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Critical Roles for Coiled-Coil Dimers of Butyrophilin 3A1 in the Sensing of Prenyl Pyrophosphates by Human Vγ2Vδ2 T Cells.

Wang H, Nada MH, Tanaka Y, Sakuraba S, Morita CT.

J Immunol. 2019 Aug 1;203(3):607-626. doi: 10.4049/jimmunol.1801252. Epub 2019 Jun 21.


Determination of human γδ T cell-mediated cytotoxicity using a non-radioactive assay system.

Tagod MSO, Mizuta S, Sakai Y, Iwasaki M, Shiraishi K, Senju H, Mukae H, Morita CT, Tanaka Y.

J Immunol Methods. 2019 Mar;466:32-40. doi: 10.1016/j.jim.2019.01.003. Epub 2019 Jan 14.


Synthesis and Immunomodulatory Activity of Fluorine-Containing Bisphosphonates.

Mizuta S, Tagod MSO, Iwasaki M, Nakamura Y, Senju H, Mukae H, Morita CT, Tanaka Y.

ChemMedChem. 2019 Feb 19;14(4):462-468. doi: 10.1002/cmdc.201800764. Epub 2019 Jan 25.


Expansion of human γδ T cells for adoptive immunotherapy using a bisphosphonate prodrug.

Tanaka Y, Murata-Hirai K, Iwasaki M, Matsumoto K, Hayashi K, Kumagai A, Nada MH, Wang H, Kobayashi H, Kamitakahara H, Okamura H, Sugie T, Minato N, Toi M, Morita CT.

Cancer Sci. 2018 Mar;109(3):587-599. doi: 10.1111/cas.13491. Epub 2018 Feb 4.


Live Cell Labeling with Terpyridine Derivative Proligands to Measure Cytotoxicity Mediated by Immune Cells.

Sakai Y, Mizuta S, Kumagai A, Tagod MSO, Senju H, Nakamura T, Morita CT, Tanaka Y.

ChemMedChem. 2017 Dec 7;12(23):2006-2013. doi: 10.1002/cmdc.201700626. Epub 2017 Dec 4.


Anti-Tumor Activity and Immunotherapeutic Potential of a Bisphosphonate Prodrug.

Tanaka Y, Iwasaki M, Murata-Hirai K, Matsumoto K, Hayashi K, Okamura H, Sugie T, Minato N, Morita CT, Toi M.

Sci Rep. 2017 Jul 20;7(1):5987. doi: 10.1038/s41598-017-05553-0.


Enhancing adoptive cancer immunotherapy with Vγ2Vδ2 T cells through pulse zoledronate stimulation.

Nada MH, Wang H, Workalemahu G, Tanaka Y, Morita CT.

J Immunother Cancer. 2017 Feb 21;5:9. doi: 10.1186/s40425-017-0209-6. eCollection 2017.


Targeting Cancer Cells with a Bisphosphonate Prodrug.

Matsumoto K, Hayashi K, Murata-Hirai K, Iwasaki M, Okamura H, Minato N, Morita CT, Tanaka Y.

ChemMedChem. 2016 Dec 16;11(24):2656-2663. doi: 10.1002/cmdc.201600465. Epub 2016 Oct 27.


Necroptosis of Dendritic Cells Promotes Activation of γδ T Cells.

Collins CC, Bashant K, Erikson C, Thwe PM, Fortner KA, Wang H, Morita CT, Budd RC.

J Innate Immun. 2016;8(5):479-92. doi: 10.1159/000446498. Epub 2016 Jul 19.


Sensor Function for Butyrophilin 3A1 in Prenyl Pyrophosphate Stimulation of Human Vγ2Vδ2 T Cells.

Wang H, Morita CT.

J Immunol. 2015 Nov 15;195(10):4583-94. doi: 10.4049/jimmunol.1500314. Epub 2015 Oct 16.


Metabolic engineering of Salmonella vaccine bacteria to boost human Vγ2Vδ2 T cell immunity.

Workalemahu G, Wang H, Puan KJ, Nada MH, Kuzuyama T, Jones BD, Jin C, Morita CT.

