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Items: 1 to 50 of 100

1.

Design and Synthesis of TASIN Analogues Specifically Targeting Colorectal Cancer Cell Lines with Mutant Adenomatous Polyposis Coli (APC).

Wang W, Zhang L, Morlock L, Williams NS, Shay JW, De Brabander JK.

J Med Chem. 2019 May 23;62(10):5217-5241. doi: 10.1021/acs.jmedchem.9b00532. Epub 2019 May 9.

PMID:
31070915
2.

PH WINS and the Future of Public Health Education.

Resnick BA, Morlock L, Diener-West M, Stuart EA, Spencer M, Sharfstein JM.

J Public Health Manag Pract. 2019 Mar/Apr;25 Suppl 2, Public Health Workforce Interests and Needs Survey 2017:S10-S12. doi: 10.1097/PHH.0000000000000955. No abstract available.

PMID:
30720612
3.

Installation of a cancer promoting WNT/SIX1 signaling axis by the oncofusion protein MLL-AF9.

Zhang LS, Kang X, Lu J, Zhang Y, Wu X, Wu G, Zheng J, Tuladhar R, Shi H, Wang Q, Morlock L, Yao H, Huang LJ, Maire P, Kim J, Williams N, Xu J, Chen C, Zhang CC, Lum L.

EBioMedicine. 2019 Jan;39:145-158. doi: 10.1016/j.ebiom.2018.11.039. Epub 2018 Dec 6.

4.

The health of Saudi older adults; results from the Saudi National Survey for Elderly Health (SNSEH) 2006-2015.

Khoja AT, Aljawadi MH, Al-Shammari SA, Mohamed AG, Al-Manaa HA, Morlock L, Ahmed S, Khoja TAM.

Saudi Pharm J. 2018 Feb;26(2):292-300. doi: 10.1016/j.jsps.2017.11.008. Epub 2017 Nov 20.

5.

Protein Engineering of the Progesterone Hydroxylating P450-Monooxygenase CYP17A1 Alters Its Regioselectivity.

Morlock LK, Grobe S, Balke K, Mauersberger S, Böttcher D, Bornscheuer UT.

Chembiochem. 2018 Sep 17;19(18):1954-1958. doi: 10.1002/cbic.201800371. Epub 2018 Aug 7.

PMID:
29981252
6.

Simultaneous detection of NADPH consumption and H2O2 production using the Ampliflu™ Red assay for screening of P450 activities and uncoupling.

Morlock LK, Böttcher D, Bornscheuer UT.

Appl Microbiol Biotechnol. 2018 Jan;102(2):985-994. doi: 10.1007/s00253-017-8636-3. Epub 2017 Nov 17.

PMID:
29150709
7.

Do Hospitals Support Second Victims? Collective Insights From Patient Safety Leaders in Maryland.

Edrees HH, Morlock L, Wu AW.

Jt Comm J Qual Patient Saf. 2017 Sep;43(9):471-483. doi: 10.1016/j.jcjq.2017.01.008. Epub 2017 Jun 28.

PMID:
28844233
8.

Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion.

Luthra P, Aguirre S, Yen BC, Pietzsch CA, Sanchez-Aparicio MT, Tigabu B, Morlock LK, García-Sastre A, Leung DW, Williams NS, Fernandez-Sesma A, Bukreyev A, Basler CF.

MBio. 2017 Apr 4;8(2). pii: e00368-17. doi: 10.1128/mBio.00368-17.

9.

Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist.

Moon J, Zhou H, Zhang LS, Tan W, Liu Y, Zhang S, Morlock LK, Bao X, Palecek SP, Feng JQ, Williams NS, Amatruda JF, Olson EN, Bassel-Duby R, Lum L.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1649-1654. doi: 10.1073/pnas.1621346114. Epub 2017 Jan 31.

10.

Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors.

Tso SC, Lou M, Wu CY, Gui WJ, Chuang JL, Morlock LK, Williams NS, Wynn RM, Qi X, Chuang DT.

