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Diastereo- and Enantioselective 1,4-Difunctionalization of Borylenynes by Catalytic Conjunctive Cross-Coupling.

Morken JP, Law C, Kativhu E, Wang J.

Angew Chem Int Ed Engl. 2020 Mar 25. doi: 10.1002/anie.202001580. [Epub ahead of print]


Catalytic Enantioselective Synthesis of anti-Vicinal Silylboronates by Conjunctive Cross-Coupling.

Meng Y, Kong Z, Morken JP.

Angew Chem Int Ed Engl. 2020 Feb 20. doi: 10.1002/anie.202000937. [Epub ahead of print]


Alkyl Group Migration in Ni-Catalyzed Conjunctive Coupling with C(sp3) Electrophiles: Reaction Development and Application to Targets of Interest.

Koo SM, Vendola AJ, Momm SN, Morken JP.

Org Lett. 2020 Jan 17;22(2):666-669. doi: 10.1021/acs.orglett.9b04453. Epub 2020 Jan 7.


Enantioselective Radical Addition/Cross-Coupling of Organozinc Reagents, Alkyl Iodides, and Alkenyl Boron Reagents.

Chierchia M, Xu P, Lovinger GJ, Morken JP.

Angew Chem Int Ed Engl. 2019 Oct 1;58(40):14245-14249. doi: 10.1002/anie.201908029. Epub 2019 Aug 28.


Stereoselective Synthesis of Trisubstituted Alkenylboron Reagents by Boron-Wittig Reaction of Ketones.

Namirembe S, Gao C, Wexler RP, Morken JP.

Org Lett. 2019 Jun 7;21(11):4392-4394. doi: 10.1021/acs.orglett.9b01663. Epub 2019 May 29.


Site-Selective Mono-Oxidation of 1,2-Bis(boronates).

Yan L, Morken JP.

Org Lett. 2019 May 17;21(10):3760-3763. doi: 10.1021/acs.orglett.9b01204. Epub 2019 May 8.


Reactions of organoboron compounds enabled by catalyst-promoted metalate shifts.

Namirembe S, Morken JP.

Chem Soc Rev. 2019 Jul 1;48(13):3464-3474. doi: 10.1039/c9cs00180h.


Catalytic Conjunctive Coupling of Carboxylic Acid Derivatives with 9-BBN-Derived Ate Complexes.

Law C, Meng Y, Koo SM, Morken JP.

Angew Chem Int Ed Engl. 2019 May 13;58(20):6654-6658. doi: 10.1002/anie.201901927. Epub 2019 Apr 4.


A Protocol for Direct Stereospecific Amination of Primary, Secondary, and Tertiary Alkylboronic Esters.

Edelstein EK, Grote AC, Palkowitz MD, Morken JP.

Synlett. 2018 Aug;29(13):1749-1752. doi: 10.1055/s-0037-1610172. Epub 2018 Jun 20.


Vinylidenation of Organoboronic Esters Enabled by a Pd-Catalyzed Metallate Shift.

Aparece MD, Gao C, Lovinger GJ, Morken JP.

Angew Chem Int Ed Engl. 2019 Jan 8;58(2):592-595. doi: 10.1002/anie.201811782. Epub 2018 Dec 12.


Practically simple reactions convert hydrocarbons to precious chemicals.

Morken JP.

Nature. 2018 Nov;563(7731):336-337. doi: 10.1038/d41586-018-07333-w. No abstract available.


Diastereoselective and Enantioselective Conjunctive Cross-Coupling Enabled by Boron Ligand Design.

Myhill JA, Wilhelmsen CA, Zhang L, Morken JP.

J Am Chem Soc. 2018 Nov 14;140(45):15181-15185. doi: 10.1021/jacs.8b09909. Epub 2018 Nov 6.


Enantioselective Construction of Tertiary Boronic Esters by Conjunctive Cross-Coupling.

Myhill JA, Zhang L, Lovinger GJ, Morken JP.

Angew Chem Int Ed Engl. 2018 Sep 24;57(39):12799-12803. doi: 10.1002/anie.201807775. Epub 2018 Aug 29.


Enantioselective Synthesis of Nonracemic Geminal Silylboronates by Pt-Catalyzed Hydrosilylation.

Szymaniak AA, Zhang C, Coombs JR, Morken JP.

ACS Catal. 2018 Apr 6;8(4):2897-2901. doi: 10.1021/acscatal.8b00221. Epub 2018 Feb 23.


Synthesis and Stereochemical Assignment of Arenolide.

Liu X, Sun C, Mlynarski S, Morken JP.

Org Lett. 2018 Apr 6;20(7):1898-1901. doi: 10.1021/acs.orglett.8b00439. Epub 2018 Mar 22.


Carbohydrate/DBU Cocatalyzed Alkene Diboration: Mechanistic Insight Provides Enhanced Catalytic Efficiency and Substrate Scope.

Yan L, Meng Y, Haeffner F, Leon RM, Crockett MP, Morken JP.

J Am Chem Soc. 2018 Mar 14;140(10):3663-3673. doi: 10.1021/jacs.7b12316. Epub 2018 Mar 2.


