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Items: 1 to 50 of 69

1.

Enabling precision medicine via standard communication of HTS provenance, analysis, and results.

Alterovitz G, Dean D, Goble C, Crusoe MR, Soiland-Reyes S, Bell A, Hayes A, Suresh A, Purkayastha A, King CH, Taylor D, Johanson E, Thompson EE, Donaldson E, Morizono H, Tsang H, Vora JK, Goecks J, Yao J, Almeida JS, Keeney J, Addepalli K, Krampis K, Smith KM, Guo L, Walderhaug M, Schito M, Ezewudo M, Guimera N, Walsh P, Kahsay R, Gottipati S, Rodwell TC, Bloom T, Lai Y, Simonyan V, Mazumder R.

PLoS Biol. 2018 Dec 31;16(12):e3000099. doi: 10.1371/journal.pbio.3000099. eCollection 2018 Dec.

2.
3.

Disease-causing mutations in the promoter and enhancer of the ornithine transcarbamylase gene.

Jang YJ, LaBella AL, Feeney TP, Braverman N, Tuchman M, Morizono H, Ah Mew N, Caldovic L.

Hum Mutat. 2018 Apr;39(4):527-536. doi: 10.1002/humu.23394. Epub 2018 Jan 16.

PMID:
29282796
4.

A Case of Recurrent Breast Cancer Identified by Pulmonary Tumor Thrombotic Microangiopathy.

Abe T, Fukada I, Shiga T, Morizono H, Ikebata K, Shibayama T, Kobayashi K, Iwase T, Ohno S, Ito Y.

Case Rep Oncol. 2017 Jul 11;10(2):620-626. doi: 10.1159/000477842. eCollection 2017 May-Aug.

5.

Genome-wide profiling of differentially spliced mRNAs in human fetal cortical tissue exposed to alcohol.

Kawasawa YI, Mohammad S, Son AI, Morizono H, Basha A, Salzberg AC, Torii M, Hashimoto-Torii K.

Alcohol. 2017 Aug;62:1-9. doi: 10.1016/j.alcohol.2017.05.001. Epub 2017 May 4.

PMID:
28755746
6.
7.

AAV gene therapy corrects OTC deficiency and prevents liver fibrosis in aged OTC-knock out heterozygous mice.

Wang L, Bell P, Morizono H, He Z, Pumbo E, Yu H, White J, Batshaw ML, Wilson JM.

Mol Genet Metab. 2017 Apr;120(4):299-305. doi: 10.1016/j.ymgme.2017.02.011. Epub 2017 Mar 2.

8.

Surgical excision without whole breast irradiation for complete resection of ductal carcinoma in situ identified using strict, unified criteria.

Sakai T, Iwase T, Teruya N, Kataoka A, Kitagawa D, Nakashima E, Ogiya A, Miyagi Y, Iijima K, Morizono H, Makita M, Gomi N, Oguchi M, Ito Y, Horii R, Akiyama F, Ohno S.

Am J Surg. 2017 Jul;214(1):111-116. doi: 10.1016/j.amjsurg.2016.10.024. Epub 2016 Nov 30.

PMID:
27964923
9.

Effect of arginine on oligomerization and stability of N-acetylglutamate synthase.

Haskins N, Mumo A, Brown PH, Tuchman M, Morizono H, Caldovic L.

Sci Rep. 2016 Dec 9;6:38711. doi: 10.1038/srep38711.

10.

Ornithine Transcarbamylase Deficiency.

Lichter-Konecki U, Caldovic L, Morizono H, Simpson K.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2019.
2013 Aug 29 [updated 2016 Apr 14].

11.

A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice.

Yang Y, Wang L, Bell P, McMenamin D, He Z, White J, Yu H, Xu C, Morizono H, Musunuru K, Batshaw ML, Wilson JM.

Nat Biotechnol. 2016 Mar;34(3):334-8. doi: 10.1038/nbt.3469. Epub 2016 Feb 1.

12.

Decreased hormonal sensitivity after childbirth rather than the tumor size influences the prognosis of very young breast cancer patients.

Makita M, Sakai T, Kataoka A, Kitagawa D, Ogiya A, Morizono H, Miyagi Y, Iijima K, Kobayashi K, Kobayashi T, Fukada I, Araki K, Takahashi S, Ito Y, Gomi N, Oguchi M, Kita M, Arai M, Akiyama F, Iwase T.

Springerplus. 2015 Jul 22;4:365. doi: 10.1186/s40064-015-1150-0. eCollection 2015.

13.

Genotype-Phenotype Correlations in Ornithine Transcarbamylase Deficiency: A Mutation Update.

Caldovic L, Abdikarim I, Narain S, Tuchman M, Morizono H.