J Med Chem. 2017 Feb 9;60(3):1142-1150. doi: 10.1021/acs.jmedchem.6b01540. Epub 2017 Jan 31.

11.

Development of a triazole class of highly potent Porcn inhibitors.

You L, Zhang C, Yarravarapu N, Morlock L, Wang X, Zhang L, Williams NS, Lum L, Chen C.

Bioorg Med Chem Lett. 2016 Dec 15;26(24):5891-5895. doi: 10.1016/j.bmcl.2016.11.012. Epub 2016 Nov 11.

12.

Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase.

Theodoropoulos PC, Gonzales SS, Winterton SE, Rodriguez-Navas C, McKnight JS, Morlock LK, Hanson JM, Cross B, Owen AE, Duan Y, Moreno JR, Lemoff A, Mirzaei H, Posner BA, Williams NS, Ready JM, Nijhawan D.

Nat Chem Biol. 2016 Apr;12(4):218-25. doi: 10.1038/nchembio.2016. Epub 2016 Feb 1.

13.

Protective efficacy of P7C3-S243 in the 6-hydroxydopamine model of Parkinson's disease.

De Jesús-Cortés H, Miller AD, Britt JK, DeMarco AJ, De Jesús-Cortés M, Stuebing E, Naidoo J, Vázquez-Rosa E, Morlock L, Williams NS, Ready JM, Narayanan NS, Pieper AA.

NPJ Parkinsons Dis. 2015;1. pii: 15010. Epub 2015 May 21.

14.

Diet-induced unresolved ER stress hinders KRAS-driven lung tumorigenesis.

Ramadori G, Konstantinidou G, Venkateswaran N, Biscotti T, Morlock L, Galié M, Williams NS, Luchetti M, Santinelli A, Scaglioni PP, Coppari R.

Cell Metab. 2015 Jan 6;21(1):117-25. doi: 10.1016/j.cmet.2014.11.020. Epub 2014 Dec 18.

15.

Early detection of subclinical visual damage after blast-mediated TBI enables prevention of chronic visual deficit by treatment with P7C3-S243.

Dutca LM, Stasheff SF, Hedberg-Buenz A, Rudd DS, Batra N, Blodi FR, Yorek MS, Yin T, Shankar M, Herlein JA, Naidoo J, Morlock L, Williams N, Kardon RH, Anderson MG, Pieper AA, Harper MM.

Invest Ophthalmol Vis Sci. 2014 Dec 2;55(12):8330-41. doi: 10.1167/iovs.14-15468.

16.

Pharmacologic rescue of motor and sensory function by the neuroprotective compound P7C3 following neonatal nerve injury.

Kemp SW, Szynkaruk M, Stanoulis KN, Wood MD, Liu EH, Willand MP, Morlock L, Naidoo J, Williams NS, Ready JM, Mangano TJ, Beggs S, Salter MW, Gordon T, Pieper AA, Borschel GH.

Neuroscience. 2015 Jan 22;284:202-16. doi: 10.1016/j.neuroscience.2014.10.005. Epub 2014 Oct 13.

PMID:
25313000
17.

Do prehospital criteria optimally assign injured children to the appropriate level of trauma team activation and emergency department disposition at a level I pediatric trauma center?

Nabaweesi R, Morlock L, Lule C, Ziegfeld S, Gielen A, Colombani PM, Bowman SM.

Pediatr Surg Int. 2014 Nov;30(11):1097-102. doi: 10.1007/s00383-014-3587-6. Epub 2014 Aug 21.

PMID:
25142797
18.

Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase.

Tso SC, Gui WJ, Wu CY, Chuang JL, Qi X, Skvora KJ, Dork K, Wallace AL, Morlock LK, Lee BH, Hutson SM, Strom SC, Williams NS, Tambar UK, Wynn RM, Chuang DT.