J Immunol. 2014 Jul 15;193(2):708-21. doi: 10.4049/jimmunol.1302746. Epub 2014 Jun 18.


Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate stimulation of human Vγ2Vδ2 T cells.

Wang H, Henry O, Distefano MD, Wang YC, Räikkönen J, Mönkkönen J, Tanaka Y, Morita CT.

J Immunol. 2013 Aug 1;191(3):1029-42. doi: 10.4049/jimmunol.1300658. Epub 2013 Jul 5.


Chemo-Immunotherapeutic Anti-Malarials Targeting Isoprenoid Biosynthesis.

Zhang Y, Zhu W, Liu YL, Wang H, Wang K, Li K, No JH, Ayong L, Gulati A, Pang R, Freitas-Junior L, Morita CT, Old-Field E.

ACS Med Chem Lett. 2013 Apr 11;4(4):423-427.


Comparison of γδ T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid.

Idrees AS, Sugie T, Inoue C, Murata-Hirai K, Okamura H, Morita CT, Minato N, Toi M, Tanaka Y.

Cancer Sci. 2013 May;104(5):536-42. doi: 10.1111/cas.12124. Epub 2013 Mar 19.


Zoledronic acid-induced expansion of γδ T cells from early-stage breast cancer patients: effect of IL-18 on helper NK cells.

Sugie T, Murata-Hirai K, Iwasaki M, Morita CT, Li W, Okamura H, Minato N, Toi M, Tanaka Y.

Cancer Immunol Immunother. 2013 Apr;62(4):677-87. doi: 10.1007/s00262-012-1368-4. Epub 2012 Nov 15.


Synthesis and immunological evaluation of the 4-β-glucoside of HMBPP.

Giner JL, Wang H, Morita CT.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):811-3. doi: 10.1016/j.bmcl.2011.12.055. Epub 2011 Dec 17.


Indirect stimulation of human Vγ2Vδ2 T cells through alterations in isoprenoid metabolism.

Wang H, Sarikonda G, Puan KJ, Tanaka Y, Feng J, Giner JL, Cao R, Mönkkönen J, Oldfield E, Morita CT.

J Immunol. 2011 Nov 15;187(10):5099-113. doi: 10.4049/jimmunol.1002697. Epub 2011 Oct 19.


Regulation and function of IL-17A- and IL-22-producing γδ T cells.

Ness-Schwickerath KJ, Morita CT.

Cell Mol Life Sci. 2011 Jul;68(14):2371-90. doi: 10.1007/s00018-011-0700-z. Epub 2011 May 15. Review.


Identification of an important immunological difference between virulent varicella-zoster virus and its avirulent vaccine: viral disruption of dendritic cell instruction.

Gutzeit C, Raftery MJ, Peiser M, Tischer KB, Ulrich M, Eberhardt M, Stockfleth E, Giese T, Sauerbrei A, Morita CT, Schönrich G.

J Immunol. 2010 Jul 1;185(1):488-97. doi: 10.4049/jimmunol.0902817. Epub 2010 Jun 4.


Vgamma2Vdelta2 T Cell Receptor recognition of prenyl pyrophosphates is dependent on all CDRs.

Wang H, Fang Z, Morita CT.

J Immunol. 2010 Jun 1;184(11):6209-22. doi: 10.4049/jimmunol.1000231. Epub 2010 May 5.


Cytokine requirements for the differentiation and expansion of IL-17A- and IL-22-producing human Vgamma2Vdelta2 T cells.

Ness-Schwickerath KJ, Jin C, Morita CT.

J Immunol. 2010 Jun 15;184(12):7268-80. doi: 10.4049/jimmunol.1000600. Epub 2010 May 14.


Lipophilic pyridinium bisphosphonates: potent gammadelta T cell stimulators.

Zhang Y, Cao R, Yin F, Lin FY, Wang H, Krysiak K, No JH, Mukkamala D, Houlihan K, Li J, Morita CT, Oldfield E.