J Genet Genomics. 2015 May 20;42(5):181-94. doi: 10.1016/j.jgg.2015.04.003. Epub 2015 May 19. Review.

14.

Non-sentinel lymph node analysis with one-step nucleic acid amplification in breast cancer patients.

Ogiya A, Iwase T, Kitagawa D, Nakashima E, Sakai T, Miyagi Y, Iijima K, Morizono H, Makita M, Horii R, Akiyama F.

Breast. 2015 Aug;24(4):476-80. doi: 10.1016/j.breast.2015.04.009. Epub 2015 May 8.

PMID:
25963136
15.

Four types of ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery: classification of IBTR based on precise pathological examination.

Sakai T, Nishimura S, Ogiya A, Tanabe M, Kimura K, Morizono H, Iijima K, Miyagi Y, Makita M, Ito Y, Oguchi M, Horii R, Akiyama F, Iwase T.

Pathol Int. 2015 Mar;65(3):113-8. doi: 10.1111/pin.12253. Epub 2015 Jan 20.

PMID:
25600703
16.

Predicting the severity of motor neuron disease progression using electronic health record data with a cloud computing Big Data approach.

Ko KD, El-Ghazawi T, Kim D, Morizono H; Pooled Resource Open-Access ALS Clinical Trials Consortium.

IEEE Symp Comput Intell Bioinforma Comput Biol Proc. 2014 May;2014. pii: 14417042.

17.

Long-term prognoses and outcomes of axillary lymph node recurrence in 2,578 sentinel lymph node-negative patients for whom axillary lymph node dissection was omitted: results from one Japanese hospital.

Ogiya A, Kimura K, Nakashima E, Sakai T, Miyagi Y, Iijima K, Morizono H, Makita M, Horii R, Akiyama F, Iwase T.

Breast Cancer. 2016 Mar;23(2):318-22. doi: 10.1007/s12282-014-0576-5. Epub 2014 Nov 7.

PMID:
25376341
18.

Optimal surveillance for postoperative metastasis in breast cancer patients.

Makita M, Sakai T, Ogiya A, Kitagawa D, Morizono H, Miyagi Y, Iijima K, Iwase T.

Breast Cancer. 2016 Mar;23(2):286-94. doi: 10.1007/s12282-014-0571-x. Epub 2014 Oct 8.

PMID:
25294313
19.

Clear cell sarcoma of the neck which metastasized to the mammary gland.

Fukada I, Nishimura S, Tanabe M, Morizono H, Makita M, Gomi N, Horii R, Akiyama F, Iwase T.

Case Rep Oncol. 2013 Jan;6(1):55-61. doi: 10.1159/000345843. Epub 2013 Jan 22.

20.

Validation study of the UICC TNM classification of malignant tumors, seventh edition, in breast cancer.

Uehiro N, Horii R, Iwase T, Tanabe M, Sakai T, Morizono H, Kimura K, Iijima K, Miyagi Y, Nishimura S, Makita M, Ito Y, Akiyama F.

Breast Cancer. 2014 Nov;21(6):748-53. doi: 10.1007/s12282-013-0453-7. Epub 2013 Feb 23.

PMID:
23435963
21.

A novel biochemically salvageable animal model of hyperammonemia devoid of N-acetylglutamate synthase.

Senkevitch E, Cabrera-Luque J, Morizono H, Caldovic L, Tuchman M.

Mol Genet Metab. 2012 Jun;106(2):160-8. doi: 10.1016/j.ymgme.2012.03.004. Epub 2012 Mar 17.

22.

Influence of lymphatic invasion on locoregional recurrence following mastectomy: indication for postmastectomy radiotherapy for breast cancer patients with one to three positive nodes.

Matsunuma R, Oguchi M, Fujikane T, Matsuura M, Sakai T, Kimura K, Morizono H, Iijima K, Izumori A, Miyagi Y, Nishimura S, Makita M, Gomi N, Horii R, Akiyama F, Iwase T.

Int J Radiat Oncol Biol Phys. 2012 Jul 1;83(3):845-52. doi: 10.1016/j.ijrobp.2011.08.029. Epub 2011 Dec 3.

PMID:
22138460
23.

Preclinical evaluation of a clinical candidate AAV8 vector for ornithine transcarbamylase (OTC) deficiency reveals functional enzyme from each persisting vector genome.

Wang L, Morizono H, Lin J, Bell P, Jones D, McMenamin D, Yu H, Batshaw ML, Wilson JM.

Mol Genet Metab. 2012 Feb;105(2):203-11. doi: 10.1016/j.ymgme.2011.10.020. Epub 2011 Nov 7.

24.

GFAP mutations, age at onset, and clinical subtypes in Alexander disease.