J Biol Chem. 2014 Jul 25;289(30):20583-93.

19.

The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis.

Walker AK, Rivera PD, Wang Q, Chuang JC, Tran S, Osborne-Lawrence S, Estill SJ, Starwalt R, Huntington P, Morlock L, Naidoo J, Williams NS, Ready JM, Eisch AJ, Pieper AA, Zigman JM.

Mol Psychiatry. 2015 Apr;20(4):500-8. doi: 10.1038/mp.2014.34. Epub 2014 Apr 22.

20.

Discovery of a neuroprotective chemical, (S)-N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with improved druglike properties.

Naidoo J, De Jesus-Cortes H, Huntington P, Estill S, Morlock LK, Starwalt R, Mangano TJ, Williams NS, Pieper AA, Ready JM.

J Med Chem. 2014 May 8;57(9):3746-54. doi: 10.1021/jm401919s. Epub 2014 Apr 16.

21.

Streamlined analysis of lactose-free dairy products.

Morlock GE, Morlock LP, Lemo C.

J Chromatogr A. 2014 Jan 10;1324:215-23. doi: 10.1016/j.chroma.2013.11.038. Epub 2013 Nov 26.

PMID:
24360255
22.

Structure-guided development of specific pyruvate dehydrogenase kinase inhibitors targeting the ATP-binding pocket.

Tso SC, Qi X, Gui WJ, Wu CY, Chuang JL, Wernstedt-Asterholm I, Morlock LK, Owens KR, Scherer PE, Williams NS, Tambar UK, Wynn RM, Chuang DT.

J Biol Chem. 2014 Feb 14;289(7):4432-43. doi: 10.1074/jbc.M113.533885. Epub 2013 Dec 19.

23.

Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase.

Tso SC, Qi X, Gui WJ, Chuang JL, Morlock LK, Wallace AL, Ahmed K, Laxman S, Campeau PM, Lee BH, Hutson SM, Tu BP, Williams NS, Tambar UK, Wynn RM, Chuang DT.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9728-33. doi: 10.1073/pnas.1303220110. Epub 2013 May 28.

24.

A phased cluster-randomized trial of rural hospitals testing a quality collaborative to improve heart failure care: organizational context matters.

Newhouse RP, Dennison Himmelfarb C, Morlock L, Frick KD, Pronovost P, Liang Y.

Med Care. 2013 May;51(5):396-403. doi: 10.1097/MLR.0b013e318286e32e.

PMID:
23579349
25.

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease.

De Jesús-Cortés H, Xu P, Drawbridge J, Estill SJ, Huntington P, Tran S, Britt J, Tesla R, Morlock L, Naidoo J, Melito LM, Wang G, Williams NS, Ready JM, McKnight SL, Pieper AA.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17010-5. doi: 10.1073/pnas.1213956109. Epub 2012 Oct 1.

26.

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis.

Tesla R, Wolf HP, Xu P, Drawbridge J, Estill SJ, Huntington P, McDaniel L, Knobbe W, Burket A, Tran S, Starwalt R, Morlock L, Naidoo J, Williams NS, Ready JM, McKnight SL, Pieper AA.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17016-21. doi: 10.1073/pnas.1213960109. Epub 2012 Oct 1.

27.

A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma.

Sivanand S, Peña-Llopis S, Zhao H, Kucejova B, Spence P, Pavia-Jimenez A, Yamasaki T, McBride DJ, Gillen J, Wolff NC, Morlock L, Lotan Y, Raj GV, Sagalowsky A, Margulis V, Cadeddu JA, Ross MT, Bentley DR, Kabbani W, Xie XJ, Kapur P, Williams NS, Brugarolas J.

Sci Transl Med. 2012 Jun 6;4(137):137ra75. doi: 10.1126/scitranslmed.3003643.

28.

Do nurse and patient injuries share common antecedents? An analysis of associations with safety climate and working conditions.

