi: 10.3389/fonc.2016.00157. eCollection 2016.


Role of Axl in T-Lymphocyte Survival in Salt-Dependent Hypertension.

Batchu N, Hughson A, Wadosky KM, Morrell CN, Fowell DJ, Korshunov VA.

Arterioscler Thromb Vasc Biol. 2016 Aug;36(8):1638-1646. doi: 10.1161/ATVBAHA.116.307848. Epub 2016 Jun 30.


Novel Antiplatelet Activity of Minocycline Involves Inhibition of MLK3-p38 Mitogen Activated Protein Kinase Axis.

Jackson JW, Singh MV, Singh VB, Jones LD, Davidson GA, Ture S, Morrell CN, Schifitto G, Maggirwar SB.

PLoS One. 2016 Jun 6;11(6):e0157115. doi: 10.1371/journal.pone.0157115. eCollection 2016.


A systematic review, evidence synthesis and meta-analysis of quantitative and qualitative studies evaluating the clinical effectiveness, the cost-effectiveness, safety and acceptability of interventions to prevent postnatal depression.

Morrell CJ, Sutcliffe P, Booth A, Stevens J, Scope A, Stevenson M, Harvey R, Bessey A, Cantrell A, Dennis CL, Ren S, Ragonesi M, Barkham M, Churchill D, Henshaw C, Newstead J, Slade P, Spiby H, Stewart-Brown S.

Health Technol Assess. 2016 May;20(37):1-414. doi: 10.3310/hta20370. Review.


Gender specific profiles of white coat and masked hypertension impacts on arterial structure and function in the SardiNIA study.

Scuteri A, Morrell CH, Orru' M, AlGhatrif M, Saba PS, Terracciano A, Ferreli LA, Loi F, Marongiu M, Pilia MG, Delitala A, Tarasov KV, Schlessinger D, Ganau A, Cucca F, Lakatta EG.

Int J Cardiol. 2016 Aug 15;217:92-8. doi: 10.1016/j.ijcard.2016.04.172. Epub 2016 May 3. No abstract available.


Pyroptosis as a Regulated Form of Necrosis: PI+/Annexin V-/High Caspase 1/Low Caspase 9 Activity in Cells = Pyroptosis?

Abe J, Morrell C.

Circ Res. 2016 May 13;118(10):1457-60. doi: 10.1161/CIRCRESAHA.116.308699. No abstract available.


Maintenance of Cognitive Performance and Mood for Individuals with Alzheimer's Disease Following Consumption of a Nutraceutical Formulation: A One-Year, Open-Label Study.

Remington R, Bechtel C, Larsen D, Samar A, Page R, Morrell C, Shea TB.

J Alzheimers Dis. 2016;51(4):991-5. doi: 10.3233/JAD-151098.


Resveratrol preserves the function of human platelets stored for transfusion.

Lannan KL, Refaai MA, Ture SK, Morrell CN, Blumberg N, Phipps RP, Spinelli SL.

Br J Haematol. 2016 Mar;172(5):794-806. doi: 10.1111/bjh.13862. Epub 2015 Dec 18.


A Novel Anti-Inflammatory Effect for High Density Lipoprotein.

Cameron SJ, Morrell CN, Bao C, Swaim AF, Rodriguez A, Lowenstein CJ.

PLoS One. 2015 Dec 17;10(12):e0144372. doi: 10.1371/journal.pone.0144372. eCollection 2015.


Glutamate Receptor Interacting Protein 1 Regulates CD4(+) CTLA-4 Expression and Transplant Rejection.

Modjeski KL, Levy SC, Ture SK, Field DJ, Shi G, Ko K, Zhu Q, Morrell CN.

Am J Transplant. 2016 May;16(5):1383-93. doi: 10.1111/ajt.13623. Epub 2016 Feb 25.


Can community midwives prevent antenatal depression? An external pilot study to test the feasibility of a cluster randomized controlled universal prevention trial.

Brugha TS, Smith J, Austin J, Bankart J, Patterson M, Lovett C, Morgan Z, Morrell CJ, Slade P.

Psychol Med. 2016 Jan;46(2):345-56. doi: 10.1017/S003329171500183X. Epub 2015 Oct 20.


A Nutritional Formulation for Cognitive Performance in Mild Cognitive Impairment: A Placebo-Controlled Trial with an Open-Label Extension.