Prust M, Wang J, Morizono H, Messing A, Brenner M, Gordon E, Hartka T, Sokohl A, Schiffmann R, Gordish-Dressman H, Albin R, Amartino H, Brockman K, Dinopoulos A, Dotti MT, Fain D, Fernandez R, Ferreira J, Fleming J, Gill D, Griebel M, Heilstedt H, Kaplan P, Lewis D, Nakagawa M, Pedersen R, Reddy A, Sawaishi Y, Schneider M, Sherr E, Takiyama Y, Wakabayashi K, Gorospe JR, Vanderver A.

Neurology. 2011 Sep 27;77(13):1287-94. doi: 10.1212/WNL.0b013e3182309f72. Epub 2011 Sep 14.

25.

Sustained correction of OTC deficiency in spf( ash) mice using optimized self-complementary AAV2/8 vectors.

Wang L, Wang H, Morizono H, Bell P, Jones D, Lin J, McMenamin D, Yu H, Batshaw ML, Wilson JM.

Gene Ther. 2012 Apr;19(4):404-10. doi: 10.1038/gt.2011.111. Epub 2011 Aug 18.

26.

Adeno-associated virus antibody profiles in newborns, children, and adolescents.

Calcedo R, Morizono H, Wang L, McCarter R, He J, Jones D, Batshaw ML, Wilson JM.

Clin Vaccine Immunol. 2011 Sep;18(9):1586-8. doi: 10.1128/CVI.05107-11. Epub 2011 Jul 20.

27.

N-acetylglutamate synthase: structure, function and defects.

Caldovic L, Ah Mew N, Shi D, Morizono H, Yudkoff M, Tuchman M.

Mol Genet Metab. 2010;100 Suppl 1:S13-9. doi: 10.1016/j.ymgme.2010.02.018. Epub 2010 Feb 26. Review.

28.

Ductal carcinoma in situ and sentinel lymph node metastasis in breast cancer.

Tada K, Ogiya A, Kimura K, Morizono H, Iijima K, Miyagi Y, Nishimura S, Makita M, Horii R, Akiyama F, Iwase T.

World J Surg Oncol. 2010 Jan 27;8:6. doi: 10.1186/1477-7819-8-6.

29.

The pleiotropic effects of natural AAV infections on liver-directed gene transfer in macaques.

Wang L, Calcedo R, Wang H, Bell P, Grant R, Vandenberghe LH, Sanmiguel J, Morizono H, Batshaw ML, Wilson JM.

Mol Ther. 2010 Jan;18(1):126-34. doi: 10.1038/mt.2009.245. Epub 2009 Nov 3.

30.

Systematic evaluation of AAV vectors for liver directed gene transfer in murine models.

Wang L, Wang H, Bell P, McCarter RJ, He J, Calcedo R, Vandenberghe LH, Morizono H, Batshaw ML, Wilson JM.

Mol Ther. 2010 Jan;18(1):118-25. doi: 10.1038/mt.2009.246. Epub 2009 Oct 27.

31.

Mechanism of allosteric inhibition of N-acetyl-L-glutamate synthase by L-arginine.

Min L, Jin Z, Caldovic L, Morizono H, Allewell NM, Tuchman M, Shi D.

J Biol Chem. 2009 Feb 20;284(8):4873-80. doi: 10.1074/jbc.M805348200. Epub 2008 Dec 18.

32.

Inversion of allosteric effect of arginine on N-acetylglutamate synthase, a molecular marker for evolution of tetrapods.

Haskins N, Panglao M, Qu Q, Majumdar H, Cabrera-Luque J, Morizono H, Tuchman M, Caldovic L.

BMC Biochem. 2008 Sep 18;9:24. doi: 10.1186/1471-2091-9-24.

33.

Genetic and clinical heterogeneity in eIF2B-related disorder.

Maletkovic J, Schiffmann R, Gorospe JR, Gordon ES, Mintz M, Hoffman EP, Alper G, Lynch DR, Singhal BS, Harding C, Amartino H, Brown CM, Chan A, Renaud D, Geraghty M, Jensen L, Senbil N, Kadom N, Nazarian J, Yuanjian Feng, Zuyi Wang, Hartka T, Morizono H, Vanderver A.

J Child Neurol. 2008 Feb;23(2):205-15. doi: 10.1177/0883073807308705.

PMID:
18263758
34.

Skin invasion and prognosis in node negative breast cancer: a retrospective study.

Tada K, Morizono H, Iijima K, Miyagi Y, Nishimura S, Makita M, Horii R, Akiyama F, Iwase T.

World J Surg Oncol. 2008 Jan 30;6:10. doi: 10.1186/1477-7819-6-10.

35.

The crystal structure of N-acetyl-L-glutamate synthase from Neisseria gonorrhoeae provides insights into mechanisms of catalysis and regulation.