Ni-Catalyzed Enantioselective Conjunctive Coupling with C(sp3) Electrophiles: A Radical-Ionic Mechanistic Dichotomy.

Lovinger GJ, Morken JP.

J Am Chem Soc. 2017 Dec 6;139(48):17293-17296. doi: 10.1021/jacs.7b10519. Epub 2017 Nov 20.


Identification and characterization of a potent and biologically-active PDE4/7 inhibitor via fission yeast-based assays.

de Medeiros AS, Wyman AR, Alaamery MA, Allain C, Ivey FD, Wang L, Le H, Morken JP, Habara A, Le C, Cui S, Lerner A, Hoffman CS.

Cell Signal. 2017 Dec;40:73-80. doi: 10.1016/j.cellsig.2017.08.011. Epub 2017 Sep 1.


Nickel-Catalyzed Enantioselective Conjunctive Cross-Coupling of 9-BBN Borates.

Chierchia M, Law C, Morken JP.

Angew Chem Int Ed Engl. 2017 Sep 18;56(39):11870-11874. doi: 10.1002/anie.201706719. Epub 2017 Aug 17.


A Boron Alkylidene-Alkene Cycloaddition Reaction: Application to the Synthesis of Aphanamal.

Liu X, Deaton TM, Haeffner F, Morken JP.

Angew Chem Int Ed Engl. 2017 Sep 11;56(38):11485-11489. doi: 10.1002/anie.201705720. Epub 2017 Aug 9.


Enantioselective Conjunctive Cross-Coupling of Bis(alkenyl)borates: A General Synthesis of Chiral Allylboron Reagents.

Edelstein EK, Namirembe S, Morken JP.

J Am Chem Soc. 2017 Apr 12;139(14):5027-5030. doi: 10.1021/jacs.7b01774. Epub 2017 Mar 29.


Pd-Catalyzed Conjunctive Cross-Coupling between Grignard-Derived Boron "Ate" Complexes and C(sp2) Halides or Triflates: NaOTf as a Grignard Activator and Halide Scavenger.

Lovinger GJ, Aparece MD, Morken JP.

J Am Chem Soc. 2017 Mar 1;139(8):3153-3160. doi: 10.1021/jacs.6b12663. Epub 2017 Feb 16.


Modular, Catalytic Enantioselective Construction of Quaternary Carbon Stereocenters by Sequential Cross-Coupling Reactions.

Potter B, Edelstein EK, Morken JP.

Org Lett. 2016 Jul 1;18(13):3286-9. doi: 10.1021/acs.orglett.6b01580. Epub 2016 Jun 16.


Nickel-Catalyzed Asymmetric Kumada Cross-Coupling of Symmetric Cyclic Sulfates.

Eno MS, Lu A, Morken JP.

J Am Chem Soc. 2016 Jun 29;138(25):7824-7. doi: 10.1021/jacs.6b03384. Epub 2016 Jun 16.


Carbohydrate-Catalyzed Enantioselective Alkene Diboration: Enhanced Reactivity of 1,2-Bonded Diboron Complexes.

Fang L, Yan L, Haeffner F, Morken JP.

J Am Chem Soc. 2016 Mar 2;138(8):2508-11. doi: 10.1021/jacs.5b13174. Epub 2016 Feb 16.


Catalytic Enantioselective Functionalization of Unactivated Terminal Alkenes.

Coombs JR, Morken JP.

Angew Chem Int Ed Engl. 2016 Feb 18;55(8):2636-49. doi: 10.1002/anie.201507151. Epub 2016 Jan 13. Review.


Catalytic conjunctive cross-coupling enabled by metal-induced metallate rearrangement.

Zhang L, Lovinger GJ, Edelstein EK, Szymaniak AA, Chierchia MP, Morken JP.

Science. 2016 Jan 1;351(6268):70-4. doi: 10.1126/science.aad6080.


Hydroxyl-Directed Cross-Coupling: A Scalable Synthesis of Debromohamigeran E and Other Targets of Interest.

Blaisdell TP, Morken JP.

J Am Chem Soc. 2015 Jul 15;137(27):8712-5. doi: 10.1021/jacs.5b05477. Epub 2015 Jul 2.


Enantioselective Hydroformylation of 1-Alkenes with Commercial Ph-BPE Ligand.

Yu Z, Eno MS, Annis AH, Morken JP.

Org Lett. 2015 Jul 2;17(13):3264-7. doi: 10.1021/acs.orglett.5b01421. Epub 2015 Jun 19.


Diastereoselective Ni-catalyzed 1,4-hydroboration of chiral dienols.

Ely RJ, Yu Z, Morken JP.

Tetrahedron Lett. 2015 Jun 3;56(23):3402-3405.


Synthesis of vinyl boronates from aldehydes by a practical boron-Wittig reaction.

Coombs JR, Zhang L, Morken JP.

Org Lett. 2015 Apr 3;17(7):1708-11. doi: 10.1021/acs.orglett.5b00480. Epub 2015 Mar 23.