Angew Chem Int Ed Engl. 2010 Feb 1;49(6):1136-8. doi: 10.1002/anie.200905933. No abstract available.


Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus.

Song Y, Lin FY, Yin F, Hensler M, Rodrígues Poveda CA, Mukkamala D, Cao R, Wang H, Morita CT, González Pacanowska D, Nizet V, Oldfield E.

J Med Chem. 2009 Feb 26;52(4):976-88. doi: 10.1021/jm801023u.


Phenotypic and functional alterations of Vgamma2Vdelta2 T cell subsets in patients with active nasopharyngeal carcinoma.

Puan KJ, Low JS, Tan TW, Wee JT, Tan EH, Fong KW, Chua ET, Jin C, Giner JL, Morita CT, Goh CH, Hui KM.

Cancer Immunol Immunother. 2009 Jul;58(7):1095-107. doi: 10.1007/s00262-008-0629-8. Epub 2008 Nov 30.


Photoaffinity antigens for human gammadelta T cells.

Sarikonda G, Wang H, Puan KJ, Liu XH, Lee HK, Song Y, Distefano MD, Oldfield E, Prestwich GD, Morita CT.

J Immunol. 2008 Dec 1;181(11):7738-50.


Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T cells.

Puan KJ, Jin C, Wang H, Sarikonda G, Raker AM, Lee HK, Samuelson MI, Märker-Hermann E, Pasa-Tolic L, Nieves E, Giner JL, Kuzuyama T, Morita CT.

Int Immunol. 2007 May;19(5):657-73. Epub 2007 Apr 19.


Synthesis of pyrophosphate-containing compounds that stimulate Vgamma2Vdelta2 T cells: application to cancer immunotherapy.

Tanaka Y, Kobayashi H, Terasaki T, Toma H, Aruga A, Uchiyama T, Mizutani K, Mikami B, Morita CT, Minato N.

Med Chem. 2007 Jan;3(1):85-99.


Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin.

Leon A, Liu L, Yang Y, Hudock MP, Hall P, Yin F, Studer D, Puan KJ, Morita CT, Oldfield E.

J Med Chem. 2006 Dec 14;49(25):7331-41.


Structural studies of Vgamma2Vdelta2 T cell phosphoantigens.

Zhang Y, Song Y, Yin F, Broderick E, Siegel K, Goddard A, Nieves E, Pasa-Tolic L, Tanaka Y, Wang H, Morita CT, Oldfield E.

Chem Biol. 2006 Sep;13(9):985-92.


Calmodulin kinase II regulates the maturation and antigen presentation of human dendritic cells.

Herrmann TL, Morita CT, Lee K, Kusner DJ.

J Leukoc Biol. 2005 Dec;78(6):1397-407. Epub 2005 Oct 4.


fldA is an essential gene required in the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis.

Puan KJ, Wang H, Dairi T, Kuzuyama T, Morita CT.

FEBS Lett. 2005 Jul 4;579(17):3802-6.


Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption.

Sanders JM, Song Y, Chan JM, Zhang Y, Jennings S, Kosztowski T, Odeh S, Flessner R, Schwerdtfeger C, Kotsikorou E, Meints GA, Gómez AO, González-Pacanowska D, Raker AM, Wang H, van Beek ER, Papapoulos SE, Morita CT, Oldfield E.

J Med Chem. 2005 Apr 21;48(8):2957-63.


A crystallographic investigation of phosphoantigen binding to isopentenyl pyrophosphate/dimethylallyl pyrophosphate isomerase.

Wouters J, Yin F, Song Y, Zhang Y, Oudjama Y, Stalon V, Droogmans L, Morita CT, Oldfield E.

J Am Chem Soc. 2005 Jan 19;127(2):536-7.


Identification of guinea pig gammadelta T cells and characterization during pulmonary tuberculosis.

Xiong X, Morita CT, Bukowski JF, Brenner MB, Dascher CC.

Vet Immunol Immunopathol. 2004 Nov;102(1-2):33-44.


Synthesis of chiral phosphoantigens and their activity in gamma delta T cell stimulation.

