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Items: 11

1.

Using default methodologies to derive an acceptable daily exposure (ADE).

Faria EC, Bercu JP, Dolan DG, Morinello EJ, Pecquet AM, Seaman C, Sehner C, Weideman PA.

Regul Toxicol Pharmacol. 2016 Aug;79 Suppl 1:S28-38. doi: 10.1016/j.yrtph.2016.05.026. Epub 2016 May 24. Review.

PMID:
27233926
2.

Point of departure (PoD) selection for the derivation of acceptable daily exposures (ADEs) for active pharmaceutical ingredients (APIs).

Bercu JP, Morinello EJ, Sehner C, Shipp BK, Weideman PA.

Regul Toxicol Pharmacol. 2016 Aug;79 Suppl 1:S48-56. doi: 10.1016/j.yrtph.2016.05.028. Epub 2016 May 24. Review.

PMID:
27233925
3.

Interplay of dissolution, solubility, and nonsink permeation determines the oral absorption of the Hedgehog pathway inhibitor GDC-0449 in dogs: an investigation using preclinical studies and physiologically based pharmacokinetic modeling.

Wong H, Theil FP, Cui Y, Marsters JC Jr, Khojasteh SC, Vernillet L, La H, Song X, Wang H, Morinello EJ, Deng Y, Hop CE.

Drug Metab Dispos. 2010 Jul;38(7):1029-38. doi: 10.1124/dmd.110.032680. Epub 2010 Apr 20.

PMID:
20406853
4.

Absence of toxic effects in F344/N rats and B6C3F1 mice following subchronic administration of chromium picolinate monohydrate.

Rhodes MC, H├ębert CD, Herbert RA, Morinello EJ, Roycroft JH, Travlos GS, Abdo KM.

Food Chem Toxicol. 2005 Jan;43(1):21-9.

PMID:
15582192
5.

Molecular dosimetry and repair of N(2),3-ethenoguanine in rats exposed to vinyl chloride.

Morinello EJ, Ham AJ, Ranasinghe A, Nakamura J, Upton PB, Swenberg JA.

Cancer Res. 2002 Sep 15;62(18):5189-95.

6.

Differential induction of N(2),3-ethenoguanine in rat brain and liver after exposure to vinyl chloride.

Morinello EJ, Koc H, Ranasinghe A, Swenberg JA.

Cancer Res. 2002 Sep 15;62(18):5183-8.

7.

Methods for measuring DNA adducts and abasic sites II: methods for measurement of DNA adducts.

Swenberg JA, Ham AJ, Koc H, La DK, Morinello EJ, Pachkowski BF, Ranasinghe A, Upton PB.

Curr Protoc Toxicol. 2002 Aug;Chapter 3:Unit3.9. doi: 10.1002/0471140856.tx0309s12.

PMID:
23045080
8.

Methods for measuring DNA adducts and abasic sites I: isolation, purification, and analysis of DNA adducts in intact DNA.

Swenberg JA, Ham AJ, McDorman KS, Morinello EJ, Nakamura J, Schoonhoven R.

Curr Protoc Toxicol. 2002 Aug;Chapter 3:Unit3.8. doi: 10.1002/0471140856.tx0308s12.

PMID:
23045079
9.

Simultaneous quantitation of N(2),3-ethenoguanine and 1,N(2)-ethenoguanine with an immunoaffinity/gas chromatography/high-resolution mass spectrometry assay.

Morinello EJ, Ham AJ, Ranasinghe A, Sangaiah R, Swenberg JA.

Chem Res Toxicol. 2001 Mar;14(3):327-34.

PMID:
11258983
10.

Formation and repair of DNA adducts in vinyl chloride- and vinyl fluoride-induced carcinogenesis.

Swenberg JA, Bogdanffy MS, Ham A, Holt S, Kim A, Morinello EJ, Ranasinghe A, Scheller N, Upton PB.

IARC Sci Publ. 1999;(150):29-43. Review.

PMID:
10626206
11.

Immunoaffinity/gas chromatography/high-resolution mass spectrometry method for the detection of N(2),3-ethenoguanine.

Ham AJ, Ranasinghe A, Morinello EJ, Nakamura J, Upton PB, Johnson F, Swenberg JA.

Chem Res Toxicol. 1999 Dec;12(12):1240-6.

PMID:
10604874

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