Nonracemic allylic boronates through enantiotopic-group-selective cross-coupling of geminal bis(boronates) and vinyl halides.

Potter B, Szymaniak AA, Edelstein EK, Morken JP.

J Am Chem Soc. 2014 Dec 31;136(52):17918-21. doi: 10.1021/ja510266x. Epub 2014 Dec 15.


Enantiomerically enriched tris(boronates): readily accessible conjunctive reagents for asymmetric synthesis.

Coombs JR, Zhang L, Morken JP.

J Am Chem Soc. 2014 Nov 19;136(46):16140-3. doi: 10.1021/ja510081r. Epub 2014 Nov 11.


Enantioselective carbocycle formation through intramolecular Pd-catalyzed allyl-aryl cross-coupling.

Schuster CH, Coombs JR, Kasun ZA, Morken JP.

Org Lett. 2014 Sep 5;16(17):4420-3. doi: 10.1021/ol5019163. Epub 2014 Aug 8.


Synthesis of (+)-discodermolide by catalytic stereoselective borylation reactions.

Yu Z, Ely RJ, Morken JP.

Angew Chem Int Ed Engl. 2014 Sep 1;53(36):9632-6. doi: 10.1002/anie.201405455. Epub 2014 Jul 15.


Simple access to elusive α-boryl carbanions and their alkylation: an umpolung construction for organic synthesis.

Hong K, Liu X, Morken JP.

J Am Chem Soc. 2014 Jul 30;136(30):10581-4. doi: 10.1021/ja505455z. Epub 2014 Jul 16.


Hydroxyl-directed stereoselective diboration of alkenes.

Blaisdell TP, Caya TC, Zhang L, Sanz-Marco A, Morken JP.

J Am Chem Soc. 2014 Jul 2;136(26):9264-7. doi: 10.1021/ja504228p. Epub 2014 Jun 24.


Catalytic bismetallative multicomponent coupling reactions: scope, applications, and mechanisms.

Cho HY, Morken JP.

Chem Soc Rev. 2014 Jul 7;43(13):4368-80. doi: 10.1039/c3cs60482a. Epub 2014 Apr 16. Review.


Congested C-C bonds by Pd-catalyzed enantioselective allyl-allyl cross-coupling, a mechanism-guided solution.

Ardolino MJ, Morken JP.

J Am Chem Soc. 2014 May 14;136(19):7092-100. doi: 10.1021/ja502280w. Epub 2014 Apr 29.


Organic chemistry: Catalysis marches on.

Morken JP.

Nature. 2014 Apr 17;508(7496):324-5. doi: 10.1038/nature13225. Epub 2014 Apr 9. No abstract available.


Catalytic stereospecific allyl-allyl cross-coupling of internal allyl electrophiles with AllylB(pin).

Le H, Batten A, Morken JP.

Org Lett. 2014 Apr 18;16(8):2096-9. doi: 10.1021/ol500456s. Epub 2014 Apr 4.


A catalytic enantiotopic-group-selective Suzuki reaction for the construction of chiral organoboronates.

Sun C, Potter B, Morken JP.

J Am Chem Soc. 2014 May 7;136(18):6534-7. doi: 10.1021/ja500029w. Epub 2014 Feb 24.


Asymmetric synthesis from terminal alkenes by cascades of diboration and cross-coupling.

Mlynarski SN, Schuster CH, Morken JP.

Nature. 2014 Jan 16;505(7483):386-90. doi: 10.1038/nature12781. Epub 2013 Dec 18. Erratum in: Nature. 2014 Feb 27;506(7489):516.


Scope and mechanism of the Pt-catalyzed enantioselective diboration of monosubstituted alkenes.

Coombs JR, Haeffner F, Kliman LT, Morken JP.

J Am Chem Soc. 2013 Jul 31;135(30):11222-31. doi: 10.1021/ja4041016. Epub 2013 Jul 18.


Catalytic enantioselective one-pot aminoborylation of aldehydes: a strategy for construction of nonracemic α-amino boronates.

Hong K, Morken JP.

J Am Chem Soc. 2013 Jun 26;135(25):9252-4. doi: 10.1021/ja402569j. Epub 2013 Jun 13.


Catalytic enantioselective allyl-allyl cross-coupling with a borylated allylboronate.

Le H, Kyne RE, Brozek LA, Morken JP.

Org Lett. 2013 Apr 5;15(7):1432-5. doi: 10.1021/ol400088g. Epub 2013 Mar 19.


A catalytic enantioselective tandem allylation strategy for rapid terpene construction: application to the synthesis of pumilaside aglycon.

Ferris GE, Hong K, Roundtree IA, Morken JP.

J Am Chem Soc. 2013 Feb 20;135(7):2501-4. doi: 10.1021/ja400506j. Epub 2013 Feb 7.


Direct stereospecific amination of alkyl and aryl pinacol boronates.

Mlynarski SN, Karns AS, Morken JP.

J Am Chem Soc. 2012 Oct 10;134(40):16449-51. doi: 10.1021/ja305448w. Epub 2012 Sep 24.

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