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Items: 5


Activity of Aromathecins against African Trypanosomes.

Nenortas NP, Cinelli MA, Morrell AE, Cushman M, Shapiro TA.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e00786-18. doi: 10.1128/AAC.00786-18. Print 2018 Nov.


Mechanically induced Ca2+ oscillations in osteocytes release extracellular vesicles and enhance bone formation.

Morrell AE, Brown GN, Robinson ST, Sattler RL, Baik AD, Zhen G, Cao X, Bonewald LF, Jin W, Kam LC, Guo XE.

Bone Res. 2018 Mar 19;6:6. doi: 10.1038/s41413-018-0007-x. eCollection 2018.


Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors: investigating the relationships involving stereochemistry, hydrogen bonding, and biological activity.

Peterson KE, Cinelli MA, Morrell AE, Mehta A, Dexheimer TS, Agama K, Antony S, Pommier Y, Cushman M.

J Med Chem. 2011 Jul 28;54(14):4937-53. doi: 10.1021/jm101338z. Epub 2011 Jun 28.


Cancer chemopreventive potential of aromathecins and phenazines, novel natural product derivatives.

Marler L, Conda-Sheridan M, Cinelli MA, Morrell AE, Cushman M, Chen L, Huang K, Van Breemen R, Pezzuto JM.

Anticancer Res. 2010 Dec;30(12):4873-82.


The structure-activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode.

Cinelli MA, Morrell AE, Dexheimer TS, Agama K, Agrawal S, Pommier Y, Cushman M.

Bioorg Med Chem. 2010 Aug 1;18(15):5535-52. doi: 10.1016/j.bmc.2010.06.040. Epub 2010 Jun 20.

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