Shi D, Sagar V, Jin Z, Yu X, Caldovic L, Morizono H, Allewell NM, Tuchman M.

J Biol Chem. 2008 Mar 14;283(11):7176-84. doi: 10.1074/jbc.M707678200. Epub 2008 Jan 9.

36.

A single mutation in the active site swaps the substrate specificity of N-acetyl-L-ornithine transcarbamylase and N-succinyl-L-ornithine transcarbamylase.

Shi D, Yu X, Cabrera-Luque J, Chen TY, Roth L, Morizono H, Allewell NM, Tuchman M.

Protein Sci. 2007 Aug;16(8):1689-99. Epub 2007 Jun 28.

38.

Mutations and polymorphisms in the human N-acetylglutamate synthase (NAGS) gene.

Caldovic L, Morizono H, Tuchman M.

Hum Mutat. 2007 Aug;28(8):754-9.

PMID:
17421020
39.

Expression, crystallization and preliminary crystallographic studies of a novel bifunctional N-acetylglutamate synthase/kinase from Xanthomonas campestris homologous to vertebrate N-acetylglutamate synthase.

Shi D, Caldovic L, Jin Z, Yu X, Qu Q, Roth L, Morizono H, Hathout Y, Allewell NM, Tuchman M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Dec 1;62(Pt 12):1218-22. Epub 2006 Nov 30.

40.

Mutations and polymorphisms in the human ornithine transcarbamylase (OTC) gene.

Yamaguchi S, Brailey LL, Morizono H, Bale AE, Tuchman M.

Hum Mutat. 2006 Jul;27(7):626-32.

PMID:
16786505
42.

Structure and catalytic mechanism of a novel N-succinyl-L-ornithine transcarbamylase in arginine biosynthesis of Bacteroides fragilis.

Shi D, Morizono H, Cabrera-Luque J, Yu X, Roth L, Malamy MH, Allewell NM, Tuchman M.

J Biol Chem. 2006 Jul 21;281(29):20623-31. Epub 2006 May 16.

43.

Long-term correction of ammonia metabolism and prolonged survival in ornithine transcarbamylase-deficient mice following liver-directed treatment with adeno-associated viral vectors.

Moscioni D, Morizono H, McCarter RJ, Stern A, Cabrera-Luque J, Hoang A, Sanmiguel J, Wu D, Bell P, Gao GP, Raper SE, Wilson JM, Batshaw ML.

Mol Ther. 2006 Jul;14(1):25-33. Epub 2006 May 3.

44.

Acetylornithine transcarbamylase: a novel enzyme in arginine biosynthesis.

Morizono H, Cabrera-Luque J, Shi D, Gallegos R, Yamaguchi S, Yu X, Allewell NM, Malamy MH, Tuchman M.

J Bacteriol. 2006 Apr;188(8):2974-82.

45.

Expression, purification, crystallization and preliminary X-ray crystallographic studies of a novel acetylcitrulline deacetylase from Xanthomonas campestris.

Shi D, Yu X, Roth L, Morizono H, Hathout Y, Allewell NM, Tuchman M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jul 1;61(Pt 7):676-9. Epub 2005 Jun 15.

46.

Biochemical properties of recombinant human and mouse N-acetylglutamate synthase.

Caldovic L, Lopez GY, Haskins N, Panglao M, Shi D, Morizono H, Tuchman M.

Mol Genet Metab. 2006 Mar;87(3):226-32.

PMID:
16321554
47.

The use of yeast mitochondria to study the properties of wild-type and mutant human mitochondrial ornithine transporter.

Morizono H, Woolston JE, Colombini M, Tuchman M.

Mol Genet Metab. 2005 Dec;86(4):431-40. Epub 2005 Oct 26.

PMID:
16256388
48.

Crystal structure of N-acetylornithine transcarbamylase from Xanthomonas campestris: a novel enzyme in a new arginine biosynthetic pathway found in several eubacteria.

Shi D, Morizono H, Yu X, Roth L, Caldovic L, Allewell NM, Malamy MH, Tuchman M.

J Biol Chem. 2005 Apr 15;280(15):14366-9. Epub 2005 Feb 24.

49.

Late onset N-acetylglutamate synthase deficiency caused by hypomorphic alleles.

Caldovic L, Morizono H, Panglao MG, Lopez GY, Shi D, Summar ML, Tuchman M.

Hum Mutat. 2005 Mar;25(3):293-8.

PMID:
15714518
50.

Restoration of ureagenesis in N-acetylglutamate synthase deficiency by N-carbamylglutamate.

Caldovic L, Morizono H, Daikhin Y, Nissim I, McCarter RJ, Yudkoff M, Tuchman M.

J Pediatr. 2004 Oct;145(4):552-4.

PMID:
15480384

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