Taylor JA, Dominici F, Agnew J, Gerwin D, Morlock L, Miller MR.

BMJ Qual Saf. 2012 Feb;21(2):101-11. doi: 10.1136/bmjqs-2011-000082. Epub 2011 Oct 19.

PMID:
22016377
29.

Are temporary staff associated with more severe emergency department medication errors?

Pham JC, Andrawis M, Shore AD, Fahey M, Morlock L, Pronovost PJ.

J Healthc Qual. 2011 Jul-Aug;33(4):9-18. doi: 10.1111/j.1945-1474.2010.00116.x. Epub 2010 Nov 11.

PMID:
21733020
30.

Triangulating case-finding tools for patient safety surveillance: a cross-sectional case study of puncture/laceration.

Taylor JA, Gerwin D, Morlock L, Miller MR.

Inj Prev. 2011 Dec;17(6):388-93. doi: 10.1136/ip.2010.029108. Epub 2011 May 5.

PMID:
21546524
31.

Rural hospital nursing: results of a national survey of nurse executives.

Newhouse RP, Morlock L, Pronovost P, Sproat SB.

J Nurs Adm. 2011 Mar;41(3):129-37. doi: 10.1097/NNA.0b013e31820c7212.

PMID:
21336041
32.

Is quality of care improving in the UK?

Pronovost PJ, Berenholtz SM, Morlock LL.

BMJ. 2011 Feb 3;342:c6646. doi: 10.1136/bmj.c6646. No abstract available.

33.

Impact of a statewide intensive care unit quality improvement initiative on hospital mortality and length of stay: retrospective comparative analysis.

Lipitz-Snyderman A, Steinwachs D, Needham DM, Colantuoni E, Morlock LL, Pronovost PJ.

BMJ. 2011 Jan 28;342:d219. doi: 10.1136/bmj.d219.

34.

Improving the Value of Patient Safety Reporting Systems.

Pronovost PJ, Morlock LL, Sexton JB, Miller MR, Holzmueller CG, Thompson DA, Lubomski LH, Wu AW.

In: Henriksen K, Battles JB, Keyes MA, Grady ML, editors. Advances in Patient Safety: New Directions and Alternative Approaches (Vol. 1: Assessment). Rockville (MD): Agency for Healthcare Research and Quality; 2008 Aug.

35.

Development of proneurogenic, neuroprotective small molecules.

MacMillan KS, Naidoo J, Liang J, Melito L, Williams NS, Morlock L, Huntington PJ, Estill SJ, Longgood J, Becker GL, McKnight SL, Pieper AA, De Brabander JK, Ready JM.

J Am Chem Soc. 2011 Feb 9;133(5):1428-37. doi: 10.1021/ja108211m. Epub 2011 Jan 6.

36.

Is there an association between risk perception and disaster preparedness in rural US hospitals?

Cliff BJ, Morlock L, Curtis AB.

Prehosp Disaster Med. 2009 Nov-Dec;24(6):512-7.

PMID:
20301069
37.

Pediatric antidepressant medication errors in a national error reporting database.

Rinke ML, Bundy DG, Shore AD, Colantuoni E, Morlock LL, Miller MR.

J Dev Behav Pediatr. 2010 Feb-Mar;31(2):129-36. doi: 10.1097/DBP.0b013e3181ce6509.

PMID:
20110823
38.

NICU medication errors: identifying a risk profile for medication errors in the neonatal intensive care unit.

Stavroudis TA, Shore AD, Morlock L, Hicks RW, Bundy D, Miller MR.

J Perinatol. 2010 Jul;30(7):459-68. doi: 10.1038/jp.2009.186. Epub 2009 Dec 31.

PMID:
20043010
39.

Patient flow variability and unplanned readmissions to an intensive care unit.

Baker DR, Pronovost PJ, Morlock LL, Geocadin RG, Holzmueller CG.

Crit Care Med. 2009 Nov;37(11):2882-7.

PMID:
19866504
40.

