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Membrane occupation and recognition nexus (MORN) motif controls protein localization and function.
Zhou J, Liu H, Lin Y, Zhao J. Zhou J, et al. FEBS Lett. 2022 Jul;596(14):1839-1850. doi: 10.1002/1873-3468.14378. Epub 2022 May 27. FEBS Lett. 2022. PMID: 35568981 Free article. Review.
Recent studies have found that MORN motif-containing proteins junctophilin-1/2 and MORN3 play a role in cardiac hypertrophy, skeletal muscle fiber stability and cancer. ...
Recent studies have found that MORN motif-containing proteins junctophilin-1/2 and MORN3 play a role in cardiac hypertrophy, skeletal …
The plasma peptides of ovarian cancer.
Dufresne J, Bowden P, Thavarajah T, Florentinus-Mefailoski A, Chen ZZ, Tucholska M, Norzin T, Ho MT, Phan M, Mohamed N, Ravandi A, Stanton E, Slutsky AS, Dos Santos CC, Romaschin A, Marshall JC, Addison C, Malone S, Heyland D, Scheltens P, Killestein J, Teunissen CE, Diamandis EP, Michael Siu KW, Marshall JG. Dufresne J, et al. Clin Proteomics. 2018 Dec 21;15:41. doi: 10.1186/s12014-018-9215-z. eCollection 2018. Clin Proteomics. 2018. PMID: 30598658 Free PMC article.

Many cellular proteins showed large changes in frequency by Chi Square (chi(2) > 60, p < 0.0001) in the ovarian cancer samples such as ZNF91, ZNF254, F13A1, LOC102723511, ZNF253, QSER1, P4HA1, GPC6, LMNB2, PYGB, NBR1, CCNI2, LOC101930455, TRPM5, IGSF1, ITGB1, CHD6, SIRT1, N

…

Many cellular proteins showed large changes in frequency by Chi Square (chi(2) > 60, p < 0.0001) in the ovarian cancer samples such as

…
A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.
Liang L, Wang H, Shi H, Li Z, Yao H, Bu Z, Song N, Li C, Xiang D, Zhang Y, Wang J, Hu Y, Xu Q, Ma Y, Cheng Z, Wang Y, Zhao S, Qian J, Chen Y, Fang JY, Xu J. Liang L, et al. Cell Chem Biol. 2018 Jun 21;25(6):761-774.e5. doi: 10.1016/j.chembiol.2018.03.010. Epub 2018 Apr 19. Cell Chem Biol. 2018. PMID: 29681526 Free article.
The molecular functions of Morn3 were validated through in vivo assays and chemico-biological intervention. A rationally designed Morn3-targeting peptide (Morncide) successfully activated p53 and suppressed tumor growth. ...
The molecular functions of Morn3 were validated through in vivo assays and chemico-biological intervention. A rationally designed …
Characterization of membrane occupation and recognition nexus repeat containing 3, meiosis expressed gene 1 binding partner, in mouse male germ cells.
Zhang L, Shang XJ, Li HF, Shi YQ, Li W, Teves ME, Wang ZQ, Jiang GF, Song SZ, Zhang ZB. Zhang L, et al. Asian J Androl. 2015 Jan-Feb;17(1):86-93. doi: 10.4103/1008-682X.138186. Asian J Androl. 2015. PMID: 25248657 Free PMC article.
Specific anti-MORN3 polyclonal antibody was generated against N-terminus of the full-length MORN3 protein, and MORN3 expression and localization was examined in vitro and in vivo. In transfected Chinese hamster ovary cells, the antibody specifically crossed-r …
Specific anti-MORN3 polyclonal antibody was generated against N-terminus of the full-length MORN3 protein, and MORN3 ex …
Identification and validation of a novel 16-gene prognostic signature for patients with breast cancer.
Zhong Z, Jiang W, Zhang J, Li Z, Fan F. Zhong Z, et al. Sci Rep. 2022 Jul 19;12(1):12349. doi: 10.1038/s41598-022-16575-8. Sci Rep. 2022. PMID: 35853971 Free PMC article.
The 16-gene nomogram incorporating the survival-related clinical factors showed improved prediction accuracies for 1-year, 3-year and 5-year survival (area under curve [AUC] = 0.91, 0.79 and 0.77 respectively). MORN3, IGJ, DERL1 exhibited high accuracy in differentiating B …
The 16-gene nomogram incorporating the survival-related clinical factors showed improved prediction accuracies for 1-year, 3-year and 5-year …
An atypical 12q24.31 microdeletion implicates six genes including a histone demethylase KDM2B and a histone methyltransferase SETD1B in syndromic intellectual disability.
Labonne JD, Lee KH, Iwase S, Kong IK, Diamond MP, Layman LC, Kim CH, Kim HG. Labonne JD, et al. Hum Genet. 2016 Jul;135(7):757-71. doi: 10.1007/s00439-016-1668-4. Epub 2016 Apr 22. Hum Genet. 2016. PMID: 27106595
These two chromatin modifiers located approximately 224 kb apart were both commonly deleted in six patients, while two additional patients had either KDM2B or SETD1B deleted. The four additional candidate genes (ORAI1, MORN3, TMEM120B, RHOF), a microRNA MIR548AQ, and a non …
These two chromatin modifiers located approximately 224 kb apart were both commonly deleted in six patients, while two additional patients h …