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Items: 20

1.

SCO-267, a GPR40 Full Agonist, Improves Glycemic and Body Weight Control in Rat Models of Diabetes and Obesity.

Ueno H, Ito R, Abe SI, Ookawara M, Miyashita H, Ogino H, Miyamoto Y, Yoshihara T, Kobayashi A, Tsujihata Y, Takeuchi K, Watanabe M, Yamada Y, Maekawa T, Nishigaki N, Moritoh Y.

J Pharmacol Exp Ther. 2019 Aug;370(2):172-181. doi: 10.1124/jpet.118.255885. Epub 2019 Jun 10.

PMID:
31182471
2.

SCO-792, an enteropeptidase inhibitor, improves disease status of diabetes and obesity in mice.

Yashiro H, Hamagami K, Hiyoshi H, Sugama J, Tsuchimori K, Yamaguchi F, Moritoh Y, Sasaki M, Maekawa T, Yamada Y, Watanabe M.

Diabetes Obes Metab. 2019 May 30. doi: 10.1111/dom.13799. [Epub ahead of print]

PMID:
31144422
3.

GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca2+ channels.

Ramracheya R, Chapman C, Chibalina M, Dou H, Miranda C, González A, Moritoh Y, Shigeto M, Zhang Q, Braun M, Clark A, Johnson PR, Rorsman P, Briant LJB.

Physiol Rep. 2018 Sep;6(17):e13852. doi: 10.14814/phy2.13852.

4.

Intractable Back Pain After Coil Embolization of Giant Veno-Venous Collaterals in a Patient With Fontan Circulation.

Okada S, Kamada M, Nakagawa N, Ishiguchi Y, Moritoh Y, Shohi M, Okamoto K, Hasegawa S, Ohga S.

Int Heart J. 2017 Apr 6;58(2):298-301. doi: 10.1536/ihj.16-194. Epub 2017 Mar 21.

5.

Inositol Hexakisphosphate Kinase 3 Regulates Metabolism and Lifespan in Mice.

Moritoh Y, Oka M, Yasuhara Y, Hozumi H, Iwachidow K, Fuse H, Tozawa R.

Sci Rep. 2016 Aug 31;6:32072. doi: 10.1038/srep32072.

6.

Siblings with Idiopathic Left Atrial Appendage Ostial Stenosis and Cor Triatriatum.

Okada S, Ishiguchi Y, Moritoh Y, Shohi M, Nakagawa N, Okamoto K, Kamada M.

Echocardiography. 2016 Jul;33(7):1098-1100. doi: 10.1111/echo.13221. Epub 2016 Mar 27.

PMID:
27018316
7.

Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554.

Maezaki H, Banno Y, Miyamoto Y, Moritoh Y, Asakawa T, Kataoka O, Takeuchi K, Suzuki N, Ikedo K, Kosaka T, Sasaki M, Tsubotani S, Tani A, Funami M, Yamamoto Y, Tawada M, Aertgeerts K, Yano J, Oi S.

Bioorg Med Chem. 2011 Aug 1;19(15):4482-98. doi: 10.1016/j.bmc.2011.06.032. Epub 2011 Jul 7. Erratum in: Bioorg Med Chem. 2011 Sep 15;19(18):5742. Moritou, Yuusuke [corrected to Moritoh, Yusuke].

PMID:
21741847
8.

Discovery of a 3-pyridylacetic acid derivative (TAK-100) as a potent, selective and orally active dipeptidyl peptidase IV (DPP-4) inhibitor.

Miyamoto Y, Banno Y, Yamashita T, Fujimoto T, Oi S, Moritoh Y, Asakawa T, Kataoka O, Yashiro H, Takeuchi K, Suzuki N, Ikedo K, Kosaka T, Tsubotani S, Tani A, Sasaki M, Funami M, Amano M, Yamamoto Y, Aertgeerts K, Yano J, Maezaki H.

J Med Chem. 2011 Feb 10;54(3):831-50. doi: 10.1021/jm101236h. Epub 2011 Jan 10.