Song Y, Zhang Y, Wang H, Raker AM, Sanders JM, Broderick E, Clark A, Morita CT, Oldfield E.

Bioorg Med Chem Lett. 2004 Sep 6;14(17):4471-7.


Quantitative structure-activity relationships for gammadelta T cell activation by bisphosphonates.

Sanders JM, Ghosh S, Chan JM, Meints G, Wang H, Raker AM, Song Y, Colantino A, Burzynska A, Kafarski P, Morita CT, Oldfield E.

J Med Chem. 2004 Jan 15;47(2):375-84.


Flexible migration program regulates gamma delta T-cell involvement in humoral immunity.

Brandes M, Willimann K, Lang AB, Nam KH, Jin C, Brenner MB, Morita CT, Moser B.

Blood. 2003 Nov 15;102(10):3693-701. Epub 2003 Jul 24.


Conservation of nonpeptide antigen recognition by rhesus monkey V gamma 2V delta 2 T cells.

Wang H, Lee HK, Bukowski JF, Li H, Mariuzza RA, Chen ZW, Nam KH, Morita CT.

J Immunol. 2003 Apr 1;170(7):3696-706.


CD1-mediated gamma/delta T cell maturation of dendritic cells.

Leslie DS, Vincent MS, Spada FM, Das H, Sugita M, Morita CT, Brenner MB.

J Exp Med. 2002 Dec 16;196(12):1575-84.


Adaptive immune response of Vgamma2Vdelta2+ T cells during mycobacterial infections.

Shen Y, Zhou D, Qiu L, Lai X, Simon M, Shen L, Kou Z, Wang Q, Jiang L, Estep J, Hunt R, Clagett M, Sehgal PK, Li Y, Zeng X, Morita CT, Brenner MB, Letvin NL, Chen ZW.

Science. 2002 Mar 22;295(5563):2255-8.


MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-dependent effector function.

Das H, Groh V, Kuijl C, Sugita M, Morita CT, Spies T, Bukowski JF.

Immunity. 2001 Jul;15(1):83-93.


Structural features of nonpeptide prenyl pyrophosphates that determine their antigenicity for human gamma delta T cells.

Morita CT, Lee HK, Wang H, Li H, Mariuzza RA, Tanaka Y.

J Immunol. 2001 Jul 1;167(1):36-41.


Superantigen recognition by gammadelta T cells: SEA recognition site for human Vgamma2 T cell receptors.

Morita CT, Li H, Lamphear JG, Rich RR, Fraser JD, Mariuzza RA, Lee HK.

Immunity. 2001 Mar;14(3):331-44.


Antigen recognition by human gamma delta T cells: pattern recognition by the adaptive immune system.

Morita CT, Mariuzza RA, Brenner MB.

Springer Semin Immunopathol. 2000;22(3):191-217. Review. No abstract available.


T cell receptor-dependent activation of human lymphocytes through cell surface ganglioside GT1b: implications for innate immunity.

Bukowski JF, Roncarolo MG, Spits H, Krangel MS, Morita CT, Brenner MB, Band H.

Eur J Immunol. 2000 Nov;30(11):3199-206.


Self-recognition of CD1 by gamma/delta T cells: implications for innate immunity.

Spada FM, Grant EP, Peters PJ, Sugita M, Melián A, Leslie DS, Lee HK, van Donselaar E, Hanson DA, Krensky AM, Majdic O, Porcelli SA, Morita CT, Brenner MB.

J Exp Med. 2000 Mar 20;191(6):937-48.


Recognition of nonpeptide prenyl pyrophosphate antigens by human gammadelta T cells.

Morita CT, Lee HK, Leslie DS, Tanaka Y, Bukowski JF, Märker-Hermann E.

Microbes Infect. 1999 Mar;1(3):175-86. Review. No abstract available.


Recognition of nonpeptide prenyl pyrophosphate antigens by human gammadelta T cells

Morita CT, Lee HK, Leslie DS, Tanaka Y, Bukowski JF, Marker-Hermann E.

Microbes Infect. 1999 Mar;1(3):175-86. No abstract available.


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