Remington R, Lortie JJ, Hoffmann H, Page R, Morrell C, Shea TB.

J Alzheimers Dis. 2015;48(3):591-5. doi: 10.3233/JAD-150057.


Axl modulates immune activation of smooth muscle cells in vein graft remodeling.

Batchu SN, Xia J, Ko KA, Doyley MM, Abe J, Morrell CN, Korshunov VA.

Am J Physiol Heart Circ Physiol. 2015 Sep 15;309(6):H1048-58. doi: 10.1152/ajpheart.00495.2015. Epub 2015 Aug 14.


A novel psychoactive substance poses a new challenge in the management of paranoid schizophrenia.

Anderson C, Morrell C, Marchevsky D.

BMJ Case Rep. 2015 May 6;2015. pii: bcr2015209573. doi: 10.1136/bcr-2015-209573.


Platelet Extracellular Regulated Protein Kinase 5 Is a Redox Switch and Triggers Maladaptive Platelet Responses and Myocardial Infarct Expansion.

Cameron SJ, Ture SK, Mickelsen D, Chakrabarti E, Modjeski KL, McNitt S, Seaberry M, Field DJ, Le NT, Abe J, Morrell CN.

Circulation. 2015 Jul 7;132(1):47-58. doi: 10.1161/CIRCULATIONAHA.115.015656. Epub 2015 May 1.


A psychometric systematic review of self-report instruments to identify anxiety in pregnancy.

Evans K, Spiby H, Morrell CJ.

J Adv Nurs. 2015 Sep;71(9):1986-2001. doi: 10.1111/jan.12649. Epub 2015 Mar 26. Review.


A Phase II Randomized Clinical Trial of a Nutritional Formulation for Cognition and Mood in Alzheimer's Disease.

Remington R, Bechtel C, Larsen D, Samar A, Doshanjh L, Fishman P, Luo Y, Smyers K, Page R, Morrell C, Shea TB.

J Alzheimers Dis. 2015;45(2):395-405. doi: 10.3233/JAD-142499.


Testing the product of slopes in related regressions.

Morrell CH, Shetty V, Phillips T, Arumugam TV, Mattson MP, Wan R.

Adv Appl Stat. 2013 Sep 1;36(1):29-46.


Stochasticity intrinsic to coupled-clock mechanisms underlies beat-to-beat variability of spontaneous action potential firing in sinoatrial node pacemaker cells.

Yaniv Y, Lyashkov AE, Sirenko S, Okamoto Y, Guiriba TR, Ziman BD, Morrell CH, Lakatta EG.

J Mol Cell Cardiol. 2014 Dec;77:1-10. doi: 10.1016/j.yjmcc.2014.09.008. Epub 2014 Sep 22.


Syntaxin-binding protein STXBP5 inhibits endothelial exocytosis and promotes platelet secretion.

Zhu Q, Yamakuchi M, Ture S, de la Luz Garcia-Hernandez M, Ko KA, Modjeski KL, LoMonaco MB, Johnson AD, O'Donnell CJ, Takai Y, Morrell CN, Lowenstein CJ.

J Clin Invest. 2014 Oct;124(10):4503-16. doi: 10.1172/JCI71245. Epub 2014 Sep 17.


Longitudinal perspective on the conundrum of central arterial stiffness, blood pressure, and aging.

Scuteri A, Morrell CH, Orrù M, Strait JB, Tarasov KV, Ferreli LA, Loi F, Pilia MG, Delitala A, Spurgeon H, Najjar SS, AlGhatrif M, Lakatta EG.

Hypertension. 2014 Dec;64(6):1219-27. doi: 10.1161/HYPERTENSIONAHA.114.04127. Epub 2014 Sep 15.


Identification of activators of ERK5 transcriptional activity by high-throughput screening and the role of endothelial ERK5 in vasoprotective effects induced by statins and antimalarial agents.

Le NT, Takei Y, Izawa-Ishizawa Y, Heo KS, Lee H, Smrcka AV, Miller BL, Ko KA, Ture S, Morrell C, Fujiwara K, Akaike M, Abe J.

J Immunol. 2014 Oct 1;193(7):3803-15. doi: 10.4049/jimmunol.1400571. Epub 2014 Sep 3.


Understanding platelets in malaria infection.

Morrell CN.

Curr Opin Hematol. 2014 Sep;21(5):445-9. doi: 10.1097/MOH.0000000000000073. Review.


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