PMID:
21218817
9.

Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125.

Miyamoto Y, Banno Y, Yamashita T, Fujimoto T, Oi S, Moritoh Y, Asakawa T, Kataoka O, Takeuchi K, Suzuki N, Ikedo K, Kosaka T, Tsubotani S, Tani A, Funami M, Amano M, Yamamoto Y, Aertgeerts K, Yano J, Maezaki H.

Bioorg Med Chem. 2011 Jan 1;19(1):172-85. doi: 10.1016/j.bmc.2010.11.038. Epub 2010 Nov 25.

PMID:
21163664
10.

Nuclear hormone retinoid X receptor (RXR) negatively regulates the glucose-stimulated insulin secretion of pancreatic ß-cells.

Miyazaki S, Taniguchi H, Moritoh Y, Tashiro F, Yamamoto T, Yamato E, Ikegami H, Ozato K, Miyazaki J.

Diabetes. 2010 Nov;59(11):2854-61. doi: 10.2337/db09-1897. Epub 2010 Aug 26.

11.

GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis.

De Marinis YZ, Salehi A, Ward CE, Zhang Q, Abdulkader F, Bengtsson M, Braha O, Braun M, Ramracheya R, Amisten S, Habib AM, Moritoh Y, Zhang E, Reimann F, Rosengren A, Shibasaki T, Gribble F, Renström E, Seino S, Eliasson L, Rorsman P.

Cell Metab. 2010 Jun 9;11(6):543-553. doi: 10.1016/j.cmet.2010.04.007.

12.
13.

Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells.

Braun M, Ramracheya R, Amisten S, Bengtsson M, Moritoh Y, Zhang Q, Johnson PR, Rorsman P.

Diabetologia. 2009 Aug;52(8):1566-78. doi: 10.1007/s00125-009-1382-z. Epub 2009 May 14.

PMID:
19440689
14.

A novel dipeptidyl peptidase-4 inhibitor, alogliptin (SYR-322), is effective in diabetic rats with sulfonylurea-induced secondary failure.

Asakawa T, Moritoh Y, Kataoka O, Suzuki N, Takeuchi K, Odaka H.

Life Sci. 2009 Jul 17;85(3-4):122-6. doi: 10.1016/j.lfs.2009.04.024. Epub 2009 May 8.

PMID:
19427871
15.

Combining a dipeptidyl peptidase-4 inhibitor, alogliptin, with pioglitazone improves glycaemic control, lipid profiles and beta-cell function in db/db mice.

Moritoh Y, Takeuchi K, Asakawa T, Kataoka O, Odaka H.

Br J Pharmacol. 2009 Jun;157(3):415-26. doi: 10.1111/j.1476-5381.2009.00145.x. Epub 2009 Apr 3.

16.
17.

The dipeptidyl peptidase-4 inhibitor alogliptin in combination with pioglitazone improves glycemic control, lipid profiles, and increases pancreatic insulin content in ob/ob mice.

Moritoh Y, Takeuchi K, Asakawa T, Kataoka O, Odaka H.

Eur J Pharmacol. 2009 Jan 14;602(2-3):448-54. doi: 10.1016/j.ejphar.2008.11.017. Epub 2008 Nov 17.

PMID:
19038243
18.

Chronic administration of alogliptin, a novel, potent, and highly selective dipeptidyl peptidase-4 inhibitor, improves glycemic control and beta-cell function in obese diabetic ob/ob mice.

Moritoh Y, Takeuchi K, Asakawa T, Kataoka O, Odaka H.

Eur J Pharmacol. 2008 Jul 7;588(2-3):325-32. doi: 10.1016/j.ejphar.2008.04.018. Epub 2008 Apr 10.

PMID:
18499100
20.

Analysis of insulin-producing cells during in vitro differentiation from feeder-free embryonic stem cells.

Moritoh Y, Yamato E, Yasui Y, Miyazaki S, Miyazaki J.

Diabetes. 2003 May;52(5):1163-8.

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