Cardiovascular medication errors in children.

Alexander DC, Bundy DG, Shore AD, Morlock L, Hicks RW, Miller MR.

Pediatrics. 2009 Jul;124(1):324-32. doi: 10.1542/peds.2008-2073.

PMID:
19564316
41.

Pediatric vaccination errors: application of the "5 rights" framework to a national error reporting database.

Bundy DG, Shore AD, Morlock LL, Miller MR.

Vaccine. 2009 Jun 12;27(29):3890-6. doi: 10.1016/j.vaccine.2009.04.005. Epub 2009 Apr 23.

PMID:
19442422
42.

Rural hospital nursing: Better environments = shared vision and quality/safety engagement.

Newhouse RP, Morlock L, Pronovost P, Colantuoni E, Johantgen M.

J Nurs Adm. 2009 Apr;39(4):189-95. doi: 10.1097/NNA.0b013e31819c9cd5.

PMID:
19359891
43.

Reducing health care hazards: lessons from the commercial aviation safety team.

Pronovost PJ, Goeschel CA, Olsen KL, Pham JC, Miller MR, Berenholtz SM, Sexton JB, Marsteller JA, Morlock LL, Wu AW, Loeb JM, Clancy CM.

Health Aff (Millwood). 2009 May-Jun;28(3):w479-89. doi: 10.1377/hlthaff.28.3.w479. Epub 2009 Apr 7.

PMID:
19351647
44.

National study on the frequency, types, causes, and consequences of voluntarily reported emergency department medication errors.

Pham JC, Story JL, Hicks RW, Shore AD, Morlock LL, Cheung DS, Kelen GD, Pronovost PJ.

J Emerg Med. 2011 May;40(5):485-92. doi: 10.1016/j.jemermed.2008.02.059. Epub 2008 Sep 26.

PMID:
18823735
45.

Medication errors in the ambulatory treatment of pediatric attention deficit hyperactivity disorder.

Bundy DG, Rinke ML, Shore AD, Hicks RW, Morlock LL, Miller MR.

Jt Comm J Qual Patient Saf. 2008 Sep;34(9):552-9, 497.

PMID:
18792660
46.

Improving patient safety in intensive care units in Michigan.

Pronovost PJ, Berenholtz SM, Goeschel C, Thom I, Watson SR, Holzmueller CG, Lyon JS, Lubomski LH, Thompson DA, Needham D, Hyzy R, Welsh R, Roth G, Bander J, Morlock L, Sexton JB.

J Crit Care. 2008 Jun;23(2):207-21. doi: 10.1016/j.jcrc.2007.09.002.

PMID:
18538214
47.

Health insurance coverage in Central and Eastern Europe: trends and challenges.

Waters HR, Hobart J, Forrest CB, Siemens KK, Pittman PM, Murthy A, Vanderver GB, Anderson GF, Morlock LL.

Health Aff (Millwood). 2008 Mar-Apr;27(2):478-86. doi: 10.1377/hlthaff.27.2.478.

PMID:
18332505
48.

Medication errors in obstetrics.

Kfuri TA, Morlock L, Hicks RW, Shore AD.

Clin Perinatol. 2008 Mar;35(1):101-17, viii-ix. doi: 10.1016/j.clp.2007.11.015. Review.

PMID:
18280878
49.

Medication errors with opioids: results from a national reporting system.

Dy SM, Shore AD, Hicks RW, Morlock LL.

J Opioid Manag. 2007 Jul-Aug;3(4):189-94.

PMID:
17957978
50.

Intensive care unit safety incidents for medical versus surgical patients: a prospective multicenter study.

Sinopoli DJ, Needham DM, Thompson DA, Holzmueller CG, Dorman T, Lubomski LH, Wu AW, Morlock LL, Makary MA, Pronovost PJ.

J Crit Care. 2007 Sep;22(3):177-83. Epub 2007 Jan 31.

PMID:
17869966

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